Hub : Genes

TMEM140

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0320 0.0160 1.6e-02 -0.002 0.015 -0.001 0.013 0.000 9.7e-01 5.0e-03 5.0e-01 8.9e-03 3.4e-01
2 NTR Blood 0.0394 0.0107 5.6e-10 0.044 0.030 0.046 0.027 0.022 4.7e-14 4.7e-10 1.2e-14 4.3e-09 1.2e-07
3 ROSMAP Brain Pre-frontal Cortex 0.0445 0.0180 9.4e-04 0.010 0.018 0.016 0.018 0.017 1.4e-02 2.1e-03 3.2e-03 2.0e-03 2.3e-03
4 YFS Blood 0.2371 0.0298 0.0e+00 0.413 0.397 0.413 0.411 0.412 1.9e-148 5.7e-141 1.8e-148 2.8e-147 4.9e-148
5 TCGA Breast Invasive Carcinoma 0.0373 0.0251 1.8e-03 0.013 0.007 0.004 NA 0.010 9.6e-04 9.5e-03 3.7e-02 NA 3.1e-03
6 TCGA Glioblastoma Multiforme 0.0930 0.0600 6.3e-03 0.086 0.066 0.047 NA 0.046 1.4e-03 4.7e-03 1.5e-02 NA 1.6e-02
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0513 0.0289 8.0e-06 0.051 0.039 0.059 NA 0.041 1.8e-06 2.8e-05 3.6e-07 NA 1.8e-05
8 TCGA Liver Hepatocellular Carcinoma 0.0960 0.0610 1.3e-03 0.090 0.051 0.072 NA 0.080 5.2e-05 1.9e-03 2.7e-04 NA 1.3e-04
9 TCGA Lung Adenocarcinoma 0.0524 0.0363 7.2e-05 0.026 0.016 0.026 NA 0.025 5.0e-04 5.2e-03 4.2e-04 NA 5.6e-04
10 TCGA Stomach Adenocarcinoma 0.0400 0.0280 4.1e-03 0.038 0.017 0.008 NA 0.020 9.4e-04 1.9e-02 8.4e-02 NA 1.3e-02
11 TCGA Testicular Germ Cell Tumors 0.1880 0.1140 3.2e-03 0.032 0.038 0.004 NA 0.014 2.6e-02 1.8e-02 2.3e-01 NA 9.9e-02
12 TCGA Uterine Corpus Endometrial Carcinoma 0.1500 0.0830 4.3e-03 0.130 0.069 0.049 NA 0.107 1.8e-04 5.6e-03 1.7e-02 NA 6.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 2.5 4.0 8.0 2.1 -2.0 1.7 -2.3 -2.1 -2.2 -2.0 -2.3 -1.1 -0.0 -2.8 -2.0
Bipolar Disorder or Schizophrenia 2.1 5.2 11.0 2.4 -2.1 1.5 -2.7 -2.3 -2.7 -2.4 -2.6 -1.1 -0.0 -3.3 -2.4
Depressed Affect (Nagel 2018) 0.1 0.2 0.6 0.6 0.4 0.5 0.6 0.2 0.6 0.1 0.6 0.3 -0.3 0.5 0.8
Depression (Nagel 2018) 0.1 0.2 0.9 0.9 0.1 0.6 -0.1 0.5 0.2 -0.4 -0.1 0.5 0.1 -0.1 0.0
Intelligence (Savage-Jansen 2018) 0.7 2.0 7.1 1.5 -1.3 -1.5 -1.0 -1.2 -1.7 -0.1 -1.0 -1.7 -2.7 -0.8 1.0
Neuroticism (Nagel 2018) 0.2 0.4 2.7 0.5 -0.1 -0.4 0.2 -0.3 0.0 0.3 0.2 -0.5 -0.9 0.5 1.6
Schizophrenia (2018) 0.8 1.7 3.6 1.5 -1.2 0.6 -1.6 -1.2 -1.6 -1.4 -1.4 -0.5 -0.0 -1.9 -1.4
Schizophrenia vs Biploar Disorder 1.3 1.7 2.9 -0.5 1.4 -0.9 1.4 1.7 1.2 1.7 1.6 1.1 0.3 1.6 1.4
Worry (Nagel 2018) 0.3 0.7 4.1 -0.2 -0.2 -1.3 0.2 -0.1 -0.2 1.0 0.2 -0.4 -1.0 0.4 2.0
Alzheimer’s Disease (in mother) 0.5 0.5 2.6 -1.3 0.3 0.3 0.1 -0.0 0.3 -1.1 -0.0 0.8 0.3 -0.3 -1.6
Alzheimer’s Disease (in father) 0.3 0.3 2.0 -1.4 0.3 -0.8 0.6 0.1 0.6 -0.1 0.5 0.3 -0.1 0.7 0.3
Alzheimer’s Disease (including proxy) 1.0 1.5 5.6 -2.4 1.3 0.1 1.2 0.9 1.5 -0.1 1.1 1.5 1.0 0.9 -0.9
Crohns Disease (2017) 0.7 1.5 3.0 0.3 1.4 -0.9 1.4 0.2 1.3 1.7 1.4 1.2 0.5 1.7 1.1
Irritable Bowel Disease (IBD) 0.9 2.1 5.6 -0.3 1.2 -1.1 1.4 1.6 1.1 2.2 1.5 0.7 -0.6 1.7 2.4
Ulcerative Colitis (UC) 1.5 2.8 8.5 -1.2 1.0 -1.3 1.3 2.5 1.0 2.3 1.5 0.4 -1.1 1.6 2.9
Major Depression (MDD) 0.2 0.3 1.1 -0.1 -0.4 -0.9 -0.4 0.3 -0.5 0.2 -0.3 -0.2 -1.1 -0.6 0.3
Reaction Time 0.9 1.8 3.1 0.6 -1.6 0.3 -1.6 -1.3 -1.8 -1.6 -1.7 -1.0 -0.5 -1.8 -1.1
Verbal and Numeric Reasoning (VNR) 0.2 0.4 2.2 -0.2 0.0 -1.5 0.2 -0.2 -0.1 0.5 0.1 -0.1 -1.2 0.3 0.5
Breast Cancer 0.8 1.9 5.7 0.3 -1.6 -1.4 -1.2 -1.8 -1.8 -1.0 -1.1 -2.4 -1.1 -0.7 0.5
Ovarian Cancer 1.0 1.3 2.7 -0.1 1.1 -0.3 1.0 1.6 1.4 1.5 1.2 1.1 0.9 1.1 1.3
Prostate Cancer 0.6 0.8 1.4 -1.1 1.2 0.3 1.1 -0.1 1.1 0.5 1.1 1.0 1.1 0.8 -0.5
Age at First Birth 0.4 0.6 2.5 1.6 -0.5 1.1 -0.7 -0.1 -0.6 -0.7 -0.8 -0.7 0.3 -0.8 -0.7
Bipolar Disorder (2011) 4.6 4.5 8.7 2.6 -2.0 2.5 -2.5 -1.5 -2.2 -1.8 -2.4 -1.3 0.7 -3.0 -1.8
Body Mass Index (BMI) (2010) 1.7 2.4 9.1 1.5 -1.4 3.0 -1.6 0.7 -1.1 -1.4 -1.5 -1.0 0.8 -1.6 -1.6
Coronary Artery Disease (CAD) 0.6 0.8 1.6 1.3 -1.1 1.0 -1.0 -0.1 -1.1 -0.7 -1.0 -1.0 -0.3 -0.7 -0.3
Crohns Disease (2012) 0.3 0.4 1.9 1.4 -0.7 -0.3 -0.7 -0.6 -0.8 -0.0 -0.5 -0.7 -0.4 -0.4 0.5
Mean Putamen Volume 0.2 0.3 1.0 0.4 0.3 0.6 0.0 0.8 0.3 -0.6 0.1 0.5 1.0 0.2 -0.6
Fasting Glucose 0.6 0.8 3.3 -0.4 -0.0 1.8 -0.2 1.3 0.1 -0.4 -0.3 0.4 1.6 -0.4 -0.9
HbA1C 0.4 0.4 1.2 0.9 -0.2 1.1 -0.4 0.6 -0.0 -0.6 -0.4 0.5 0.6 -0.7 -1.0
HDL Cholesterol 2.4 4.0 8.6 -2.0 1.9 -2.2 2.4 0.7 1.9 2.1 2.5 0.9 -0.1 2.9 2.2
LDL Cholesterol 0.5 0.7 2.0 -0.2 -0.9 -0.1 -0.7 -0.9 -1.1 0.1 -0.7 -1.2 -1.4 -0.9 0.7
