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chr6:46,757,276-48,139,602

Best TWAS P=1.05e-17 · Best GWAS P=4.74e-17 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Esophagus Mucosa	RP11-385F7.1	0.20	0.10	lasso	20	0.07	1.6e-05	7.3	-8.6	1.0e-17	0.56	0.34	0.65	TRUE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPR111	0.03	0.01	lasso	2	0.02	2.5e-05	-7.5	8.5	1.4e-17	-0.64	0.20	0.69	TRUE
13	The Cancer Genome Atlas	Esophageal Carcinoma	GPR111	0.19	0.14	lasso	2	0.14	3.9e-05	-7.6	7.8	5.6e-15	-0.86	0.19	0.72	TRUE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPR111	0.10	0.16	enet	17	0.16	9.4e-18	-7.5	7.0	1.9e-12	-0.78	0.52	0.48	TRUE
18	The Cancer Genome Atlas	Rectum Adenocarcinoma	GPR111	0.22	0.09	blup	94	0.14	4.5e-04	-5.4	6.0	1.7e-09	-0.73	0.11	0.72	TRUE
8	GTEx	Skin Sun Exposed Lower leg	RP11-385F7.1	0.09	0.05	enet	6	0.05	6.1e-05	7.3	-7.6	2.8e-14	0.43	0.27	0.43	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GPR111	0.04	0.08	lasso	1	0.05	6.7e-04	-7.6	7.6	4.0e-14	-0.81	0.20	0.35	FALSE
5	GTEx	Esophagus Muscularis	RP11-385F7.1	0.13	0.06	lasso	4	0.06	2.1e-04	7.2	-7.5	6.4e-14	0.33	0.68	0.08	FALSE
19	The Cancer Genome Atlas	Stomach Adenocarcinoma	GPR111	0.03	0.04	lasso	1	0.03	2.4e-03	-7.4	7.4	1.1e-13	-0.80	0.14	0.61	FALSE
7	GTEx	Pituitary	RP11-385F7.1	0.26	0.21	lasso	5	0.16	7.7e-05	7.3	-7.4	1.8e-13	0.36	0.20	0.20	FALSE
1	GTEx	Brain Cerebellum	RP11-385F7.1	0.35	0.32	lasso	4	0.30	1.5e-09	7.3	-7.3	2.5e-13	0.37	0.95	0.03	FALSE
9	GTEx	Thyroid	RP11-385F7.1	0.23	0.20	lasso	3	0.19	2.0e-14	7.3	-6.9	5.4e-12	0.30	0.97	0.03	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPR115	0.06	0.11	lasso	8	0.13	2.5e-14	-7.6	6.9	6.3e-12	-0.77	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GPR115	0.08	0.09	blup	90	0.06	3.4e-03	-5.3	6.5	7.7e-11	-0.71	0.06	0.77	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	GPR111	0.13	0.08	blup	97	0.11	5.0e-07	-7.4	6.5	8.9e-11	-0.84	0.02	0.98	FALSE
3	GTEx	Colon Transverse	RP11-385F7.1	0.15	0.03	enet	7	0.05	2.1e-03	7.2	-6.3	2.8e-10	0.29	0.24	0.53	FALSE
6	GTEx	Lung	RP11-385F7.1	0.11	0.04	lasso	5	0.03	1.8e-03	7.3	-6.2	4.2e-10	0.25	0.82	0.03	FALSE
2	GTEx	Cells EBV-transformed lymphocytes	RP11-385F7.1	0.22	0.06	enet	40	0.10	3.1e-04	-3.8	-6.1	8.9e-10	0.46	0.06	0.39	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPR115	0.01	0.00	blup	90	0.01	7.2e-03	-3.9	6.1	1.2e-09	-0.67	0.12	0.55	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	GPR111	0.02	0.01	blup	94	0.02	1.1e-03	-5.1	6.0	2.1e-09	-0.79	0.05	0.63	FALSE