Best TWAS P=7.02e-13 · Best GWAS P=1.12e-09 conditioned to 0.428
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BBS7 | 0.19 | 0.21 | bslmm | 423 | 0.23 | 1.8e-27 | -5.3 | -6.4 | 1.3e-10 | -0.70 | 0.15 | 0.85 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | EXOSC9 | 0.29 | 0.17 | lasso | 7 | 0.16 | 6.6e-06 | 5.2 | 5.7 | 9.8e-09 | 0.96 | 0.05 | 0.94 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | BBS7 | 0.16 | 0.09 | lasso | 7 | 0.16 | 2.9e-12 | -5.4 | -5.8 | 6.8e-09 | -0.83 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Testis | EXOSC9 | 0.17 | 0.07 | lasso | 8 | 0.10 | 2.5e-05 | -4.2 | 5.8 | 7.8e-09 | 0.80 | 0.04 | 0.95 | FALSE |
| 5 | YFS | Blood | EXOSC9 | 0.06 | 0.09 | bslmm | 401 | 0.09 | 7.0e-28 | 5.0 | 5.4 | 5.5e-08 | 0.94 | 0.08 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EXOSC9 | 0.03 | 0.04 | enet | 9 | 0.04 | 2.8e-08 | 6.0 | 6.3 | 3.4e-10 | 0.96 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | BBS7 | 0.05 | 0.00 | blup | 47 | 0.02 | 1.9e-02 | 6.1 | -5.8 | 5.7e-09 | -0.92 | 0.01 | 0.73 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCNA2 | 0.03 | 0.01 | blup | 34 | 0.02 | 1.5e-03 | -5.3 | 7.2 | 7.0e-13 | 0.78 | 0.02 | 0.90 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BBS7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 6.1e-04 | -5.3 | -5.3 | 1.4e-07 | -0.56 | 0.13 | 0.81 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EXOSC9 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.0e-03 | 5.0 | 5.6 | 2.5e-08 | 0.88 | 0.02 | 0.87 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | EXOSC9 | 0.04 | 0.05 | lasso | 2 | 0.04 | 7.1e-05 | 6.0 | 6.4 | 1.4e-10 | 0.96 | 0.00 | 0.99 | FALSE |