Best TWAS P=1.6e-24 · Best GWAS P=4.89e-24 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AKR1C1 | 0.30 | 0.16 | bslmm | 703 | 0.18 | 3.5e-21 | 3.2 | 5.7 | 9.3e-09 | -0.55 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | AKR1C2 | 0.31 | 0.06 | bslmm | 665 | 0.16 | 2.1e-19 | 1.4 | -7.2 | 6.8e-13 | 0.74 | 0.09 | 0.91 | FALSE |
| 3 | GTEx | Artery Tibial | AKR1C2 | 0.14 | 0.10 | enet | 10 | 0.15 | 1.2e-11 | -9.9 | -9.4 | 4.8e-21 | 0.94 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | AKR1C1 | 0.46 | 0.14 | lasso | 4 | 0.23 | 1.4e-06 | -3.6 | 7.7 | 1.0e-14 | -0.85 | 0.01 | 0.96 | FALSE |
| 5 | GTEx | Brain Cerebellum | AKR1C2 | 0.27 | 0.04 | enet | 12 | 0.11 | 4.1e-04 | -10.1 | -5.9 | 4.2e-09 | 0.68 | 0.01 | 0.97 | FALSE |
| 6 | GTEx | Brain Cortex | AKR1C2 | 0.49 | 0.10 | lasso | 11 | 0.26 | 1.1e-07 | -10.1 | -8.4 | 5.8e-17 | 0.85 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Brain Hippocampus | AKR1C2 | 0.35 | 0.13 | lasso | 9 | 0.16 | 1.3e-04 | -6.0 | -5.4 | 7.4e-08 | 0.49 | 0.07 | 0.78 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | AKR1C2 | 0.28 | 0.23 | lasso | 6 | 0.21 | 1.9e-15 | -10.1 | -10.2 | 1.6e-24 | 1.00 | 0.00 | 1.00 | TRUE |
| 9 | GTEx | Esophagus Muscularis | AKR1C2 | 0.30 | 0.21 | lasso | 2 | 0.19 | 8.5e-12 | -10.1 | -10.2 | 3.2e-24 | 1.00 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | AKR1C2 | 0.28 | 0.37 | lasso | 3 | 0.29 | 1.2e-13 | -9.9 | -9.9 | 5.3e-23 | 0.98 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Muscle Skeletal | AKR1C2 | 0.11 | 0.03 | enet | 9 | 0.05 | 2.0e-05 | -1.7 | 5.2 | 1.7e-07 | -0.55 | 0.07 | 0.82 | FALSE |
| 12 | GTEx | Ovary | AKR1C3 | 0.35 | 0.20 | lasso | 9 | 0.22 | 3.9e-06 | -10.1 | -9.7 | 4.2e-22 | 0.91 | 0.00 | 0.97 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | AKR1C2 | 0.17 | 0.18 | lasso | 2 | 0.18 | 4.0e-15 | -10.1 | -10.1 | 5.6e-24 | 1.00 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Testis | AKR1C2 | 0.44 | 0.36 | lasso | 4 | 0.36 | 8.5e-17 | -10.1 | -10.0 | 1.9e-23 | 1.00 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Testis | AKR1C1 | 0.28 | 0.04 | enet | 39 | 0.07 | 3.7e-04 | -9.8 | 7.7 | 1.3e-14 | -0.62 | 0.01 | 0.94 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | AKR1C2 | 0.56 | 0.40 | enet | 28 | 0.46 | 1.0e-65 | -10.1 | -9.6 | 1.3e-21 | 0.93 | 0.00 | 1.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | AKR1C1 | 0.39 | 0.28 | lasso | 6 | 0.32 | 9.1e-42 | 3.3 | 6.1 | 1.4e-09 | -0.61 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AKR1C1 | 0.07 | 0.04 | enet | 10 | 0.02 | 1.0e-03 | -9.8 | 9.6 | 5.8e-22 | -0.88 | 0.00 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AKR1C2 | 0.12 | 0.11 | lasso | 6 | 0.09 | 1.6e-10 | -10.1 | -10.0 | 9.3e-24 | 1.00 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AKR1C1 | 0.15 | 0.02 | blup | 81 | 0.06 | 2.0e-04 | 3.3 | 6.4 | 1.8e-10 | -0.59 | 0.00 | 0.86 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AKR1C2 | 0.29 | 0.21 | lasso | 1 | 0.21 | 4.7e-12 | -9.9 | -9.9 | 6.0e-23 | 0.98 | 0.01 | 0.99 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AKR1C2 | 0.09 | 0.05 | blup | 62 | 0.05 | 3.4e-06 | -9.8 | -8.9 | 6.9e-19 | 0.89 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AKR1C2 | 0.39 | 0.18 | enet | 14 | 0.23 | 2.5e-23 | -10.1 | -8.7 | 4.7e-18 | 0.85 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Soft Tissue Sarcoma | AKR1C2 | 0.07 | 0.04 | enet | 5 | 0.06 | 1.1e-04 | -3.6 | -6.5 | 6.7e-11 | 0.74 | 0.02 | 0.77 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | AKR1C2 | 0.09 | 0.08 | lasso | 3 | 0.08 | 7.2e-08 | -9.8 | -9.2 | 5.9e-20 | 0.90 | 0.00 | 1.00 | FALSE |