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chr10:103,718,818-105,647,095

Best TWAS P=6.93e-11 · Best GWAS P=1e-09 conditioned to 0.948

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	3.5	5.3	1.1e-07	0.65	0.10	0.72	FALSE
2	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	6.0	-6.0	1.7e-09	-0.92	0.02	0.94	FALSE
3	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	6.0	5.9	3.2e-09	0.89	0.02	0.98	FALSE
4	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	5.7	5.8	8.0e-09	0.61	0.08	0.83	FALSE
5	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	-2.4	-5.5	3.0e-08	-0.41	0.06	0.42	FALSE
6	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	5.7	5.4	7.5e-08	0.79	0.05	0.84	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	5.5	5.4	6.5e-08	0.78	0.09	0.64	FALSE
8	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	4.7	5.6	1.8e-08	0.64	0.04	0.45	FALSE
9	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	5.5	5.4	5.2e-08	0.78	0.10	0.88	FALSE
10	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	5.5	5.6	1.8e-08	0.77	0.11	0.83	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	5.7	5.9	4.5e-09	0.77	0.13	0.86	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	6.1	-6.5	6.9e-11	-0.94	0.01	0.99	TRUE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	6.1	-5.2	1.8e-07	-0.94	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	6.1	-6.1	1.1e-09	-1.00	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	6.0	-5.4	7.1e-08	-0.93	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	6.0	-5.8	5.4e-09	-0.94	0.02	0.81	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	6.1	-5.9	4.5e-09	-1.00	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	5.7	-5.6	2.8e-08	-0.68	0.06	0.91	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	6.1	-6.1	1.1e-09	-0.85	0.01	0.88	FALSE