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chr10:28,113,533-29,610,861

Best TWAS P=1.03e-15 · Best GWAS P=9.84e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	WAC-AS1	0.39	0.46	lasso	5	0.45	1.1e-40	6.6	6.0	1.5e-09	0.91	0.80	0.20	FALSE
2	GTEx	Adipose Visceral Omentum	WAC-AS1	0.21	0.17	enet	16	0.18	2.0e-09	6.6	5.8	6.4e-09	0.88	0.04	0.96	FALSE
3	GTEx	Adrenal Gland	WAC-AS1	0.28	0.19	lasso	4	0.14	7.2e-06	6.6	6.5	7.9e-11	0.91	0.08	0.90	FALSE
4	GTEx	Artery Aorta	WAC-AS1	0.39	0.38	lasso	6	0.38	3.1e-22	6.6	5.8	4.8e-09	0.91	0.79	0.21	FALSE
5	GTEx	Artery Coronary	WAC-AS1	0.41	0.21	lasso	6	0.19	4.0e-07	6.6	6.6	4.0e-11	0.91	0.16	0.83	FALSE
6	GTEx	Artery Tibial	WAC	0.10	0.00	enet	32	0.00	5.6e-01	-6.2	-5.6	1.8e-08	-0.37	0.07	0.19	FALSE
7	GTEx	Artery Tibial	WAC-AS1	0.44	0.43	lasso	4	0.44	4.0e-37	6.7	6.1	1.0e-09	0.90	0.72	0.28	FALSE
8	GTEx	Brain Hippocampus	WAC-AS1	0.29	0.01	enet	10	-0.01	8.5e-01	6.4	6.2	4.2e-10	0.81	0.04	0.54	FALSE
9	GTEx	Breast Mammary Tissue	WAC-AS1	0.29	0.32	lasso	2	0.31	2.1e-16	6.6	6.6	4.5e-11	0.92	0.38	0.62	FALSE
10	GTEx	Breast Mammary Tissue (Female)	WAC-AS1	0.30	0.30	enet	13	0.33	1.7e-10	6.6	5.8	6.7e-09	0.91	0.18	0.82	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	WAC-AS1	0.45	0.36	enet	12	0.41	1.1e-14	6.6	5.5	3.2e-08	0.85	0.07	0.93	FALSE
12	GTEx	Cells Transformed fibroblasts	WAC-AS1	0.58	0.62	lasso	12	0.64	9.7e-62	6.6	6.3	2.3e-10	0.92	0.81	0.19	FALSE
13	GTEx	Colon Sigmoid	WAC-AS1	0.36	0.23	lasso	9	0.22	2.6e-08	6.7	6.4	1.4e-10	0.88	0.35	0.65	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	WAC-AS1	0.37	0.16	lasso	6	0.20	9.1e-08	7.4	6.4	1.6e-10	0.91	0.02	0.98	FALSE
15	GTEx	Esophagus Mucosa	WAC-AS1	0.52	0.44	lasso	16	0.51	1.2e-38	6.6	5.2	2.5e-07	0.86	0.63	0.37	FALSE
16	GTEx	Heart Atrial Appendage	WAC-AS1	0.18	0.12	enet	6	0.15	2.5e-07	6.7	6.3	2.4e-10	0.85	0.20	0.79	FALSE
17	GTEx	Liver	WAC-AS1	0.37	0.34	lasso	3	0.34	3.1e-10	6.6	6.7	1.7e-11	0.90	0.08	0.92	FALSE
18	GTEx	Lung	WAC-AS1	0.32	0.13	enet	26	0.24	4.7e-18	6.6	5.5	3.1e-08	0.86	0.04	0.96	FALSE
19	GTEx	Nerve Tibial	WAC-AS1	0.45	0.55	lasso	5	0.56	1.4e-46	6.6	6.4	1.6e-10	0.92	0.80	0.20	FALSE
20	GTEx	Pancreas	WAC-AS1	0.45	0.33	lasso	8	0.34	6.4e-15	6.6	6.3	3.7e-10	0.92	0.09	0.91	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	WAC-AS1	0.48	0.48	enet	37	0.56	6.1e-37	6.7	5.2	1.5e-07	0.86	0.40	0.60	FALSE
22	GTEx	Stomach	WAC-AS1	0.39	0.31	lasso	8	0.33	1.1e-16	6.6	5.8	8.0e-09	0.90	0.07	0.93	FALSE
23	GTEx	Testis	WAC-AS1	0.45	0.47	lasso	3	0.48	4.3e-24	6.6	6.6	3.4e-11	0.92	0.77	0.23	FALSE
24	GTEx	Vagina	WAC-AS1	0.55	0.25	lasso	5	0.22	1.0e-05	6.7	7.6	3.7e-14	0.85	0.05	0.91	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	WAC	0.21	0.29	lasso	5	0.29	5.9e-37	7.4	7.6	4.0e-14	0.99	0.01	0.99	FALSE
26	YFS	Blood	WAC	0.06	0.08	bslmm	649	0.08	2.2e-24	7.2	-7.2	6.8e-13	-0.99	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	WAC	0.11	0.04	blup	83	0.07	1.3e-03	7.4	5.7	1.6e-08	0.91	0.02	0.86	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	WAC	0.06	0.04	lasso	3	0.03	4.2e-04	7.4	8.0	1.0e-15	0.98	0.01	0.94	TRUE