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chr6:41,005,502-44,034,691

Best TWAS P=1.32e-20 · Best GWAS P=9.34e-27 conditioned to 7.02e-18

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	The Cancer Genome Atlas	Colon Adenocarcinoma	MED20	0.05	0.00	blup	50	0.04	2.8e-03	7.34	9.3	1.3e-20	0.24	0.08	0.07	TRUE
35	ROSMAP	Brain Pre-frontal Cortex	KLC4	0.06	0.00	blup	362	0.01	5.6e-03	-6.03	7.1	1.4e-12	0.02	0.21	0.43	TRUE
17	GTEx	Liver	CRIP3	0.46	-0.01	enet	27	0.01	2.1e-01	-0.39	-6.6	4.6e-11	-0.06	0.05	0.07	TRUE
31	NTR	Blood	ZNF318	0.04	0.03	lasso	8	0.02	1.3e-08	-5.92	-6.2	6.9e-10	-0.01	0.64	0.36	TRUE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	GNMT	0.10	0.07	enet	6	0.07	1.1e-07	-6.00	-5.7	1.6e-08	0.05	0.05	0.95	TRUE
18	GTEx	Lung	BYSL	0.08	0.03	lasso	4	0.02	4.9e-03	9.40	-9.0	1.9e-19	-0.29	0.51	0.16	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	MED20	0.09	0.08	enet	12	0.09	5.5e-10	7.73	8.9	4.5e-19	0.43	1.00	0.00	FALSE
37	YFS	Blood	CCND3	0.02	0.01	enet	13	0.02	2.3e-06	7.63	-8.9	4.8e-19	-0.24	0.84	0.09	FALSE
10	GTEx	Colon Transverse	MED20	0.17	0.01	enet	10	0.06	6.0e-04	7.65	8.8	9.3e-19	0.27	0.37	0.17	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	MED20	0.10	0.10	enet	21	0.09	6.0e-12	7.74	8.4	4.3e-17	0.21	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED20	0.04	0.06	enet	6	0.05	2.6e-06	7.34	8.3	8.0e-17	0.23	0.92	0.01	FALSE
29	METSIM	Adipose	MED20	0.13	0.11	enet	27	0.11	2.3e-16	7.63	8.1	8.1e-16	0.21	1.00	0.00	FALSE
26	GTEx	Thyroid	MED20	0.05	0.05	lasso	2	0.02	8.1e-03	7.74	7.8	4.4e-15	0.22	0.72	0.06	FALSE
16	GTEx	Heart Left Ventricle	MED20	0.22	0.19	enet	8	0.12	5.8e-07	7.65	7.8	6.4e-15	0.22	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MED20	0.09	0.07	lasso	5	0.07	3.4e-04	-6.67	7.8	8.2e-15	0.18	0.31	0.20	FALSE
5	GTEx	Artery Tibial	MED20	0.14	0.11	lasso	2	0.09	9.7e-08	7.73	7.7	1.1e-14	0.21	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	MED20	0.08	0.07	enet	9	0.05	4.7e-05	7.61	7.6	3.7e-14	0.22	0.97	0.00	FALSE
14	GTEx	Heart Atrial Appendage	MED20	0.14	0.12	enet	11	0.09	5.9e-05	7.53	7.5	4.7e-14	0.20	0.91	0.01	FALSE
23	GTEx	Nerve Tibial	MED20	0.13	0.11	enet	8	0.10	1.5e-07	7.53	7.5	4.7e-14	0.21	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	MED20	0.16	0.15	lasso	4	0.16	6.7e-16	7.34	7.5	5.0e-14	0.22	1.00	0.00	FALSE
15	GTEx	Heart Left Ventricle	PRICKLE4	0.11	0.05	lasso	4	0.03	9.8e-03	7.34	-7.4	9.7e-14	-0.21	0.26	0.05	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	BYSL	0.05	0.06	enet	7	0.06	4.3e-06	7.74	-7.4	1.1e-13	-0.18	0.90	0.01	FALSE
12	GTEx	Esophagus Muscularis	MED20	0.15	0.05	lasso	7	0.04	1.0e-03	-7.02	7.4	1.3e-13	0.24	0.76	0.14	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED20	0.04	0.03	lasso	3	0.04	7.3e-05	-7.21	7.4	1.4e-13	0.14	0.57	0.01	FALSE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	MED20	0.03	0.05	lasso	2	0.04	1.2e-03	-7.21	7.4	1.7e-13	0.13	0.11	0.06	FALSE
8	GTEx	Cells Transformed fibroblasts	MED20	0.11	0.05	lasso	4	0.08	9.4e-07	-7.21	7.3	2.1e-13	0.11	0.94	0.01	FALSE
