Hub : Genes

CCDC3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1410	0.0350	2.4e-05	0.019	0.042	0.024	0.050	0.038	1.9e-03	7.4e-06	6.2e-04	8.4e-07	1.9e-05
2	GTEx	Artery Aorta	0.2300	0.0690	1.6e-03	0.125	NA	0.127	NA	0.019	2.2e-07	NA	1.8e-07	NA	3.0e-02
3	GTEx	Artery Tibial	0.1660	0.0538	2.8e-03	0.024	NA	0.033	NA	0.047	5.1e-03	NA	1.2e-03	NA	1.3e-04
4	GTEx	Lung	0.2596	0.0648	2.7e-04	0.044	NA	0.076	NA	0.059	2.7e-04	NA	2.0e-06	NA	2.8e-05
5	GTEx	Skin Sun Exposed Lower leg	0.2270	0.0520	1.7e-05	0.013	NA	0.064	NA	0.086	2.5e-02	NA	5.3e-06	NA	1.3e-07
6	ROSMAP	Brain Pre-frontal Cortex	0.1543	0.0331	1.3e-06	0.027	0.054	0.123	0.105	0.111	1.7e-04	1.6e-07	1.5e-15	2.0e-13	4.4e-14
7	YFS	Blood	0.0965	0.0204	1.9e-10	0.061	0.035	0.059	0.066	0.061	2.5e-19	9.1e-12	1.5e-18	1.0e-20	4.3e-19
8	TCGA	Colon Adenocarcinoma	0.1500	0.0610	6.1e-03	-0.005	0.052	-0.003	NA	-0.004	8.2e-01	5.8e-04	5.2e-01	NA	6.7e-01
9	TCGA	Brain Lower Grade Glioma	0.1139	0.0336	6.2e-06	0.040	0.056	0.037	NA	0.030	2.0e-05	6.0e-07	4.8e-05	NA	2.0e-04
10	TCGA	Lung Adenocarcinoma	0.0573	0.0237	3.2e-03	0.000	0.015	0.023	NA	0.015	2.9e-01	6.9e-03	8.2e-04	NA	5.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.9	3.2	0.2	-1.8	-0.3	0.5	0.7	-1.4	0.6	-0.9	0.5	1.0
Bipolar Disorder or Schizophrenia	0.4	1.0	2.4	0.4	-1.6	-1.3	1.5	-0.2	-1.3	0.1	-0.8	-0.3	1.2
Depressed Affect (Nagel 2018)	0.5	1.0	3.5	-0.3	-1.8	-1.1	-1.1	0.6	-1.9	-0.3	-0.4	-0.1	0.1
Depression (Nagel 2018)	0.3	0.4	1.6	0.4	-0.5	-0.6	0.2	0.2	-1.3	-0.1	-0.8	0.2	-1.0
Intelligence (Savage-Jansen 2018)	0.5	1.6	6.4	-1.9	0.1	-0.1	-0.2	-0.7	-1.0	-0.9	-0.9	-1.6	2.5
Neuroticism (Nagel 2018)	0.2	0.6	3.2	-0.3	-0.9	-0.7	-0.4	0.8	-1.8	-0.4	-0.3	0.2	0.2
Schizophrenia (2018)	0.3	0.7	2.2	0.3	-0.6	-1.4	1.5	-0.9	-0.6	-0.3	-0.3	-0.8	0.7
Schizophrenia vs Biploar Disorder	1.1	1.5	4.2	0.0	2.0	1.4	-0.2	-1.7	-0.2	-0.0	0.4	-1.7	-1.6
Worry (Nagel 2018)	0.4	0.8	2.5	-0.3	-0.8	-0.9	-0.3	0.1	-1.6	-1.3	-1.2	-1.0	0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.9	0.1	-1.3	0.0	-0.1	-1.4	-0.6	-0.4	1.2	-0.4	-0.6
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.5	0.1	-0.3	0.9	-0.7	0.6	0.6	0.4	-0.1	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	2.6	0.8	-0.2	-0.8	-0.1	-1.6	-0.3	-0.1	0.3	-0.1	-0.4
Crohns Disease (2017)	0.1	0.3	0.9	-0.3	-0.5	-0.7	-0.4	1.0	-0.7	-0.2	-0.8	-0.0	0.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	-0.4	-0.9	-0.9	0.6	0.3	0.2	-0.5	-0.3	0.3	1.1
Ulcerative Colitis (UC)	0.4	0.7	1.7	-0.7	-1.2	-0.9	1.0	-0.1	0.7	-0.9	0.0	-0.1	1.3
Major Depression (MDD)	1.1	1.3	4.7	0.0	-0.8	0.2	-1.8	-0.2	0.6	-1.5	2.2	-0.2	-1.6
Reaction Time	3.3	6.2	36.7	-3.1	-2.7	-1.3	-1.0	0.3	-6.1	0.4	-1.7	-1.6	0.4
Verbal and Numeric Reasoning (VNR)	0.7	1.7	5.7	-1.1	0.5	2.4	-0.8	-1.6	-0.2	-0.5	-0.7	-1.2	2.0
Breast Cancer	0.6	1.6	9.4	-0.0	1.4	3.1	0.7	-1.1	0.2	0.1	-1.3	0.5	0.6
Ovarian Cancer	0.5	0.6	1.4	0.5	1.2	1.1	0.9	-0.8	1.1	-0.2	0.7	-0.7	-0.4
Prostate Cancer	0.5	0.7	2.4	-0.8	0.3	-0.2	-1.5	0.1	0.9	0.4	1.0	1.5	0.0
Age at First Birth	1.0	1.4	8.3	-0.9	-0.0	-0.3	-0.7	1.8	0.2	-1.1	-0.3	-0.1	2.9
Bipolar Disorder (2011)	0.7	0.6	2.9	1.4	-0.5	0.5	1.7	0.6	-0.2	-0.1	-0.4	-0.1	0.7
Body Mass Index (BMI) (2010)	1.2	1.6	6.3	1.2	-1.9	-0.8	2.5	-0.6	1.1	1.5	0.5	0.1	0.2
Coronary Artery Disease (CAD)	1.3	1.5	5.2	-1.1	2.3	1.8	-0.4	-1.0	-1.3	0.6	-1.3	-0.5	-0.5
Crohns Disease (2012)	0.2	0.3	0.9	-0.3	0.2	-0.3	0.1	0.9	-0.5	-0.8	-0.3	-0.7	-0.1
Mean Putamen Volume	0.3	0.4	1.1	0.8	0.3	0.4	1.0	-0.1	0.2	-0.3	0.9	0.9	-0.2
Fasting Glucose	0.4	0.5	1.4	0.5	-1.0	-0.7	-0.0	0.1	-1.2	0.3	0.1	-1.2	-0.3
HbA1C	0.3	0.3	1.6	-0.0	-0.4	0.3	0.6	-1.2	-0.3	0.1	-0.9	0.4	0.2
HDL Cholesterol	0.6	1.0	2.9	-0.6	-0.2	-0.7	-1.5	-0.9	-0.8	-0.8	-1.5	-1.7	-0.4
LDL Cholesterol	0.7	1.2	3.3	0.2	-1.5	-1.8	0.7	1.8	0.6	-0.4	0.3	1.3	-0.0
Lupus	0.7	1.1	3.5	-0.5	-0.0	-0.3	-0.7	1.6	-0.5	0.6	-0.2	1.7	1.9
