Best TWAS P=1.59e-25 · Best GWAS P=1.65e-21 conditioned to 0.479
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | SUPT3H | 0.27 | 0.10 | lasso | 7 | 0.06 | 3.4e-04 | 7.3 | -9.4 | 5.1e-21 | 0.63 | 0.92 | 0.06 | FALSE |
2 | GTEx | Artery Tibial | SUPT3H | 0.13 | 0.01 | enet | 21 | 0.02 | 1.9e-02 | -7.9 | -9.4 | 4.4e-21 | 0.55 | 0.25 | 0.63 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | SUPT3H | 0.20 | 0.08 | lasso | 6 | 0.10 | 3.0e-04 | 7.4 | -7.2 | 5.0e-13 | 0.66 | 0.24 | 0.45 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | SUPT3H | 0.27 | 0.01 | lasso | 3 | 0.00 | 2.7e-01 | -8.7 | -8.2 | 2.4e-16 | 0.83 | 0.03 | 0.78 | FALSE |
5 | GTEx | Esophagus Mucosa | SUPT3H | 0.08 | 0.09 | lasso | 3 | 0.08 | 6.4e-06 | 7.3 | -8.2 | 3.8e-16 | 0.55 | 0.76 | 0.14 | FALSE |
6 | GTEx | Esophagus Muscularis | SUPT3H | 0.10 | 0.03 | enet | 20 | 0.02 | 1.3e-02 | -8.7 | -8.6 | 8.7e-18 | 0.71 | 0.01 | 0.95 | FALSE |
7 | GTEx | Lung | SUPT3H | 0.10 | 0.06 | enet | 21 | 0.03 | 1.3e-03 | 7.0 | -7.4 | 1.1e-13 | 0.49 | 0.68 | 0.21 | FALSE |
8 | GTEx | Nerve Tibial | SUPT3H | 0.17 | 0.12 | lasso | 5 | 0.10 | 2.2e-07 | 7.0 | -7.0 | 2.5e-12 | 0.51 | 1.00 | 0.00 | FALSE |
9 | GTEx | Pancreas | SUPT3H | 0.11 | 0.07 | lasso | 2 | 0.05 | 3.6e-03 | 7.6 | -7.6 | 2.3e-14 | 0.53 | 0.14 | 0.63 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | SUPT3H | 0.07 | 0.03 | lasso | 5 | 0.04 | 4.2e-04 | 7.0 | -7.2 | 6.6e-13 | 0.46 | 0.48 | 0.04 | FALSE |
11 | GTEx | Spleen | SUPT3H | 0.32 | 0.06 | enet | 12 | 0.11 | 9.5e-04 | 6.2 | -7.1 | 1.6e-12 | 0.41 | 0.29 | 0.20 | FALSE |
12 | GTEx | Thyroid | SUPT3H | 0.29 | 0.07 | lasso | 8 | 0.07 | 7.3e-06 | -8.5 | -10.0 | 2.4e-23 | 0.52 | 0.88 | 0.06 | TRUE |
13 | METSIM | Adipose | SUPT3H | 0.11 | 0.04 | bslmm | 657 | 0.06 | 2.7e-09 | 7.4 | -7.2 | 6.5e-13 | 0.59 | 0.92 | 0.08 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUPT3H | 0.02 | 0.01 | blup | 191 | 0.01 | 3.0e-03 | 7.3 | -6.7 | 1.5e-11 | 0.41 | 0.84 | 0.02 | FALSE |
15 | The Cancer Genome Atlas | Colon Adenocarcinoma | SUPT3H | 0.08 | 0.01 | blup | 191 | 0.05 | 1.0e-03 | 7.8 | -10.4 | 1.6e-25 | 0.85 | 0.02 | 0.94 | TRUE |
16 | The Cancer Genome Atlas | Lung Adenocarcinoma | SUPT3H | 0.03 | 0.03 | lasso | 2 | 0.02 | 8.9e-04 | 8.0 | -7.4 | 1.4e-13 | 0.48 | 0.31 | 0.05 | FALSE |
17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SUPT3H | 0.12 | 0.08 | blup | 191 | 0.09 | 2.8e-04 | 8.0 | -8.3 | 6.9e-17 | 0.62 | 0.49 | 0.29 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | SUPT3H | 0.06 | 0.04 | lasso | 4 | 0.05 | 2.1e-05 | 7.4 | -9.6 | 1.1e-21 | 0.65 | 0.56 | 0.26 | FALSE |