Best TWAS P=3.41e-09 · Best GWAS P=1.21e-08 conditioned to 0.00385
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | AC012146.7 | 0.30 | 0.03 | enet | 23 | 0.03 | 7.6e-02 | 4.4 | -5.7 | 1.5e-08 | -0.45 | 0.08 | 0.26 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | DHX33 | 0.12 | 0.08 | lasso | 5 | 0.07 | 1.8e-03 | 5.7 | -5.4 | 7.5e-08 | -0.96 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | RABEP1 | 0.19 | -0.01 | lasso | 13 | 0.00 | 4.2e-01 | 4.5 | -5.5 | 3.1e-08 | -0.82 | 0.03 | 0.80 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | GP1BA | 0.35 | 0.16 | lasso | 11 | 0.18 | 5.9e-07 | 4.1 | 5.9 | 3.4e-09 | 0.56 | 0.23 | 0.63 | TRUE |
| 5 | GTEx | Esophagus Muscularis | RABEP1 | 0.13 | 0.09 | lasso | 10 | 0.10 | 2.1e-06 | 5.7 | -5.4 | 7.0e-08 | -0.94 | 0.02 | 0.98 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RPAIN | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.1e-08 | 5.7 | -5.9 | 4.4e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | RABEP1 | 0.23 | 0.13 | blup | 79 | 0.15 | 3.4e-05 | 4.6 | -5.6 | 2.1e-08 | -0.77 | 0.06 | 0.84 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GP1BA | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 4.5 | 5.3 | 1.2e-07 | 0.33 | 0.01 | 0.53 | FALSE |