TWAS
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Models
Genes
Traits
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Traits
:
Hip circumference
:
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chr6:125,370,626-126,767,600
Best TWAS P=7.36e-10 · Best GWAS P=5.61e-10 conditioned to 1
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Testis
HEY2
0.31
0.17
lasso
5
0.19
7.4e-09
-6.2
-6.2
7.4e-10
1.00
0.00
1.00
TRUE
3
GTEx
Thyroid
HEY2
0.22
0.24
lasso
6
0.23
1.0e-17
-6.2
-6.0
2.2e-09
0.99
0.00
1.00
FALSE
1
CommonMind
Brain Pre-frontal Cortex
HEY2
0.15
0.20
lasso
10
0.21
6.7e-25
-5.9
-5.9
2.9e-09
0.98
0.01
0.99
FALSE
4
ROSMAP
Brain Pre-frontal Cortex
HEY2
0.10
0.12
enet
15
0.13
9.8e-17
5.7
-5.3
1.3e-07
0.97
0.01
0.99
FALSE