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chr4:55,517,005-57,110,821

Best TWAS P=1.84e-13 · Best GWAS P=5.39e-12 conditioned to 0.00483

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Colon Sigmoid	SRD5A3-AS1	0.16	0.14	enet	18	0.13	2.9e-05	6.8	7.4	1.8e-13	0.64	0.02	0.96	TRUE
2	GTEx	Adipose Subcutaneous	TMEM165	0.09	0.01	lasso	3	0.03	1.6e-03	6.8	-7.2	8.5e-13	-0.76	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM165	0.02	0.04	lasso	3	0.03	1.0e-07	6.8	-7.0	3.5e-12	-0.77	0.01	0.99	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	CLOCK	0.08	0.08	lasso	5	0.05	1.4e-03	6.8	6.8	1.4e-11	0.71	0.02	0.96	FALSE
32	METSIM	Adipose	TMEM165	0.07	0.07	enet	12	0.07	1.1e-10	6.8	-6.6	5.0e-11	-0.70	0.01	0.99	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	TMEM165	0.09	0.07	blup	404	0.08	4.9e-11	5.3	-6.5	7.1e-11	-0.67	0.58	0.42	FALSE
13	GTEx	Cells Transformed fibroblasts	SRD5A3-AS1	0.36	0.19	enet	52	0.30	1.2e-22	5.6	6.5	7.2e-11	0.57	0.06	0.94	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRD5A3	0.03	0.03	enet	4	0.05	3.1e-06	-5.4	6.4	1.3e-10	0.80	0.02	0.95	FALSE
22	GTEx	Nerve Tibial	CLOCK	0.14	0.06	lasso	4	0.10	1.6e-07	4.1	6.3	3.6e-10	0.71	0.07	0.93	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM165	0.19	0.16	lasso	4	0.17	2.1e-18	6.7	-6.2	4.8e-10	-0.65	0.00	1.00	FALSE
25	GTEx	Skin Sun Exposed Lower leg	CLOCK	0.07	0.05	lasso	5	0.07	3.5e-06	-5.4	6.2	5.5e-10	0.70	0.35	0.63	FALSE
14	GTEx	Colon Sigmoid	SRD5A3	0.34	0.18	enet	30	0.31	1.5e-11	5.6	6.1	8.1e-10	0.49	0.02	0.98	FALSE
16	GTEx	Esophagus Mucosa	CLOCK	0.12	0.11	enet	22	0.09	9.3e-07	5.6	6.1	1.2e-09	0.69	0.03	0.96	FALSE
17	GTEx	Esophagus Muscularis	TMEM165	0.07	0.04	lasso	2	0.02	1.7e-02	-6.1	-6.0	1.8e-09	-0.66	0.13	0.63	FALSE
28	GTEx	Spleen	TMEM165	0.17	0.13	enet	10	0.11	7.7e-04	5.3	-6.0	1.8e-09	-0.64	0.03	0.78	FALSE
7	GTEx	Brain Cortex	TMEM165	0.31	0.08	lasso	6	0.04	2.2e-02	5.3	-6.0	2.0e-09	-0.59	0.05	0.65	FALSE
6	GTEx	Artery Tibial	TMEM165	0.07	0.02	lasso	5	0.01	3.2e-02	-4.7	-6.0	2.4e-09	-0.67	0.10	0.78	FALSE
12	GTEx	Cells Transformed fibroblasts	SRD5A3	0.39	0.22	enet	51	0.36	2.9e-28	5.6	6.0	2.4e-09	0.52	0.22	0.78	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM165	0.22	0.20	enet	47	0.26	1.7e-31	5.3	-6.0	2.6e-09	-0.76	0.23	0.77	FALSE
21	GTEx	Nerve Tibial	TMEM165	0.18	0.22	enet	29	0.27	1.6e-19	5.2	-6.0	2.6e-09	-0.62	0.02	0.98	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	CLOCK	0.21	0.06	lasso	3	0.04	1.5e-02	-5.2	5.9	2.8e-09	0.65	0.11	0.41	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM165	0.06	0.07	enet	11	0.06	2.1e-04	6.8	-5.9	2.8e-09	-0.62	0.01	0.96	FALSE
