TWAS hub - GPR115

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0149	0.0097	9.8e-04	0.001	0.008	0.003	NA	0.003	2.1e-01	7.2e-03	7.0e-02	NA	8.3e-02
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0561	0.0217	1.0e-12	0.113	0.129	0.123	NA	0.129	1.2e-12	2.8e-14	9.7e-14	NA	2.5e-14
3	TCGA	Testicular Germ Cell Tumors	0.0790	0.0430	1.1e-03	0.090	0.061	0.023	NA	0.051	4.5e-04	3.4e-03	5.0e-02	NA	7.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	7.7	88.9	99.8	8.9	10.0	9.4
Back pain experienced in last month	7.7	11.2	12.6	-3.5	-3.2	-3.3
Average weekly spirits intake	5.6	6.9	8.0	2.6	2.8	2.5
Maternal smoking around birth	5.1	7.4	8.1	-2.8	-2.5	-2.8
Pulse wave Arterial Stiffness index	4.8	5.6	7.4	2.0	2.7	2.3
Comparative height size at age 10	4.7	25.9	28.1	4.7	5.3	5.3
Height	4.6	88.5	96.6	8.9	9.8	9.4
Medication: Co-codamol	4.5	5.2	5.4	-2.3	-2.2	-2.3
Supplements: Calcium	4.5	5.0	5.6	2.2	2.1	2.4
Standing height	4.3	42.2	47.2	6.1	6.9	6.5
Alcohol drinker status: Previous	4.3	4.9	5.8	1.9	2.3	2.4
Loud music exposure frequency	4.2	4.6	5.2	-2.1	-2.0	-2.3
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.5	6.6	-2.5	-2.6	-2.6
Lupus	3.9	5.9	7.1	-2.7	-2.3	-2.3
Diverticular disease/diverticulitis (self-reported)	3.9	4.7	5.0	-2.2	-2.1	-2.2
Alzheimer’s Disease (including proxy)	3.6	5.2	7.2	2.7	2.0	2.1
Impedance of arm (left)	3.5	16.0	19.4	3.4	4.4	4.1
Pulse wave peak to peak time	3.5	4.1	5.6	-1.7	-2.4	-2.0
Ever taken oral contraceptive pill	3.2	3.6	4.1	-1.7	-2.0	-2.0
Illnesses of father: None of the above (group 1)	3.1	3.8	4.2	2.0	1.8	2.0
Impedance of arm (right)	3.0	14.1	16.9	3.2	4.1	3.9
Had menopause	2.9	3.6	4.7	1.5	2.2	2.0
Number of full sisters	2.9	3.5	4.7	-2.2	-1.7	-1.7
Supplements: Zinc	2.8	3.0	4.0	1.5	2.0	1.7
Noisy workplace	2.8	3.4	3.8	-2.0	-1.8	-1.8
Illnesses of father: Heart disease	2.8	3.9	4.1	-1.9	-2.0	-2.0
Impedance of whole body	2.8	14.1	16.6	3.2	4.1	3.9
Worry too long after embarrassment	2.7	4.5	4.6	-2.1	-2.1	-2.1
Number of children fathered	2.6	2.9	3.5	1.8	1.4	1.9
Breastfed as a baby	2.5	3.1	3.4	-1.8	-1.8	-1.6
Alzheimer’s Disease (in mother)	2.4	2.9	3.5	1.9	1.5	1.6
Ever used hormone-replacement therapy (HRT)	2.4	3.1	4.1	1.5	2.0	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.1	3.8	-1.9	-1.7	-1.7
Chest pain or discomfort	2.4	3.5	4.7	-2.2	-1.5	-1.9
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	4.4	-1.8	-2.0	-2.1
Miserableness	2.4	4.1	4.4	-2.1	-1.9	-2.1
BMI	2.3	13.3	14.4	-3.4	-3.7	-3.8
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	3.3	-1.8	-1.7	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	3.0	1.6	1.6	1.7
Depression (Nagel 2018)	1.9	2.8	2.9	-1.7	-1.7	-1.6
Fed-up feelings	1.9	3.5	3.9	-1.8	-2.0	-1.9
Financial situation satisfaction	1.8	2.3	2.6	-1.4	-1.6	-1.5
Age started oral contraceptive pill	1.8	2.2	2.4	1.5	1.5	1.4
Medication: Atenolol	1.7	2.1	2.4	1.3	1.5	1.5
Angina (self-reported)	1.7	2.2	2.9	1.4	1.3	1.7
Fractured/broken bones in last 5 years	1.6	2.1	2.4	-1.3	-1.5	-1.5
Angina	1.5	2.0	2.6	1.4	1.2	1.6
Impedance of leg (right)	1.5	7.2	8.3	2.3	2.9	2.8
Townsend deprivation index at recruitment	1.5	2.2	2.9	-1.7	-1.1	-1.5
Ovarian Cancer	1.4	1.8	2.1	1.4	1.3	1.4