Neuroticism (2016)	0.6	0.9	3.1	-1.1	-0.7	0.7	-0.7	1.3	-1.8	-0.7	0.8	-0.6	0.5
Primary Biliary Cirrhosis	0.8	1.1	2.5	0.9	-0.6	-0.9	1.6	0.9	1.5	0.7	1.2	0.2	1.2
Rheumatoid Arthritis	0.8	1.1	3.2	-0.4	-1.3	-0.9	0.2	-0.5	-1.1	-1.8	-0.4	-1.4	1.3
Schizophrenia (2014)	0.5	1.1	3.0	0.7	-0.9	-0.9	1.6	-1.7	-0.1	0.9	0.4	-1.2	0.8
Triglycerides	0.5	0.7	2.4	1.6	-1.1	-0.7	0.9	-0.7	0.9	0.8	0.7	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.3	-0.6	-1.4	-1.2	0.1	0.6	0.4	2.1	0.2	0.6	1.2
Ulcerative Colitis	0.5	0.7	2.2	-0.4	-1.1	-1.1	1.5	0.2	0.7	-0.8	0.2	-0.3	1.0
Blood Eosinophil Count	0.1	1.0	4.2	0.8	0.2	-1.6	1.2	-0.6	0.3	-0.4	0.9	-0.0	-2.0
Blood Platelet Count	0.1	0.8	4.0	2.0	-0.3	-0.5	-0.0	-0.9	0.8	0.3	1.0	0.5	-0.8
Blood Red Count	0.1	0.8	3.4	-0.8	-1.3	-1.8	1.4	0.2	0.2	0.2	-0.2	0.0	0.3
Blood White Count	0.2	1.7	8.1	1.0	0.3	-0.7	0.9	-2.0	-0.5	-0.1	1.1	-0.9	-2.9
Heel T-Score	0.8	6.7	11.9	-2.9	-3.5	-2.8	-2.0	-2.6	-2.1	-2.0	-2.6	-3.3	1.5
BMI	0.3	1.8	11.6	-0.9	-1.4	-1.0	0.5	0.0	-3.4	0.4	0.6	1.4	0.5
Height	1.0	19.9	83.4	3.7	6.4	5.8	-1.8	3.8	9.1	-0.9	-1.1	0.8	2.9
Waist Hip Ratio (WHR)	0.2	0.7	2.7	0.2	1.6	0.7	0.6	-0.2	1.1	1.3	-0.2	-0.3	-0.7
Systolic Blood Pressure	0.1	0.5	2.8	-0.7	-0.3	0.1	-0.1	0.8	0.6	1.7	0.5	0.3	-0.2
Smoking Status	0.2	0.6	2.8	-0.3	-0.4	0.1	-0.6	-1.7	-1.0	-0.6	0.0	0.0	-1.0
Allergy or Eczema	0.4	1.0	4.8	-0.8	0.2	-0.3	-1.1	2.2	0.0	-1.5	-0.1	-0.2	-0.6
Cardiovascular Disease	0.6	2.1	6.2	1.6	-2.3	-1.5	1.1	-0.2	1.2	2.5	1.0	0.7	0.6
Hypothyroidism (self reported)	0.7	1.7	7.1	-1.0	-2.4	-0.6	-0.4	-0.7	-2.7	0.3	-0.3	-1.2	-0.1
Respiratory disease	0.6	1.4	6.0	0.9	-0.6	-0.7	-0.1	-1.1	-0.4	0.8	-1.0	-1.8	-2.5
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.9	0.8	-1.1	-1.4	1.4	1.2	-0.0	2.2	0.0	1.5	2.0
Lung FEV1/FVC ratio	0.2	1.1	7.5	1.1	-0.6	0.8	-0.0	-0.7	0.1	-2.7	0.5	-0.6	-0.7
Lung FVC	0.1	0.7	2.8	-1.6	0.0	-0.2	1.0	0.1	-0.6	-1.7	-0.2	-0.3	0.3
Neuroticism	0.3	0.7	2.3	-0.6	-0.6	-0.5	-0.9	1.5	-1.5	-0.4	-0.3	-0.0	-0.5
Chronotype (morning person)	0.6	1.4	4.0	1.6	1.9	2.0	0.3	0.5	0.9	-0.5	0.8	1.2	0.6
Hair Pigment	0.0	0.6	1.6	-0.0	-0.5	0.3	-1.0	0.6	1.3	-0.4	1.2	1.0	0.0
Tanning	0.0	0.1	0.5	-0.1	-0.1	-0.2	-0.1	-0.2	-0.1	0.1	-0.7	-0.5	0.7
Hand grip strength (left)	0.2	0.5	2.5	0.1	0.9	0.9	0.2	0.5	1.6	0.1	-0.1	0.4	-0.1
Number of treatments/medications taken	1.2	2.1	9.2	0.7	-1.4	-0.9	2.6	-0.2	-0.4	3.0	1.0	-0.1	-0.8
Average weekly spirits intake	0.7	0.9	2.0	0.1	-0.4	0.9	-1.3	1.3	-0.6	-0.1	1.4	1.4	-0.7
Sensitivity / hurt feelings	1.0	1.7	4.6	0.6	1.8	2.2	0.1	0.8	-0.8	1.7	1.5	1.4	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.6	-0.2	-0.5	-0.1	-0.4	1.3	-1.2	-0.4	-0.5	0.6	-0.5
Hearing difficulty/problems: Yes	0.7	1.0	3.1	-1.5	-0.3	1.8	-1.3	-0.3	-0.4	0.4	0.6	-0.1	1.6
Relative age of first facial hair	0.1	0.3	1.1	-0.5	0.2	-0.1	-0.4	-0.7	-0.6	-0.2	0.1	-0.2	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.1	-0.8	-0.3	0.6	-0.4	0.4	-0.3	1.0	-0.0	0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.6	0.7	-0.7	-1.6	-0.1	-0.6	0.0	1.1	0.7	-0.6	-1.2
Ever had hysterectomy (womb removed)	1.6	1.8	6.2	1.5	-0.2	-0.6	-1.0	-2.1	0.3	-0.2	-0.9	-2.5	-1.7
Systolic blood pressure, automated reading	0.1	0.3	0.9	-0.9	-0.2	-0.5	-0.1	0.7	-0.3	0.6	0.2	-0.0	-0.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.8	0.6	-1.6	-0.5	1.7	0.9	0.8	0.7	1.1	1.2	0.9
Angina	1.3	1.7	3.8	-1.9	-2.0	0.1	-0.4	0.9	-1.9	1.6	0.0	1.3	0.9
Medication for hormone replacement therapy	1.6	1.8	8.9	0.2	1.9	1.1	-0.1	-0.2	1.1	1.7	0.1	0.2	-3.0
Vitamin and mineral supplements	0.4	0.6	3.0	-1.7	-0.0	0.5	-0.6	-0.2	-1.3	0.0	0.3	0.4	0.1
Supplements: Zinc	1.3	1.5	4.5	0.3	-1.7	-1.4	-0.8	0.1	-0.7	-2.1	-1.1	-1.4	0.9
Medication: Co-codamol	0.7	0.8	2.3	0.4	1.2	0.3	0.6	-0.0	0.7	1.5	1.0	1.1	0.9
Medication: Metformin	0.5	0.8	2.5	0.4	-0.8	-1.0	1.6	0.4	0.7	1.3	0.6	-0.4	0.7
Diabetes (father)	0.8	1.0	5.4	0.7	0.4	-1.2	0.3	2.3	-0.4	1.0	-0.5	0.9	0.5
