Best TWAS P=5.83e-13 · Best GWAS P=4.83e-13 conditioned to 0.0138
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | -2.6 | 7.2 | 5.8e-13 | -0.51 | 0.13 | 0.54 | TRUE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOT1L | 0.09 | 0.08 | blup | 60 | 0.07 | 4.1e-04 | -5.1 | 5.8 | 6.4e-09 | 0.07 | 0.02 | 0.95 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOT1L | 0.08 | 0.12 | enet | 8 | 0.10 | 2.5e-11 | 5.2 | 5.5 | 3.4e-08 | 0.08 | 0.01 | 0.99 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ATP8B3 | 0.04 | 0.01 | blup | 49 | 0.02 | 2.2e-03 | -7.2 | -6.7 | 1.6e-11 | 0.84 | 0.00 | 0.76 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | KLF16 | 0.12 | 0.08 | bslmm | 372 | 0.08 | 1.0e-10 | -7.2 | -6.7 | 2.3e-11 | 0.85 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ATP8B3 | 0.06 | 0.00 | blup | 49 | 0.03 | 2.7e-04 | -1.9 | -5.9 | 3.8e-09 | 0.54 | 0.06 | 0.18 | FALSE |
| 2 | GTEx | Artery Tibial | DOT1L | 0.09 | 0.06 | lasso | 5 | 0.05 | 7.3e-05 | 5.2 | 5.4 | 5.7e-08 | 0.09 | 0.76 | 0.02 | FALSE |
| 3 | GTEx | Esophagus Muscularis | CTB-31O20.6 | 0.16 | 0.07 | lasso | 5 | 0.05 | 7.8e-04 | -5.1 | -5.2 | 2.0e-07 | 0.50 | 0.59 | 0.04 | FALSE |