Best TWAS P=3.28e-12 · Best GWAS P=4.74e-09 conditioned to 0.093
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP9 | 0.11 | 0.10 | lasso | 4 | 0.09 | 1.6e-07 | -5.1 | -5.4 | 6.5e-08 | -0.47 | 0.23 | 0.77 | FALSE |
2 | GTEx | Adrenal Gland | RP9 | 0.19 | 0.16 | lasso | 6 | 0.14 | 1.3e-05 | -5.2 | -5.4 | 6.8e-08 | -0.44 | 0.07 | 0.93 | FALSE |
3 | GTEx | Artery Aorta | RP9P | 0.13 | 0.07 | lasso | 5 | 0.08 | 2.1e-05 | -5.1 | 5.7 | 1.2e-08 | 0.49 | 0.08 | 0.91 | FALSE |
4 | GTEx | Artery Tibial | RP9 | 0.16 | 0.05 | enet | 16 | 0.07 | 4.2e-06 | -5.1 | -7.0 | 3.3e-12 | -0.66 | 0.05 | 0.95 | TRUE |
5 | GTEx | Artery Tibial | RP9P | 0.13 | 0.14 | lasso | 2 | 0.13 | 1.6e-10 | -5.2 | 5.7 | 1.5e-08 | 0.43 | 0.20 | 0.80 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | FKBP9 | 0.27 | 0.26 | lasso | 7 | 0.27 | 9.8e-08 | -5.7 | 5.9 | 2.9e-09 | 0.52 | 0.02 | 0.96 | FALSE |
7 | GTEx | Brain Cerebellum | FKBP9 | 0.18 | 0.24 | lasso | 3 | 0.23 | 2.0e-07 | -5.7 | 5.7 | 1.2e-08 | 0.48 | 0.02 | 0.96 | FALSE |
8 | GTEx | Brain Nucleus accumbens basal ganglia | AVL9 | 0.32 | 0.03 | lasso | 12 | 0.15 | 9.0e-05 | -3.2 | -5.3 | 1.2e-07 | -0.17 | 0.09 | 0.17 | FALSE |
9 | GTEx | Brain Putamen basal ganglia | RP9 | 0.37 | 0.18 | lasso | 9 | 0.15 | 1.9e-04 | -5.7 | -6.1 | 8.3e-10 | -0.53 | 0.03 | 0.75 | FALSE |
10 | GTEx | Colon Sigmoid | RP9 | 0.17 | 0.09 | lasso | 3 | 0.12 | 6.8e-05 | -5.7 | -5.6 | 2.1e-08 | -0.44 | 0.04 | 0.91 | FALSE |
11 | GTEx | Esophagus Gastroesophageal Junction | RP9P | 0.15 | 0.13 | enet | 10 | 0.12 | 3.5e-05 | -5.4 | 6.0 | 1.5e-09 | 0.50 | 0.04 | 0.94 | FALSE |
12 | GTEx | Esophagus Mucosa | RP9 | 0.10 | 0.03 | lasso | 6 | 0.03 | 5.3e-03 | -5.1 | -5.1 | 2.9e-07 | -0.50 | 0.09 | 0.71 | FALSE |
13 | GTEx | Esophagus Mucosa | RP9P | 0.06 | 0.10 | lasso | 1 | 0.09 | 1.6e-06 | -5.2 | 5.2 | 2.2e-07 | 0.42 | 0.19 | 0.76 | FALSE |
14 | GTEx | Esophagus Muscularis | RP9 | 0.15 | 0.12 | lasso | 3 | 0.12 | 9.0e-08 | -5.7 | -5.7 | 1.6e-08 | -0.47 | 0.03 | 0.97 | FALSE |
15 | GTEx | Esophagus Muscularis | RP9P | 0.28 | 0.17 | enet | 16 | 0.19 | 8.8e-12 | -5.1 | 5.5 | 3.1e-08 | 0.55 | 0.16 | 0.84 | FALSE |
16 | GTEx | Lung | RP9P | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.5e-05 | -5.1 | 5.3 | 1.1e-07 | 0.41 | 0.21 | 0.76 | FALSE |
17 | GTEx | Muscle Skeletal | KBTBD2 | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.8e-04 | -5.1 | -5.1 | 3.0e-07 | -0.42 | 0.16 | 0.78 | FALSE |
18 | GTEx | Nerve Tibial | RP9 | 0.18 | 0.19 | lasso | 2 | 0.18 | 2.1e-12 | -5.1 | -5.4 | 8.1e-08 | -0.44 | 0.24 | 0.76 | FALSE |
19 | GTEx | Nerve Tibial | RP9P | 0.23 | 0.23 | lasso | 3 | 0.22 | 1.2e-15 | -5.2 | 5.2 | 1.5e-07 | 0.43 | 0.25 | 0.75 | FALSE |
20 | GTEx | Pituitary | FKBP9 | 0.38 | 0.13 | lasso | 4 | 0.24 | 7.5e-07 | -5.8 | 6.2 | 6.2e-10 | 0.81 | 0.02 | 0.93 | FALSE |
21 | GTEx | Pituitary | RP9 | 0.32 | 0.27 | lasso | 9 | 0.26 | 2.9e-07 | -5.7 | -5.7 | 1.4e-08 | -0.47 | 0.04 | 0.95 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | RP9P | 0.08 | 0.03 | lasso | 7 | 0.02 | 4.4e-03 | -5.2 | 5.7 | 1.5e-08 | 0.39 | 0.19 | 0.56 | FALSE |
23 | GTEx | Testis | RP9 | 0.23 | 0.16 | lasso | 5 | 0.24 | 7.7e-11 | -5.1 | -6.2 | 6.8e-10 | -0.83 | 0.03 | 0.97 | FALSE |
24 | ROSMAP | Brain Pre-frontal Cortex | RP9P | 0.22 | 0.20 | bslmm | 340 | 0.20 | 3.9e-25 | -5.2 | 5.2 | 1.6e-07 | 0.39 | 0.24 | 0.76 | FALSE |
25 | The Cancer Genome Atlas | Colon Adenocarcinoma | KBTBD2 | 0.10 | 0.06 | lasso | 3 | 0.05 | 4.7e-04 | 5.8 | -5.3 | 8.6e-08 | -0.81 | 0.00 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC441208 | 0.03 | 0.02 | blup | 24 | 0.02 | 3.9e-03 | -4.2 | -5.5 | 4.8e-08 | -0.52 | 0.02 | 0.81 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KBTBD2 | 0.04 | 0.03 | lasso | 1 | 0.03 | 6.8e-04 | 5.8 | -5.8 | 7.5e-09 | -0.82 | 0.00 | 0.94 | FALSE |