Diabetes (mother)	1.0	1.3	5.4	1.7	1.0	-0.2	0.7	-2.3	0.5	0.8	-1.1	-1.0	-0.3
Severe depression (siblings)	1.4	1.6	8.0	2.8	0.1	0.3	0.2	-0.2	2.0	1.5	0.2	0.3	-1.2
Pack years adult smoking proportion	0.6	0.8	2.8	1.0	1.2	1.1	0.4	-0.7	0.0	0.6	1.7	0.6	-0.8
Impedance of leg (right)	0.2	1.2	3.1	0.1	1.8	0.2	0.7	1.7	1.3	-0.8	0.1	-0.2	-1.6
Leg fat-free mass (left)	0.2	1.2	3.3	1.0	0.5	1.3	-0.8	0.1	1.6	0.9	-0.6	1.0	1.8
Trunk fat percentage	0.2	0.9	2.0	0.5	-1.2	-1.2	1.4	0.4	-0.2	0.7	1.2	1.2	0.6
Hand grip strength (right)	0.4	1.0	4.1	0.4	1.6	1.1	0.0	0.6	2.0	-1.3	-0.3	-0.1	0.3
Townsend deprivation index at recruitment	0.5	0.7	2.8	-0.2	0.2	-1.4	-0.8	1.7	-0.7	-0.5	-0.1	-0.8	0.1
Current tobacco smoking	0.3	0.5	1.7	-1.3	-0.6	0.4	-0.0	-1.0	-0.9	-0.4	0.2	-0.4	0.5
Average weekly fortified wine intake	0.7	0.8	4.0	-1.3	0.3	-0.9	-0.6	2.0	-0.9	0.6	-0.0	0.1	-0.2
Maternal smoking around birth	1.3	1.9	3.8	1.9	-0.4	-0.5	2.0	-1.9	0.8	1.2	1.8	-0.8	-1.2
Fed-up feelings	0.2	0.4	1.1	0.3	-1.0	-0.2	-1.0	-0.2	-0.9	-0.4	-1.0	-0.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	7.4	0.4	-0.3	0.2	-0.4	0.1	-1.5	1.4	-1.1	-0.3	-2.7
Relative age voice broke	0.6	0.9	3.7	0.6	-0.0	-0.7	-1.9	-0.3	-0.2	-1.3	-0.2	0.4	-1.4
Taking other prescription medications	1.4	2.2	13.2	0.7	-1.1	-1.5	1.9	-0.2	-0.8	3.6	0.3	-0.6	-0.7
Age when periods started (menarche)	0.3	0.7	2.2	-0.3	-0.3	-0.5	-0.1	0.5	-1.1	-1.5	-0.6	-1.2	1.2
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.7	0.8	-0.4	-0.2	-1.4	-1.6	-0.2	0.5	-1.6	-0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	6.6	-1.0	-1.8	-0.4	-2.6	-1.5	-2.0	-1.3	-2.5	-1.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.6	1.1	0.3	-0.2	-1.0	-0.9	-0.3	-0.8	-1.6	-0.4	0.0
Qualifications: CSEs or equivalent	1.0	1.4	4.6	-0.2	-2.1	-0.8	-0.7	-0.0	-2.0	1.3	-1.1	-0.5	-0.7
Serious illness, injury or assault to yourself	0.8	0.9	2.4	-0.0	-1.1	1.6	0.9	-0.6	0.4	-0.6	1.1	1.4	1.0
High blood pressure	0.9	2.4	6.4	0.4	-2.0	-1.6	1.4	-0.2	2.0	2.5	2.0	1.1	0.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.8	-1.0	-0.3	-0.4	-1.6	1.9	-0.6	-1.5	-0.9	-0.6	-1.3
Multivitamins +/- minerals	0.6	0.8	3.7	1.9	-0.5	-1.0	0.7	0.4	0.9	-1.1	-0.1	-0.7	0.3
Stomach or abdominal pain in last month	0.9	1.2	3.7	1.0	-1.4	-1.1	1.1	0.3	-1.4	1.9	-0.5	-0.3	0.4
Supplements: Glucosamine	0.6	0.7	1.9	-0.7	-0.5	-0.2	0.6	-0.7	-1.4	0.9	-0.8	-1.2	0.9
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	4.1	1.6	1.4	0.7	1.3	0.7	2.0	0.5	-0.6	1.7	0.4
Medication: Atenolol	1.0	1.3	5.6	-0.5	-2.4	-0.7	0.1	-0.9	-0.1	1.6	-0.4	-1.8	-0.1
Medication: Levothyroxine sodium	0.8	1.3	4.7	-0.1	-2.2	-0.7	0.9	-1.2	-1.4	1.7	0.2	-0.6	0.0
Sitting height	0.7	4.9	21.1	1.2	3.0	3.8	0.2	0.5	4.6	0.2	0.9	0.2	1.5
Chronic bronchitis/emphysema (father)	0.8	1.0	4.4	-0.5	-1.5	-1.0	-0.7	-0.2	0.9	0.7	2.1	-0.2	0.2
High blood pressure (mother)	0.7	1.0	2.4	1.5	-0.9	-1.3	0.7	0.2	1.4	-0.7	0.7	-0.9	-0.6
Body mass index (BMI)	0.3	1.2	3.4	0.3	-1.8	-0.7	0.5	-0.8	-1.8	1.1	0.6	1.3	0.7
Impedance of leg (left)	0.2	1.0	2.0	0.2	1.4	0.6	1.2	1.3	1.4	-1.0	0.6	-0.6	-1.1
Leg predicted mass (left)	0.2	1.2	3.2	1.0	0.6	1.4	-0.7	0.1	1.7	0.9	-0.6	0.9	1.8
Trunk fat mass	0.2	0.7	2.2	0.7	-0.5	-0.1	0.8	0.5	0.5	0.9	0.8	1.5	1.2
Waist circumference	0.2	0.6	2.4	0.7	-0.3	0.2	0.6	-0.6	-0.1	1.5	0.6	1.2	0.9
Number of incorrect matches in round	0.9	1.5	7.0	1.3	-0.0	0.2	0.5	-0.7	0.2	2.6	0.8	0.3	-2.1
Past tobacco smoking	0.3	0.6	2.3	-0.8	0.4	-0.2	0.7	0.5	-1.2	0.1	-0.7	-0.3	1.5
Alcohol usually taken with meals	0.3	0.6	1.5	-0.6	0.7	1.2	-0.3	-1.1	0.7	-1.2	0.1	0.0	-0.0
Nervous feelings	0.6	1.1	5.1	0.1	0.2	-0.9	0.3	0.3	-1.4	-2.3	-0.7	-0.8	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	6.1	-0.4	-2.5	-0.4	-0.2	0.7	-1.8	-0.2	-0.4	0.5	-0.1
Hearing difficulty/problems with background noise	1.3	2.1	6.0	-1.7	-0.2	1.7	-0.3	0.7	0.3	0.6	2.5	1.5	2.4
Hair/balding pattern: Pattern 2	1.2	1.5	3.6	-1.5	-0.1	0.3	-1.1	-0.9	-1.4	-1.8	-0.9	-1.3	1.9
