Best TWAS P=1.81e-10 · Best GWAS P=1.11e-13 conditioned to 3.91e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | GTEx | Brain Caudate basal ganglia | SLC22A3 | 0.15 | 0.10 | enet | 39 | 0.11 | 5.6e-04 | -6.8 | -6.4 | 1.8e-10 | -0.71 | 0.06 | 0.86 | TRUE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | SLC22A3 | 0.15 | 0.05 | lasso | 9 | 0.05 | 9.9e-04 | -4.4 | -6.2 | 4.0e-10 | -0.65 | 0.08 | 0.90 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | SLC22A3 | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.5e-02 | -4.5 | -6.0 | 2.3e-09 | -0.63 | 0.14 | 0.62 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | SLC22A3 | 0.29 | 0.14 | lasso | 10 | 0.20 | 3.7e-16 | 3.4 | -5.6 | 2.7e-08 | -0.48 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Nerve Tibial | SLC22A3 | 0.20 | 0.10 | lasso | 7 | 0.13 | 3.2e-09 | -5.1 | -5.5 | 3.1e-08 | -0.56 | 0.99 | 0.00 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC22A3 | 0.10 | 0.02 | blup | 582 | 0.05 | 4.4e-07 | -4.6 | -5.4 | 5.5e-08 | -0.63 | 0.70 | 0.29 | FALSE |