TWAS hub - KBTBD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1130	0.0520	7.3e-03	0.043	NA	0.025	NA	0.021	2.0e-03	NA	1.6e-02	NA	2.5e-02
2	GTEx	Muscle Skeletal	0.0545	0.0239	2.4e-03	0.051	NA	0.024	NA	0.036	9.9e-06	NA	1.8e-03	NA	1.8e-04
3	GTEx	Skin Sun Exposed Lower leg	0.1710	0.0570	6.2e-04	0.079	NA	0.053	NA	0.059	4.6e-07	NA	3.2e-05	NA	1.2e-05
4	GTEx	Spleen	0.4720	0.1250	1.2e-04	0.198	NA	0.072	NA	0.159	8.6e-06	NA	6.6e-03	NA	7.0e-05
5	GTEx	Thyroid	0.1090	0.0450	1.5e-03	0.057	NA	0.030	NA	0.029	3.5e-05	NA	2.1e-03	NA	2.7e-03
6	METSIM	Adipose	0.0893	0.0299	7.8e-06	0.043	0.048	0.042	0.050	0.044	4.7e-07	8.8e-08	6.6e-07	4.9e-08	3.5e-07
7	ROSMAP	Brain Pre-frontal Cortex	0.1174	0.0361	2.0e-06	0.086	0.060	0.096	0.072	0.103	3.1e-11	3.1e-08	2.4e-12	1.4e-09	4.1e-13
8	TCGA	Breast Invasive Carcinoma	0.0162	0.0091	1.3e-03	0.009	0.008	0.009	NA	0.008	5.2e-03	5.8e-03	5.4e-03	NA	6.1e-03
9	TCGA	Colon Adenocarcinoma	0.0960	0.0510	1.0e-04	0.059	0.051	0.047	NA	0.054	2.6e-04	6.3e-04	9.8e-04	NA	4.7e-04
10	TCGA	Lung Squamous Cell Carcinoma	0.0559	0.0328	6.6e-03	0.009	0.004	-0.001	NA	0.005	3.3e-02	9.7e-02	4.4e-01	NA	7.2e-02
11	TCGA	Prostate Adenocarcinoma	0.0374	0.0209	2.9e-03	0.031	0.023	0.018	NA	0.027	3.0e-04	1.7e-03	4.6e-03	NA	6.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Eye problems/disorders: Diabetes related eye disease	8.1	8.9	22.1	2.8	-1.1	2.7	2.7	3.3	3.1	4.0	2.5	2.2	4.7	2.0
Reaction Time	6.5	12.5	26.9	2.9	2.3	2.2	1.8	2.3	3.4	4.2	4.5	4.1	5.2	4.2
Chronotype (morning person)	5.2	12.0	25.9	2.4	2.7	2.6	3.2	2.2	3.0	3.0	4.7	4.9	2.6	5.1
Ever depressed for a whole week	4.9	6.0	10.7	-2.8	-0.5	-2.6	-2.9	-2.8	-1.7	-2.3	-3.3	-2.9	-0.3	-2.8
Mean Putamen Volume	4.8	5.5	8.9	2.6	-0.1	2.7	2.8	2.8	3.0	2.4	2.2	2.4	0.6	2.3
Bipolar Disorder (2011)	4.7	4.5	10.0	1.6	-0.2	2.6	3.2	1.8	2.3	2.4	2.0	2.5	1.0	2.4
Serious illness, injury or assault of a close relative in last 2 years	4.7	5.4	8.7	-2.7	-0.6	-2.2	-2.0	-2.0	-2.9	-2.4	-3.0	-2.6	-1.6	-2.5
Tinnitus: Yes, but not now, but have in the past	4.5	4.9	9.7	-1.9	-0.8	-2.4	-2.6	-2.0	-1.3	-1.9	-3.1	-3.0	0.1	-3.0
Qualifications: None of the above	4.2	9.0	14.2	3.5	0.5	2.4	1.6	2.7	3.6	3.2	3.8	3.4	3.3	3.3
Had major operations	4.1	4.8	8.9	-1.9	2.0	-2.4	-2.5	-2.4	-2.1	-2.6	-2.0	-1.3	-3.0	-1.1
Myopia	4.1	6.0	10.2	-2.3	0.3	-3.0	-3.2	-2.7	-2.0	-2.8	-2.6	-2.8	-0.6	-2.7
Mean time to correctly identify matches	3.9	7.5	19.7	2.1	2.9	0.7	0.3	1.1	2.5	2.9	3.5	3.2	4.4	3.4
Peak expiratory flow (PEF)	3.8	8.7	18.3	-1.7	-1.8	-2.1	-2.4	-2.0	-2.8	-2.6	-4.1	-4.2	-2.9	-4.3
Pulse wave Arterial Stiffness index	3.7	4.3	7.1	2.7	-0.5	2.1	1.9	1.6	2.3	2.6	2.4	1.8	2.3	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.3	8.5	1.6	0.5	1.9	1.1	1.2	2.3	2.9	2.7	2.5	2.2	2.5
Depression (self-reported)	3.6	4.3	9.1	-1.6	-0.8	-2.1	-2.9	-1.6	-1.3	-1.7	-2.4	-3.0	0.4	-3.0
Severe depression (siblings)	3.4	3.8	8.5	-1.3	-2.0	-0.8	-1.2	-0.0	-2.7	-1.2	-2.5	-2.7	-1.7	-2.9
Qualifications: A levels/AS levels or equivalent	3.2	7.0	14.8	-2.2	0.8	-2.7	-2.0	-2.2	-3.9	-3.1	-3.0	-2.4	-3.5	-2.1
Illnesses of mother	3.1	3.9	8.6	2.2	-1.2	2.9	1.7	2.1	1.7	2.7	1.4	1.6	1.8	1.4
Happiness	3.0	3.6	7.1	-1.9	-0.3	-1.1	-1.2	-1.9	-2.7	-1.6	-2.3	-2.0	-2.5	-2.0
Medication for cholesterol	3.0	4.6	9.0	-1.9	-0.1	-2.5	-1.7	-2.4	-1.6	-1.9	-3.0	-2.7	-1.9	-2.5
Ever had prostate specific antigen (PSA) test	3.0	3.4	6.6	-2.2	-0.4	-2.1	-1.4	-1.9	-1.4	-2.0	-2.6	-2.2	-1.0	-2.1
Waist Hip Ratio (WHR)	2.9	12.9	26.5	3.8	3.2	2.3	3.5	2.9	3.4	2.0	4.8	5.0	1.0	5.2
Ever had hysterectomy (womb removed)	2.9	3.3	7.3	1.3	0.7	2.1	1.6	1.9	0.9	1.2	2.5	2.7	-0.0	2.7
Heart disease (mother)	2.9	3.5	6.4	-2.1	0.3	-1.8	-1.8	-2.1	-2.5	-1.9	-1.9	-1.9	-1.8	-1.8
Hip circumference	2.8	12.1	33.4	-2.7	-5.1	-1.5	-2.8	-0.7	-2.4	-1.4	-4.3	-5.3	0.7	-5.8
Pulse wave peak to peak time	2.8	3.3	5.3	-2.3	0.4	-1.7	-1.6	-1.3	-2.1	-2.3	-2.1	-1.6	-2.2	-1.5
Current tobacco smoking	2.7	4.4	5.9	2.3	-0.4	2.3	1.8	2.4	2.3	2.4	2.0	2.4	1.9	2.2
Diverticular disease/diverticulitis (self-reported)	2.7	3.3	7.8	1.1	1.6	1.0	0.9	1.0	2.2	1.1	2.8	2.4	2.0	2.5
Overall health rating	2.7	5.8	16.2	0.8	-0.4	2.6	1.4	1.7	2.9	2.8	2.7	2.5	4.0	2.4
