Best TWAS P=1.04e-10 · Best GWAS P=1.14e-08 conditioned to 0.0609
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | CRELD1 | 0.19 | 0.12 | lasso | 4 | 0.10 | 4.1e-06 | -5.7 | -5.9 | 4.7e-09 | 0.91 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | RP11-1020A11.1 | 0.15 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -5.7 | -6.2 | 4.3e-10 | 0.91 | 0.02 | 0.76 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | CRELD1 | 0.25 | 0.19 | lasso | 6 | 0.18 | 2.2e-09 | -5.7 | -5.4 | 5.8e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | CRELD1 | 0.39 | 0.19 | enet | 39 | 0.28 | 4.5e-21 | -5.7 | -5.7 | 1.3e-08 | 0.79 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-1020A11.1 | 0.20 | 0.10 | enet | 67 | 0.09 | 1.9e-07 | -5.7 | -5.6 | 2.6e-08 | 0.66 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Esophagus Muscularis | CRELD1 | 0.21 | 0.10 | lasso | 1 | 0.08 | 1.7e-05 | -5.7 | -5.7 | 1.1e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | AC034193.5 | 0.15 | 0.09 | enet | 11 | 0.08 | 3.3e-05 | 4.7 | 5.3 | 1.3e-07 | -0.34 | 0.17 | 0.77 | FALSE |
| 8 | GTEx | Testis | CRELD1 | 0.22 | 0.22 | lasso | 8 | 0.26 | 1.1e-11 | 4.7 | -6.5 | 1.0e-10 | 0.67 | 0.10 | 0.90 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VHL | 0.03 | 0.00 | blup | 61 | 0.01 | 8.2e-02 | 4.6 | -5.3 | 1.4e-07 | 0.50 | 0.04 | 0.20 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | C3orf10 | 0.05 | 0.02 | blup | 49 | 0.04 | 9.3e-05 | 4.6 | -5.3 | 1.0e-07 | 0.48 | 0.17 | 0.79 | FALSE |