Had menopause	1.1	1.3	6.2	2.5	0.5	0.7	0.5	0.1	1.2	0.4	1.9	0.7	-0.7
Had other major operations	0.3	0.4	1.8	-0.3	-0.0	0.8	0.2	1.3	0.4	0.1	0.4	1.0	0.5
Forced vital capacity (FVC)	0.3	1.3	3.3	0.1	1.8	1.8	-0.0	0.5	1.4	-1.7	-0.9	0.0	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.7	-1.5	-1.8	-0.4	-2.2	-1.2	-2.1	-1.0	-1.7	-1.6	0.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.0	1.6	0.4	0.3	0.1	1.7	-0.3	-1.3	-1.2	1.1	0.4
Qualifications: None of the above	0.6	1.4	6.1	0.1	-0.7	-0.2	0.9	-1.2	-0.9	1.7	2.5	-0.7	-0.7
Financial difficulties in last 2 years	0.2	0.3	0.9	0.3	0.5	0.2	-0.6	0.6	-0.9	0.4	0.1	0.2	-0.9
Mouth/teeth dental problems	0.6	0.9	3.9	0.4	2.0	0.3	-0.1	0.5	0.4	-1.2	-1.4	-0.3	-0.7
Heart attack	0.8	1.1	3.3	-1.8	-0.7	-0.5	-0.7	1.3	-1.6	0.8	0.3	1.0	0.3
Allergy	0.5	1.1	6.7	-0.9	-0.0	0.8	0.5	-1.1	-0.4	-0.2	0.9	0.8	2.6
Pain all over the body in last month	0.7	0.7	2.5	1.1	-0.1	-0.1	1.6	-0.3	1.1	-0.6	1.3	0.0	0.8
Diabetes (self-reported)	1.2	1.8	7.9	1.1	-0.3	-0.5	1.7	0.6	1.4	2.8	0.6	1.2	1.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.2	-0.8	1.4	0.2	-1.9	1.5	-0.2	-1.5	-2.3	0.4	-0.2
Medication: Ramipril	1.0	1.3	3.6	-1.3	-1.9	-1.9	0.1	0.4	-0.8	1.2	-0.1	-0.1	1.6
Medication: Simvastatin	1.3	1.9	6.7	1.4	-1.4	-1.6	1.6	0.6	-0.3	1.1	2.6	0.9	-0.6
Fluid intelligence score	0.9	1.9	5.8	-0.6	0.7	1.5	-1.7	-2.4	-0.6	0.2	-1.6	-1.9	1.0
Illnesses of siblings	1.0	1.4	7.0	0.4	-0.2	-0.1	0.1	-1.5	-0.2	-2.6	-1.9	-1.0	0.6
Neuroticism score	0.3	0.7	3.1	-0.7	-0.2	0.1	-0.3	1.6	-1.8	-0.5	0.2	0.2	-0.4
Weight	0.2	0.9	2.9	1.1	0.2	0.9	-0.2	0.3	1.3	0.9	0.2	1.4	1.7
Impedance of arm (right)	0.3	1.5	6.1	-0.4	-0.3	-2.5	1.5	1.9	1.1	-0.4	0.7	0.0	-0.9
Arm fat percentage (right)	0.5	1.8	4.3	0.3	-2.1	-2.0	1.6	0.2	-1.0	1.2	1.5	1.7	0.1
Trunk fat-free mass	0.6	3.3	10.9	1.2	2.3	3.3	-1.8	0.6	2.3	0.4	-1.1	0.9	2.0
Hip circumference	0.2	0.8	4.3	0.5	-0.8	0.0	-0.0	0.0	-0.4	0.4	0.4	1.4	2.1
Time employed in main current job	1.4	1.6	5.2	0.1	1.8	1.7	0.7	0.1	2.3	-1.0	1.6	0.8	-0.5
Alcohol intake versus 10 years previously	0.6	0.8	2.4	-0.1	0.9	-0.4	1.5	1.0	-0.3	1.0	0.8	0.9	1.2
Father’s age at death	0.5	0.7	2.2	-0.2	-1.3	-0.8	-0.8	0.7	-0.2	0.4	0.3	1.1	1.5
Worrier / anxious feelings	0.2	0.4	1.9	0.0	-0.2	-0.2	-0.5	1.4	-1.1	0.5	-0.4	0.3	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.5	4.9	1.4	-2.2	-1.5	1.3	-1.0	-1.5	0.7	-0.7	-0.3	-0.8
Falls in the last year	0.7	0.9	2.6	1.6	-0.6	-0.9	1.2	0.3	1.0	0.2	0.4	0.7	1.5
Hair/balding pattern: Pattern 3	0.7	1.1	4.6	0.9	-0.1	-0.8	0.6	-0.8	0.6	1.8	-0.0	-0.4	-2.2
Number of live births	1.4	2.0	7.9	0.3	0.9	1.4	-0.8	-1.1	0.6	2.8	1.9	0.5	-1.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	5.2	0.2	1.1	1.2	0.2	0.7	1.2	-2.3	-0.9	0.2	0.6
Pulse rate	0.4	0.7	3.3	-0.5	-0.5	-0.1	0.7	0.1	0.7	-1.3	0.4	0.2	1.8
Happiness	0.7	0.8	3.9	-0.2	-0.3	1.3	-1.1	2.0	-0.2	0.0	0.1	0.7	-0.9
Noisy workplace	1.5	1.8	4.9	0.6	1.5	1.9	2.2	0.7	0.5	0.7	1.5	1.9	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	4.0	-0.8	0.8	0.6	-1.0	0.2	0.8	-2.0	-0.3	-0.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	-0.9	1.5	0.7	-1.1	0.7	-0.4	-0.5	-1.0	-1.2	-1.1
Mouth/teeth dental problems: Dentures	0.7	1.1	7.2	-0.4	-2.7	0.2	0.5	-1.3	-0.7	0.6	0.7	0.1	0.6
Asthma	0.9	1.8	6.3	2.0	0.1	-0.0	0.1	-1.5	0.7	0.5	-1.1	-1.8	-2.5
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	6.4	-1.7	-2.3	-0.2	0.4	-0.4	-2.4	-0.2	-1.3	0.1	2.5
Medication: Cholesterol lowering	0.3	0.5	1.4	0.7	0.3	0.4	0.6	-0.5	-0.2	1.2	1.1	0.4	-0.7
Depression (self-reported)	2.0	2.4	7.7	2.8	-0.4	0.1	0.1	-2.1	-0.1	1.9	-0.9	-0.7	-2.7
Medication: Lansoprazole	0.5	0.5	2.0	0.7	-0.6	0.2	1.2	0.0	0.3	1.4	0.6	-0.1	-0.7
Prospective memory result	2.3	2.9	7.6	1.9	2.8	1.3	2.3	0.8	0.6	0.9	1.8	2.3	-0.2
Lung cancer (father)	0.5	0.5	1.7	0.7	-0.7	0.2	-0.1	-1.3	-1.3	-0.0	-0.9	-0.4	0.2