Medication: Aspirin	2.7	3.6	7.2	-2.7	-0.5	-1.9	-2.2	-2.1	-1.2	-1.6	-2.4	-2.1	-0.5	-2.1
Maternal smoking around birth	2.6	3.8	8.1	1.6	-0.8	2.9	2.5	1.8	2.1	2.0	2.5	1.7	0.9	1.6
Smoking status: Current	2.6	4.1	5.7	2.2	-0.6	2.2	1.7	2.4	2.2	2.3	2.0	2.2	1.7	2.1
Friendships satisfaction	2.5	3.1	5.8	-2.2	-1.1	-1.2	-1.2	-1.5	-2.4	-1.9	-1.8	-2.0	-1.3	-2.1
Alcohol usually taken with meals	2.4	3.9	9.3	-1.6	0.4	-2.4	-2.1	-1.6	-1.7	-3.0	-1.9	-2.2	-1.7	-2.0
Number of live births	2.4	3.3	5.4	1.7	0.1	2.1	1.5	1.1	2.1	2.1	2.1	2.3	1.5	2.3
Exposure to tobacco smoke at home	2.4	2.7	4.7	1.6	-0.2	2.2	1.8	1.9	1.3	1.9	1.9	1.7	0.8	1.6
Glaucoma (self-reported)	2.4	2.9	8.7	-1.1	-1.0	-1.6	-1.6	-1.4	-0.7	-1.0	-1.8	-2.9	0.5	-3.0
Irritability	2.4	4.1	10.8	-1.6	-2.6	-0.9	-1.8	-0.8	-1.0	-1.6	-2.8	-3.0	-0.3	-3.3
Neuroticism	2.3	5.5	11.8	-1.6	0.4	-3.1	-3.4	-2.7	-1.0	-2.1	-3.0	-2.8	0.1	-2.6
Qualifications: College or University degree	2.3	7.4	13.0	-3.6	-2.0	-1.4	-1.5	-1.6	-3.6	-2.6	-3.3	-2.7	-3.4	-2.8
Medication: Aspirin	2.3	3.0	5.4	-2.3	-0.6	-1.7	-2.1	-1.9	-1.0	-1.4	-2.1	-2.1	-0.2	-2.1
Fractured/broken bones in last 5 years	2.3	3.0	5.3	-1.6	0.1	-2.1	-2.1	-2.3	0.2	-1.7	-2.3	-2.1	0.3	-1.9
Blood Red Count	2.0	19.2	29.8	-5.4	-0.5	-5.2	-4.8	-4.4	-3.2	-4.5	-5.5	-5.1	-1.4	-4.8
Serious illness, injury or assault to yourself	2.0	2.5	5.0	-1.4	-0.3	-1.7	-2.1	-1.3	-0.9	-1.3	-1.9	-2.2	0.4	-2.2
Exposure to tobacco smoke outside home	2.0	2.7	5.7	1.2	0.5	1.6	0.8	1.6	1.8	1.5	2.4	1.8	2.2	1.8
Sensitivity / hurt feelings	1.9	3.3	6.0	-0.9	-0.5	-2.4	-2.2	-1.9	-0.7	-1.8	-2.5	-2.5	-0.2	-2.4
Diabetes (mother)	1.9	2.4	8.6	-2.9	-0.6	-0.9	-1.1	-1.4	-1.1	-1.5	-1.7	-1.4	-1.9	-1.5
Sitting height	1.9	13.2	33.2	4.6	-3.9	5.5	4.5	5.8	1.4	3.9	2.2	1.5	-0.2	0.8
Mouth/teeth dental problems	1.9	2.9	7.6	-1.2	-0.5	-1.8	-1.6	-1.4	-0.7	-1.3	-2.0	-2.8	-0.4	-2.8
Pain all over the body in last month	1.9	2.0	5.2	2.2	-0.0	1.6	1.5	1.7	0.8	1.2	2.3	1.1	-0.5	1.1
Neuroticism score	1.9	4.0	7.7	-1.4	-0.3	-2.4	-2.8	-2.2	-1.0	-2.0	-2.6	-2.5	-0.1	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	4.5	1.2	-1.0	1.8	2.1	1.5	2.0	2.0	1.2	0.6	1.3	0.5
Pulse rate, automated reading	1.9	6.0	13.5	2.5	-0.4	3.1	2.3	3.2	1.3	2.2	3.7	2.8	0.5	2.6
Financial situation satisfaction	1.9	2.4	3.9	-1.7	0.2	-1.7	-1.9	-2.0	-1.9	-1.5	-1.5	-1.4	-0.9	-1.4
Angina	1.8	2.3	17.1	0.1	-0.1	0.4	0.1	0.1	1.8	2.2	0.4	0.5	4.1	0.4
Body mass index (BMI)	1.8	7.8	15.9	-2.8	-1.7	-2.8	-3.5	-1.9	-1.8	-2.3	-3.4	-3.9	1.0	-4.0
Age at first live birth	1.8	3.2	9.2	-1.3	1.6	-1.5	-1.3	-1.9	-2.7	-2.1	-1.3	-0.6	-3.0	-0.4
Mother’s age at death	1.8	2.2	4.5	-1.7	1.3	-1.7	-1.6	-2.1	-2.0	-1.0	-1.2	-1.4	-0.6	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	6.3	-1.7	0.0	-1.9	-2.5	-1.4	-1.2	-1.5	-1.9	-1.7	0.1	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.2	-0.5	-1.9	-1.0	-0.8	-0.4	-2.0	-1.1	-1.8	-1.8	-0.2	-2.0
Medication: Bendroflumethiazide	1.7	2.6	5.4	1.7	-1.0	1.6	1.3	2.3	1.6	2.1	1.2	0.9	2.3	0.9
Unable to work because of sickness or disability	1.7	2.2	4.8	1.2	-0.5	1.8	1.0	1.5	1.1	2.2	1.7	1.7	1.4	1.6
Neuroticism (Nagel 2018)	1.6	3.8	7.1	-1.6	-0.0	-2.4	-2.7	-1.9	-1.3	-1.8	-2.6	-2.3	-0.0	-2.2
Worry (Nagel 2018)	1.6	3.4	8.0	-1.3	0.8	-2.8	-2.4	-2.3	-1.3	-2.0	-2.0	-2.0	0.2	-1.7
BMI	1.6	9.5	19.7	-3.4	-1.8	-3.1	-3.5	-2.0	-1.6	-2.2	-4.1	-4.3	1.0	-4.4
Age when periods started (menarche)	1.6	3.8	8.6	2.0	-0.5	2.9	1.8	2.2	1.2	2.4	1.0	2.5	0.7	2.4
Alcohol intake versus 10 years previously	1.6	2.4	4.8	0.9	0.0	2.0	1.2	1.0	1.5	2.2	1.5	1.9	1.7	1.9
Number of children fathered	1.6	1.8	7.0	2.6	-0.5	1.0	1.4	2.4	0.3	0.9	1.7	0.5	0.3	0.4
Commuting to job workplace: Cycle	1.6	2.0	4.1	1.1	-0.9	2.0	2.0	2.0	0.9	1.2	1.3	1.5	-0.4	1.3
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.7	-1.1	1.4	-2.1	-2.2	-1.8	-0.5	-1.8	-1.2	-1.1	0.3	-0.8
Intelligence (Savage-Jansen 2018)	1.5	4.7	11.0	-2.6	-0.5	-2.2	-1.5	-1.6	-2.9	-3.3	-1.9	-2.2	-1.6	-2.2
Schizophrenia vs Biploar Disorder	1.5	2.0	4.5	-2.1	0.8	-1.4	-1.3	-1.6	-1.1	-1.6	-1.4	-1.4	-1.0	-1.3
Arm fat percentage (right)	1.5	5.8	12.1	-2.7	-2.6	-1.9	-2.4	-1.1	-1.2	-1.0	-2.7	-3.3	2.5	-3.5
