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chr7:133,637,381-136,094,817

Best TWAS P=6.07e-18 · Best GWAS P=2.1e-19 conditioned to 5.87e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Esophagus Mucosa	C7orf73	0.42	0.31	lasso	6	0.38	1.3e-26	7.94	-8.6	6.1e-18	0.30	0.89	0.11	TRUE
17	GTEx	Colon Sigmoid	RP11-134L10.1	0.17	-0.01	lasso	5	0.00	5.1e-01	6.82	-7.2	4.1e-13	0.09	0.06	0.06	TRUE
26	GTEx	Nerve Tibial	BPGM	0.17	0.05	enet	28	0.12	5.4e-09	1.45	-5.5	4.2e-08	0.05	0.84	0.07	TRUE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	PL-5283	0.33	0.24	enet	14	0.24	1.5e-48	7.95	-8.6	7.9e-18	0.37	0.00	1.00	FALSE
9	GTEx	Breast Mammary Tissue	C7orf73	0.15	0.11	lasso	6	0.15	4.3e-08	7.95	-8.5	2.4e-17	0.30	0.91	0.06	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	C7orf73	0.38	0.33	lasso	5	0.37	2.3e-21	7.95	-8.4	5.1e-17	0.32	0.89	0.11	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC13A4	0.27	0.04	enet	10	0.15	4.8e-09	7.95	8.4	5.6e-17	-0.25	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	PL-5283	0.59	0.38	lasso	6	0.42	1.5e-44	7.95	-8.4	5.8e-17	0.32	0.00	1.00	FALSE
16	GTEx	Colon Sigmoid	C7orf73	0.25	0.22	lasso	2	0.21	6.1e-08	7.94	-8.4	6.5e-17	0.27	0.58	0.08	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	PL-5283	0.40	0.24	lasso	5	0.26	4.2e-30	7.95	-8.3	6.9e-17	0.29	0.00	1.00	FALSE
24	GTEx	Lung	C7orf73	0.26	0.21	lasso	10	0.22	1.5e-16	7.94	-8.3	7.5e-17	0.34	0.91	0.09	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC13A4	0.46	0.24	lasso	3	0.24	2.4e-14	7.95	8.3	7.6e-17	-0.30	0.00	1.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	C7orf73	0.29	0.28	enet	21	0.32	3.2e-27	7.95	-8.3	8.2e-17	0.31	0.89	0.11	FALSE
8	GTEx	Artery Tibial	C7orf73	0.18	0.18	lasso	5	0.18	2.5e-14	7.95	-8.3	9.8e-17	0.31	0.89	0.11	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC13A4	0.14	0.05	lasso	5	0.07	1.5e-13	7.95	8.3	1.0e-16	-0.30	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Soft Tissue Sarcoma	PL-5283	0.20	0.12	lasso	2	0.11	5.1e-07	7.95	-8.3	1.2e-16	0.27	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	PL-5283	0.52	0.40	lasso	4	0.42	6.8e-26	7.95	-8.2	1.7e-16	0.30	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SLC13A4	0.33	0.16	lasso	3	0.16	5.5e-07	7.95	8.2	1.7e-16	-0.32	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	SLC13A4	0.44	0.18	blup	56	0.24	2.0e-23	7.95	8.2	1.9e-16	-0.31	0.00	1.00	FALSE
6	GTEx	Artery Aorta	C7orf73	0.27	0.23	lasso	4	0.21	1.5e-11	7.94	-8.2	2.4e-16	0.27	0.89	0.11	FALSE
28	GTEx	Pancreas	C7orf73	0.22	0.28	lasso	8	0.28	4.5e-12	7.95	-8.2	2.5e-16	0.29	0.89	0.11	FALSE
37	GTEx	Vagina	C7orf73	0.27	0.19	lasso	3	0.17	9.3e-05	6.78	-8.2	2.5e-16	0.36	0.24	0.10	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	C7orf73	0.25	0.19	lasso	3	0.14	8.6e-06	7.95	-8.2	3.5e-16	0.29	0.50	0.10	FALSE
21	GTEx	Esophagus Muscularis	C7orf73	0.22	0.31	lasso	2	0.29	8.8e-18	7.94	-8.2	3.7e-16	0.31	0.90	0.10	FALSE
15	GTEx	Cells Transformed fibroblasts	C7orf73	0.44	0.49	lasso	8	0.53	5.3e-46	7.95	-8.1	4.6e-16	0.32	0.89	0.11	FALSE