19	GTEx	Lung	SRD5A3-AS1	0.19	0.07	enet	26	0.14	8.6e-11	5.3	5.8	5.6e-09	0.50	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	SRD5A3	0.04	0.03	lasso	4	0.02	1.0e-03	5.6	5.8	6.1e-09	0.67	0.02	0.95	FALSE
20	GTEx	Muscle Skeletal	SRD5A3-AS1	0.20	0.13	enet	25	0.20	1.4e-19	5.6	5.8	8.8e-09	0.54	0.09	0.91	FALSE
29	GTEx	Thyroid	SRD5A3-AS1	0.32	0.14	enet	56	0.21	1.1e-15	5.2	5.7	9.3e-09	0.54	0.08	0.92	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM165	0.12	0.08	enet	12	0.08	2.1e-08	6.7	-5.7	9.6e-09	-0.62	0.00	1.00	FALSE
18	GTEx	Lung	TMEM165	0.09	0.01	lasso	6	0.01	3.4e-02	5.1	-5.6	2.0e-08	-0.66	0.02	0.91	FALSE
33	NTR	Blood	CLOCK	0.02	0.01	lasso	2	0.01	5.4e-05	5.3	5.6	2.3e-08	0.62	0.02	0.98	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	SRD5A3	0.19	0.06	enet	21	0.13	5.9e-05	5.3	5.6	2.4e-08	0.64	0.03	0.92	FALSE
4	GTEx	Artery Aorta	SRD5A3	0.34	0.05	lasso	12	0.23	1.0e-12	4.1	5.5	2.8e-08	0.49	0.07	0.92	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM165	0.05	0.06	enet	5	0.05	4.3e-06	6.7	-5.5	4.2e-08	-0.56	0.01	0.99	FALSE
30	GTEx	Whole Blood	SRD5A3	0.37	0.19	enet	57	0.30	1.3e-27	5.6	5.5	4.7e-08	0.50	0.18	0.82	FALSE
8	GTEx	Breast Mammary Tissue	TMEM165	0.10	0.12	lasso	5	0.12	6.4e-07	5.3	-5.5	4.8e-08	-0.58	0.03	0.96	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	PDCL2	0.07	0.03	blup	50	0.02	5.4e-03	-4.4	-5.4	5.3e-08	-0.59	0.16	0.32	FALSE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRD5A3	0.12	0.07	lasso	2	0.06	4.2e-05	5.6	5.4	6.0e-08	0.58	0.03	0.81	FALSE
31	GTEx	Whole Blood	SRD5A3-AS1	0.33	0.17	lasso	9	0.21	4.1e-19	5.6	5.4	6.1e-08	0.55	0.18	0.82	FALSE
9	GTEx	Breast Mammary Tissue (Male)	TMEM165	0.18	0.11	lasso	10	0.11	1.4e-03	5.3	-5.3	9.6e-08	-0.57	0.04	0.78	FALSE
3	GTEx	Adipose Visceral Omentum	TMEM165	0.14	0.04	enet	20	0.06	3.3e-04	-1.0	-5.3	1.4e-07	-0.43	0.04	0.65	FALSE
27	GTEx	Small Intestine Terminal Ileum	SRD5A3-AS1	0.40	0.32	lasso	3	0.28	4.5e-07	5.3	5.2	1.5e-07	0.57	0.07	0.74	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRD5A3	0.21	0.14	lasso	4	0.14	2.6e-15	5.6	5.2	1.7e-07	0.59	0.61	0.39	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM165	0.03	0.01	blup	55	0.02	1.4e-03	6.7	-5.2	1.7e-07	-0.67	0.01	0.94	FALSE
26	GTEx	Small Intestine Terminal Ileum	SRD5A3	0.38	0.28	lasso	4	0.25	2.2e-06	5.3	5.2	2.1e-07	0.56	0.06	0.71	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRD5A3	0.04	0.03	blup	44	0.03	1.1e-04	6.8	5.1	2.8e-07	0.47	0.01	0.98	FALSE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRD5A3	0.26	0.12	lasso	6	0.10	7.0e-05	5.6	5.1	2.9e-07	0.56	0.05	0.87	FALSE
5	GTEx	Artery Aorta	TMEM165	0.10	0.00	lasso	3	0.00	7.5e-01	4.1	-5.1	3.0e-07	-0.59	0.06	0.42	FALSE
23	GTEx	Prostate	SRD5A3-AS1	0.32	0.14	enet	41	0.22	3.1e-06	5.6	5.1	3.0e-07	0.50	0.05	0.81	FALSE