Serious illness, injury or assault to yourself	1.4	1.6	2.9	-1.7	-1.0	-1.1
Medication: Ramipril	1.4	1.8	2.7	1.6	0.9	1.4
Time employed in main current job	1.4	1.6	1.9	-1.4	-1.3	-1.1
Birth weight of first child	1.4	2.6	3.3	-1.4	-1.8	-1.6
Overall health rating	1.4	3.1	3.6	-1.8	-1.9	-1.5
Stomach or abdominal pain in last month	1.3	1.6	2.4	-0.9	-1.5	-1.2
Medication: Simvastatin	1.3	1.8	2.3	-1.5	-1.3	-1.2
Father’s age at death	1.3	1.8	2.7	1.0	1.7	1.2
Pulse wave reflection index	1.3	1.7	3.0	0.8	1.7	1.2
Qualifications: College or University degree	1.3	4.2	5.0	1.9	2.2	2.1
Cholesterol lowering medication	1.3	1.9	2.0	-1.4	-1.4	-1.3
High blood pressure (siblings)	1.2	1.7	2.2	-1.5	-1.1	-1.3
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.9	1.4	0.8	1.3
Ever had prostate specific antigen (PSA) test	1.2	1.3	1.8	-1.2	-1.3	-0.8
Ever depressed for a whole week	1.2	1.5	1.7	-1.3	-1.2	-1.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	1.6	-1.3	-1.1	-1.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.6	-0.9	-1.3	-1.0
Tanning	1.0	12.5	13.7	3.7	3.4	3.5
Impedance of leg (left)	1.0	4.6	5.4	1.7	2.3	2.3
Had other major operations	1.0	1.3	1.4	-1.1	-1.2	-1.0
Worrier / anxious feelings	1.0	1.9	2.9	-1.7	-1.2	-1.2
Number of live births	1.0	1.4	2.2	-1.5	-0.9	-1.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	1.4	1.1	1.2	1.1
Myopia	1.0	1.4	1.6	-1.0	-1.3	-1.3
Major Depression (MDD)	0.9	1.1	1.5	-1.2	-0.9	-0.9
Schizophrenia (2014)	0.9	2.0	2.2	1.5	1.4	1.4
Age when periods started (menarche)	0.9	2.1	2.8	-1.7	-1.1	-1.6
Body mass index (BMI)	0.9	3.9	4.4	-1.7	-2.1	-2.1
Medication: Ventolin 100micrograms inhaler	0.9	1.2	1.3	-1.0	-1.1	-1.1
Wheeze or whistling in the chest in last year	0.9	1.7	2.3	-1.5	-0.9	-1.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.4	1.1	0.7	1.2
Asthma (self-reported)	0.9	1.9	2.4	-1.6	-1.2	-1.3
Medication: Bendroflumethiazide	0.9	1.3	1.7	1.3	1.0	1.2
Number of operations (self-reported)	0.9	1.4	1.6	-1.2	-1.3	-1.1
Primary Biliary Cirrhosis	0.8	1.1	1.4	-1.1	-0.8	-1.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.1	-1.1	-0.8	-0.9
Mouth/teeth dental problems	0.8	1.2	1.3	1.0	1.1	1.1
Falls in the last year	0.8	1.1	1.2	-1.1	-1.1	-1.0
Asthma	0.8	1.5	1.9	-1.4	-1.0	-1.2
Hair/balding pattern: Pattern 4	0.8	1.8	2.4	1.1	1.6	1.4
Forced vital capacity (FVC), Best measure	0.8	2.8	3.0	1.7	1.7	1.5
Eye problems/disorders: None of the above	0.8	1.0	1.3	0.9	1.1	0.9
Leg pain on walking	0.8	1.0	1.7	-1.3	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	1.7	1.3	1.3	1.3
High cholesterol (Self-reported)	0.8	1.4	2.0	-1.0	-1.4	-1.2
Triglycerides	0.7	1.2	1.5	1.1	0.9	1.2
Systolic Blood Pressure	0.7	3.7	4.3	-2.0	-2.1	-1.7
Cardiovascular Disease	0.7	2.2	3.1	-1.2	-1.8	-1.4
Forced vital capacity (FVC)	0.7	2.9	3.1	1.7	1.8	1.6
Medication: Lansoprazole	0.7	0.8	0.9	0.9	1.0	0.8
Emphysema/chronic bronchitis	0.7	0.8	1.0	0.8	0.8	1.0
Medication: Seretide 50 evohaler	0.7	0.8	1.0	0.8	0.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.3	-0.8	-1.1	-0.9
Pulse rate, automated reading	0.7	2.4	2.8	-1.4	-1.7	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	0.8	0.9	0.9	0.9
Average weekly red wine intake	0.7	1.0	1.3	-1.0	-1.2	-0.9
Friendships satisfaction	0.7	0.8	1.1	0.9	0.8	1.0