Lupus 1.1 1.6 2.9 -1.1 1.3 -0.7 1.4 1.6 1.3 1.7 1.5 0.6 -0.9 1.3 1.5
Neuroticism (2016) 0.7 1.0 5.7 -0.9 0.4 -0.9 0.6 2.4 0.7 0.8 0.5 0.3 -0.9 0.8 1.3
Primary Biliary Cirrhosis 1.2 1.7 5.0 2.2 -1.3 0.7 -1.5 0.2 -1.1 -1.4 -1.5 -0.3 0.4 -1.8 -1.3
Rheumatoid Arthritis 3.2 4.4 10.3 -1.9 1.7 -2.3 2.2 1.0 1.6 2.7 2.3 0.7 -1.2 2.6 3.2
Schizophrenia (2014) 2.2 4.8 8.8 2.5 -2.3 0.8 -2.7 -1.8 -2.8 -2.2 -2.6 -1.6 -0.3 -3.0 -2.0
Triglycerides 0.6 1.0 5.2 0.1 0.7 2.3 0.3 0.9 1.0 0.2 0.2 1.2 1.1 -0.0 -1.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 0.9 0.6 -1.0 1.0 -0.9 -0.1 -0.8 -0.9 -0.8 -0.8 -0.4 -0.8 -0.6
Ulcerative Colitis 2.1 3.1 8.2 -1.2 1.3 -1.9 1.5 2.3 1.3 2.0 1.8 0.9 -1.3 1.7 2.9
Blood Eosinophil Count 2.0 15.1 26.0 2.0 -5.0 -1.7 -4.6 -3.5 -5.1 -4.4 -4.8 -4.8 -2.8 -3.8 -1.5
Blood Platelet Count 0.8 9.7 14.6 -3.8 3.5 -3.6 3.4 2.0 3.1 3.8 3.3 3.3 1.1 3.1 2.1
Blood Red Count 0.9 9.1 29.5 -1.6 2.0 -5.4 3.0 -0.2 1.6 2.6 3.0 0.3 -3.8 3.5 4.4
Blood White Count 0.1 0.7 6.2 -2.5 0.4 0.1 0.1 0.8 0.3 -0.3 0.0 0.4 0.4 0.3 -1.2
Heel T-Score 0.2 1.6 5.9 0.9 -1.0 0.6 -1.4 -0.5 -0.9 -2.0 -1.4 -0.5 0.8 -1.2 -2.4
BMI 0.9 5.0 7.9 2.2 -2.7 2.8 -2.7 -0.1 -2.4 -2.1 -2.7 -2.6 -0.3 -2.3 -1.4
Height 0.2 4.7 53.1 7.3 0.1 -0.0 -0.1 0.8 0.2 0.5 0.1 0.6 -0.3 -0.3 1.4
Waist Hip Ratio (WHR) 1.1 4.9 8.3 0.4 -2.5 0.9 -2.8 -2.5 -2.8 -2.5 -2.9 -1.7 0.5 -2.7 -2.1
Systolic Blood Pressure 1.3 6.6 12.9 -3.0 2.9 2.5 2.3 0.7 3.0 0.8 2.1 3.5 3.6 2.0 -2.5
Smoking Status 0.5 1.2 3.2 -1.3 1.1 -0.3 1.0 1.1 1.1 0.8 1.1 1.2 1.8 1.3 0.8
Allergy or Eczema 1.4 3.8 12.0 0.4 -1.5 -2.5 -0.8 -2.4 -1.8 0.2 -0.8 -2.7 -3.5 0.0 2.7
Cardiovascular Disease 1.3 4.3 12.5 -2.6 1.8 2.0 1.3 2.0 2.4 1.0 1.0 2.9 3.5 1.0 -1.6
Hypothyroidism (self reported) 2.0 4.6 8.0 1.0 -2.8 -0.1 -2.5 -1.3 -2.8 -1.9 -2.6 -2.7 -2.6 -2.5 -0.4
Respiratory disease 0.1 0.3 0.8 -0.2 -0.5 -0.1 -0.5 -0.9 -0.7 -0.5 -0.5 -0.4 -0.4 -0.6 -0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.7 0.3 -0.1 -0.9 0.1 0.4 -0.2 0.3 0.1 -0.1 -0.8 0.5 0.7
Lung FEV1/FVC ratio 1.3 6.5 24.1 -2.4 -0.2 -4.9 0.9 0.0 -0.5 1.2 1.0 -2.3 -4.7 1.8 3.7
Lung FVC 0.9 4.5 11.3 2.0 -1.2 3.2 -1.9 -1.3 -1.4 -2.8 -1.9 -0.7 2.0 -2.2 -3.4
Neuroticism 0.2 0.5 1.2 1.0 -0.9 -0.3 -0.5 -0.3 -0.6 -0.6 -0.6 -1.1 -0.9 -0.1 1.0
Chronotype (morning person) 0.4 1.0 3.4 0.8 1.3 1.2 0.4 -0.4 0.8 0.3 0.5 1.8 1.3 -0.0 -1.4
Hair Pigment 0.1 2.2 3.3 -0.9 1.7 1.7 1.5 1.5 1.8 1.1 1.4 1.8 1.8 1.6 -0.2
Tanning 0.2 2.8 7.2 -1.9 1.4 -2.7 1.9 -0.2 1.2 1.5 1.9 0.5 -1.4 1.7 2.1
Hand grip strength (left) 0.1 0.2 0.6 0.4 0.0 -0.5 -0.1 -0.7 -0.1 -0.4 -0.1 0.1 -0.2 -0.6 -0.8
Number of treatments/medications taken 0.1 0.2 0.6 -0.1 -0.4 0.0 -0.6 -0.3 -0.8 -0.3 -0.5 0.2 -0.2 -0.8 0.3
Average weekly spirits intake 0.8 1.0 2.2 0.6 1.1 -1.3 1.1 -1.1 0.4 1.5 1.1 0.4 -0.1 1.1 1.1
Sensitivity / hurt feelings 0.2 0.3 1.0 0.3 0.6 0.5 0.7 -0.4 0.5 0.1 0.6 0.2 -0.7 1.0 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.6 5.0 0.4 -0.1 -0.6 0.1 2.2 0.2 0.3 0.1 0.1 -0.3 -0.0 1.1
Hearing difficulty/problems: Yes 0.3 0.4 1.7 -0.8 0.2 0.5 0.0 -1.1 0.1 -0.6 -0.0 0.4 0.7 -0.1 -1.3
Relative age of first facial hair 1.2 2.5 7.7 -1.7 1.7 -2.8 1.6 -0.9 1.1 1.2 1.9 0.8 -0.5 1.9 1.6
Other serious medical condition/disability diagnosed by doctor 2.5 3.3 6.1 1.8 -2.1 1.1 -2.0 -2.3 -2.4 -1.5 -1.9 -2.5 -0.9 -1.7 -0.7
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.8 0.4 -1.6 -0.1 -1.5 -0.4 -1.7 -1.2 -1.3 -1.5 -1.1 -1.2 -0.0
Ever had hysterectomy (womb removed) 0.5 0.5 1.8 0.2 -0.9 -0.5 -0.7 -0.2 -0.8 -0.5 -0.8 -0.7 -1.3 -0.8 -0.2
Systolic blood pressure, automated reading 0.3 0.8 2.7 -0.6 1.0 1.7 0.7 0.3 0.8 0.1 0.7 0.9 0.6 0.7 -1.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.3 -0.9 0.3 -1.1 0.5 -0.0 -0.1 0.4 0.6 -0.1 -1.1 0.8 0.6
Angina 0.6 0.8 1.8 -0.5 1.0 -0.9 1.0 0.1 0.6 1.2 1.1 0.6 -0.4 1.1 1.3
Medication for hormone replacement therapy 0.5 0.6 2.2 0.8 -0.7 -0.4 -0.5 0.4 -0.8 0.1 -0.4 -0.7 -1.2 -0.2 1.5
Vitamin and mineral supplements 0.4 0.5 1.1 -0.5 0.9 -0.2 1.0 -0.4 0.9 0.6 0.8 0.8 0.5 1.0 -0.5
Supplements: Zinc 0.6 0.7 1.2 0.9 -0.9 0.0 -1.0 0.1 -1.1 -0.4 -0.8 -1.0 -1.1 -1.1 0.2
Medication: Co-codamol 0.8 0.9 1.6 0.1 -1.2 0.1 -1.2 -1.2 -1.2 -1.1 -1.2 -1.2 -0.5 -1.0 0.0
Medication: Metformin 0.7 1.0 2.2 0.9 -1.3 -0.3 -1.1 -0.2 -1.4 -0.6 -1.0 -1.5 -1.3 -0.6 0.5