Worrier / anxious feelings	1.5	2.7	4.9	-1.9	0.5	-2.2	-1.8	-1.7	-1.5	-2.0	-1.8	-1.5	-1.2	-1.4
Medication: Cholesterol lowering	1.5	2.3	4.3	-1.4	0.3	-2.1	-1.9	-2.0	-0.9	-0.8	-1.7	-1.9	0.5	-1.7
Commuting to job workplace: Car/motor vehicle	1.5	1.7	5.3	-0.5	0.5	-1.3	-1.0	-1.6	-1.2	-1.5	-1.3	-1.1	-2.3	-1.0
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	4.0	2.0	0.1	1.5	1.7	1.1	1.5	1.4	1.3	1.5	0.3	1.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.6	-1.6	-1.9	-0.8	-1.0	-0.6	-1.0	-0.8	-1.5	-2.0	0.3	-2.1
Leg fat percentage (left)	1.5	5.4	11.2	-2.7	-0.8	-2.5	-3.3	-1.8	-1.6	-1.9	-2.2	-3.0	1.2	-3.0
Height	1.4	26.1	58.7	7.7	-3.3	6.7	6.5	7.0	2.5	5.0	5.2	3.6	-1.0	3.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.2	-1.1	0.1	-0.8	-1.8	-1.4	-1.8	-1.2	-1.6	-1.4	-0.7	-1.3
Leg fat percentage (right)	1.4	5.0	10.5	-2.6	-1.2	-2.3	-3.2	-1.6	-1.5	-1.8	-2.0	-2.9	1.4	-2.9
Suffer from ‘nerves’	1.4	2.2	5.0	-1.1	1.0	-2.1	-2.2	-2.1	-0.7	-1.2	-1.4	-1.2	1.1	-1.0
Illnesses of father: High blood pressure	1.4	1.7	3.5	1.0	-1.7	1.6	1.7	1.8	1.9	1.1	0.2	0.6	0.7	0.4
Leg fat mass (left)	1.4	5.5	12.6	-2.2	-1.9	-2.1	-2.9	-1.2	-1.5	-1.7	-2.7	-3.4	0.8	-3.5
Chronic bronchitis/emphysema (father)	1.3	1.6	5.1	-2.3	-0.3	-0.9	-0.9	-1.0	-0.2	-0.4	-1.9	-1.6	0.2	-1.6
Mouth/teeth dental problems: Dentures	1.3	2.2	4.2	1.4	0.6	1.6	1.5	1.5	1.5	1.5	2.0	1.4	1.4	1.4
Impedance of arm (left)	1.3	6.0	13.9	1.5	-1.0	2.8	3.7	2.4	2.8	2.9	2.3	2.3	2.1	2.1
Standing height	1.3	12.7	26.8	5.0	-3.1	4.9	4.8	5.2	1.8	3.7	2.7	1.9	-0.9	1.4
Angina (self-reported)	1.3	1.7	14.3	-0.3	0.5	-0.2	-0.5	-0.4	1.1	1.6	0.1	0.2	3.8	0.2
Knee pain experienced in last month	1.3	2.0	9.7	-0.1	-0.2	0.6	0.6	0.2	2.8	1.6	0.2	0.5	3.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	4.2	-1.0	0.4	-1.9	-2.1	-1.4	-0.2	-0.9	-1.1	-1.4	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.3	1.8	-1.7	2.5	2.2	2.2	1.2	2.0	0.8	1.0	0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	5.4	-1.4	2.3	-1.3	-1.2	-1.6	-1.6	-1.5	0.3	1.0	-1.3	1.3
Eye problems/disorders: Glaucoma	1.3	1.6	5.3	-0.6	-0.6	-1.1	-1.2	-1.1	0.1	-0.7	-1.4	-2.2	0.4	-2.3
Medication: Blood pressure	1.3	2.5	5.4	1.2	0.2	1.5	1.6	1.9	0.4	1.2	2.0	2.3	0.9	2.3
Impedance of whole body	1.3	6.7	12.3	1.8	0.6	2.6	3.5	2.1	2.3	2.8	3.2	3.3	1.4	3.2
HDL Cholesterol	1.2	2.0	3.5	-1.7	-0.3	-0.9	-0.8	-1.4	-1.5	-1.4	-1.9	-1.7	-1.3	-1.7
Neuroticism (2016)	1.2	1.7	4.7	-0.7	0.4	-2.1	-2.2	-1.6	-1.0	-1.3	-1.6	-0.8	-0.8	-0.6
Smoking Status	1.2	2.8	5.8	2.0	-1.5	2.1	1.6	2.4	1.9	1.6	1.3	1.5	0.5	1.2
Father’s age at death	1.2	1.7	4.6	-0.9	-1.9	-0.5	-0.1	0.1	-0.9	-0.7	-2.1	-1.9	-0.6	-2.0
Hair/balding pattern: Pattern 3	1.2	1.7	2.9	-1.5	0.3	-1.3	-1.1	-1.6	-1.0	-1.6	-1.4	-1.2	-1.7	-1.2
Length of working week for main job	1.2	1.3	4.6	0.8	-0.8	1.3	1.9	1.4	2.1	0.8	0.8	0.2	0.1	0.0
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.9	-2.2	-0.2	-0.8	-0.2	-1.5	-1.8	-1.6	-1.5	-1.2	-1.7	-1.1
Blood clot in the leg (DVT)	1.2	1.6	7.8	-0.3	-2.8	0.4	0.8	0.7	1.1	-0.4	-0.5	-1.6	0.6	-2.0
Leg fat mass (right)	1.2	4.8	11.6	-2.0	-2.2	-1.7	-2.7	-0.9	-1.3	-1.4	-2.3	-3.2	1.1	-3.4
Arm fat percentage (left)	1.2	5.0	11.0	-2.5	-2.7	-1.5	-2.1	-1.0	-0.6	-0.9	-2.5	-3.1	2.4	-3.3
Stomach or abdominal pain in last month	1.1	1.4	6.2	-0.3	2.5	-1.3	-1.1	-1.4	-0.2	-0.7	0.8	0.9	1.0	1.2
Medication: Ramipril	1.1	1.4	3.4	-1.8	-1.1	-0.8	-1.3	-0.4	-1.3	-1.0	-1.7	-1.1	-0.3	-1.2
Arm fat mass (right)	1.1	4.5	11.8	-1.8	-2.6	-1.4	-2.1	-0.6	-1.2	-1.0	-2.5	-3.2	1.4	-3.4
Gout (self-reported)	1.1	1.5	4.9	-0.0	-2.2	0.7	0.9	1.3	0.9	1.1	-0.2	-1.2	1.7	-1.4
Qualifications: nursing, teaching	1.1	1.8	6.2	-1.1	-0.5	-0.5	-0.7	-0.5	-1.8	-1.2	-1.1	-1.5	-2.5	-1.6
Tinnitus: Yes, now most or all of the time	1.1	1.2	2.9	-1.6	-0.0	-1.1	-1.4	-0.6	-1.3	-1.7	-1.0	-0.5	-1.2	-0.5
Cholesterol lowering medication	1.1	1.7	3.4	0.8	0.0	1.3	1.1	0.9	0.9	1.4	1.5	1.9	1.5	1.8
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	6.4	-0.1	-2.5	0.4	0.8	0.6	1.1	-0.3	-0.4	-1.5	0.8	-1.8
Depressed Affect (Nagel 2018)	1.0	2.2	5.0	-1.2	0.2	-1.4	-2.2	-1.2	-1.4	-1.3	-2.1	-1.7	-0.8	-1.6