11	GTEx	Esophagus Mucosa	MED20	0.09	0.07	enet	10	0.02	2.7e-02	-7.19	7.3	3.1e-13	0.22	0.84	0.04	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCND3	0.04	0.00	blup	99	0.01	1.8e-03	-6.72	7.2	4.1e-13	0.27	0.02	0.10	FALSE
25	GTEx	Testis	MED20	0.13	0.03	lasso	6	0.00	2.0e-01	-6.67	7.1	9.9e-13	0.15	0.17	0.08	FALSE
38	YFS	Blood	MED20	0.04	0.03	lasso	5	0.03	3.6e-11	7.34	7.0	2.0e-12	0.18	1.00	0.00	FALSE
20	GTEx	Lung	MED20	0.10	0.01	lasso	4	0.00	2.7e-01	-1.43	6.7	2.3e-11	0.20	0.08	0.08	FALSE
27	GTEx	Thyroid	FRS3	0.20	0.16	lasso	4	0.16	5.2e-12	7.60	6.7	2.6e-11	0.09	1.00	0.00	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	PGC	0.13	0.06	blup	520	0.06	3.2e-08	7.60	-6.6	4.4e-11	-0.24	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MED20	0.15	0.11	blup	471	0.13	3.1e-15	-7.19	6.5	9.7e-11	0.19	1.00	0.00	FALSE
24	GTEx	Spleen	MED20	0.44	0.13	enet	23	0.07	6.4e-03	7.73	6.3	2.5e-10	0.17	0.19	0.15	FALSE
9	GTEx	Cells Transformed fibroblasts	USP49	0.13	0.02	lasso	4	0.02	2.4e-02	-6.70	-6.2	5.8e-10	-0.15	0.29	0.03	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	PRICKLE4	0.04	0.03	lasso	3	0.04	1.1e-04	6.03	-6.1	1.0e-09	-0.13	0.08	0.83	FALSE
36	YFS	Blood	BYSL	0.07	0.06	lasso	7	0.09	2.8e-28	7.73	-6.1	1.2e-09	-0.19	1.00	0.00	FALSE
19	GTEx	Lung	PRICKLE4	0.12	0.05	lasso	3	0.06	2.2e-05	7.34	-6.1	1.4e-09	-0.21	0.63	0.02	FALSE
21	GTEx	Lung	USP49	0.09	0.08	lasso	2	0.05	6.2e-05	-6.70	-6.1	1.4e-09	-0.11	0.84	0.01	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRICKLE4	0.03	0.01	blup	43	0.02	1.6e-03	-1.63	-6.0	1.5e-09	-0.18	0.04	0.91	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CUL9	0.15	0.12	bslmm	386	0.14	3.1e-16	-5.26	6.0	1.7e-09	-0.01	0.85	0.15	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	MED20	0.25	0.01	lasso	5	0.07	3.0e-03	-6.93	6.0	1.8e-09	0.20	0.16	0.06	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF318	0.05	0.06	lasso	3	0.05	1.1e-06	-5.82	5.9	2.9e-09	-0.01	0.03	0.97	FALSE
4	GTEx	Adipose Subcutaneous	FRS3	0.15	0.04	enet	22	0.04	5.9e-04	7.60	5.8	5.1e-09	0.11	0.39	0.14	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CRIP3	0.08	0.08	blup	34	0.07	1.0e-04	-5.98	-5.8	7.2e-09	-0.02	0.01	0.98	FALSE
30	NTR	Blood	KLHDC3	0.01	0.00	blup	368	0.01	3.6e-03	-3.27	5.8	8.1e-09	-0.02	0.04	0.72	FALSE
50	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZNF318	0.04	0.02	blup	48	0.04	2.2e-03	-5.98	-5.6	1.8e-08	-0.02	0.01	0.73	FALSE
13	GTEx	Heart Atrial Appendage	PRICKLE4	0.16	0.07	enet	19	0.10	4.6e-05	-1.83	-5.4	8.3e-08	-0.13	0.44	0.12	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	PPP2R5D	0.05	0.00	bslmm	366	0.03	1.1e-04	-5.75	5.3	8.9e-08	-0.01	0.18	0.16	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP3-475N16.1	0.08	-0.01	lasso	3	0.06	2.1e-02	-5.96	5.3	1.1e-07	0.05	0.03	0.28	FALSE
28	METSIM	Adipose	BYSL	0.05	0.00	blup	476	0.02	2.3e-04	7.34	-5.3	1.1e-07	-0.20	0.18	0.02	FALSE
39	YFS	Blood	MRPL2	0.15	0.07	bslmm	352	0.10	1.1e-31	-5.26	-5.1	2.8e-07	0.01	0.98	0.02	FALSE