Diabetes (father) 0.4 0.5 1.4 1.1 0.2 -0.3 0.5 -0.9 0.1 0.5 0.5 -0.6 -0.9 0.8 1.2
Diabetes (mother) 0.2 0.3 0.7 -0.4 -0.6 -0.4 -0.2 0.6 -0.3 -0.8 -0.5 -0.2 -0.8 -0.5 -0.2
Severe depression (siblings) 1.3 1.4 5.4 0.9 -1.2 0.1 -0.9 -2.3 -1.3 -1.2 -1.0 -1.7 -1.0 -0.4 0.1
Pack years adult smoking proportion 2.1 3.2 7.6 0.9 -1.8 2.2 -2.1 0.1 -1.6 -2.2 -2.2 -0.9 0.3 -2.8 -1.9
Impedance of leg (right) 0.1 0.7 3.1 1.0 -0.1 0.3 -0.7 -1.7 -0.7 -0.4 -0.4 0.5 1.2 -0.8 -0.5
Leg fat-free mass (left) 0.3 1.8 11.0 3.3 -0.7 1.9 -0.6 2.0 -0.0 -0.4 -0.7 -0.3 -0.1 -0.9 -0.4
Trunk fat percentage 1.7 6.7 11.0 3.3 -3.3 2.6 -3.2 0.1 -2.6 -2.7 -3.3 -3.0 -0.0 -2.5 -1.3
Hand grip strength (right) 0.1 0.3 1.1 -0.1 -0.2 -0.4 -0.3 -0.9 -0.3 -0.8 -0.3 0.0 -0.5 -0.8 -1.0
Townsend deprivation index at recruitment 1.3 1.8 4.9 -0.3 -2.0 -0.9 -1.3 -0.5 -1.7 -1.1 -1.4 -2.2 -1.7 -0.7 0.9
Current tobacco smoking 0.5 0.8 1.7 -0.4 -1.3 0.2 -1.3 -0.3 -1.1 -1.2 -1.3 -0.9 0.2 -1.1 -0.3
Average weekly fortified wine intake 0.3 0.4 1.3 0.8 0.7 0.4 0.2 -0.8 0.4 -0.1 0.1 1.1 0.4 -0.1 -1.1
Maternal smoking around birth 0.2 0.3 0.9 0.4 -0.9 0.2 -0.7 0.4 -0.3 -0.6 -0.9 -0.3 -0.3 -0.7 0.0
Fed-up feelings 0.4 0.8 2.2 -0.3 0.8 -0.1 0.9 1.3 0.9 0.9 1.0 0.6 -0.1 0.8 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.7 0.5 0.8 1.2 0.5 1.7 1.0 -0.0 0.5 1.5 1.4 0.2 -0.5
Relative age voice broke 1.2 1.9 3.7 -1.2 1.7 -1.5 1.6 -0.5 1.0 1.5 1.9 0.8 -0.7 1.8 1.2
Taking other prescription medications 0.2 0.3 0.7 0.1 -0.6 -0.1 -0.6 -0.5 -0.8 0.1 -0.6 -0.5 -0.3 -0.5 0.7
Age when periods started (menarche) 0.3 0.7 1.9 0.4 -0.7 -0.4 -0.9 -1.4 -1.0 -0.7 -0.8 -0.7 -0.7 -1.0 -0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 2.1 -1.4 0.5 -0.1 0.4 0.9 0.5 0.5 0.4 0.7 -0.2 0.1 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.8 0.9 -1.3 0.0 -1.3 -1.4 -1.6 -1.0 -1.1 -1.7 -1.3 -1.3 -0.6
Tinnitus: Yes, but not now, but have in the past 2.5 2.7 4.5 2.1 -1.8 1.0 -1.8 -1.6 -1.9 -1.9 -1.9 -1.8 -0.3 -1.5 -1.1
Qualifications: CSEs or equivalent 0.2 0.3 1.6 -0.5 -0.0 -0.2 0.1 1.3 0.3 -0.0 -0.1 0.7 0.6 -0.2 0.3
Serious illness, injury or assault to yourself 0.3 0.3 1.9 0.6 -0.2 1.4 -0.0 0.5 -0.1 0.2 -0.1 -0.4 -0.7 0.3 0.6
High blood pressure 0.5 1.3 5.2 -0.8 0.2 2.3 -0.1 1.4 0.6 -0.3 -0.3 0.9 2.0 -0.3 -1.5
Hayfever, allergic rhinitis or eczema 0.7 1.6 4.9 -0.0 -0.5 -1.8 0.0 -1.5 -0.8 1.0 0.0 -1.4 -2.2 0.6 2.1
Multivitamins +/- minerals 1.0 1.3 3.2 1.0 -1.4 0.9 -1.4 -0.5 -1.1 -1.8 -1.2 -1.2 -0.2 -1.3 -0.7
Stomach or abdominal pain in last month 0.3 0.4 2.2 0.5 0.3 0.6 0.2 1.5 0.6 -0.3 0.0 0.9 0.1 -0.0 -0.5
Supplements: Glucosamine 0.3 0.3 0.8 0.9 -0.5 0.9 -0.5 -0.5 -0.6 0.1 -0.4 -0.9 0.2 -0.2 0.5
Diverticular disease/diverticulitis (self-reported) 3.9 4.6 10.6 2.4 -1.5 2.5 -2.0 -2.5 -1.6 -2.8 -1.9 -0.9 1.1 -1.9 -3.2
Medication: Atenolol 0.7 0.9 2.4 -0.1 0.8 0.0 0.8 1.1 0.7 1.6 0.9 0.3 0.0 1.4 1.5
Medication: Levothyroxine sodium 1.0 1.7 3.8 0.3 -1.9 0.3 -1.6 -0.2 -1.8 -1.0 -1.6 -1.9 -1.1 -1.3 0.0
Sitting height 0.7 5.2 50.6 7.1 0.2 2.2 -0.4 1.5 0.3 0.3 -0.2 1.1 1.4 -0.7 -0.3
Chronic bronchitis/emphysema (father) 0.7 0.9 4.6 -0.1 0.4 2.2 -0.2 0.1 0.2 -0.0 -0.2 0.8 1.9 -0.5 -0.9
High blood pressure (mother) 1.3 1.9 3.7 -0.3 1.6 0.8 1.4 0.8 1.9 1.3 1.4 1.9 1.7 1.5 0.2
Body mass index (BMI) 1.4 5.8 9.5 2.0 -3.1 2.9 -2.9 0.0 -2.4 -2.7 -3.1 -2.7 -0.3 -2.6 -1.9
Impedance of leg (left) 0.2 1.0 4.3 0.9 -0.4 0.5 -1.0 -2.1 -0.8 -0.9 -0.8 0.2 1.4 -1.0 -0.8
Leg predicted mass (left) 0.3 1.7 10.9 3.3 -0.6 1.8 -0.5 2.0 0.1 -0.3 -0.6 -0.1 -0.1 -0.8 -0.4
Trunk fat mass 1.7 7.1 16.9 4.1 -3.2 3.0 -3.1 0.1 -2.5 -2.6 -3.2 -2.8 0.1 -2.6 -1.5
Waist circumference 1.8 6.5 11.0 2.7 -3.3 2.5 -3.2 -0.2 -2.7 -2.8 -3.3 -2.8 -0.1 -2.8 -1.6
Number of incorrect matches in round 0.7 1.1 3.5 0.2 -0.6 1.9 -1.0 0.5 -0.5 -1.1 -1.1 -0.0 1.1 -1.1 -1.6
Past tobacco smoking 0.7 1.4 3.0 1.7 -0.8 1.7 -1.0 -0.6 -0.7 -1.2 -1.0 -0.4 0.7 -1.4 -1.7
Alcohol usually taken with meals 0.8 1.3 3.3 -0.3 1.8 -0.0 1.5 -0.1 1.4 1.3 1.6 1.4 0.4 1.3 0.1
Nervous feelings 0.2 0.5 2.3 -0.5 -0.0 -1.5 0.3 -0.3 0.2 0.4 0.3 0.1 -1.0 0.2 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 3.9 0.3 0.6 -0.4 0.6 2.0 0.5 1.1 0.9 0.5 -0.6 0.3 1.4