Average weekly champagne plus white wine intake	0.7	0.9	1.0	-0.9	-1.0	-1.0
Wears glasses or contact lenses	0.7	0.8	0.8	0.9	0.9	0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	0.9	-0.8	-0.9	-0.9
Diastolic blood pressure, automated reading	0.7	2.0	2.4	-1.5	-1.4	-1.3
Rheumatoid Arthritis	0.6	0.8	0.9	-0.7	-0.9	-1.0
Heel T-Score	0.6	4.7	5.5	1.8	2.3	2.3
Number of treatments/medications taken	0.6	1.0	1.2	1.0	0.9	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	0.9	-0.9	-0.9	-1.0
Hearing difficulty/problems: Yes	0.6	0.9	1.1	-0.9	-1.0	-0.9
Relative age voice broke	0.6	0.9	1.1	-0.9	-0.8	-1.1
Sitting height	0.6	4.3	5.8	1.7	2.4	2.0
High blood pressure (mother)	0.6	0.9	1.3	-1.1	-0.8	-0.8
Number of incorrect matches in round	0.6	1.0	1.5	1.2	0.9	0.9
Number of full brothers	0.6	0.7	0.9	0.8	0.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-0.7	-0.6	-1.2
Illnesses of father: High blood pressure	0.6	0.8	1.2	-0.9	-0.5	-1.1
Neuroticism (2016)	0.5	0.7	1.0	-1.0	-1.0	-0.5
Medication: Metformin	0.5	0.8	1.1	-0.8	-1.1	-0.8
Trunk fat percentage	0.5	2.2	2.6	1.3	1.6	1.5
Hand grip strength (right)	0.5	1.3	1.4	1.2	1.2	1.1
Trunk fat mass	0.5	2.4	2.8	1.4	1.7	1.5
Past tobacco smoking	0.5	0.9	1.0	0.9	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.4	1.0	1.2	1.1
Happiness	0.5	0.6	0.7	-0.7	-0.8	-0.8
Lung cancer (father)	0.5	0.6	0.9	0.7	0.7	0.9
Length of working week for main job	0.5	0.5	0.8	0.9	0.6	0.7
Ever highly irritable/argumentative for 2 days	0.5	0.5	0.7	0.7	0.7	0.9
Medication: Amlodipine	0.5	0.7	1.4	1.2	0.6	0.7
Shortness of breath walking on level ground	0.5	0.6	1.0	0.5	1.0	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.6	-0.8	-0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.6	-0.7	-0.7	-0.8
Ulcerative Colitis (UC)	0.4	0.7	0.7	0.9	0.8	0.8
Alcohol usually taken with meals	0.4	0.7	1.0	-0.8	-1.0	-0.8
Financial difficulties in last 2 years	0.4	0.5	0.7	-0.7	-0.8	-0.7
Heart attack	0.4	0.5	0.8	0.9	0.5	0.6
Fluid intelligence score	0.4	0.8	1.1	0.8	0.8	1.0
Neuroticism score	0.4	0.9	1.0	-1.0	-1.0	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	1.1	-0.6	-1.0	-0.7
Illnesses of mother	0.4	0.5	0.7	-0.6	-0.8	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	-1.1	-0.5	-0.7
Gout (self-reported)	0.4	0.5	0.5	-0.7	-0.7	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	0.6	0.9	0.5
Medication: Blood pressure	0.4	0.7	1.2	-0.7	-1.1	-0.6
Medication: Allopurinol	0.4	0.5	0.7	-0.6	-0.7	-0.8
Mood swings	0.4	0.7	1.0	-1.0	-0.8	-0.8
Mineral and other dietary supplements	0.4	0.5	0.7	-0.8	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.2	-0.8	-1.1	-0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.8	0.9	0.6	0.5
Medication: Atorvastatin	0.4	0.5	0.9	1.0	0.4	0.7
Commuting to job workplace: Cycle	0.4	0.5	0.8	-0.9	-0.4	-0.8
Bipolar Disorder (2018)	0.3	0.5	0.8	0.9	0.5	0.6
Coronary Artery Disease (CAD)	0.3	0.4	0.4	-0.7	-0.6	-0.6
Blood Eosinophil Count	0.3	1.9	2.6	1.6	1.3	1.3
Leg fat-free mass (left)	0.3	1.4	1.7	1.2	1.3	1.0
Supplements: Glucosamine	0.3	0.4	0.7	0.5	0.8	0.6
Leg predicted mass (left)	0.3	1.4	1.6	1.2	1.3	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.6	-0.8	-0.6	-0.8
