Best TWAS P=3.34e-09 · Best GWAS P=3.22e-09 conditioned to 0.155
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | ROSMAP | Brain Pre-frontal Cortex | SGCB | 0.03 | 0.03 | enet | 9 | 0.03 | 7.0e-05 | 5.4 | 5.9 | 3.3e-09 | 0.89 | 0.04 | 0.95 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | DCUN1D4 | 0.02 | 0.03 | lasso | 1 | 0.02 | 8.2e-02 | 5.7 | 5.7 | 1.4e-08 | 0.99 | 0.02 | 0.21 | FALSE |
| 5 | GTEx | Thyroid | DCUN1D4 | 0.03 | 0.05 | lasso | 1 | 0.04 | 2.4e-04 | 5.7 | 5.7 | 1.4e-08 | 0.99 | 0.03 | 0.93 | FALSE |
| 3 | GTEx | Nerve Tibial | DCUN1D4 | 0.10 | 0.09 | lasso | 3 | 0.10 | 6.8e-08 | 5.0 | 5.5 | 3.0e-08 | 0.95 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Testis | DCUN1D4 | 0.19 | 0.17 | enet | 14 | 0.16 | 8.7e-08 | 5.3 | 5.4 | 6.4e-08 | 0.88 | 0.08 | 0.92 | FALSE |
| 1 | GTEx | Breast Mammary Tissue | DCUN1D4 | 0.08 | 0.02 | enet | 11 | 0.04 | 2.4e-03 | 5.7 | 5.3 | 1.2e-07 | 0.91 | 0.04 | 0.90 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | LRRC66 | 0.07 | 0.03 | lasso | 3 | 0.05 | 8.0e-04 | 4.9 | -5.2 | 2.5e-07 | -0.63 | 0.03 | 0.40 | FALSE |