Hearing difficulty/problems with background noise 0.1 0.1 1.0 -0.1 0.0 -0.4 0.1 -1.0 0.0 0.1 0.1 -0.1 -0.0 0.4 -0.5
Hair/balding pattern: Pattern 2 1.2 1.6 3.9 0.5 -1.6 -0.5 -1.2 -0.8 -1.6 -1.0 -1.4 -2.0 -1.8 -0.9 0.5
Had menopause 1.5 1.9 3.4 1.5 -1.8 0.8 -1.8 -0.0 -1.7 -1.3 -1.7 -1.8 -0.5 -1.4 -0.2
Had other major operations 1.3 1.6 2.9 1.7 -1.3 1.2 -1.6 -0.6 -1.0 -1.3 -1.7 -0.4 0.4 -1.6 -1.2
Forced vital capacity (FVC) 0.5 1.8 6.5 2.6 -0.1 2.0 -0.6 -0.2 -0.0 -1.2 -0.6 0.7 1.8 -1.0 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.3 0.7 -0.8 -0.6 -0.8 -1.0 -1.0 -0.8 -0.7 -1.1 -1.1 -0.8 -0.6
Ever unenthusiastic/disinterested for a whole week 1.5 1.9 4.6 1.1 -1.3 -1.3 -1.3 -1.5 -1.8 -0.8 -1.0 -1.6 -2.1 -1.2 0.6
Qualifications: None of the above 0.5 1.1 4.1 -2.0 0.8 0.8 0.9 0.8 1.3 0.2 0.6 0.9 1.5 0.8 -0.5
Financial difficulties in last 2 years 0.1 0.1 0.3 -0.0 0.1 0.5 0.3 0.6 0.4 0.2 0.2 0.4 0.5 0.5 0.1
Mouth/teeth dental problems 0.3 0.5 1.8 -0.2 -0.9 0.2 -0.9 -0.1 -0.8 -0.5 -1.0 -0.1 -0.4 -1.3 -0.5
Heart attack 0.2 0.3 1.3 0.9 0.3 1.1 0.3 0.3 0.3 -0.0 0.2 -0.0 0.2 0.7 0.4
Allergy 0.4 0.9 3.2 -0.0 0.9 0.8 0.5 1.4 1.1 0.0 0.6 1.4 1.8 0.2 -0.8
Pain all over the body in last month 0.1 0.2 0.5 -0.7 0.5 -0.2 0.2 -0.0 0.0 0.6 0.2 0.7 0.1 -0.0 0.4
Diabetes (self-reported) 0.5 0.8 2.8 -0.2 -0.9 -1.4 -0.3 0.2 -0.8 0.0 -0.3 -1.1 -1.7 0.3 1.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.4 -0.8 -0.0 -1.1 0.4 -0.8 -0.2 0.6 0.1 -0.3 -1.2 0.5 1.1
Medication: Ramipril 0.3 0.4 2.2 0.5 -0.2 1.5 -0.1 1.2 0.2 0.3 -0.3 0.4 0.9 -0.1 -0.4
Medication: Simvastatin 0.3 0.5 1.7 -0.8 0.5 0.9 0.5 0.2 0.5 -0.3 0.4 0.5 1.3 0.9 -1.0
Fluid intelligence score 0.5 1.0 4.9 0.5 -0.3 -1.6 -0.2 -1.4 -0.7 0.3 -0.1 -0.5 -2.2 -0.1 1.0
Illnesses of siblings 0.1 0.1 0.9 0.1 -0.0 -0.9 0.0 -0.0 -0.0 0.3 0.1 0.1 -0.3 -0.4 0.0
Neuroticism score 0.3 0.5 2.4 0.1 -0.1 -1.2 0.3 0.1 0.0 0.3 0.3 -0.2 -1.5 0.3 1.5
Weight 1.2 6.0 18.7 4.3 -2.7 3.0 -2.7 0.5 -2.0 -2.2 -2.8 -2.1 -0.1 -2.5 -1.5
Impedance of arm (right) 1.0 4.9 11.5 -2.0 2.1 -3.4 2.4 0.7 1.7 2.5 2.5 1.3 -0.5 2.7 2.8
Arm fat percentage (right) 0.6 2.4 5.7 1.2 -2.2 1.5 -1.8 0.7 -1.6 -1.5 -1.9 -2.4 -0.6 -1.2 -0.4
Trunk fat-free mass 0.3 1.9 14.3 3.8 -0.3 2.1 -0.5 1.2 -0.0 -0.4 -0.5 0.3 0.2 -1.0 -0.8
Hip circumference 0.4 1.5 7.5 2.7 -1.1 1.7 -1.0 1.3 -0.6 -0.9 -1.1 -1.0 -0.2 -0.8 -0.4
Time employed in main current job 0.5 0.5 2.6 0.6 0.1 0.9 -0.4 0.0 -0.2 -0.3 -0.4 0.2 1.6 -0.6 -1.3
Alcohol intake versus 10 years previously 0.9 1.3 2.6 -0.3 -1.2 1.5 -1.2 -0.9 -0.8 -1.6 -1.4 -0.6 0.2 -1.4 -1.6
Father’s age at death 0.6 0.8 3.6 0.2 0.6 -1.9 0.8 -0.2 0.2 0.9 0.9 -0.2 -1.0 1.2 1.0
Worrier / anxious feelings 0.5 0.9 1.8 0.9 -1.1 -0.6 -0.8 -1.1 -1.0 -0.4 -0.8 -1.3 -1.3 -0.5 0.8
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.3 5.9 2.4 -2.3 1.2 -2.1 -0.7 -2.2 -2.0 -2.0 -2.2 -0.4 -2.0 -0.3
Falls in the last year 0.7 0.9 1.5 1.2 -1.1 1.2 -1.1 0.2 -1.1 -0.8 -0.9 -1.1 -0.1 -1.1 -0.4
Hair/balding pattern: Pattern 3 0.3 0.4 1.3 0.4 0.6 1.1 0.3 0.5 0.6 0.4 0.3 1.1 0.7 -0.1 -0.9
Number of live births 1.6 2.3 4.8 -0.7 1.4 -0.8 1.7 1.7 1.4 2.0 1.8 1.0 -0.9 1.8 2.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 2.7 1.6 -0.0 0.3 -0.1 -0.1 -0.0 -0.6 -0.2 0.1 0.0 -0.3 -0.6
Pulse rate 0.3 0.5 2.6 0.1 -0.3 1.4 -0.1 1.6 0.4 0.3 -0.2 0.2 1.0 0.1 0.0
Happiness 0.5 0.6 1.5 1.0 0.6 0.6 0.4 1.2 0.9 0.0 0.4 1.1 1.1 0.1 -0.9
Noisy workplace 0.1 0.1 0.3 -0.3 0.1 0.3 0.2 0.3 0.4 -0.1 0.2 0.1 0.6 0.3 0.1
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.5 1.3 1.6 -0.9 1.3 -0.0 0.9 1.6 1.5 1.5 0.6 1.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.9 -0.1 -0.3 0.2 0.0 -0.3 -0.1 -0.5 -0.0 -0.7 1.0 0.8 -0.4
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 -0.4 0.4 0.5 0.4 -0.6 0.4 -0.3 0.3 -0.1 0.7 0.7 -0.3
Asthma 0.1 0.1 0.4 -0.4 0.3 -0.1 0.2 0.4 0.2 -0.1 0.2 0.6 -0.2 0.0 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.3 -0.4 1.0 -1.0 0.7 0.9 0.4 1.0 0.9 1.2 -0.9 -0.1 0.7
Medication: Cholesterol lowering 2.0 3.1 5.8 -1.3 2.4 0.4 2.2 0.8 2.0 1.9 2.1 2.0 1.3 2.4 0.7
Depression (self-reported) 0.5 0.6 1.8 0.2 -0.8 0.1 -0.8 -0.0 -0.8 -0.8 -0.9 -0.3 -1.1 -1.3 -0.5
Medication: Lansoprazole 0.8 0.9 2.7 -0.9 -0.7 1.0 -0.8 -0.9 -0.6 -1.6 -0.9 -0.5 0.8 -0.4 -1.4
Prospective memory result 0.7 0.8 2.2 -0.3 -0.7 1.5 -0.8 0.5 -0.4 -1.3 -0.9 0.1 1.2 -0.8 -1.2