Hair/balding pattern: Pattern 2	0.3	0.3	0.5	0.6	0.4	0.7
Trunk fat-free mass	0.3	1.5	2.0	1.4	1.2	1.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.2	1.1	1.1	0.9
Trunk predicted mass	0.3	1.7	2.1	1.4	1.3	1.1
Blood clot in the leg (DVT)	0.3	0.4	0.6	-0.5	-0.7	-0.8
Migraine (self-reported)	0.3	0.3	0.5	-0.7	-0.7	-0.3
Medication: Omeprazole	0.3	0.3	0.4	-0.6	-0.5	-0.6
Mean time to correctly identify matches	0.3	0.6	0.9	0.6	0.8	1.0
Whole body fat mass	0.3	1.2	1.5	1.0	1.2	1.0
Alcohol intake frequency.	0.3	0.7	0.9	0.7	0.9	0.9
Had major operations	0.3	0.3	0.5	0.7	0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.4	-0.5	-0.8
Medication: Aspirin	0.3	0.4	0.4	-0.6	-0.7	-0.6
Ever had bowel cancer screening	0.3	0.4	0.4	-0.6	-0.7	-0.5
Medication: Aspirin	0.3	0.4	0.6	-0.6	-0.8	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.1	-1.0	-0.6	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.8	0.4	0.5
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	0.7	0.4	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.7	0.2	0.2
Reaction Time	0.2	0.4	0.7	0.3	0.6	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.0	0.5	0.7	1.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.3	-0.5	-0.5	-0.4
HDL Cholesterol	0.2	0.3	0.3	-0.6	-0.5	-0.5
Blood Red Count	0.2	2.4	3.1	1.8	1.4	1.4
Blood White Count	0.2	1.6	2.1	1.5	1.2	1.1
Neuroticism	0.2	0.4	0.5	-0.7	-0.6	-0.5
Current tobacco smoking	0.2	0.3	0.3	0.6	0.5	0.5
Average weekly fortified wine intake	0.2	0.3	0.5	-0.2	-0.6	-0.7
Weight	0.2	1.1	1.2	1.1	1.1	1.0
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.9	-0.3	-0.4
Pulse rate	0.2	0.4	0.5	-0.6	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.7	0.8	0.8	0.6
Tense / ‘highly strung’	0.2	0.3	0.4	0.5	0.5	0.6
Medication: Paracetamol	0.2	0.3	0.4	-0.6	-0.4	-0.5
Glaucoma (self-reported)	0.2	0.2	0.3	0.4	0.3	0.6
Body fat percentage	0.2	0.6	0.8	0.7	0.9	0.8
Exposure to tobacco smoke outside home	0.2	0.3	0.4	0.4	0.5	0.6
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.6	-0.5	-0.6
Family relationship satisfaction	0.2	0.3	0.4	-0.2	-0.6	-0.6
Whole body fat-free mass	0.2	1.3	1.5	1.2	1.1	1.0
Loneliness, isolation	0.2	0.2	0.4	-0.3	-0.7	-0.4
Eye problems/disorders: Cataract	0.2	0.3	0.3	-0.3	-0.6	-0.6
Whole body water mass	0.2	1.1	1.4	1.2	1.1	0.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.6	-0.5	-0.3
Basal metabolic rate	0.2	1.2	1.4	1.2	1.1	1.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	0.6	0.4	0.5
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.2	0.4	0.8
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	0.4	0.6	0.6
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	-0.5	-0.1
Fasting Glucose	0.1	0.2	0.2	-0.5	-0.4	-0.4
HbA1C	0.1	0.1	0.2	-0.3	-0.3	-0.5
Ulcerative Colitis	0.1	0.2	0.3	0.5	0.3	0.5
Waist Hip Ratio (WHR)	0.1	0.6	0.9	0.7	0.6	1.0
Lung FEV1/FVC ratio	0.1	0.4	0.4	-0.7	-0.5	-0.6
Hand grip strength (left)	0.1	0.2	0.2	-0.4	-0.4	-0.4
Relative age of first facial hair	0.1	0.2	0.3	0.5	0.4	0.3
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	-0.5	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.1	0.2	0.3	0.2
Diabetes (mother)	0.1	0.1	0.2	0.4	0.2	0.2