Illnesses of mother	1.2	1.5	2.9	-0.7	1.4	1.5	-1.1	1.2	-0.3	1.3	-1.7	1.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	5.9	-0.4	0.0	0.7	0.8	0.7	1.2	-2.4	-0.1	0.1	1.0
Pulse wave Arterial Stiffness index	1.2	1.4	8.4	1.1	1.1	-0.1	0.3	-0.5	2.9	0.7	1.2	0.6	-0.3
Impedance of arm (left)	0.4	1.9	7.5	-0.6	-0.3	-2.7	1.5	2.5	1.5	-0.5	0.3	0.2	0.1
Arm fat mass (right)	0.2	0.7	2.0	0.5	-1.1	-0.6	0.7	0.2	-0.3	1.0	0.9	1.4	0.8
Trunk predicted mass	0.6	3.3	10.8	1.1	2.2	3.3	-1.9	0.7	2.4	0.3	-1.0	1.0	2.0
Standing height	0.9	9.0	38.7	1.5	4.5	3.9	-1.4	2.4	6.2	-0.4	-0.8	0.4	2.2
Length of working week for main job	1.1	1.2	5.4	-1.5	0.4	-0.1	-1.4	2.3	0.0	-0.6	0.0	1.2	0.8
Exposure to tobacco smoke at home	0.7	0.7	3.1	0.2	0.9	0.4	-0.7	-0.6	-1.2	-0.9	0.5	0.2	-1.7
Breastfed as a baby	1.2	1.4	6.1	-0.2	0.5	1.6	-2.5	-0.7	0.1	-0.2	-2.2	-0.3	0.5
Tense / ‘highly strung’	0.5	0.8	2.1	-0.1	-1.5	-1.1	1.1	1.2	0.2	-0.2	1.4	0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	8.3	-0.7	-1.1	-1.1	-0.4	0.7	-2.9	-0.6	-1.7	-1.0	-0.4
Hair/balding pattern: Pattern 4	0.6	1.5	4.0	-0.6	-2.0	-1.7	0.8	0.8	-1.7	-0.0	-1.0	0.3	1.5
Birth weight of first child	1.7	3.1	11.4	1.9	2.2	-0.1	2.1	-0.0	3.4	1.1	1.5	1.7	0.8
Peak expiratory flow (PEF)	0.3	0.7	4.1	0.5	0.9	-0.2	-0.2	0.2	0.5	-2.0	-1.1	-0.3	-0.2
Pulse wave reflection index	1.0	1.3	3.0	1.2	0.7	-0.4	1.2	-0.3	1.7	1.7	1.3	1.1	0.3
Ever highly irritable/argumentative for 2 days	1.5	1.9	4.7	-0.3	0.5	0.9	-2.1	1.4	-2.2	-1.0	-1.8	-0.6	-1.3
Loud music exposure frequency	1.9	2.0	4.3	-1.2	-1.6	-2.0	0.9	2.1	-1.7	0.8	-0.4	0.6	1.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.3	-0.3	1.5	0.7	-0.6	0.3	0.6	0.2	-1.4	0.1	-1.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.8	-1.3	0.1	-1.7	-0.7	1.9	-0.3	1.0	0.3	0.2	0.0
Blood clot in the leg (DVT)	0.3	0.4	2.5	-0.4	1.6	0.4	0.1	0.9	0.4	-0.1	0.1	0.6	-0.4
Medication: Paracetamol	0.4	0.7	2.7	0.5	0.3	0.3	0.4	-0.3	-1.6	1.6	0.5	0.5	-0.8
Headache pain in last month	1.0	1.7	5.4	0.4	-2.1	-1.6	1.5	0.0	-1.5	2.3	0.2	-0.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.3	0.5	0.5	-0.0	-1.5	-0.3	-0.0	-1.5	-1.2	-0.7	-0.1
Glaucoma (self-reported)	0.8	0.9	3.5	0.4	0.2	-1.0	1.3	0.1	0.9	0.9	1.1	1.9	0.1
Gout (self-reported)	0.4	0.5	3.9	0.2	0.6	0.1	0.9	0.1	0.0	0.4	0.1	0.1	-2.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	5.0	0.0	-2.2	-0.9	0.6	-1.0	-2.0	1.6	-0.4	-0.8	-0.7
Medication: Amlodipine	0.8	1.2	4.0	-1.1	0.1	1.4	0.9	2.0	-0.2	0.5	1.1	1.5	-0.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.8	1.0	2.0	2.0	0.2	-1.2	0.2	0.5	0.3	-1.1	-2.2
Birth weight	0.2	0.5	1.8	1.3	0.4	0.7	0.2	0.2	1.0	0.8	0.0	0.1	-1.0
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.0	1.7	1.4	1.3	1.7	-0.4	0.6	1.6	1.7	-0.1	-0.5
High blood pressure (siblings)	0.3	0.5	1.4	-0.1	0.5	0.3	-0.6	0.6	-0.8	1.2	0.6	-0.2	-1.2
Forced vital capacity (FVC), Best measure	0.3	1.1	4.6	-0.5	1.0	1.6	0.3	0.4	1.2	-2.1	-0.2	0.0	1.1
Body fat percentage	0.3	1.1	2.4	0.3	-1.5	-1.4	1.3	0.3	-0.7	0.9	1.1	1.4	0.4
Leg fat percentage (right)	0.4	1.3	2.8	0.6	-1.5	-1.3	1.4	-0.2	-0.8	1.2	1.3	1.7	0.1
Arm fat-free mass (right)	0.5	2.8	11.9	1.3	1.9	3.4	-1.3	0.1	2.1	0.5	-0.8	0.9	1.8
Exposure to tobacco smoke outside home	1.5	2.0	8.3	-0.6	0.7	1.9	0.6	0.1	-0.3	1.6	2.1	2.9	0.3
Comparative body size at age 10	0.6	1.5	5.5	-1.7	-2.3	-2.0	-0.5	-0.8	-0.3	0.9	0.2	-0.9	-0.1
Number of full brothers	0.8	1.0	5.0	0.1	-2.2	0.2	-0.3	-1.3	-0.4	-0.2	0.2	-1.6	-0.2
Worry too long after embarrassment	0.9	1.4	4.0	-2.0	0.7	0.3	-1.9	1.7	0.1	0.5	1.3	1.0	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	13.6	-0.8	-1.5	-0.3	-1.1	0.3	-3.7	-2.0	-2.0	-1.0	-0.8
Wheeze or whistling in the chest in last year	1.2	2.1	4.2	2.1	0.7	0.6	1.7	-1.9	1.2	1.7	0.5	-1.3	-1.8
Number of children fathered	1.7	1.9	6.8	-2.6	-0.7	-0.7	-2.0	-0.1	-0.3	-1.7	-1.6	-0.8	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.8	-1.0	-0.9	-1.3	0.6	0.1	-0.7	-0.5	-0.2	-1.3	-0.1
