TWAS
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Traits
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Traits
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Standing height
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chr10:11,167,624-13,839,729
Best TWAS P=5.44e-13 · Best GWAS P=4.04e-32 conditioned to 1.09e-26
11.5M
12M
12.5M
13M
13.5M
0
5
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20
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30
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Whole Blood
PROSER2
0.11
0.07
enet
12
0.07
2.5e-07
7.5
7.2
5.4e-13
0.07
0.01
0.99
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
CCDC3
0.15
0.03
enet
34
0.12
1.5e-15
3.1
6.2
5.0e-10
-0.45
0.43
0.57
TRUE
4
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
NUDT5
0.13
-0.01
blup
55
0.01
1.1e-01
-3.3
-5.3
9.9e-08
0.00
0.00
0.30
TRUE
1
GTEx
Cells Transformed fibroblasts
NUDT5
0.13
0.07
enet
14
0.07
3.3e-06
-4.7
-5.1
2.8e-07
-0.01
0.93
0.00
FALSE