Best TWAS P=7.78e-11 · Best GWAS P=3.67e-11 conditioned to 0.458
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Brain Cerebellum | RP11-179B2.2 | 0.37 | 0.21 | lasso | 4 | 0.20 | 1.4e-06 | 5.7 | 6.5 | 7.8e-11 | 0.70 | 0.20 | 0.56 | TRUE |
| 7 | METSIM | Adipose | SFXN3 | 0.12 | 0.00 | blup | 415 | 0.04 | 1.6e-06 | 2.0 | 6.0 | 1.8e-09 | 0.26 | 0.16 | 0.03 | TRUE |
| 2 | GTEx | Artery Aorta | RP11-179B2.2 | 0.16 | 0.11 | lasso | 2 | 0.09 | 7.6e-06 | 5.8 | 5.8 | 8.6e-09 | 0.73 | 0.19 | 0.74 | FALSE |
| 5 | GTEx | Heart Left Ventricle | RP11-179B2.2 | 0.15 | 0.18 | enet | 2 | 0.14 | 4.8e-08 | 5.7 | 5.7 | 9.5e-09 | 0.74 | 0.20 | 0.80 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-179B2.2 | 0.15 | 0.16 | lasso | 3 | 0.16 | 8.1e-10 | 5.3 | 5.3 | 1.2e-07 | 0.71 | 0.44 | 0.56 | FALSE |
| 1 | GTEx | Adipose Visceral Omentum | RP11-179B2.2 | 0.13 | 0.02 | lasso | 3 | 0.03 | 6.5e-03 | 5.7 | 5.3 | 1.4e-07 | 0.71 | 0.18 | 0.66 | FALSE |
| 6 | GTEx | Lung | RP11-179B2.2 | 0.18 | 0.12 | lasso | 3 | 0.12 | 1.7e-09 | 5.7 | 5.2 | 1.7e-07 | 0.71 | 0.26 | 0.74 | FALSE |