Age at first live birth	0.3	0.5	2.6	-0.3	-0.5	-0.8	-0.4	0.1	-0.1	-1.3	-0.3	-0.0	1.6
Pulse wave peak to peak time	0.9	1.1	5.7	-0.9	-0.7	0.3	-0.5	0.8	-2.4	-0.9	-1.3	-0.6	0.3
Health satisfaction	0.3	0.4	1.3	0.5	0.4	0.2	-0.4	-0.0	0.5	-0.5	-1.2	-0.2	-1.0
Shortness of breath walking on level ground	0.9	1.1	4.3	1.5	0.2	-1.4	-0.3	0.3	0.5	1.1	0.6	0.7	-2.1
Qualifications: College or University degree	0.4	1.3	8.5	-0.4	-1.1	0.1	-0.5	0.6	0.5	-2.9	-1.3	0.3	0.4
Eye problems/disorders: None of the above	0.9	1.0	4.3	-1.4	1.1	2.1	-0.8	-0.1	-0.5	-0.8	0.8	0.2	-0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.8	-0.9	-0.3	0.3	-0.1	-0.9	-0.7	-0.5	2.0	1.0	0.8
Emphysema/chronic bronchitis	1.2	1.4	2.9	1.7	0.5	-0.1	-0.1	-1.7	1.6	1.3	0.6	-1.1	-1.5
Medication for pain relief, constipation, heartburn	1.2	2.1	8.9	0.2	1.1	-0.5	-1.6	0.6	2.6	-3.0	-0.6	0.6	0.1
Neck or shoulder pain in last month	0.5	0.7	2.7	0.7	0.9	0.2	-1.3	-0.2	-0.0	-0.4	0.0	-1.1	-1.6
Medication: Blood pressure	0.5	0.9	2.9	-1.1	-1.0	-0.6	1.3	0.6	0.3	0.1	1.7	0.8	0.8
Angina (self-reported)	1.3	1.7	3.4	-1.8	-1.8	0.3	-0.2	0.8	-1.7	1.8	0.2	1.6	1.0
Migraine (self-reported)	1.5	1.9	7.5	-0.6	-2.7	-1.7	1.4	0.0	-2.0	0.8	0.1	-0.8	0.7
Medication: Ibuprofen	1.7	2.0	7.4	-1.5	-2.7	-0.5	0.1	-0.6	-1.9	0.2	-1.1	-0.4	2.2
Medication: Allopurinol	0.5	0.7	2.8	0.3	-0.1	-1.2	0.6	0.7	0.7	-0.2	0.9	0.5	-1.7
Medication: Omeprazole	1.2	1.5	11.3	0.1	0.2	-0.0	0.6	-0.2	0.7	3.4	1.0	1.0	-0.4
Medication: Seretide 50 evohaler	2.2	2.6	15.5	0.4	0.2	0.2	-0.8	-1.8	0.6	1.7	0.3	-1.6	-3.9
Mean time to correctly identify matches	3.0	5.7	30.1	-3.3	-2.8	-0.4	-1.7	0.2	-5.5	0.4	-1.5	-1.5	0.2
Heart disease (mother)	0.7	0.8	3.5	-0.9	-0.7	-1.9	-0.0	0.8	-1.1	0.8	0.8	-0.5	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.0	1.4	1.5	0.8	-1.9	0.3	0.1	-0.6	-0.4	-1.0	-2.0
Whole body fat mass	0.2	1.0	3.3	0.8	-0.5	-0.0	1.1	0.5	0.3	1.2	1.1	1.8	1.1
Leg fat mass (right)	0.2	0.8	2.9	1.0	-0.6	-0.1	0.9	-0.1	0.1	1.4	0.8	1.7	0.6
Arm predicted mass (right)	0.6	2.9	11.6	1.3	1.7	3.4	-1.4	0.0	2.1	0.6	-0.9	0.7	2.1
Pulse rate, automated reading	0.6	2.1	6.7	1.1	-0.9	-0.1	2.6	-1.1	1.9	0.5	1.5	1.0	1.8
Alcohol intake frequency.	0.7	1.6	5.9	-1.0	-0.9	-1.3	1.6	0.7	-2.4	0.2	-1.2	-0.7	1.1
Comparative height size at age 10	0.9	4.9	20.8	-0.6	3.0	1.9	-1.0	2.8	4.6	-0.9	0.4	0.6	2.4
Number of full sisters	0.5	0.7	2.6	0.5	-0.3	-0.5	-0.2	-0.8	0.5	0.1	0.2	-1.6	-1.6
Suffer from ‘nerves’	1.3	2.0	5.6	-1.0	-1.4	-2.3	-0.7	-0.1	-2.4	-1.6	-1.1	-1.3	0.6
Overall health rating	0.9	1.9	11.5	1.3	-1.0	0.2	1.1	-0.7	-0.1	3.4	0.1	0.4	-1.6
Chest pain or discomfort	0.8	1.1	4.5	0.4	-0.5	-0.2	-0.1	-1.4	0.2	2.1	0.6	-0.8	-1.8
Had major operations	0.9	1.1	7.4	-2.7	-0.1	-0.1	-0.1	1.5	0.2	-1.0	-0.2	0.2	-0.3
Age at last live birth	0.4	0.6	1.4	-0.8	-0.3	1.1	-1.1	0.4	-0.1	-0.8	0.9	0.4	1.2
Family relationship satisfaction	1.3	1.6	9.0	-1.4	-0.2	0.8	-1.1	3.0	-1.5	-0.5	-0.1	0.9	0.6
Leg pain on walking	1.2	1.5	4.9	1.3	-0.7	-1.7	-1.5	-0.3	-0.1	-0.9	-1.4	-0.4	-2.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.1	1.7	0.6	-0.5	0.7	0.6	1.8	0.7	0.0	1.8	1.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.8	-0.4	-1.0	-0.4	0.4	-0.9	-1.0	0.7	-0.9	-1.4	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	-0.6	-0.6	-0.7	-0.0	0.2	0.6	-0.1	-0.6	0.3	0.5
Medication: Aspirin	0.8	1.0	3.2	-0.6	-1.8	-0.1	0.1	0.5	-1.6	1.5	0.8	-0.4	0.9
Supplements: Vitamin C	0.3	0.3	1.3	0.1	-0.1	0.2	-0.0	-0.9	0.9	-0.2	0.1	-0.6	-1.2
Knee pain experienced in last month	0.6	0.9	2.8	1.7	-0.4	-1.3	-0.6	0.2	0.2	1.4	-1.2	0.7	0.3
Hypertension (Self-reported)	0.7	2.1	4.1	0.4	-2.0	-1.7	1.6	-0.0	1.7	1.9	1.8	1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.9	0.0	-0.0	0.2	1.7	0.4	-0.9	1.4	0.8	0.5	-0.1
Illnesses of father: Heart disease	0.6	0.9	3.5	-0.3	0.3	0.2	-0.9	-0.0	0.1	1.9	1.3	0.6	-1.4