Lung cancer (father) 1.0 1.2 2.6 -1.0 0.7 -0.9 0.9 1.6 1.2 1.4 0.6 1.0 -0.4 1.0 1.5
Illnesses of mother 0.4 0.5 2.9 0.6 -0.4 -0.9 -0.5 -1.7 -0.9 -0.0 -0.3 -0.9 -0.6 -0.4 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.9 2.0 -0.9 0.5 -0.9 -0.3 -0.6 -1.1 -1.1 -0.4 0.0 -0.9 -0.7
Pulse wave Arterial Stiffness index 1.9 2.2 6.5 0.7 -1.5 -0.9 -1.4 -2.0 -1.8 -1.0 -1.6 -1.5 -2.5 -1.3 0.0
Impedance of arm (left) 0.7 3.2 10.8 -1.6 1.3 -3.3 1.6 0.6 1.1 1.9 1.7 0.7 -0.7 2.0 2.7
Arm fat mass (right) 0.9 3.8 6.6 2.6 -2.4 2.4 -2.2 0.7 -1.8 -1.9 -2.3 -2.3 -0.4 -1.8 -1.0
Trunk predicted mass 0.3 1.8 14.1 3.8 -0.2 2.0 -0.4 1.2 0.1 -0.3 -0.4 0.3 0.1 -0.9 -0.7
Standing height 0.3 2.9 32.1 5.7 0.3 0.7 -0.0 0.7 0.4 0.3 0.1 1.0 0.6 -0.5 0.3
Length of working week for main job 0.7 0.8 1.9 1.3 -0.8 1.4 -1.0 1.1 -0.6 -0.4 -1.0 -0.4 0.0 -1.3 -0.6
Exposure to tobacco smoke at home 0.3 0.3 2.8 -0.3 -0.1 -0.3 -0.0 0.6 -0.4 -0.0 -0.2 -0.2 -1.7 -0.3 0.2
Breastfed as a baby 0.8 1.0 3.7 0.1 -1.0 -0.2 -0.9 -0.8 -1.1 -0.9 -1.0 -1.3 -1.9 -0.8 -0.3
Tense / ‘highly strung’ 0.7 1.1 4.1 -0.6 0.4 -1.0 0.4 1.9 0.3 1.6 0.6 0.6 -0.8 0.1 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 2.7 -0.0 -0.5 -0.6 -0.3 -0.1 -0.6 -0.4 -0.2 -0.6 -1.6 -0.7 0.6
Hair/balding pattern: Pattern 4 0.1 0.2 0.4 0.3 0.3 0.5 0.3 0.1 0.1 0.1 0.5 0.2 0.7 0.6 0.6
Birth weight of first child 2.8 5.1 12.5 3.5 -2.9 0.2 -2.7 -0.8 -2.5 -1.9 -2.8 -2.0 -1.8 -2.7 -0.3
Peak expiratory flow (PEF) 0.4 0.9 3.0 -0.5 0.3 -1.6 0.9 0.3 0.5 0.5 0.7 -0.3 -1.7 1.1 1.3
Pulse wave reflection index 0.8 0.9 5.3 -0.0 -0.4 -0.7 -0.5 -2.3 -0.8 -1.0 -0.6 -0.2 -1.2 -0.9 -0.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.6 0.9 -0.3 1.6 -0.4 0.7 -0.4 -0.5 -0.2 -0.2 0.9 -0.5 -0.6
Loud music exposure frequency 1.7 1.8 3.7 -0.8 1.4 -1.3 1.6 0.9 1.5 1.4 1.8 1.1 -0.2 1.9 1.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.9 0.4 1.2 -0.3 1.0 -0.7 0.9 0.6 1.0 1.4 0.1 1.0 -0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.6 0.6 0.4 -0.5 0.6 1.0 0.7 0.8 0.5 0.2 0.2 1.3 1.0
Blood clot in the leg (DVT) 0.7 0.9 3.6 -0.2 -1.4 -0.1 -0.8 -0.3 -1.2 -0.6 -1.0 -1.9 -1.3 -0.4 0.4
Medication: Paracetamol 0.1 0.2 1.2 -1.1 -0.1 -0.1 -0.1 -0.4 -0.3 0.3 -0.2 0.1 -0.2 -0.0 0.7
Headache pain in last month 0.3 0.5 1.1 0.5 -0.8 -0.4 -0.7 0.6 -0.7 -0.2 -0.8 -0.6 -1.1 -0.8 0.7
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 5.7 0.2 -1.9 -1.8 -1.3 -1.7 -1.6 -1.2 -1.4 -2.2 -2.4 -1.2 0.3
Glaucoma (self-reported) 0.7 0.8 2.1 0.1 0.8 -1.2 0.9 0.7 0.6 1.3 0.9 0.4 -0.7 1.1 1.4
Gout (self-reported) 0.4 0.6 1.8 0.8 0.6 0.7 0.2 -1.3 0.5 -0.1 0.1 0.9 1.1 0.2 -1.1
Hypothyroidism/myxoedema (self-reported) 1.3 2.6 5.0 0.7 -2.2 -0.2 -1.8 -0.8 -2.2 -1.4 -1.9 -2.2 -2.0 -1.7 0.0
Medication: Amlodipine 0.2 0.3 1.4 -0.8 -0.5 -1.2 -0.2 0.9 -0.1 -0.1 -0.4 -0.3 -0.6 0.0 0.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.1 -1.0 0.1 -0.8 0.3 -0.9 -0.7 -0.8 -0.9 -0.1 -0.5 -0.2
Birth weight 1.9 4.1 15.8 4.0 -1.9 3.2 -2.0 -0.4 -1.7 -1.2 -1.8 -1.7 0.3 -1.9 -1.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.8 0.1 -0.7 0.9 -0.5 0.1 -0.4 -0.3 -0.7 -0.4 -0.3 -0.2 0.2
High blood pressure (siblings) 1.0 1.4 3.9 1.0 -0.9 2.0 -1.2 -0.2 -0.9 -1.6 -1.3 -0.5 0.7 -1.1 -1.6
Forced vital capacity (FVC), Best measure 0.6 2.2 10.3 3.2 -0.8 1.9 -1.2 -0.5 -0.6 -1.4 -1.3 -0.1 1.4 -1.3 -1.5
Body fat percentage 1.8 7.2 11.4 3.1 -3.4 2.9 -3.3 -0.4 -2.7 -2.8 -3.4 -3.0 0.0 -2.6 -1.6
Leg fat percentage (right) 2.7 9.7 14.5 3.1 -3.6 3.8 -3.7 -1.3 -3.2 -3.5 -3.7 -3.1 0.2 -3.4 -2.5
Arm fat-free mass (right) 0.9 4.8 20.5 4.5 -1.8 3.3 -2.0 0.8 -1.1 -1.8 -2.1 -0.8 0.4 -2.3 -1.8
Exposure to tobacco smoke outside home 0.6 0.8 4.1 0.2 -0.1 2.0 -0.5 -0.4 -0.2 -0.8 -0.4 -0.0 0.9 -0.9 -1.5
Comparative body size at age 10 1.6 4.5 15.8 1.5 -1.1 2.9 -1.6 -1.6 -1.0 -2.6 -1.8 -0.5 2.5 -2.0 -4.0
Number of full brothers 2.3 2.9 5.1 0.2 -2.3 -0.4 -2.0 -1.1 -2.3 -2.1 -2.2 -1.8 -1.1 -2.2 -0.9
Worry too long after embarrassment 0.2 0.4 2.7 1.6 -0.4 -0.3 -0.3 -0.9 -0.6 -0.4 -0.2 -0.4 -0.2 -0.3 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.3 0.8 -0.8 0.4 -0.6 0.8 -0.6 -0.2 -0.5 -0.7 -0.9 -1.1 0.1
Wheeze or whistling in the chest in last year 0.7 1.3 4.1 0.1 -1.0 2.0 -1.0 0.8 -0.3 -1.6 -1.3 0.1 1.0 -1.1 -1.6