Medication for hormone replacement therapy	1.0	1.1	3.2	1.3	-0.1	1.8	0.8	1.7	0.7	0.6	1.2	1.0	-0.4	0.8
Impedance of leg (right)	1.0	4.7	10.8	1.2	1.6	1.8	2.3	1.2	1.3	1.9	3.3	3.3	0.4	3.3
Impedance of arm (right)	1.0	4.6	10.2	1.0	-1.0	2.3	3.2	2.3	1.8	2.8	2.0	2.1	2.4	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	6.4	-0.3	-1.7	0.1	-0.3	-0.1	0.6	1.3	-0.9	-1.0	2.5	-1.1
Comparative height size at age 10	1.0	5.3	12.6	3.2	-2.5	3.4	2.6	3.5	1.1	2.4	1.9	0.8	-0.5	0.4
Average weekly red wine intake	1.0	1.5	2.6	-0.9	-1.6	-0.9	-0.9	-1.1	-1.3	-1.4	-1.3	-1.5	-0.4	-1.6
Medication: Gliclazide	1.0	1.2	5.2	0.5	1.5	-0.3	0.0	-0.1	0.9	1.1	0.5	1.1	2.3	1.3
Arm fat mass (left)	1.0	4.1	10.7	-1.9	-2.7	-1.2	-1.9	-0.5	-1.0	-0.9	-2.3	-3.1	1.5	-3.3
Miserableness	1.0	1.8	3.5	-1.6	-0.2	-1.4	-1.9	-0.9	-1.0	-1.7	-1.7	-1.2	-1.0	-1.2
Medication: Lisinopril	1.0	1.3	3.3	1.3	-0.7	1.3	1.8	1.5	0.8	1.5	0.8	0.7	0.7	0.6
Ever smoked	1.0	1.7	3.2	1.0	-0.8	1.7	1.4	1.8	1.0	1.4	1.2	1.2	1.4	1.1
Bipolar Disorder (2018)	0.9	1.4	2.6	1.4	-0.4	1.4	1.6	1.2	0.9	1.6	0.9	1.1	0.4	1.1
Depression (Nagel 2018)	0.9	1.4	5.3	-1.5	2.3	-0.9	-1.2	-1.5	-1.2	-1.1	-0.0	0.4	-0.4	0.6
Lupus	0.9	1.4	2.8	1.5	-0.1	1.0	1.7	1.6	1.4	0.9	0.9	1.2	0.8	1.1
Heel T-Score	0.9	7.3	13.7	1.5	-0.1	2.9	2.6	2.2	1.9	3.0	3.5	3.2	3.7	3.1
Medication: Co-codamol	0.9	1.1	2.4	-0.8	0.5	-1.5	-1.5	-0.9	-0.2	-0.7	-1.1	-1.1	1.2	-0.9
Multivitamins +/- minerals	0.9	1.1	2.9	-0.8	-0.2	-1.1	-1.2	-0.9	-1.5	-0.2	-1.7	-1.4	-0.2	-1.3
High blood pressure (mother)	0.9	1.2	3.3	-1.0	1.0	-1.8	-1.1	-1.2	-1.1	-1.1	-1.1	-1.0	0.7	-0.8
Impedance of leg (left)	0.9	4.4	10.8	1.1	1.9	1.6	2.3	1.0	1.2	1.8	3.0	3.2	0.3	3.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.2	1.3	-1.4	1.3	1.5	1.3	0.3	0.7	0.6	1.1	-0.1	0.8
Number of full brothers	0.9	1.2	2.9	0.8	0.0	1.7	0.7	1.1	1.2	0.9	1.4	1.3	0.5	1.3
Medication for pain relief, constipation, heartburn	0.9	1.6	3.5	1.9	0.9	1.0	1.7	1.2	0.1	0.5	1.8	1.3	-0.9	1.3
Mood swings	0.9	1.6	4.4	-0.4	-1.4	-0.7	-1.4	-0.2	-0.4	-0.9	-2.0	-1.9	-0.3	-2.1
Loneliness, isolation	0.9	1.3	2.9	-1.3	0.4	-1.2	-1.6	-1.1	-0.6	-0.5	-1.7	-1.1	1.0	-1.0
Bipolar Disorder or Schizophrenia	0.8	2.1	4.9	1.4	-0.3	1.1	1.3	1.0	2.2	2.1	0.9	1.1	2.0	1.1
Blood Platelet Count	0.8	8.8	19.8	-4.5	-1.0	-2.5	-2.0	-2.5	-3.6	-2.8	-3.6	-3.1	-2.7	-3.1
Relative age voice broke	0.8	1.2	3.0	-0.2	1.1	-1.6	-1.3	-1.7	-0.9	-0.6	-1.1	-0.8	-0.8	-0.6
Nervous feelings	0.8	1.4	4.1	-0.6	0.3	-1.9	-2.0	-1.5	-0.6	-1.1	-1.3	-1.0	0.7	-0.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.7	0.3	-1.4	1.6	1.4	0.8	0.0	1.3	0.6	1.1	0.3	1.0
Hair/balding pattern: Pattern 4	0.8	1.8	4.5	1.9	-0.8	0.4	1.3	1.3	2.0	1.5	1.2	-0.1	2.1	-0.3
High blood pressure (siblings)	0.8	1.2	2.6	-0.8	-0.7	-1.1	-1.0	-0.6	-0.5	-1.5	-1.2	-1.6	0.6	-1.6
Comparative body size at age 10	0.8	2.3	4.7	-1.4	-1.4	-1.7	-1.4	-1.1	-1.1	-0.6	-1.5	-2.1	1.5	-2.2
Migraine (self-reported)	0.8	1.0	3.2	-0.5	0.7	-1.1	-1.0	-1.0	-0.9	-1.8	-0.7	-0.4	-1.6	-0.3
Medication: Ibuprofen	0.8	1.0	1.9	-1.4	-1.1	-0.5	-1.0	-1.0	-0.9	-0.5	-1.3	-1.2	0.2	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.4	-1.6	-0.8	-0.0	-0.9	-1.0	-0.6	-1.1	-0.5	-0.9	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.4	-1.6	0.9	-1.2	-0.8	-1.5	-1.1	-1.8	-1.2	-0.8	-2.1	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	3.5	0.2	0.6	-0.9	-1.2	-0.6	-1.6	-1.5	-0.5	-0.7	-1.9	-0.7
Ever taken oral contraceptive pill	0.8	0.9	7.0	-0.4	0.2	0.2	-0.7	-0.9	-0.7	-1.0	0.2	-0.1	-2.6	-0.1
Medication: Paracetamol	0.8	1.3	4.4	-2.1	0.1	-0.8	-1.3	-0.8	-0.3	-0.3	-1.7	-0.9	1.6	-0.8
Medication: Atorvastatin	0.8	1.0	3.3	-0.5	1.8	-1.2	-1.5	-0.9	-0.1	-0.3	0.3	0.7	1.2	0.9
Heart disease (siblings)	0.8	1.0	4.3	2.1	1.4	0.4	0.3	0.1	0.9	0.5	1.3	0.8	0.7	0.8
Past tobacco smoking	0.7	1.2	2.6	-1.2	1.0	-1.6	-1.2	-1.6	-0.8	-0.9	-1.0	-0.8	-0.7	-0.7
Hearing difficulty/problems with background noise	0.7	1.2	3.7	-0.2	1.2	-1.7	-1.9	-1.5	-0.6	-1.3	-0.2	-0.5	-0.2	-0.3
Weight	0.7	3.4	10.5	-0.4	-3.2	-0.4	-1.2	0.6	-0.8	-0.5	-2.1	-3.0	0.7	-3.2
Falls in the last year	0.7	0.9	3.2	1.7	0.6	-0.4	-0.1	1.0	0.6	0.8	0.9	0.5	1.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.1	-1.2	-1.8	0.0	-0.7	-0.4	-0.8	-0.3	-1.3	-1.0	0.2	-1.2
