Best TWAS P=1.9e-08 · Best GWAS P=4.45e-08 conditioned to 0.163
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | TRMT61B | 0.21 | 0.16 | lasso | 3 | 0.17 | 2.8e-06 | 4.5 | 5.2 | 1.6e-07 | 0.73 | 0.08 | 0.91 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | PPP1CB | 0.13 | 0.04 | lasso | 5 | 0.08 | 1.4e-10 | 5.5 | -5.3 | 1.4e-07 | -0.85 | 0.02 | 0.98 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PPP1CB | 0.04 | 0.02 | blup | 39 | 0.02 | 1.6e-04 | 5.5 | -5.4 | 5.5e-08 | -0.95 | 0.01 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | PPP1CB | 0.05 | 0.02 | blup | 39 | 0.03 | 4.7e-03 | 5.3 | -5.6 | 1.9e-08 | -0.84 | 0.02 | 0.92 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPP1CB | 0.04 | 0.04 | lasso | 1 | 0.03 | 9.8e-05 | -5.1 | -5.1 | 2.9e-07 | -0.77 | 0.04 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP1CB | 0.11 | 0.06 | lasso | 7 | 0.10 | 2.4e-10 | -5.1 | -5.1 | 2.8e-07 | -0.84 | 0.03 | 0.97 | FALSE |