Number of children fathered 0.6 0.7 3.1 -0.3 0.8 0.2 0.6 0.6 0.9 0.8 0.7 0.8 1.8 0.9 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.5 0.6 -0.4 -0.7 -0.2 0.0 -0.2 0.0 -0.1 -0.4 -0.1 -0.1 0.6
Age at first live birth 0.5 1.0 2.5 -1.4 0.9 -0.7 0.9 1.6 0.9 0.9 0.9 1.0 0.6 1.0 0.4
Pulse wave peak to peak time 1.8 2.1 6.6 -0.2 1.4 1.0 1.3 1.9 1.7 1.0 1.5 1.5 2.6 1.2 -0.0
Health satisfaction 0.7 0.9 2.7 0.2 0.8 -0.2 1.0 0.7 0.9 1.5 1.1 0.5 0.2 1.3 1.6
Shortness of breath walking on level ground 0.9 1.1 5.5 -1.0 0.1 -1.0 0.4 1.6 0.3 1.1 0.5 -0.0 -1.0 0.6 2.3
Qualifications: College or University degree 0.2 0.7 3.6 0.9 0.1 -1.9 0.1 0.3 -0.3 1.0 0.4 -0.1 -1.4 -0.2 1.0
Eye problems/disorders: None of the above 0.3 0.4 2.8 -1.7 -0.2 -0.6 -0.0 0.8 0.1 0.4 -0.0 -0.2 -0.5 0.1 0.6
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.5 -0.2 0.3 -0.7 0.1 0.4 -0.1 0.2 0.2 0.4 -0.3 0.2 0.4
Emphysema/chronic bronchitis 0.3 0.3 1.3 -0.5 -0.4 0.9 -0.4 1.2 -0.0 -0.4 -0.4 -0.2 0.2 -0.4 -0.3
Medication for pain relief, constipation, heartburn 0.5 0.9 4.6 0.8 -0.4 1.5 -0.4 -0.7 0.1 -1.1 -0.5 -0.3 0.8 -0.6 -2.1
Neck or shoulder pain in last month 0.5 0.7 2.0 -0.1 -1.0 0.1 -0.8 -0.9 -1.1 0.0 -0.6 -1.2 -0.8 -0.4 1.4
Medication: Blood pressure 0.6 1.1 3.9 -0.8 1.1 1.0 0.7 2.0 1.0 1.1 0.7 1.3 1.2 0.6 0.1
Angina (self-reported) 0.6 0.8 1.5 -0.5 1.1 -0.9 1.1 0.0 0.7 1.1 1.2 0.8 -0.3 1.2 1.2
Migraine (self-reported) 0.2 0.3 0.8 -0.5 -0.1 -0.8 0.1 -0.9 -0.2 0.7 -0.0 -0.0 -0.6 0.1 0.7
Medication: Ibuprofen 0.7 0.9 2.7 -0.2 1.1 -0.4 1.0 1.6 0.7 1.0 1.1 1.5 -0.1 0.3 0.7
Medication: Allopurinol 0.7 0.9 3.4 0.0 0.8 0.5 0.3 -1.3 0.6 -0.1 0.2 1.3 1.8 0.1 -1.4
Medication: Omeprazole 2.4 2.8 6.2 0.8 -2.1 -0.3 -1.9 -1.2 -2.5 -0.5 -1.8 -2.5 -1.8 -1.8 1.3
Medication: Seretide 50 evohaler 1.3 1.5 3.0 1.2 -1.3 1.2 -1.4 -0.1 -1.4 -1.2 -1.3 -0.8 0.3 -1.7 -1.5
Mean time to correctly identify matches 0.9 1.8 3.8 0.8 -1.5 -0.2 -1.6 -1.1 -1.9 -1.6 -1.5 -1.4 -0.9 -1.6 -0.8
Heart disease (mother) 0.5 0.6 1.9 -0.4 -1.1 -0.2 -0.5 0.2 -0.7 -1.1 -0.6 -1.4 -0.9 0.1 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 3.0 -1.3 0.8 0.9 0.9 0.7 1.3 -0.1 0.8 0.7 1.7 1.1 -0.7
Whole body fat mass 1.8 7.3 14.4 3.8 -3.2 3.3 -3.2 -0.1 -2.5 -2.8 -3.2 -2.7 0.1 -2.7 -1.8
Leg fat mass (right) 2.1 8.2 14.4 3.8 -3.2 3.8 -3.3 -0.4 -2.7 -3.0 -3.3 -2.7 0.4 -3.0 -2.2
Arm predicted mass (right) 0.9 4.5 20.4 4.5 -1.6 3.3 -1.9 0.6 -1.0 -1.7 -2.0 -0.6 0.6 -2.1 -1.8
Pulse rate, automated reading 0.9 2.9 9.6 1.1 -1.4 3.1 -1.7 -1.6 -1.4 -1.3 -1.8 -0.8 1.1 -1.8 -1.9
Alcohol intake frequency. 1.4 3.2 5.6 1.0 -2.1 0.8 -2.2 -1.3 -2.2 -2.2 -2.2 -1.9 -1.2 -2.4 -0.9
Comparative height size at age 10 0.3 1.7 18.2 4.3 -0.3 0.2 -0.4 0.7 -0.2 0.3 -0.3 -0.1 -0.1 -0.6 0.7
Number of full sisters 0.4 0.5 1.3 -0.9 -0.7 -0.6 -0.1 1.0 -0.2 -0.2 -0.4 -0.8 -1.0 0.4 1.1
Suffer from ‘nerves’ 1.3 2.0 7.8 -1.9 0.1 -2.8 0.4 0.4 -0.1 1.1 0.5 -0.1 -2.0 0.1 2.6
Overall health rating 0.9 1.9 3.4 1.2 -1.8 0.4 -1.8 -0.9 -1.8 -1.0 -1.7 -1.5 -1.3 -1.5 0.4
Chest pain or discomfort 0.7 1.0 2.7 1.0 -1.1 -0.6 -1.1 -0.7 -1.6 -0.0 -0.7 -1.6 -0.7 -1.0 0.9
Had major operations 0.3 0.3 0.9 0.9 -0.4 -0.3 -0.5 -0.2 -0.8 0.1 -0.3 -1.0 -0.8 -0.2 0.5
Age at last live birth 2.3 3.3 5.5 -2.3 1.9 -1.1 2.2 2.0 2.0 1.9 2.1 1.5 0.4 2.2 1.4
Family relationship satisfaction 0.2 0.2 0.8 0.9 0.5 -0.2 0.5 0.6 0.4 -0.1 0.7 0.3 -0.2 0.3 -0.1
Leg pain on walking 0.2 0.3 1.4 -1.2 -0.1 -0.8 0.1 1.0 -0.0 -0.1 0.0 0.1 -0.4 -0.0 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.4 0.3 -0.2 0.6 -0.2 0.4 -0.0 0.2 -0.1 -0.2 0.6 -0.4 0.1
Commuting to job workplace: Car/motor vehicle 1.8 2.1 5.6 -1.0 1.9 -0.0 1.5 1.2 1.9 1.0 1.6 2.4 1.6 1.0 -0.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.5 0.5 -0.4 0.3 0.1 0.3 0.7 0.5 0.5 -0.7 -0.0 0.6
Medication: Aspirin 0.4 0.5 1.7 0.1 0.3 -1.0 0.4 1.3 0.2 0.7 0.4 0.2 -0.5 0.7 1.3
Supplements: Vitamin C 0.5 0.6 2.0 1.4 -0.0 -0.2 -0.3 0.3 -0.8 0.5 0.0 -0.7 -1.4 -0.3 1.3
Knee pain experienced in last month 0.3 0.5 2.6 0.3 -0.5 1.1 -0.5 -0.8 -0.1 -0.3 -0.5 0.0 1.6 -0.5 -0.0
Hypertension (Self-reported) 0.5 1.5 5.5 -0.6 0.3 2.3 -0.2 1.4 0.6 -0.3 -0.3 1.0 2.3 -0.4 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.4 -0.4 -0.6 0.1 -0.6 0.1 -0.6 -0.6 -0.6 -0.5 0.4 -0.6 -0.4
Illnesses of father: Heart disease 0.5 0.6 2.5 0.8 0.8 0.9 0.7 1.6 0.9 0.0 0.7 0.5 0.3 1.0 -0.0