Lung cancer (father)	0.7	0.9	2.2	0.3	-1.0	1.4	0.9	1.0	1.0	1.5	0.2	0.7	0.6	0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.5	1.1	0.4	0.9	1.1	1.0	-0.2	-0.3	1.1	1.4	-1.9	1.4
Forced vital capacity (FVC), Best measure	0.7	2.5	7.7	1.7	-1.4	2.5	2.8	1.7	0.3	1.1	0.7	0.6	-2.0	0.4
Body fat percentage	0.7	2.9	6.6	-1.8	-2.1	-1.1	-1.8	-0.5	-0.7	-0.7	-1.6	-2.4	2.0	-2.6
Wheeze or whistling in the chest in last year	0.7	1.3	6.9	1.3	-0.4	0.8	0.3	1.3	0.7	1.1	0.9	0.8	2.6	0.7
Eye problems/disorders: None of the above	0.7	0.9	4.6	1.0	0.5	0.5	1.0	0.7	0.1	-0.6	0.5	0.8	-2.1	0.8
Neck or shoulder pain in last month	0.7	1.0	3.7	-0.1	-0.4	-0.8	-1.0	-0.2	0.4	-0.6	-0.3	-1.5	1.9	-1.6
Medication: Allopurinol	0.7	1.0	2.8	0.7	-1.1	0.4	0.7	1.3	1.2	1.0	0.5	-0.7	1.7	-0.9
Whole body fat mass	0.7	2.9	8.1	-1.0	-2.6	-0.8	-1.6	0.0	-0.8	-0.6	-1.7	-2.6	1.4	-2.9
Family relationship satisfaction	0.7	0.9	2.1	-1.4	-0.3	-0.5	-0.3	-0.9	-1.2	-0.7	-1.2	-1.0	-1.1	-1.0
High cholesterol (Self-reported)	0.7	1.2	3.1	0.2	1.6	-0.3	0.1	-0.1	1.2	0.7	1.2	1.6	1.4	1.8
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	1.3	-1.0	0.7	0.9	1.2	1.4	0.8	0.4	-0.2	0.4	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	2.6	1.6	0.6	-0.1	-0.2	0.3	1.6	-0.3	1.2	1.0	0.1	0.9
Coronary Artery Disease (CAD)	0.6	0.7	2.4	0.2	0.3	-1.2	-1.1	-0.4	-1.6	-0.8	-0.6	-0.8	0.1	-0.7
Number of treatments/medications taken	0.6	1.1	4.0	-0.5	-1.0	-0.4	-1.1	-0.7	0.4	0.6	-0.7	-1.4	2.0	-1.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.3	-0.7	1.5	-0.7	-0.9	-1.2	-1.2	-0.9	-0.1	0.1	-1.2	0.2
Supplements: Zinc	0.6	0.6	2.2	-0.7	0.4	-0.7	-1.1	-0.9	-0.4	-0.5	-1.5	-0.6	-0.7	-0.5
Hand grip strength (right)	0.6	1.5	9.8	0.5	-0.8	1.6	1.2	1.0	-0.2	0.5	0.2	0.7	-3.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	2.2	-1.3	1.5	-0.2	-0.8	-1.1	-0.8	-1.0	0.3	0.4	-0.6	0.5
Taking other prescription medications	0.6	0.9	1.9	-0.4	-0.2	-1.1	-1.4	-0.9	-0.6	-0.5	-0.5	-1.3	1.3	-1.2
Waist circumference	0.6	2.2	5.9	-0.9	-2.4	-0.6	-1.1	0.4	-0.2	-0.5	-1.6	-2.2	1.6	-2.4
Forced vital capacity (FVC)	0.6	2.3	11.4	1.1	-1.5	2.0	2.0	1.2	-0.8	0.1	-0.1	0.2	-3.4	0.0
Time employed in main current job	0.6	0.6	1.6	-0.6	-1.3	0.6	0.8	0.8	1.0	0.1	-0.4	-0.5	-1.1	-0.8
Pulse wave reflection index	0.6	0.7	1.9	0.3	0.7	0.7	0.7	0.0	0.9	0.8	0.9	1.4	0.1	1.4
Medication: Paracetamol	0.6	1.1	3.2	-1.7	-1.0	-0.6	-1.1	-0.2	0.1	-0.3	-1.8	-0.8	1.3	-0.9
Medication: Blood pressure	0.6	1.1	3.4	-1.1	-1.2	-0.5	-0.7	-0.3	0.5	0.5	-1.2	-1.2	1.8	-1.3
Eye problems/disorders: Cataract	0.6	0.7	5.0	0.1	-0.6	0.3	-0.2	-0.3	0.3	1.4	0.0	0.1	2.2	0.1
Illnesses of father: None of the above (group 1)	0.6	0.8	2.4	-1.5	0.1	-0.4	-1.0	-1.3	-1.3	-0.7	-0.3	-0.4	-0.8	-0.4
Schizophrenia (2018)	0.5	1.1	5.0	0.8	-0.1	0.3	0.4	0.3	1.9	1.3	0.4	0.6	2.2	0.5
Fasting Glucose	0.5	0.6	2.1	-1.4	-0.8	-0.4	-0.6	0.5	-0.1	-0.4	-0.7	-1.1	-0.4	-1.2
Schizophrenia (2014)	0.5	1.1	3.5	1.0	-0.4	0.6	0.1	0.6	1.9	1.5	0.3	0.5	1.8	0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	1.1	-0.5	0.5	0.4	0.2	1.3	1.2	-0.0	0.1	1.3	0.1
Lung FVC	0.5	2.7	10.8	-2.4	-0.1	-0.4	-0.4	-1.9	-1.5	-1.9	-1.1	-0.9	-3.3	-0.8
Hand grip strength (left)	0.5	1.2	9.0	-0.4	-0.5	0.5	0.3	-0.0	-1.7	-0.6	-0.9	-0.1	-3.0	-0.2
Diabetes (father)	0.5	0.6	4.6	-0.6	0.0	-0.1	-0.7	0.4	0.2	0.6	-0.2	0.2	2.1	0.1
Trunk fat percentage	0.5	1.9	6.2	-1.0	-2.5	-0.2	-0.8	0.3	-0.1	0.0	-1.0	-1.7	2.2	-2.0
Townsend deprivation index at recruitment	0.5	0.7	2.2	-0.4	1.0	-0.6	-1.5	-0.4	-0.7	-0.6	1.1	0.8	0.7	0.8
Supplements: Glucosamine	0.5	0.7	1.7	-1.0	0.5	-0.7	-0.7	-1.3	0.1	-1.1	-0.6	-0.7	-1.1	-0.6
Medication: Atenolol	0.5	0.6	3.5	0.2	1.2	-0.8	-0.2	-0.1	0.0	-0.1	0.4	0.4	1.9	0.6
Trunk fat mass	0.5	2.2	8.6	-0.6	-2.9	-0.0	-0.8	0.6	-0.2	0.1	-1.2	-2.1	1.9	-2.4
Had other major operations	0.5	0.6	1.8	-1.3	-0.7	-0.1	-0.6	-0.2	-0.9	-0.4	-1.3	-0.5	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	10.4	0.3	-1.3	1.1	1.0	0.3	-1.4	-0.4	-0.9	-0.6	-3.2	-0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.9	0.5	0.1	-0.6	-0.9	-0.9	-0.4	-0.6	-0.5	-1.4	-0.5	-1.4
Medication: Seretide 50 evohaler	0.5	0.6	2.1	-0.2	-0.2	-0.7	-0.5	-0.6	-1.5	-0.7	-0.5	-1.1	-0.6	-1.1
