Best TWAS P=5.59e-09 · Best GWAS P=6.35e-21 conditioned to 9.71e-17
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EFCAB1 | 0.62 | 0.53 | lasso | 6 | 0.57 | 1.0e-83 | 5.4 | 5.6 | 2.1e-08 | 0.20 | 1.00 | 0.00 | FALSE |
2 | ROSMAP | Brain Pre-frontal Cortex | EFCAB1 | 0.67 | 0.53 | lasso | 20 | 0.55 | 5.8e-86 | 5.4 | 5.4 | 7.2e-08 | 0.20 | 1.00 | 0.00 | FALSE |
3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | EFCAB1 | 0.07 | 0.09 | lasso | 1 | 0.08 | 5.1e-07 | 5.5 | 5.5 | 4.9e-08 | 0.18 | 0.59 | 0.39 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFCAB1 | 0.03 | 0.03 | lasso | 2 | 0.03 | 6.5e-07 | 5.5 | 5.5 | 4.9e-08 | 0.18 | 0.65 | 0.34 | FALSE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | EFCAB1 | 0.05 | 0.08 | enet | 4 | 0.08 | 3.9e-05 | 5.4 | 5.5 | 3.0e-08 | 0.16 | 0.11 | 0.19 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | EFCAB1 | 0.04 | 0.03 | enet | 7 | 0.02 | 1.3e-03 | 5.4 | 5.3 | 1.0e-07 | 0.17 | 0.18 | 0.11 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EFCAB1 | 0.08 | 0.13 | lasso | 2 | 0.12 | 1.1e-13 | 5.5 | 5.4 | 5.1e-08 | 0.18 | 0.65 | 0.35 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EFCAB1 | 0.08 | 0.04 | blup | 34 | 0.08 | 3.1e-05 | 5.4 | 5.8 | 5.6e-09 | 0.22 | 0.31 | 0.32 | TRUE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EFCAB1 | 0.07 | 0.09 | enet | 6 | 0.08 | 8.2e-10 | 5.5 | 5.7 | 1.4e-08 | 0.15 | 0.64 | 0.36 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | EFCAB1 | 0.16 | 0.17 | lasso | 6 | 0.16 | 2.9e-07 | 5.4 | 5.5 | 4.9e-08 | 0.17 | 0.56 | 0.32 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EFCAB1 | 0.14 | 0.13 | lasso | 3 | 0.12 | 3.6e-12 | 5.4 | 5.4 | 7.1e-08 | 0.18 | 0.66 | 0.34 | FALSE |