Taking other prescription medications	0.1	0.1	0.1	-0.3	-0.4	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.4	0.2	-0.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	-0.1	0.3
High blood pressure	0.1	0.3	0.5	0.7	0.3	0.7
Multivitamins +/- minerals	0.1	0.2	0.3	0.3	0.6	0.3
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.2	0.4	0.5
Pain all over the body in last month	0.1	0.1	0.2	-0.4	-0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.3	-0.3	-0.2
Hip circumference	0.1	0.6	0.7	0.9	0.8	0.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.4	-0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	0.5	0.5	0.6
Prospective memory result	0.1	0.1	0.2	-0.1	-0.3	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.2	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.6	0.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.1	0.4	0.3
Comparative body size at age 10	0.1	0.3	0.6	0.0	-0.5	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.5	-0.4	-0.2
Age at first live birth	0.1	0.3	0.4	0.5	0.4	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.1	0.2	0.4
Arm predicted mass (right)	0.1	0.5	0.7	0.8	0.8	0.6
Supplements: Vitamin C	0.1	0.1	0.2	-0.2	-0.2	-0.5
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	-0.4	-0.1
Hypertension (Self-reported)	0.1	0.3	0.5	0.7	0.2	0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.2	0.7	0.2
Smoking status: Previous	0.1	0.2	0.2	-0.4	-0.5	-0.5
Leg fat-free mass (right)	0.1	0.5	0.6	0.8	0.8	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.3	0.5	0.2	0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.5	-0.1	-0.4
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.3	-0.2	-0.3
Leg predicted mass (right)	0.1	0.5	0.6	0.7	0.8	0.6
Hearing aid user	0.1	0.1	0.2	0.1	0.4	0.3
Mother’s age at death	0.1	0.1	0.3	-0.1	-0.5	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.4	-0.1
Medication: Blood pressure	0.1	0.1	0.2	0.5	0.2	0.4
Medication: Lisinopril	0.1	0.1	0.1	-0.3	-0.3	-0.3
Arm fat-free mass (left)	0.1	0.3	0.5	0.7	0.6	0.4
Average weekly beer plus cider intake	0.1	0.2	0.3	0.6	0.2	0.5
Irritability	0.1	0.1	0.2	0.2	0.4	0.5
Risk taking	0.1	0.1	0.2	0.5	0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.2	-0.2	-0.4	-0.5
Arm predicted mass (left)	0.1	0.3	0.5	0.7	0.5	0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.2	-0.3	-0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.0	-0.1	0.1
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0	0.1
Worry (Nagel 2018)	0.0	0.0	0.1	-0.1	0.1	0.3
Crohns Disease (2017)	0.0	0.1	0.1	-0.4	-0.0	-0.2
Breast Cancer	0.0	0.0	0.1	0.0	0.3	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.1	0.1	0.4	0.2	0.0
Crohns Disease (2012)	0.0	0.1	0.1	-0.3	-0.1	-0.2
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.0	-0.1
LDL Cholesterol	0.0	0.1	0.2	0.4	-0.2	0.1
Smoking Status	0.0	0.1	0.1	0.3	0.4	0.1
Allergy or Eczema	0.0	0.1	0.1	0.3	0.1	0.3
Hypothyroidism (self reported)	0.0	0.0	0.0	0.2	0.0	-0.1
Respiratory disease	0.0	0.1	0.2	-0.1	0.5	0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.1	-0.1	0.1
Lung FVC	0.0	0.1	0.1	0.2	-0.4	-0.2
Chronotype (morning person)	0.0	0.0	0.0	0.0	0.1	-0.1
Hair Pigment	0.0	0.0	0.0	0.0	0.1	-0.0