Illnesses of siblings: Diabetes 0.2 0.3 0.6 -0.2 0.7 0.5 0.7 -0.2 0.4 -0.1 0.8 0.2 -0.6 0.7 0.5
Smoking status: Previous 1.1 1.6 2.7 -1.4 1.3 -0.8 1.4 1.2 1.4 1.3 1.4 1.3 0.5 1.6 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 3.9 2.0 0.2 0.2 0.2 1.0 0.7 0.6 0.2 0.8 1.1 0.3 0.4
Whole body fat-free mass 0.4 2.1 15.0 3.9 -0.6 2.2 -0.7 1.5 -0.1 -0.5 -0.7 0.0 0.1 -1.1 -0.8
Leg fat-free mass (right) 0.3 1.5 9.5 3.1 -0.7 1.6 -0.6 2.0 0.0 -0.4 -0.7 -0.3 -0.2 -0.7 -0.3
Arm fat percentage (left) 0.9 3.8 8.0 1.7 -2.8 1.7 -2.4 0.5 -2.1 -1.9 -2.5 -2.8 -0.7 -1.7 -0.6
Average weekly red wine intake 0.2 0.3 0.9 0.7 -0.1 -0.0 -0.3 -0.9 0.0 -0.3 -0.2 0.2 0.9 -0.1 -0.8
Handedness (chirality/laterality): Left-handed 1.3 1.6 3.8 0.5 1.2 -0.8 1.0 1.9 1.1 1.9 1.1 1.3 0.1 0.8 1.9
Mood swings 0.1 0.2 0.4 -0.6 0.4 0.1 0.6 0.0 0.6 -0.0 0.5 0.6 -0.1 0.4 0.3
Loneliness, isolation 0.7 1.0 2.6 1.6 -1.0 0.1 -1.0 -0.5 -1.2 -1.0 -0.9 -0.9 -1.2 -1.3 0.2
Long-standing illness, disability or infirmity 0.5 0.8 1.5 1.1 -1.1 0.3 -1.0 -1.1 -1.2 -0.7 -0.9 -1.0 -0.6 -0.8 0.1
Ever had bowel cancer screening 0.6 0.7 2.6 1.6 -0.8 1.1 -0.8 0.4 -0.4 -0.8 -0.9 -0.5 0.5 -0.9 -0.8
Diabetes diagnosed by doctor 0.1 0.2 0.7 -0.0 -0.5 -0.7 -0.2 0.1 -0.4 -0.2 -0.2 -0.6 -0.8 0.3 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.1 -0.7 0.5 0.1 0.5 0.3 0.3 0.7 0.5 -0.1 -0.1 0.8 1.0
Friendships satisfaction 0.7 0.9 1.6 -0.1 1.0 -1.2 1.2 1.0 1.2 0.9 1.2 1.0 -0.4 1.1 0.4
Qualifications: nursing, teaching 0.3 0.5 1.8 0.6 -0.4 0.3 -0.8 -1.4 -0.7 -0.8 -0.7 -0.2 -0.1 -0.7 -1.1
Commuting to job workplace: Walk 3.5 3.7 6.0 2.1 -2.5 0.5 -2.3 -1.4 -2.2 -2.2 -2.4 -2.0 -1.6 -2.0 -1.0
Eye problems/disorders: Cataract 2.2 2.5 5.7 2.4 -1.5 1.0 -1.6 -1.2 -1.6 -2.1 -1.7 -1.2 -0.0 -1.7 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.2 -0.6 1.3 0.0 1.3 1.4 1.3 1.4 1.5 0.9 0.4 0.9 0.6
Medication for cholesterol 0.6 0.9 1.8 -1.0 1.3 -1.2 1.0 -1.3 0.6 0.8 1.0 1.1 0.1 0.6 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 3.8 -0.7 -0.3 -1.4 0.3 0.7 0.2 1.1 0.3 -0.7 -0.7 0.9 2.0
Back pain experienced in last month 1.7 2.5 4.9 1.8 -1.4 1.9 -1.5 -2.2 -1.5 -1.9 -1.4 -1.5 0.4 -1.4 -1.5
Mineral and other dietary supplements 0.3 0.5 1.4 -0.5 0.8 -0.0 0.8 1.0 0.8 0.5 0.6 1.2 0.5 0.3 -0.2
Breast cancer (self-reported) 1.3 1.6 3.1 0.9 -1.5 0.5 -1.6 -0.9 -1.4 -1.8 -1.5 -1.3 -0.1 -1.6 -1.0
Asthma (self-reported) 0.0 0.1 0.3 -0.4 0.1 -0.2 0.1 0.3 0.0 -0.3 -0.0 0.4 -0.2 -0.1 -0.6
Osteoporosis (self-reported) 0.4 0.5 1.5 -0.7 -0.7 -0.7 -0.4 -0.8 -0.7 -0.4 -0.5 -1.2 -1.2 -0.1 0.6
Osteoarthritis (self-reported) 0.2 0.3 1.8 0.3 -0.2 1.3 -0.2 -0.3 0.1 0.1 -0.2 -0.2 0.8 0.5 0.3
Medication: Aspirin 0.6 0.7 2.5 -0.3 0.3 -1.3 0.6 1.2 0.3 0.8 0.6 0.2 -0.7 1.1 1.6
Medication: Gliclazide 0.3 0.3 0.6 0.7 -0.8 -0.4 -0.8 -0.5 -0.8 -0.4 -0.7 -0.6 -0.1 -0.6 0.2
Illnesses of father: None of the above (group 1) 2.1 2.7 4.6 -0.6 -2.1 -1.5 -1.8 -0.8 -2.0 -1.0 -1.9 -2.0 -2.0 -2.0 0.3
Smoking status: Current 0.3 0.5 0.9 -0.7 -1.0 -0.2 -0.9 -0.4 -0.9 -0.8 -1.0 -0.7 -0.1 -0.8 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 1.1 1.0 0.5 1.0 0.2 -0.1 0.5 -0.1 0.2 0.7 0.8 0.2 -0.6
Whole body water mass 0.4 2.2 15.1 3.9 -0.6 2.3 -0.7 1.6 -0.1 -0.5 -0.7 0.0 0.1 -1.1 -0.8
Leg predicted mass (right) 0.3 1.6 9.9 3.1 -0.8 1.7 -0.6 1.9 -0.1 -0.4 -0.8 -0.4 -0.2 -0.8 -0.3
Arm fat mass (left) 1.2 5.0 8.2 2.8 -2.9 2.5 -2.6 0.5 -2.1 -2.3 -2.8 -2.5 -0.3 -2.1 -1.3
Number of self-reported non-cancer illnesses 1.2 2.1 3.5 0.8 -1.2 1.9 -1.7 -1.6 -1.6 -1.6 -1.7 -0.6 0.4 -1.8 -1.5
Average weekly champagne plus white wine intake 3.8 5.2 9.6 -1.8 3.1 -0.5 2.9 0.9 3.0 2.3 3.0 2.6 1.6 2.7 0.2
Miserableness 1.3 2.2 4.2 -0.4 1.7 0.0 1.9 1.3 2.1 1.4 1.9 1.6 0.4 1.9 1.3
Guilty feelings 0.6 0.9 4.6 -0.2 -0.3 -1.3 0.3 0.6 0.1 0.8 0.3 -0.7 -1.5 0.6 2.1
Wears glasses or contact lenses 1.0 1.2 2.9 -0.1 -0.9 0.4 -1.3 -1.7 -1.6 -0.9 -1.0 -1.4 -0.7 -1.2 -0.6
Ever taken oral contraceptive pill 0.8 0.9 2.1 -1.3 1.2 -0.5 0.8 -0.1 0.9 0.7 1.0 1.5 1.3 0.4 -0.4
Hearing aid user 0.7 0.8 1.8 -1.2 0.9 -0.8 1.1 0.3 1.1 0.7 0.9 0.9 0.6 1.4 0.1
Mother’s age at death 0.1 0.2 0.5 -0.0 0.7 0.0 0.4 -0.5 0.0 0.5 0.6 0.1 0.4 0.5 0.5
Financial situation satisfaction 0.5 0.6 1.7 0.5 0.6 0.8 0.4 1.1 0.7 -0.3 0.3 1.2 1.1 -0.1 -1.3