Illnesses of siblings: Diabetes	1.1	1.4	6.5	-0.5	-1.1	-2.1	0.4	0.2	-0.4	2.5	0.8	-0.3	-0.3
Smoking status: Previous	0.5	0.7	2.5	1.4	0.2	-0.0	-0.4	-0.1	1.3	0.4	0.4	0.8	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.6	0.9	-0.1	2.2	0.2	0.4	2.1	0.5	-1.6	-0.8	1.3
Whole body fat-free mass	0.4	2.3	7.3	1.1	1.6	2.7	-1.4	0.3	2.0	0.6	-0.9	0.9	2.0
Leg fat-free mass (right)	0.2	1.3	5.2	0.9	0.3	1.6	-0.6	-0.1	1.7	0.7	-0.3	0.8	2.3
Arm fat percentage (left)	0.5	1.9	4.9	0.1	-2.2	-2.1	1.5	0.4	-1.1	1.0	1.1	1.7	0.7
Average weekly red wine intake	1.3	1.9	5.4	0.7	2.3	0.9	0.2	1.4	1.2	-1.2	0.6	1.7	-2.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	4.2	0.9	-2.1	-0.8	-0.1	-0.2	1.0	0.5	0.4	0.3	-1.3
Mood swings	0.7	1.3	3.8	-2.0	-1.3	-0.9	-0.9	1.6	-1.2	-0.6	0.4	-0.1	0.9
Loneliness, isolation	1.2	1.7	8.5	-0.1	-1.5	-0.7	1.3	1.1	-2.9	1.2	0.3	1.0	0.0
Long-standing illness, disability or infirmity	0.8	1.2	3.8	0.8	-1.0	-1.3	1.3	0.4	-0.4	2.0	-1.5	-0.1	0.9
Ever had bowel cancer screening	1.2	1.5	6.5	0.6	0.0	1.5	0.8	-2.5	0.3	-1.3	-0.8	-0.4	1.5
Diabetes diagnosed by doctor	1.2	2.0	4.7	1.7	-0.3	-1.2	2.1	0.5	1.5	2.2	0.4	1.3	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.0	0.4	-1.3	-1.7	-0.5	-1.2	-0.9	0.5	-1.0	-0.8	-0.4
Friendships satisfaction	0.8	1.0	2.9	-1.4	-0.3	1.1	-0.9	1.6	-1.7	0.6	0.0	0.9	0.2
Qualifications: nursing, teaching	0.9	1.4	4.7	-1.0	1.1	-0.3	0.1	2.2	1.1	-1.6	-0.7	0.7	1.3
Commuting to job workplace: Walk	0.4	0.4	1.7	-0.4	0.3	-0.6	0.5	0.4	0.8	-0.1	1.3	0.6	0.5
Eye problems/disorders: Cataract	0.4	0.4	1.8	0.5	-0.2	-0.5	0.3	-0.8	-0.2	-0.6	-0.6	-0.5	1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.4	1.2	-0.0	-0.5	0.1	0.7	0.8	0.2	-0.2	0.9	0.5
Medication for cholesterol	0.9	1.3	6.1	-0.7	0.9	0.7	-0.4	-0.6	-0.9	-2.5	-1.4	-1.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	7.0	-0.4	-2.6	-0.3	-0.6	-1.3	-1.3	0.4	-0.6	-2.6	-1.1
Back pain experienced in last month	1.0	1.5	5.8	2.0	-0.2	-0.7	0.5	-1.7	0.9	2.4	-0.3	0.4	0.1
Mineral and other dietary supplements	0.4	0.6	2.0	0.5	1.2	1.4	-1.1	0.0	0.5	0.8	-0.1	0.3	-0.3
Breast cancer (self-reported)	1.6	1.9	6.4	2.1	-1.2	-0.5	1.8	-2.5	0.7	1.5	-0.7	-0.3	-0.2
Asthma (self-reported)	0.8	1.5	5.7	1.8	-0.1	0.0	0.0	-1.2	0.6	0.6	-1.3	-1.6	-2.4
Osteoporosis (self-reported)	0.8	1.0	3.5	1.9	0.3	0.9	1.2	-0.0	1.1	0.1	1.2	1.1	-0.1
Osteoarthritis (self-reported)	1.6	2.0	4.7	0.4	1.2	1.6	0.4	-0.4	2.2	0.9	1.3	2.1	2.1
Medication: Aspirin	0.6	0.8	2.3	0.0	-1.3	0.2	0.0	0.6	-1.1	1.5	1.0	-0.3	1.2
Medication: Gliclazide	0.9	1.0	4.6	1.6	0.3	-0.5	1.1	-0.3	0.3	2.1	0.8	0.1	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.0	-1.2	0.9	0.6	-0.0	-0.7	-0.5	-0.4	0.5	1.0
Smoking status: Current	0.3	0.5	2.0	-1.4	-0.5	0.3	-0.3	-0.6	-0.9	-0.8	0.4	0.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.2	-0.4	-1.2	-1.4	0.6	-0.7	-1.0	-1.7	-1.8	-0.4	1.6
Whole body water mass	0.4	2.3	7.7	1.0	1.6	2.8	-1.4	0.3	1.9	0.6	-0.9	0.9	2.0
Leg predicted mass (right)	0.2	1.3	5.2	0.9	0.4	1.5	-0.6	-0.1	1.7	0.8	-0.3	0.8	2.3
Arm fat mass (left)	0.2	0.8	2.9	0.2	-1.2	-0.7	0.7	0.4	-0.5	0.8	0.8	1.7	1.2
Number of self-reported non-cancer illnesses	1.1	2.0	4.8	2.0	-0.6	-0.0	2.0	-2.0	0.4	2.2	-0.2	-1.5	-0.5
Average weekly champagne plus white wine intake	0.6	0.9	2.3	-0.4	0.1	-0.6	-0.2	-1.2	-0.5	-0.9	-1.1	-1.5	1.4
Miserableness	1.7	3.0	10.5	-1.4	-2.5	-1.3	-1.6	1.8	-3.2	-0.9	-1.1	-0.3	1.1
Guilty feelings	0.4	0.5	3.5	-0.5	0.6	0.7	-0.3	-0.2	-1.9	0.4	0.2	-0.3	0.5
Wears glasses or contact lenses	1.3	1.5	2.2	-0.9	-1.2	-1.4	-1.4	0.1	-1.2	-1.4	-1.5	-1.2	1.4
Ever taken oral contraceptive pill	1.2	1.3	4.5	-0.5	0.0	-0.6	-2.1	-1.5	-0.8	0.7	-0.3	-1.6	-1.4
Hearing aid user	1.1	1.3	4.5	-0.8	-2.1	-0.1	0.1	-0.5	-1.8	0.0	0.4	0.2	2.0
Mother’s age at death	0.9	1.1	4.5	0.6	-0.6	-0.6	0.5	-2.1	0.3	-0.0	-1.2	-1.8	0.9
Financial situation satisfaction	1.2	1.5	5.7	0.1	1.5	2.4	-1.8	-0.0	-0.7	-0.8	-0.4	0.5	-1.4