Alcohol intake frequency.	0.5	1.1	4.5	0.8	0.2	0.5	0.0	0.8	1.0	2.0	0.2	0.7	2.1	0.7
Commuting to job workplace: Walk	0.5	0.6	1.4	0.4	0.5	0.6	0.5	0.7	0.6	0.5	1.1	1.2	0.3	1.2
Breast cancer (self-reported)	0.5	0.6	1.6	0.9	1.2	0.1	-0.2	-0.0	-0.1	0.3	1.0	1.0	0.4	1.2
Leg predicted mass (right)	0.5	2.4	9.7	0.7	-3.1	0.5	-0.4	1.2	-0.6	-0.1	-1.8	-2.2	-0.4	-2.5
Guilty feelings	0.5	0.8	2.2	-0.7	0.3	-1.2	-1.0	-1.3	-0.5	-0.2	-1.5	-0.8	0.6	-0.7
Age started oral contraceptive pill	0.5	0.6	1.7	-1.3	-0.8	-0.2	-0.6	-0.6	-0.7	-0.7	-0.4	-0.7	-1.1	-0.7
Pain experienced in last month	0.5	0.8	6.1	0.4	-0.8	0.2	0.7	0.4	-1.0	-0.6	-0.3	0.1	-2.5	0.0
Supplements: Calcium	0.5	0.6	1.3	-0.9	-0.3	-0.3	-0.7	-1.1	-1.0	-0.8	-0.4	-0.9	-0.6	-0.9
Alcohol drinker status: Previous	0.5	0.6	1.8	0.4	-1.3	0.9	0.8	1.2	-0.1	1.1	-0.5	-0.0	0.1	-0.2
Alzheimer’s Disease (in father)	0.4	0.4	1.2	0.9	-0.5	-0.5	-0.4	-0.1	0.3	-0.7	-0.2	-0.8	-1.1	-0.8
Crohns Disease (2017)	0.4	1.0	2.7	1.7	-0.4	0.5	1.3	0.6	0.3	1.4	1.3	0.0	1.3	-0.0
Major Depression (MDD)	0.4	0.5	3.1	0.1	0.7	0.0	-0.4	0.0	0.2	0.5	0.6	0.6	1.8	0.7
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	0.3	0.4	-1.1	-0.9	-0.3	0.1	-0.6	-0.6	-1.0	0.7	-0.9
Ulcerative Colitis	0.4	0.6	2.5	-0.5	1.6	-0.1	0.4	-0.7	-0.5	-0.1	0.4	0.6	-1.3	0.9
Blood Eosinophil Count	0.4	2.8	6.8	-2.6	-1.1	-1.1	-1.5	-1.0	-2.3	-1.8	-1.9	-1.3	-1.4	-1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	-0.4	-1.2	0.3	0.3	0.8	-0.2	1.2	-0.3	-0.8	1.6	-0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.2	-0.2	1.1	0.2	0.6	0.1	0.1	1.0	1.1	-1.1	1.0
Leg fat-free mass (left)	0.4	2.3	10.5	0.9	-3.2	0.6	-0.3	1.4	-0.3	0.1	-1.5	-2.0	-0.1	-2.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	-0.5	-0.1	0.8	0.6	0.4	0.4	0.6	1.0	1.0	-0.0	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.4	-0.1	0.7	0.5	0.8	0.6	0.4	0.3	1.2	1.2	1.5	1.2
Qualifications: CSEs or equivalent	0.4	0.6	1.3	1.1	0.8	-1.0	-1.0	-0.4	0.1	-0.3	-0.4	-1.0	0.0	-0.9
Leg predicted mass (left)	0.4	2.4	10.6	0.8	-3.2	0.6	-0.3	1.4	-0.2	0.1	-1.5	-2.0	-0.1	-2.4
Had menopause	0.4	0.4	1.3	-0.3	0.7	0.3	0.5	-0.0	0.2	-0.2	1.1	1.1	-0.6	1.1
Heart attack	0.4	0.5	2.4	-1.1	0.4	-0.4	-0.8	-0.3	-0.1	0.1	-0.3	-0.4	1.6	-0.3
Allergy	0.4	0.8	2.4	-1.1	1.2	-0.8	-1.1	-1.5	-1.1	-0.2	-0.7	-0.6	-0.5	-0.5
Fluid intelligence score	0.4	0.8	4.5	-1.3	-0.7	0.5	0.3	-0.2	-2.1	-0.8	0.3	-0.2	-1.1	-0.2
Illnesses of siblings	0.4	0.6	1.6	-0.3	0.8	0.4	0.6	-0.3	0.0	0.4	0.5	1.2	-1.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.9	-1.4	0.8	-0.0	-1.2	-0.6	-0.7	-0.5	0.3	1.0	0.2	1.0
Prospective memory result	0.4	0.5	2.0	-0.5	0.2	-0.6	-0.8	-1.0	1.4	-0.1	-0.9	-0.1	0.0	-0.2
Tense / ‘highly strung’	0.4	0.7	1.7	0.8	0.3	-1.3	-1.3	-0.6	0.0	-0.3	-0.7	-0.7	1.3	-0.7
Birth weight of first child	0.4	0.7	4.0	-0.1	2.0	-0.4	0.1	-0.5	0.1	-0.4	0.3	0.9	-0.8	1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.5	-0.1	0.7	-0.6	-1.1	-0.3	-1.0	-1.0	-0.2	0.4	-1.2	0.5
Health satisfaction	0.4	0.5	2.1	-0.7	0.7	-0.4	-0.7	-0.9	-1.1	-0.0	-0.2	-0.4	1.5	-0.3
Shortness of breath walking on level ground	0.4	0.4	2.1	0.1	-1.4	0.1	-0.9	0.3	-0.4	-0.2	-0.3	-0.7	0.6	-0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.3	-0.6	-0.2	0.9	0.6	0.2	-0.4	0.3	0.6	1.1	0.3	1.0
Emphysema/chronic bronchitis	0.4	0.5	1.5	0.4	0.5	0.2	0.1	0.2	0.9	1.2	0.6	0.5	1.2	0.6
Leg fat-free mass (right)	0.4	2.4	9.2	0.6	-3.0	0.4	-0.5	1.1	-0.6	-0.2	-1.8	-2.2	-0.4	-2.5
Back pain experienced in last month	0.4	0.6	3.4	0.4	1.2	-0.2	-0.4	-0.3	0.8	0.4	0.5	0.3	1.8	0.4
Osteoarthritis (self-reported)	0.4	0.5	2.1	0.3	1.4	-0.2	0.0	-0.4	-0.1	-0.6	0.5	0.5	-1.4	0.7
Number of self-reported non-cancer illnesses	0.4	0.7	4.4	0.3	-1.1	-0.6	-0.6	0.2	0.3	-0.2	-0.0	-0.6	2.1	-0.8
Alcohol drinker status: Never	0.4	0.5	1.7	0.9	0.4	0.2	-0.1	0.6	0.0	1.3	0.4	0.5	1.3	0.6
Basal metabolic rate	0.4	2.0	7.2	0.7	-2.7	0.3	-0.6	1.0	-0.9	-0.1	-1.5	-2.1	-0.5	-2.3
Average weekly beer plus cider intake	0.4	0.6	1.4	-1.0	-0.4	-0.6	-0.8	-0.8	-0.7	-0.8	-1.0	-0.6	-1.2	-0.6
Risk taking	0.4	0.6	3.2	-0.3	-1.8	0.7	-0.1	-0.3	-0.2	0.5	-0.7	-0.8	-0.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.9	-1.4	0.3	-0.5	-0.9	-0.4	-0.1	-0.0	-0.6	-0.5	1.4	-0.4