Tinnitus: Yes, now most or all of the time 3.0 3.4 8.4 -1.2 1.7 -1.5 2.0 1.8 1.5 2.3 2.2 1.1 -1.0 2.2 2.9
Commuting to job workplace: Public transport 0.6 0.7 2.9 0.2 -0.6 -1.4 -0.3 0.1 -0.8 0.6 -0.3 -0.8 -1.7 -0.1 1.1
Eye problems/disorders: Glaucoma 0.6 0.7 2.6 0.3 0.7 -1.0 0.8 0.4 0.5 1.0 0.8 0.3 -0.8 0.8 1.6
Medication: Blood pressure 0.3 0.6 2.0 -0.0 -0.6 1.4 -0.5 1.1 0.1 -0.8 -0.7 -0.2 0.9 -0.3 -0.8
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.5 -0.5 0.1 0.4 0.1 -0.7 -0.1 -0.4 0.3 -0.2 0.0 -0.0 -0.3
Supplements: Fish oil (including cod liver oil) 1.5 1.9 2.7 1.3 -1.5 1.1 -1.7 -1.4 -1.6 -1.6 -1.5 -1.6 -0.4 -1.6 -1.0
High cholesterol (Self-reported) 0.7 1.2 4.1 -0.8 1.0 1.6 0.6 0.4 0.8 -0.2 0.6 1.4 2.0 0.6 -1.5
Medication: Bendroflumethiazide 1.2 1.9 10.0 -0.5 1.3 1.2 1.2 3.2 1.4 1.2 1.2 1.3 0.4 0.9 0.5
Medication: Paracetamol 0.3 0.4 1.6 -1.3 0.3 -0.0 0.5 0.3 0.4 0.8 0.5 0.4 0.6 0.8 0.9
Medication: Lisinopril 0.3 0.4 0.9 0.7 0.9 0.6 0.5 -0.3 0.5 0.2 0.8 0.8 0.9 0.5 -0.5
Medication: Atorvastatin 0.1 0.1 1.0 1.0 0.1 0.4 -0.2 0.1 -0.1 -0.0 -0.0 0.4 0.2 -0.3 -0.1
Illnesses of father: High blood pressure 0.5 0.6 1.6 0.9 0.7 0.9 0.4 0.1 0.8 -0.1 0.5 1.2 1.1 0.2 -1.2
Alcohol drinker status: Never 2.5 3.0 5.1 1.4 -2.1 1.0 -2.0 -0.9 -2.0 -2.1 -2.2 -1.7 -0.4 -2.1 -1.5
Ever smoked 0.8 1.5 5.6 -1.3 -0.2 -2.3 0.3 -0.5 -0.3 1.1 0.4 -0.9 -1.3 1.0 2.4
Basal metabolic rate 0.5 2.9 17.0 4.1 -1.1 2.5 -1.2 1.4 -0.5 -0.9 -1.2 -0.5 0.1 -1.5 -1.0
Leg fat percentage (left) 3.1 11.3 16.7 3.1 -4.0 3.9 -4.1 -1.7 -3.4 -3.9 -4.1 -3.5 0.3 -3.5 -2.7
Arm fat-free mass (left) 0.6 3.3 18.1 4.2 -1.1 3.0 -1.3 1.0 -0.5 -1.2 -1.3 -0.2 0.5 -1.6 -1.5
Number of operations (self-reported) 2.6 3.9 7.5 2.7 -2.0 1.4 -2.3 -2.4 -2.2 -1.7 -2.2 -1.6 -0.4 -2.4 -1.1
Average weekly beer plus cider intake 0.8 1.1 6.5 -2.5 0.7 -0.2 0.9 0.8 1.0 -0.0 0.7 1.0 1.3 0.7 -0.4
Irritability 0.8 1.3 5.4 0.5 -0.9 -1.4 -0.6 -0.5 -1.2 -0.0 -0.5 -1.5 -2.3 -0.6 1.5
Risk taking 1.3 2.0 6.0 -1.8 0.5 -2.1 0.9 1.2 0.3 1.3 0.9 0.1 -2.5 0.5 2.1
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.9 0.2 0.9 -0.2 0.8 -0.1 0.7 0.3 0.9 0.7 0.1 0.6 -0.1
Fractured/broken bones in last 5 years 0.6 0.8 2.8 0.4 0.3 -1.1 0.6 1.2 0.4 0.8 0.6 0.1 -1.7 0.4 1.3
Age started oral contraceptive pill 0.1 0.1 0.4 -0.0 -0.3 0.7 -0.3 0.6 -0.3 0.2 -0.4 -0.3 -0.0 -0.3 0.0
Diastolic blood pressure, automated reading 0.2 0.7 5.6 -0.3 0.2 2.4 -0.1 -0.0 0.2 -0.4 -0.2 0.6 0.6 -0.3 -1.5
Ever depressed for a whole week 0.4 0.5 1.4 0.9 -0.4 -0.1 -0.6 -1.0 -1.1 -0.3 -0.3 -0.8 -1.2 -0.9 -0.1
Unable to work because of sickness or disability 0.1 0.1 0.4 -0.1 -0.3 -0.3 -0.4 -0.4 -0.5 -0.1 -0.2 -0.3 -0.6 -0.5 0.3
Commuting to job workplace: Cycle 3.5 4.3 7.7 0.7 -2.5 -0.4 -2.5 -2.8 -2.6 -2.2 -2.4 -2.2 -0.9 -2.4 -1.3
Myopia 0.3 0.4 1.3 -0.5 -0.6 0.1 -0.7 -0.2 -0.6 -1.0 -0.6 -0.4 0.2 -0.8 -1.1
Vascular/heart problems diagnosed by doctor 0.5 1.3 5.5 0.3 -0.4 -2.4 -0.1 -1.4 -0.8 0.0 0.0 -0.9 -2.1 -0.1 1.1
Cholesterol lowering medication 1.0 1.5 4.1 0.6 -1.5 1.5 -1.4 0.3 -0.9 -2.0 -1.4 -0.8 0.6 -1.0 -1.6
Medication: Omeprazole (e.g. Zanprol) 4.0 4.9 10.7 1.0 -2.9 -0.2 -2.7 -1.8 -3.3 -1.4 -2.5 -3.3 -1.8 -2.3 0.8
Pain experienced in last month 0.4 0.7 2.0 -1.1 0.7 -0.6 0.9 1.4 1.1 0.5 0.8 0.4 -0.1 1.1 0.1
Supplements: Calcium 0.2 0.2 1.5 1.2 0.3 0.4 -0.1 -0.4 0.1 0.3 0.1 0.3 0.7 -0.2 0.3
Basal cell carcinoma (self-reported) 1.0 1.1 2.7 0.8 -1.3 -0.2 -1.0 -0.7 -1.5 -0.5 -0.9 -1.6 -1.6 -0.9 0.6
Heart attack/myocardial infarction (self-reported) 0.2 0.2 1.0 0.7 0.2 1.0 0.2 0.0 0.2 -0.0 0.2 -0.2 0.0 0.7 0.4
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 3.6 0.1 -1.6 0.4 -1.1 -0.3 -1.4 -1.0 -1.3 -1.9 -1.1 -0.7 0.0
Heart disease (siblings) 0.1 0.1 0.4 -0.2 0.0 0.6 0.0 -0.3 -0.0 -0.6 0.0 -0.2 0.1 0.3 -0.4
Alcohol drinker status: Previous 0.3 0.3 1.7 0.0 -0.4 1.3 -0.4 -0.7 -0.4 -0.3 -0.2 -0.8 0.4 -0.1 0.4
Pack years of smoking 2.2 3.2 7.0 0.9 -1.6 2.5 -2.0 -0.3 -1.5 -2.2 -2.1 -0.8 0.7 -2.6 -2.3
Impedance of whole body 0.1 0.4 2.2 -0.2 0.3 -1.5 0.3 -0.9 0.1 0.4 0.4 0.4 0.5 0.5 0.9
Leg fat mass (left) 2.3 8.9 15.4 3.7 -3.3 3.9 -3.4 -0.5 -2.7 -3.3 -3.5 -2.8 0.5 -3.1 -2.4
Arm predicted mass (left) 0.8 4.0 20.3 4.5 -1.1 3.4 -1.4 1.0 -0.6 -1.3 -1.5 -0.2 0.6 -1.8 -1.8