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chr8:56,094,665-57,683,880

Best TWAS P=4.38e-41 · Best GWAS P=7.76e-78 conditioned to 1.01e-48

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Skin Not Sun Exposed Suprapubic	RPS20	0.18	0.03	enet	12	0.07	1.5e-04	-10.8	-13.4	4.4e-41	0.81	0.11	0.60	TRUE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS20	0.33	0.07	enet	8	0.07	1.7e-08	-8.4	-10.7	1.6e-26	0.49	0.96	0.03	TRUE
6	GTEx	Esophagus Muscularis	RPS20	0.12	0.04	lasso	6	0.05	7.2e-04	-11.0	-10.5	1.2e-25	0.76	0.22	0.65	TRUE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	PENK	0.03	0.04	enet	7	0.05	6.2e-10	8.7	-9.2	2.9e-20	-0.06	0.01	0.99	TRUE
5	GTEx	Cells EBV-transformed lymphocytes	LYN	0.35	0.07	enet	37	0.17	4.5e-06	16.2	-9.1	1.1e-19	-0.07	0.15	0.04	TRUE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS20	0.04	0.02	blup	29	0.03	4.8e-04	-8.2	-7.6	4.1e-14	0.49	0.03	0.03	TRUE
2	GTEx	Brain Cerebellum	RPS20	0.26	0.07	enet	17	0.10	5.4e-04	-11.0	-9.5	1.5e-21	0.60	0.30	0.22	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PENK	0.23	0.15	lasso	5	0.22	8.2e-10	8.7	-9.2	5.1e-20	-0.02	0.02	0.98	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PENK	0.03	0.01	blup	40	0.03	9.1e-04	-7.0	-9.1	6.6e-20	-0.01	0.02	0.75	FALSE
15	The Cancer Genome Atlas	Esophageal Carcinoma	PENK	0.35	0.21	enet	12	0.33	3.8e-11	8.6	-9.1	1.1e-19	-0.02	0.04	0.96	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PENK	0.07	0.06	enet	8	0.08	2.4e-09	-7.3	-8.7	2.9e-18	0.04	0.54	0.46	FALSE
1	GTEx	Artery Tibial	RP11-446E9.1	0.07	0.00	lasso	6	0.00	6.6e-01	-7.9	8.6	6.5e-18	-0.76	0.02	0.75	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS20	0.04	0.03	lasso	3	0.04	1.3e-04	-8.4	-8.2	3.5e-16	0.58	0.15	0.05	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	PENK	0.11	0.13	lasso	2	0.14	2.6e-08	-7.4	-8.1	7.9e-16	0.06	0.60	0.38	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	RP11-446E9.1	0.23	0.32	lasso	7	0.34	2.0e-45	-6.5	7.5	5.2e-14	-0.53	1.00	0.00	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	RPS20	0.24	0.20	lasso	6	0.23	3.4e-29	-8.4	-7.5	8.2e-14	0.51	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Rectum Adenocarcinoma	PENK	0.18	0.11	lasso	1	0.09	3.4e-03	-7.4	-7.4	1.5e-13	0.08	0.02	0.13	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	PENK	0.07	0.08	lasso	2	0.06	2.0e-05	-7.2	-7.2	7.4e-13	0.11	0.82	0.14	FALSE
7	GTEx	Muscle Skeletal	RPS20	0.07	0.09	lasso	1	0.07	1.5e-07	-6.4	-6.4	1.4e-10	0.49	0.99	0.01	FALSE
3	GTEx	Brain Cerebellum	RP11-446E9.1	0.15	0.05	lasso	3	0.03	3.7e-02	-6.4	6.3	3.5e-10	-0.53	0.05	0.55	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	LYN	0.09	0.12	lasso	2	0.12	8.4e-12	-5.9	6.2	5.0e-10	-0.49	1.00	0.00	FALSE
4	GTEx	Brain Nucleus accumbens basal ganglia	RPS20	0.41	0.05	lasso	8	0.13	3.1e-04	-6.7	-6.0	1.7e-09	0.53	0.05	0.23	FALSE
9	GTEx	Stomach	RP11-446E9.1	0.12	0.08	lasso	4	0.03	1.7e-02	-5.9	5.9	4.1e-09	-0.48	0.30	0.08	FALSE