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.8	0.6	1.5	1.7	-1.5	-0.1	-0.6	-1.2	-1.0	-0.1	0.1
Commuting to job workplace: Public transport	0.4	0.5	1.6	-0.9	-0.6	-0.4	-0.5	0.1	-0.0	-0.8	0.2	0.9	1.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	0.5	-0.2	-1.3	1.1	-0.5	0.0	0.8	-0.2	0.7	1.0
Medication: Blood pressure	0.7	1.4	4.4	1.2	-1.3	-0.9	0.6	0.9	1.5	2.1	0.8	1.3	0.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	6.2	-0.6	-1.9	-1.2	-2.5	-1.4	-0.6	1.1	-0.9	-1.5	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.6	-0.0	-1.2	-0.8	1.3	0.1	-0.0	-0.5	0.5	-0.4	0.1
High cholesterol (Self-reported)	0.3	0.5	2.1	0.7	-0.6	-0.1	1.0	-0.5	-0.6	0.8	1.5	0.5	-0.1
Medication: Bendroflumethiazide	0.7	1.0	3.0	-0.1	-1.5	-1.1	-1.7	0.4	-0.6	-0.2	-1.7	-0.5	-0.5
Medication: Paracetamol	0.6	0.9	4.9	0.2	-0.4	-0.6	0.1	-0.8	-1.5	2.2	0.3	-0.0	-0.9
Medication: Lisinopril	0.7	0.9	4.3	-0.8	-0.6	-0.4	-0.8	0.6	-0.7	0.4	1.4	0.4	-2.1
Medication: Atorvastatin	0.3	0.4	3.0	0.2	0.3	1.7	-0.3	-0.2	0.5	0.2	-0.4	-0.1	0.3
Illnesses of father: High blood pressure	0.8	0.9	2.5	-0.2	-0.3	-1.4	-0.5	0.4	0.1	-1.4	-1.6	-1.2	-1.0
Alcohol drinker status: Never	1.0	1.2	2.6	-1.1	-1.5	-1.5	-0.2	0.5	-1.6	-0.2	-1.3	-0.2	1.5
Ever smoked	0.4	0.7	3.0	-0.0	-1.7	-0.5	-0.6	-1.2	-0.0	0.1	0.2	-1.1	-0.9
Basal metabolic rate	0.3	1.9	5.3	1.0	1.3	2.3	-1.0	0.4	1.8	0.6	-0.7	1.1	2.0
Leg fat percentage (left)	0.4	1.5	3.4	0.6	-1.9	-1.1	1.7	-0.6	-0.8	1.1	1.6	1.5	0.5
Arm fat-free mass (left)	0.5	2.5	10.8	1.2	1.9	3.3	-1.2	-0.1	1.9	0.6	-0.7	0.7	1.7
Number of operations (self-reported)	1.3	2.0	5.3	0.9	1.6	1.7	-0.9	1.1	2.2	1.1	-0.5	0.5	-2.3
Average weekly beer plus cider intake	1.0	1.4	9.1	-1.3	0.2	-0.7	-0.3	3.0	-1.4	0.5	0.2	0.6	-0.1
Irritability	0.4	0.6	2.4	0.2	-0.7	-0.4	0.8	1.6	-0.4	-0.2	-0.6	0.7	1.3
Risk taking	1.2	1.7	4.4	0.2	-0.9	1.6	-0.6	-1.7	-1.5	-0.0	-1.0	-2.1	-1.7
Ever had prostate specific antigen (PSA) test	1.1	1.2	4.1	-1.6	0.3	0.1	-1.4	1.6	-0.7	-2.0	-0.7	-0.1	0.2
Fractured/broken bones in last 5 years	1.0	1.3	5.0	0.1	-1.0	-0.1	0.4	2.2	0.6	0.9	1.1	2.0	0.8
Age started oral contraceptive pill	1.4	1.7	5.9	1.5	-0.2	-1.5	2.4	-1.0	1.2	-0.5	1.5	-0.3	1.3
Diastolic blood pressure, automated reading	0.1	0.4	1.3	-0.6	0.2	0.5	0.1	-0.1	0.8	0.8	1.2	0.6	-0.3
Ever depressed for a whole week	0.4	0.5	2.7	0.4	0.4	-0.5	-0.8	0.6	-0.3	-0.7	-1.6	-0.1	0.1
Unable to work because of sickness or disability	0.6	0.8	2.4	-0.6	-0.7	1.6	0.8	-0.9	-1.2	0.6	-0.1	-1.0	-0.5
Commuting to job workplace: Cycle	0.7	0.8	3.4	0.6	-0.8	0.9	-0.0	0.1	1.3	-0.3	0.1	1.0	1.8
Myopia	0.5	0.7	2.2	-1.2	0.4	0.5	-0.4	-0.1	-1.5	-0.8	-1.1	-0.6	0.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	8.6	0.0	1.9	1.5	-1.1	-0.6	-1.6	-2.9	-2.3	-1.6	-0.4
Cholesterol lowering medication	1.2	1.7	5.1	1.2	-2.0	-1.8	1.5	0.3	0.6	0.7	2.2	0.4	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	14.7	0.8	0.5	0.5	1.2	-0.5	1.1	3.8	1.0	0.6	-0.4
Pain experienced in last month	0.6	1.0	5.8	-1.0	-0.2	1.0	0.4	0.3	0.2	-2.4	0.3	-1.1	-0.7
Supplements: Calcium	1.2	1.3	3.6	-0.1	-1.0	0.1	1.6	1.0	1.3	0.8	1.2	0.8	1.9
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	0.5	-1.2	0.1	-0.8	-1.4	-0.1	-0.6	-0.5	-1.1	0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.8	-1.9	-0.9	-0.5	-0.8	1.4	-1.9	0.9	0.4	1.0	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.5	-0.5	1.2	0.1	0.0	1.0	0.2	-0.2	0.3	0.7	-0.2
Heart disease (siblings)	0.9	1.1	2.0	-0.8	-1.0	0.4	1.3	1.2	-0.7	1.4	1.3	0.7	1.2
Alcohol drinker status: Previous	0.9	1.1	5.0	-1.0	-1.3	-0.1	0.6	-0.2	-2.2	-1.5	-0.5	-0.2	0.0
Pack years of smoking	0.7	1.0	2.9	1.0	1.5	1.1	0.5	-0.7	0.3	0.7	1.7	0.4	-0.9
Impedance of whole body	0.2	1.1	3.3	-0.1	0.7	-1.0	1.3	1.8	1.7	-0.9	0.5	-0.2	-0.7
Leg fat mass (left)	0.2	1.0	2.8	1.1	-0.7	0.1	1.1	-0.4	0.1	1.5	1.1	1.7	0.7
Arm predicted mass (left)	0.5	2.4	12.8	0.9	1.9	3.6	-1.4	-0.0	1.4	0.5	-0.5	0.8	1.4