Best TWAS P=1.68e-39 · Best GWAS P=8.64e-137 conditioned to 1.09e-57
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FTO | 0.11 | 0.00 | bslmm | 739 | 0.02 | 1.6e-03 | -0.2 | 12.8 | 1.6e-37 | 0.38 | 0.09 | 0.55 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | RBL2 | 0.22 | 0.24 | enet | 15 | 0.26 | 1.8e-31 | 4.6 | -5.8 | 5.6e-09 | 0.02 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | RBL2 | 0.34 | 0.28 | enet | 18 | 0.30 | 1.0e-24 | 4.7 | -5.3 | 8.8e-08 | 0.02 | 1.00 | 0.00 | FALSE |
4 | GTEx | Artery Tibial | RBL2 | 0.16 | 0.17 | enet | 11 | 0.20 | 2.1e-15 | 4.7 | -5.7 | 1.1e-08 | 0.02 | 1.00 | 0.00 | FALSE |
5 | GTEx | Brain Cortex | RBL2 | 0.51 | 0.45 | enet | 12 | 0.46 | 3.5e-14 | 4.5 | -5.9 | 3.9e-09 | 0.02 | 1.00 | 0.00 | FALSE |
6 | GTEx | Colon Sigmoid | RBL2 | 0.38 | 0.37 | lasso | 12 | 0.29 | 8.4e-11 | 4.7 | -5.4 | 7.6e-08 | 0.03 | 1.00 | 0.00 | FALSE |
7 | GTEx | Muscle Skeletal | RBL2 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.9e-01 | 6.3 | -9.2 | 3.5e-20 | -0.10 | 0.28 | 0.23 | FALSE |
8 | GTEx | Spleen | RBL2 | 0.59 | 0.47 | enet | 51 | 0.46 | 3.2e-13 | 4.7 | -5.7 | 1.0e-08 | -0.06 | 1.00 | 0.00 | FALSE |
9 | GTEx | Testis | AKTIP | 0.19 | 0.00 | enet | 26 | 0.00 | 1.9e-01 | 4.5 | 13.2 | 1.7e-39 | 0.51 | 0.03 | 0.40 | TRUE |
10 | GTEx | Vagina | RBL2 | 0.41 | 0.37 | enet | 13 | 0.34 | 1.6e-08 | 4.9 | -5.2 | 2.1e-07 | 0.03 | 0.89 | 0.01 | FALSE |
11 | YFS | Blood | AKTIP | 0.19 | 0.27 | lasso | 13 | 0.30 | 3.3e-99 | 6.9 | 6.1 | 1.3e-09 | -0.01 | 1.00 | 0.00 | FALSE |
12 | The Cancer Genome Atlas | Esophageal Carcinoma | RBL2 | 0.08 | 0.04 | lasso | 3 | 0.03 | 4.4e-02 | 6.9 | 5.4 | 5.4e-08 | 0.00 | 0.01 | 0.82 | FALSE |
13 | The Cancer Genome Atlas | Glioblastoma Multiforme | FTO | 0.27 | 0.16 | enet | 13 | 0.14 | 6.7e-05 | -3.1 | 10.7 | 7.0e-27 | 0.33 | 0.11 | 0.32 | TRUE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RBL2 | 0.03 | 0.06 | enet | 5 | 0.05 | 8.2e-07 | 4.5 | -5.3 | 1.0e-07 | 0.04 | 0.77 | 0.23 | FALSE |
15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBL2 | 0.11 | 0.08 | blup | 44 | 0.06 | 1.5e-03 | 6.4 | -6.1 | 1.1e-09 | -0.03 | 0.01 | 0.79 | FALSE |