Sensitivity / hurt feelings	0.0	0.1	0.2	-0.2	-0.4	-0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	0.1	0.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.3	0.1	0.2
Vitamin and mineral supplements	0.0	0.0	0.1	0.0	-0.3	-0.1
Diabetes (father)	0.0	0.0	0.0	-0.1	0.0	-0.1
Severe depression (siblings)	0.0	0.1	0.2	-0.4	-0.1	0.0
Pack years adult smoking proportion	0.0	0.1	0.1	-0.4	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	0.0	0.2	0.2
Qualifications: CSEs or equivalent	0.0	0.1	0.1	-0.2	-0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.4	0.1	0.3
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.1	-0.2	-0.2
Waist circumference	0.0	0.0	0.0	0.1	-0.1	-0.0
Nervous feelings	0.0	0.1	0.2	-0.4	-0.2	-0.0
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.1	0.1	0.3
Qualifications: None of the above	0.0	0.0	0.0	0.1	-0.1	0.2
Allergy	0.0	0.1	0.1	-0.3	-0.2	-0.3
Diabetes (self-reported)	0.0	0.1	0.1	-0.1	-0.4	-0.1
Illnesses of siblings	0.0	0.1	0.1	0.3	0.2	0.3
Arm fat percentage (right)	0.0	0.2	0.3	-0.4	-0.4	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.1	-0.2	-0.1
Medication: Cholesterol lowering	0.0	0.0	0.1	0.3	0.1	0.2
Depression (self-reported)	0.0	0.1	0.1	-0.4	-0.0	-0.1
Arm fat mass (right)	0.0	0.0	0.0	0.1	0.1	-0.1
Peak expiratory flow (PEF)	0.0	0.0	0.1	-0.1	-0.0	-0.3
Headache pain in last month	0.0	0.1	0.1	0.1	0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.1	-0.1	0.0
Birth weight	0.0	0.1	0.1	-0.3	-0.2	-0.2
Leg fat percentage (right)	0.0	0.0	0.1	0.2	0.1	0.1
Arm fat-free mass (right)	0.0	0.2	0.2	0.5	0.5	0.4
Health satisfaction	0.0	0.1	0.1	-0.2	-0.3	-0.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	-0.2	-0.2	-0.3
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	-0.2	-0.1
Heart disease (mother)	0.0	0.0	0.1	0.2	0.3	0.2
Leg fat mass (right)	0.0	0.1	0.1	0.4	0.4	0.2
Suffer from ‘nerves’	0.0	0.0	0.1	-0.2	-0.3	-0.1
Age at last live birth	0.0	0.1	0.2	0.1	0.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.2	0.2	-0.2
Arm fat percentage (left)	0.0	0.1	0.1	-0.2	-0.2	-0.3
Long-standing illness, disability or infirmity	0.0	0.0	0.0	0.1	0.1	0.2
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.3	-0.1	0.0
Medication for cholesterol	0.0	0.0	0.0	-0.1	0.2	0.2
Breast cancer (self-reported)	0.0	0.0	0.1	-0.2	0.1	0.1
Osteoporosis (self-reported)	0.0	0.1	0.2	0.4	0.1	0.1
Medication: Gliclazide	0.0	0.0	0.0	0.0	-0.2	0.1
Smoking status: Current	0.0	0.0	0.0	0.1	0.1	-0.0
Arm fat mass (left)	0.0	0.0	0.0	0.1	0.1	-0.1
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	-0.2	-0.1	0.2
Guilty feelings	0.0	0.0	0.0	0.2	0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	0.1	0.1	0.4
Medication: Paracetamol	0.0	0.0	0.0	-0.1	-0.1	-0.0
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	0.1	-0.0
Ever smoked	0.0	0.1	0.1	-0.4	-0.0	-0.3
Leg fat percentage (left)	0.0	0.0	0.1	-0.2	-0.3	-0.2
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.3	-0.1	-0.3
Pain experienced in last month	0.0	0.1	0.1	0.3	0.3	0.0
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.2	-0.2	-0.0
Heart disease (siblings)	0.0	0.0	0.1	0.2	0.0	0.2
Pack years of smoking	0.0	0.1	0.1	0.1	0.2	0.4
Leg fat mass (left)	0.0	0.0	0.0	0.1	0.1	-0.0

Hub : Genes

GPR115

Models

Trait associations