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chr10:4,236,655-5,844,628

Best TWAS P=1.6e-24 · Best GWAS P=4.89e-24 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Cells Transformed fibroblasts	AKR1C2	0.28	0.23	lasso	6	0.21	1.9e-15	-10.1	-10.2	1.6e-24	1.00	0.00	1.00	TRUE
9	GTEx	Esophagus Muscularis	AKR1C2	0.30	0.21	lasso	2	0.19	8.5e-12	-10.1	-10.2	3.2e-24	1.00	0.00	1.00	FALSE
13	GTEx	Skin Sun Exposed Lower leg	AKR1C2	0.17	0.18	lasso	2	0.18	4.0e-15	-10.1	-10.1	5.6e-24	1.00	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C2	0.12	0.11	lasso	6	0.09	1.6e-10	-10.1	-10.0	9.3e-24	1.00	0.00	1.00	FALSE
14	GTEx	Testis	AKR1C2	0.44	0.36	lasso	4	0.36	8.5e-17	-10.1	-10.0	1.9e-23	1.00	0.00	1.00	FALSE
10	GTEx	Heart Atrial Appendage	AKR1C2	0.28	0.37	lasso	3	0.29	1.2e-13	-9.9	-9.9	5.3e-23	0.98	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1C2	0.29	0.21	lasso	1	0.21	4.7e-12	-9.9	-9.9	6.0e-23	0.98	0.01	0.99	FALSE
12	GTEx	Ovary	AKR1C3	0.35	0.20	lasso	9	0.22	3.9e-06	-10.1	-9.7	4.2e-22	0.91	0.00	0.97	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C1	0.07	0.04	enet	10	0.02	1.0e-03	-9.8	9.6	5.8e-22	-0.88	0.00	0.99	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	AKR1C2	0.56	0.40	enet	28	0.46	1.0e-65	-10.1	-9.6	1.3e-21	0.93	0.00	1.00	FALSE
3	GTEx	Artery Tibial	AKR1C2	0.14	0.10	enet	10	0.15	1.2e-11	-9.9	-9.4	4.8e-21	0.94	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	AKR1C2	0.09	0.08	lasso	3	0.08	7.2e-08	-9.8	-9.2	5.9e-20	0.90	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKR1C2	0.09	0.05	blup	62	0.05	3.4e-06	-9.8	-8.9	6.9e-19	0.89	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	AKR1C2	0.39	0.18	enet	14	0.23	2.5e-23	-10.1	-8.7	4.7e-18	0.85	0.00	1.00	FALSE
6	GTEx	Brain Cortex	AKR1C2	0.49	0.10	lasso	11	0.26	1.1e-07	-10.1	-8.4	5.8e-17	0.85	0.01	0.98	FALSE
4	GTEx	Brain Cerebellar Hemisphere	AKR1C1	0.46	0.14	lasso	4	0.23	1.4e-06	-3.6	7.7	1.0e-14	-0.85	0.01	0.96	FALSE
15	GTEx	Testis	AKR1C1	0.28	0.04	enet	39	0.07	3.7e-04	-9.8	7.7	1.3e-14	-0.62	0.01	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	AKR1C2	0.31	0.06	bslmm	665	0.16	2.1e-19	1.4	-7.2	6.8e-13	0.74	0.09	0.91	FALSE
24	The Cancer Genome Atlas	Soft Tissue Sarcoma	AKR1C2	0.07	0.04	enet	5	0.06	1.1e-04	-3.6	-6.5	6.7e-11	0.74	0.02	0.77	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1C1	0.15	0.02	blup	81	0.06	2.0e-04	3.3	6.4	1.8e-10	-0.59	0.00	0.86	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	AKR1C1	0.39	0.28	lasso	6	0.32	9.1e-42	3.3	6.1	1.4e-09	-0.61	1.00	0.00	FALSE
5	GTEx	Brain Cerebellum	AKR1C2	0.27	0.04	enet	12	0.11	4.1e-04	-10.1	-5.9	4.2e-09	0.68	0.01	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AKR1C1	0.30	0.16	bslmm	703	0.18	3.5e-21	3.2	5.7	9.3e-09	-0.55	1.00	0.00	FALSE
7	GTEx	Brain Hippocampus	AKR1C2	0.35	0.13	lasso	9	0.16	1.3e-04	-6.0	-5.4	7.4e-08	0.49	0.07	0.78	FALSE
11	GTEx	Muscle Skeletal	AKR1C2	0.11	0.03	enet	9	0.05	2.0e-05	-1.7	5.2	1.7e-07	-0.55	0.07	0.82	FALSE