Breast Cancer	0.3	0.6	1.3	-1.0	-1.1	0.1	0.1	0.1	0.5	0.3	-1.2	-0.9	0.9	-1.1
Ovarian Cancer	0.3	0.4	1.9	1.0	0.1	0.0	-0.3	0.6	-0.2	0.9	-0.3	-0.5	1.4	-0.5
Crohns Disease (2012)	0.3	0.5	1.5	0.1	0.2	-1.2	-0.1	-0.9	-1.1	-0.6	-0.3	-1.0	-0.3	-0.9
HbA1C	0.3	0.4	1.1	1.1	-0.4	0.9	0.9	0.7	0.1	0.4	0.8	-0.1	-0.2	-0.1
Rheumatoid Arthritis	0.3	0.4	1.0	0.6	-0.1	-0.9	-0.7	-0.1	-0.6	-0.7	-0.4	-1.0	0.1	-1.0
Triglycerides	0.3	0.5	2.8	0.3	0.9	-0.6	-0.7	-0.1	0.1	0.3	0.9	0.4	1.7	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.2	0.4	-1.1	1.0	0.0	0.5	0.6	0.2	0.3	-0.3	0.4	-0.5
Medication: Metformin	0.3	0.4	1.7	-0.1	-0.5	0.6	0.1	0.5	-0.9	1.2	0.5	0.0	1.3	-0.0
Average weekly fortified wine intake	0.3	0.3	1.9	0.7	-0.3	0.2	0.6	0.1	-0.5	-0.2	-0.1	-0.3	-1.4	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.5	1.0	-1.6	0.7	0.8	1.2	0.5	0.3	-0.1	-0.1	-0.5	-0.3
Medication: Levothyroxine sodium	0.3	0.6	2.9	0.3	0.9	-1.1	-0.4	-0.5	0.2	-0.7	0.6	-0.3	1.7	-0.1
Number of incorrect matches in round	0.3	0.5	1.6	-0.6	0.8	-0.7	-1.1	-1.3	0.5	-0.0	-0.3	-0.7	0.3	-0.6
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	-0.0	-1.2	0.7	-0.5	0.8	-0.1	0.7	-0.3	0.2	0.8	0.0
Financial difficulties in last 2 years	0.3	0.4	1.4	0.3	0.9	-0.5	-0.9	-0.9	-1.2	-0.2	0.3	0.2	-0.2	0.4
Diabetes (self-reported)	0.3	0.4	2.2	-1.1	0.2	-0.0	-0.4	-0.1	-0.6	0.9	0.1	0.1	1.5	0.1
Medication: Simvastatin	0.3	0.4	1.3	-0.9	-0.3	-0.4	-0.1	-0.6	-0.1	0.3	-0.6	-0.9	1.1	-0.8
Trunk fat-free mass	0.3	1.5	4.2	1.2	-2.1	0.4	-0.3	1.1	-1.1	-0.0	-1.0	-1.6	-1.2	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.2	0.7	-1.3	1.6	1.8	0.8	-0.1	0.8	-0.3	-0.1	-1.6	-0.3
Trunk predicted mass	0.3	1.4	4.1	1.2	-2.0	0.5	-0.3	1.1	-1.2	0.0	-0.9	-1.5	-1.2	-1.7
Headache pain in last month	0.3	0.5	2.0	-0.2	1.4	-0.9	-1.0	-0.2	-0.0	-0.5	-0.2	0.6	0.5	0.8
Medication: Amlodipine	0.3	0.5	1.2	1.0	0.1	0.5	-0.2	0.0	-0.9	-0.0	0.8	1.1	-0.3	1.1
Number of full sisters	0.3	0.4	1.9	0.9	0.4	-0.1	1.4	0.7	0.9	-0.2	0.6	0.2	-0.0	0.2
Chest pain or discomfort	0.3	0.4	1.6	0.6	-0.0	0.5	0.1	0.4	0.5	0.7	1.3	0.6	0.8	0.5
Leg pain on walking	0.3	0.4	1.5	-1.2	-1.1	0.8	-0.4	0.2	-0.5	0.6	-0.3	0.2	0.7	0.1
Supplements: Vitamin C	0.3	0.4	1.1	1.0	-0.5	0.1	0.1	-0.2	-0.5	0.4	0.2	-1.0	-0.2	-1.0
Illnesses of father: Heart disease	0.3	0.4	1.5	0.7	-1.2	0.3	0.8	1.0	-0.4	-0.2	0.0	-0.4	-0.2	-0.5
Whole body fat-free mass	0.3	1.8	6.2	0.9	-2.5	0.4	-0.5	1.1	-0.9	-0.1	-1.3	-1.8	-1.0	-2.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	0.3	1.1	0.0	0.5	0.1	0.1	-0.5	0.4	0.7	-0.7	0.8
Long-standing illness, disability or infirmity	0.3	0.5	1.7	-0.3	-0.7	-0.3	-0.6	-0.1	-0.6	-0.2	-0.1	-1.1	1.3	-1.1
Ever had bowel cancer screening	0.3	0.3	1.2	1.1	-0.3	0.3	0.1	0.5	1.0	0.2	0.8	0.1	0.2	0.1
Diabetes diagnosed by doctor	0.3	0.5	2.7	-0.9	-0.4	0.0	-0.2	0.3	-0.6	1.1	-0.0	-0.4	1.6	-0.4
Mineral and other dietary supplements	0.3	0.4	1.1	-1.0	-0.3	-0.5	-0.5	-0.3	-1.0	-0.7	-0.8	-0.6	0.1	-0.6
Osteoporosis (self-reported)	0.3	0.3	0.9	0.4	-0.9	0.9	0.5	0.3	0.5	0.9	0.4	-0.1	0.4	-0.2
Whole body water mass	0.3	1.7	5.9	1.1	-2.4	0.4	-0.4	1.1	-0.9	-0.0	-1.2	-1.8	-0.9	-2.0
Hearing aid user	0.3	0.3	1.3	-0.5	-0.5	-0.1	-0.7	0.1	-1.1	-0.7	-0.4	-0.3	-0.5	-0.3
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.9	-0.2	-0.4	-0.2	0.2	-0.4	-0.5	-0.9	-0.8	-0.4	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.0	1.0	1.0	-0.4	0.3	-0.1	0.4	-0.3	0.6	0.4	-0.7	0.6
Arm fat-free mass (left)	0.3	1.4	3.8	0.8	-1.9	0.1	-0.8	0.9	-1.2	-0.4	-0.9	-1.7	-1.1	-1.9
Number of operations (self-reported)	0.3	0.4	0.9	-1.0	0.3	-0.3	-1.0	-0.4	-0.7	-0.8	-0.2	0.0	-0.8	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	7.6	-0.2	0.5	-0.2	-0.1	-0.9	-0.7	-1.0	-0.0	-0.4	-2.8	-0.4
Arm predicted mass (left)	0.3	1.5	3.2	0.9	-1.8	0.1	-0.8	0.8	-1.5	-0.5	-1.1	-1.6	-1.4	-1.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	0.5	-0.1	0.1	0.2	0.1	1.0	-0.6	0.5	0.4	-0.3	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	0.8	0.7	0.3	1.0	-0.2	-0.4	1.0	1.2	0.3	0.3	0.5