35	GTEx	Thyroid	C7orf73	0.18	0.11	lasso	7	0.16	2.1e-12	6.78	-8.1	5.6e-16	0.40	0.99	0.01	FALSE
70	The Cancer Genome Atlas	Rectum Adenocarcinoma	SLC13A4	0.55	0.21	lasso	3	0.17	7.1e-05	7.95	8.1	6.1e-16	-0.30	0.00	0.98	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC13A4	0.45	0.17	lasso	6	0.23	3.6e-24	7.95	8.1	6.6e-16	-0.31	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PL-5283	0.26	0.22	lasso	6	0.20	2.5e-10	7.95	-8.0	1.0e-15	0.30	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PL-5283	0.28	0.22	lasso	4	0.24	1.4e-26	7.95	-8.0	1.0e-15	0.28	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PL-5283	0.22	0.16	lasso	3	0.15	5.6e-17	7.95	-8.0	1.2e-15	0.30	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PL-5283	0.40	0.26	enet	9	0.23	1.5e-08	7.95	-8.0	1.2e-15	0.30	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	C7orf73	0.23	0.14	lasso	7	0.18	9.5e-15	6.78	-8.0	1.3e-15	0.30	0.99	0.01	FALSE
11	GTEx	Breast Mammary Tissue (Female)	C7orf73	0.20	0.17	lasso	4	0.12	1.5e-04	7.94	-8.0	1.3e-15	0.33	0.29	0.07	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	PL-5283	0.35	0.28	lasso	5	0.28	1.2e-31	7.95	-8.0	1.6e-15	0.30	0.00	1.00	FALSE
27	GTEx	Nerve Tibial	C7orf73	0.19	0.10	lasso	9	0.18	9.5e-13	7.95	-8.0	1.8e-15	0.24	0.95	0.05	FALSE
33	GTEx	Stomach	C7orf73	0.29	0.17	lasso	6	0.13	6.3e-07	7.94	-8.0	1.9e-15	0.29	0.89	0.11	FALSE
5	GTEx	Adrenal Gland	C7orf73	0.24	0.23	lasso	1	0.21	3.8e-08	7.94	-7.9	2.0e-15	0.31	0.72	0.10	FALSE
57	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PL-5283	0.34	0.18	lasso	2	0.15	1.2e-07	7.95	-7.9	2.8e-15	0.29	0.00	1.00	FALSE
7	GTEx	Artery Coronary	C7orf73	0.40	0.29	enet	18	0.30	1.3e-10	6.78	-7.9	2.9e-15	0.35	0.99	0.01	FALSE
18	GTEx	Colon Transverse	C7orf73	0.25	0.29	lasso	5	0.24	1.1e-11	7.94	-7.9	3.0e-15	0.28	0.90	0.10	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	PL-5283	0.40	0.31	enet	7	0.33	3.8e-35	7.95	-7.8	5.4e-15	0.31	0.00	1.00	FALSE
75	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC13A4	0.31	0.17	lasso	5	0.24	3.4e-17	7.95	7.8	5.6e-15	-0.30	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PL-5283	0.22	0.14	lasso	4	0.12	2.0e-07	7.95	-7.8	5.7e-15	0.29	0.00	1.00	FALSE
34	GTEx	Testis	C7orf73	0.38	0.27	lasso	4	0.30	1.1e-13	7.95	-7.8	7.3e-15	0.28	0.89	0.11	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	PL-5283	0.34	0.09	enet	13	0.11	3.4e-04	7.95	-7.8	8.3e-15	0.22	0.00	0.98	FALSE
23	GTEx	Heart Left Ventricle	C7orf73	0.14	0.09	lasso	12	0.07	2.1e-04	7.08	-7.7	9.9e-15	0.38	0.89	0.02	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PL-5283	0.50	0.34	enet	12	0.37	3.1e-16	7.95	-7.7	1.2e-14	0.25	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Skin Cutaneous Melanoma	PL-5283	0.48	0.03	lasso	4	0.15	7.7e-05	7.95	-7.7	1.9e-14	0.23	0.00	0.92	FALSE
48	The Cancer Genome Atlas	Esophageal Carcinoma	PL-5283	0.39	0.23	lasso	3	0.20	5.0e-07	7.95	-7.6	2.4e-14	0.28	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PL-5283	0.24	0.10	lasso	4	0.17	2.2e-14	4.76	-7.6	2.8e-14	0.26	0.00	1.00	FALSE
69	The Cancer Genome Atlas	Rectum Adenocarcinoma	PL-5283	0.37	0.07	enet	7	0.22	5.5e-06	4.89	-7.6	3.1e-14	0.27	0.00	0.95	FALSE
