Best TWAS P=1.43e-13 · Best GWAS P=4.93e-27 conditioned to 5.69e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | GTEx | Cells Transformed fibroblasts | HECTD2 | 0.12 | 0.14 | lasso | 4 | 0.13 | 9.6e-10 | 6.1 | 7.4 | 1.4e-13 | 0.60 | 0.88 | 0.12 | TRUE |
| 1 | GTEx | Artery Aorta | TNKS2 | 0.25 | 0.07 | enet | 9 | 0.12 | 4.3e-07 | -5.2 | -6.0 | 2.3e-09 | -0.01 | 0.90 | 0.02 | TRUE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPP1R3C | 0.03 | 0.02 | lasso | 3 | 0.02 | 6.5e-03 | 5.5 | -5.5 | 3.0e-08 | -0.05 | 0.01 | 0.93 | TRUE |
| 4 | GTEx | Muscle Skeletal | HECTD2 | 0.10 | 0.04 | enet | 16 | 0.07 | 2.0e-07 | 5.3 | 6.1 | 1.1e-09 | 0.19 | 0.94 | 0.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TNKS2 | 0.16 | 0.06 | lasso | 10 | 0.09 | 3.3e-11 | 1.5 | -5.5 | 3.2e-08 | -0.07 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Mucosa | PPP1R3C | 0.17 | 0.12 | enet | 17 | 0.14 | 9.8e-10 | -2.3 | -5.2 | 1.8e-07 | -0.06 | 1.00 | 0.00 | FALSE |