Ulcerative Colitis (UC)	0.2	0.4	1.4	-0.2	1.2	0.2	0.5	-0.6	-0.7	0.2	0.5	0.5	-0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.4	-0.7	0.1	0.3	0.2	-0.2	-1.5	-0.9	0.6	0.4	-0.9	0.5
Prostate Cancer	0.2	0.3	1.2	0.0	1.1	-0.5	0.0	-0.4	-0.4	-0.5	-0.7	-0.4	-0.0	-0.3
Age at First Birth	0.2	0.3	0.6	-0.6	-0.2	-0.8	0.6	-0.4	-0.5	-0.5	-0.7	-0.7	-0.3	-0.6
LDL Cholesterol	0.2	0.3	1.5	0.6	0.6	-0.4	-0.6	-0.1	0.0	0.4	0.7	-0.0	1.2	0.0
Primary Biliary Cirrhosis	0.2	0.3	1.0	0.1	0.8	-0.0	-0.1	-0.2	0.5	0.2	0.5	0.9	-0.3	1.0
Allergy or Eczema	0.2	0.5	1.3	0.8	-1.0	-0.0	-0.3	0.2	0.0	-0.5	-0.6	-0.8	-1.2	-0.9
Cardiovascular Disease	0.2	0.7	2.8	0.1	-0.9	0.8	0.5	1.0	0.5	0.9	0.3	0.6	1.7	0.4
Lung FEV1/FVC ratio	0.2	0.9	2.3	0.2	-0.3	1.5	0.8	0.3	0.7	1.5	1.4	1.1	0.1	1.0
Average weekly spirits intake	0.2	0.2	1.1	-0.1	-0.4	-0.4	-0.5	-0.2	-0.2	0.6	-0.1	-0.5	1.1	-0.6
High blood pressure	0.2	0.5	4.3	-0.2	-0.4	-0.1	-0.2	0.6	0.3	0.4	-0.3	0.3	2.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.4	-0.5	1.2	-0.3	0.4	0.1	0.3	-0.8	0.5	0.6	0.8	0.6
Pulse rate	0.2	0.4	1.3	1.1	-0.6	0.9	0.5	0.9	0.3	0.7	0.5	0.1	-0.0	0.1
Noisy workplace	0.2	0.2	0.9	0.1	0.4	0.1	0.3	0.3	0.9	0.3	-0.1	0.3	0.9	0.2
Medication: Lansoprazole	0.2	0.3	1.1	-0.8	-0.4	-0.1	-0.3	-0.3	0.7	0.5	-0.2	-0.1	1.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.3	1.1	0.7	-0.2	0.6	0.1	0.3	-0.5	0.9	0.2	1.0	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	-0.4	0.8	0.1	0.5	-0.1	0.1	0.4	0.9	0.4	0.2	0.5
Arm fat-free mass (right)	0.2	1.1	3.1	1.2	-1.8	0.5	-0.2	0.9	-0.5	-0.2	-0.8	-1.3	-1.4	-1.4
Worry too long after embarrassment	0.2	0.3	1.2	-0.6	-0.8	0.0	-0.5	-0.2	0.5	0.3	-0.2	-0.1	1.1	-0.2
Medication: Omeprazole	0.2	0.3	0.8	0.0	0.4	-0.5	-0.7	-0.3	0.7	-0.5	-0.2	-0.3	0.9	-0.2
Arm predicted mass (right)	0.2	1.1	3.4	1.3	-1.9	0.7	-0.1	1.1	-0.4	-0.1	-0.6	-1.1	-1.6	-1.3
Age at last live birth	0.2	0.4	1.7	-0.2	0.3	-0.0	0.2	-0.4	-1.2	-0.4	-0.7	-0.2	-1.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.8	0.1	-0.9	0.3	0.6	0.3	0.5	0.3	-0.5	-0.4	0.5	-0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.1	0.4	-0.2	-0.5	-0.3	0.6	0.3	-0.4	-0.7	0.7	-0.6
Wears glasses or contact lenses	0.2	0.2	0.7	0.5	-0.2	0.8	0.3	0.5	-0.3	-0.3	0.4	-0.0	-0.8	-0.0
Blood White Count	0.1	0.8	3.1	-1.0	-0.7	-0.5	-1.0	0.4	0.5	-0.4	-1.8	-1.1	0.4	-1.1
Systolic Blood Pressure	0.1	0.4	1.5	-0.3	-1.2	0.6	0.2	1.1	-1.0	-0.0	-0.1	0.0	0.1	-0.2
Hypothyroidism (self reported)	0.1	0.2	0.9	0.9	0.9	-0.4	0.4	0.0	0.3	-0.5	0.5	0.0	0.0	0.2
Respiratory disease	0.1	0.2	0.6	-0.6	-0.0	-0.2	-0.8	-0.1	0.1	-0.3	-0.7	-0.4	-0.5	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.3	0.0	-0.6	-0.6	-0.3	-0.0	-0.6	0.1	-0.6	0.1	-0.5
Relative age of first facial hair	0.1	0.1	0.5	0.4	0.5	-0.4	-0.4	-0.7	-0.4	-0.1	-0.3	-0.1	-0.0	0.0
Systolic blood pressure, automated reading	0.1	0.3	0.7	0.3	0.4	0.1	-0.2	0.4	-0.8	-0.7	0.8	0.7	-0.6	0.7
Vitamin and mineral supplements	0.1	0.2	0.8	-0.6	0.3	-0.2	-0.2	0.0	0.2	-0.9	0.1	0.3	-0.6	0.2
Pack years adult smoking proportion	0.1	0.2	1.0	0.0	0.3	0.2	-0.4	0.2	0.2	0.6	0.2	0.2	1.0	0.2
Fed-up feelings	0.1	0.1	0.5	0.7	-0.3	0.1	-0.1	0.1	-0.2	0.4	-0.3	-0.4	0.3	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	0.1	-0.2	0.5	0.5	0.1	0.1	0.6	0.2	0.5	0.1	0.4
Asthma	0.1	0.2	0.5	0.3	-0.1	0.3	0.1	0.6	0.4	-0.0	0.7	0.7	0.5	0.7
Breastfed as a baby	0.1	0.2	0.9	0.2	-0.3	0.5	0.9	0.4	-0.3	0.2	-0.4	0.3	-0.5	0.2
Loud music exposure frequency	0.1	0.1	0.4	-0.7	-0.7	0.0	-0.3	0.2	-0.3	-0.2	-0.2	-0.2	0.1	-0.4
Birth weight	0.1	0.3	0.8	-0.1	0.9	0.1	-0.0	0.1	-0.4	-0.3	0.7	0.7	-0.2	0.9
Hypertension (Self-reported)	0.1	0.4	3.2	-0.3	-0.3	-0.2	-0.4	0.5	0.1	0.2	-0.2	0.3	1.8	0.3
Smoking status: Previous	0.1	0.1	0.5	0.7	0.0	0.5	0.3	0.6	-0.0	-0.3	0.5	0.2	-0.2	0.3
Asthma (self-reported)	0.1	0.3	0.8	0.2	0.1	0.4	0.2	0.5	0.4	0.0	0.8	0.9	0.3	0.9
Diastolic blood pressure, automated reading	0.1	0.3	1.6	1.3	0.3	-0.0	0.0	0.8	0.3	-0.1	0.9	0.3	0.4	0.3
Pack years of smoking	0.1	0.2	0.7	-0.2	0.6	-0.1	-0.8	-0.0	-0.1	0.2	0.2	0.2	0.7	0.2
Hair Pigment	0.0	0.7	3.6	1.9	-1.4	0.4	0.2	1.0	0.8	0.1	0.0	-0.4	-0.7	-0.5
Tanning	0.0	0.5	1.3	-0.0	-0.5	0.0	0.2	0.5	1.0	1.0	-0.9	-0.7	1.1	-0.7

Hub : Genes

KBTBD2

Models

Trait associations