38	GTEx	Whole Blood	C7orf73	0.08	0.01	lasso	3	0.01	1.8e-02	7.95	-7.5	5.5e-14	0.35	0.14	0.12	FALSE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	PL-5283	0.28	0.20	lasso	5	0.19	1.5e-13	7.95	-7.5	5.6e-14	0.28	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Soft Tissue Sarcoma	NUP205	0.07	0.05	lasso	4	0.04	2.7e-03	7.73	-7.5	8.0e-14	0.27	0.01	0.75	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	C7orf73	0.49	0.28	enet	33	0.44	7.4e-16	7.95	-7.5	8.5e-14	0.21	0.90	0.10	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PL-5283	0.33	0.23	blup	49	0.24	1.3e-16	7.95	-7.4	1.3e-13	0.25	0.00	1.00	FALSE
39	METSIM	Adipose	C7orf73	0.11	0.05	lasso	7	0.07	7.5e-11	4.89	-7.3	2.5e-13	0.27	0.96	0.04	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PL-5283	0.40	0.32	lasso	4	0.36	2.6e-42	7.95	-7.3	3.4e-13	0.27	0.00	1.00	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	C7orf73	0.23	0.16	enet	28	0.26	1.4e-33	3.95	-7.2	5.3e-13	0.24	0.96	0.04	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC13A4	0.19	0.06	enet	15	0.09	3.8e-10	7.95	7.2	8.4e-13	-0.21	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC13A4	0.10	0.04	blup	57	0.06	6.7e-05	7.95	7.1	1.1e-12	-0.24	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PL-5283	0.40	0.15	lasso	7	0.18	1.2e-07	7.95	-7.1	1.5e-12	0.29	0.00	1.00	FALSE
4	GTEx	Adipose Visceral Omentum	C7orf73	0.18	0.11	lasso	4	0.09	2.8e-05	6.78	-7.0	1.8e-12	0.36	0.93	0.02	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC13A4	0.14	0.01	enet	9	0.07	2.3e-08	1.78	6.9	4.1e-12	-0.24	0.02	0.89	FALSE
22	GTEx	Heart Atrial Appendage	C7orf73	0.14	0.12	enet	10	0.09	7.4e-05	6.12	-6.9	4.6e-12	0.31	0.63	0.09	FALSE
36	GTEx	Uterus	C7orf73	0.35	0.23	lasso	5	0.21	4.8e-05	6.78	-6.8	8.8e-12	0.38	0.07	0.14	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC13A4	0.35	0.08	blup	56	0.20	1.8e-22	7.95	6.8	1.4e-11	-0.23	0.00	1.00	FALSE
40	NTR	Blood	SLC13A4	0.02	0.01	bslmm	490	0.01	1.6e-03	7.94	6.7	2.4e-11	-0.21	0.20	0.03	FALSE
29	GTEx	Prostate	C7orf73	0.50	0.21	enet	46	0.29	5.3e-08	7.95	-6.6	4.3e-11	0.19	0.46	0.07	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C7orf73	0.19	0.19	lasso	8	0.22	1.3e-26	7.95	-6.5	7.0e-11	0.22	0.89	0.11	FALSE
25	GTEx	Muscle Skeletal	C7orf73	0.11	0.06	lasso	6	0.08	4.2e-08	6.59	-6.5	8.0e-11	0.34	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue (Male)	C7orf73	0.24	0.08	lasso	8	0.14	3.5e-04	-6.25	-6.3	2.2e-10	0.10	0.07	0.05	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC13A4	0.20	0.11	enet	12	0.15	2.9e-17	7.95	6.3	2.5e-10	-0.23	0.00	1.00	FALSE
14	GTEx	Cells Transformed fibroblasts	CALD1	0.15	0.03	enet	41	0.04	9.7e-04	-2.12	-6.1	9.3e-10	-0.02	0.12	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM140	0.03	0.00	blup	467	0.02	5.0e-03	-0.37	5.7	1.5e-08	-0.05	0.14	0.02	FALSE
31	GTEx	Skin Sun Exposed Lower leg	NUP205	0.07	0.03	lasso	4	0.04	6.2e-04	-4.65	5.5	3.5e-08	-0.09	0.18	0.03	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	CNOT4	0.19	0.03	enet	8	0.07	3.3e-03	-0.29	-5.2	2.6e-07	0.16	0.08	0.05	FALSE