TWAS hub - HECTD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1200	0.0450	0.00600	0.142	NA	0.117	NA	0.127	9.0e-11	NA	4.1e-09	NA	9.6e-10
2	GTEx	Esophagus Mucosa	0.2200	0.0740	0.00130	0.086	NA	0.053	NA	0.072	2.2e-06	NA	1.8e-04	NA	1.4e-05
3	GTEx	Muscle Skeletal	0.0967	0.0318	0.00023	0.037	NA	0.070	NA	0.040	1.5e-04	NA	2.0e-07	NA	7.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Suffer from ‘nerves’	8.0	12.6	26.0	5.1	-1.4	3.1
Bilateral oophorectomy (both ovaries removed)	3.6	4.1	8.6	1.3	-1.4	2.9
Worry (Nagel 2018)	3.4	7.1	14.6	3.8	0.1	2.6
Height	3.3	63.6	110.2	10.5	-4.0	8.0
Standing height	3.3	32.3	54.6	7.4	-2.2	6.1
Ever had hysterectomy (womb removed)	3.2	3.6	4.5	1.9	-1.7	2.1
Supplements: Calcium	3.2	3.5	4.3	2.1	-1.8	1.8
Mouth/teeth dental problems	2.8	4.2	9.9	-1.6	-0.3	-3.1
Breast cancer (self-reported)	2.8	3.4	5.2	-1.9	-1.1	-2.3
Alcohol drinker status: Previous	2.7	3.1	7.6	1.3	-2.8	-0.5
Intelligence (Savage-Jansen 2018)	2.5	7.7	12.8	3.1	-3.6	0.7
Verbal and Numeric Reasoning (VNR)	2.5	6.1	10.2	3.2	-2.4	1.5
Chronotype (morning person)	2.5	5.7	13.7	3.7	-0.3	1.8
Worrier / anxious feelings	2.5	4.7	9.8	2.1	-0.1	3.1
Pulse rate	2.5	4.2	9.0	-1.9	-0.3	-3.0
High cholesterol (Self-reported)	2.5	4.5	7.3	-1.7	2.7	-1.8
Exposure to tobacco smoke outside home	2.4	3.2	9.1	3.0	-0.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	4.0	-1.9	2.0	-1.1
Comparative height size at age 10	2.4	13.1	22.3	4.0	-1.0	4.7
Sitting height	2.3	16.2	30.0	5.5	-1.2	4.1
Nervous feelings	2.3	4.3	12.0	3.5	0.5	0.9
Alcohol drinker status: Never	2.3	2.8	8.1	2.9	0.3	-0.4
Alzheimer’s Disease (in mother)	2.2	2.5	4.8	1.5	-0.8	2.2
Medication: Amlodipine	2.2	3.1	5.9	-0.9	1.6	2.4
Irritability	2.2	3.6	8.1	-2.8	1.7	0.1
Alcohol intake frequency.	2.1	5.0	9.9	3.1	-1.9	1.2
Maternal smoking around birth	2.0	2.9	4.1	-2.0	0.8	-2.0
Hearing aid user	1.9	2.2	6.0	0.7	-2.4	-0.2
Heart disease (siblings)	1.9	2.3	5.8	-2.4	0.8	-0.8
Hearing difficulty/problems with background noise	1.8	2.9	8.5	2.9	-0.1	0.6
Trunk fat-free mass	1.8	10.4	25.4	2.2	-0.9	5.0
Trunk predicted mass	1.8	10.1	24.0	2.3	-0.9	4.9
Schizophrenia vs Biploar Disorder	1.7	2.2	4.5	1.4	-0.1	2.1
Stomach or abdominal pain in last month	1.7	2.1	4.4	0.9	-1.0	2.1
Medication: Ibuprofen	1.7	2.1	3.7	-1.0	1.9	-1.2
Systolic blood pressure, automated reading	1.6	4.5	6.2	-1.5	-2.3	2.5
Forced vital capacity (FVC)	1.6	6.1	12.8	3.6	0.9	2.1
Happiness	1.6	1.9	5.6	0.1	-0.3	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.9	2.4	0.1	-0.6
Commuting to job workplace: Walk	1.6	1.7	3.6	-0.3	1.2	-1.9
Financial situation satisfaction	1.6	1.9	4.9	-0.3	-0.9	-2.2
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.8	0.4	1.2	-2.0
Age started oral contraceptive pill	1.6	2.0	5.2	0.9	-2.3	0.2
Schizophrenia (2014)	1.5	3.3	7.2	2.7	0.5	1.6
Pain all over the body in last month	1.5	1.6	4.2	-0.3	-0.7	2.0
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	9.1	3.0	1.8	1.8
Blood clot in the leg (DVT)	1.5	1.9	4.1	1.1	-0.7	2.0
Arm fat-free mass (right)	1.5	7.6	20.8	1.0	-0.9	4.6
Pulse wave peak to peak time	1.5	1.8	3.8	1.9	-1.1	0.6
Illnesses of siblings: Diabetes	1.5	1.9	2.7	-1.0	1.4	1.6
Medication: Blood pressure	1.5	2.8	6.4	-1.4	0.4	2.5
Blood White Count	1.4	10.5	16.1	-3.0	2.6	-4.0
Townsend deprivation index at recruitment	1.4	2.0	3.7	-1.9	-0.4	-1.4
Fed-up feelings	1.4	2.5	6.3	-1.1	2.5	0.2
Supplements: Glucosamine	1.4	1.9	4.0	-2.0	0.9	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.2	-1.2	1.3	-1.5
Depression (self-reported)	1.4	1.7	3.6	1.0	1.9	-0.6
Lung cancer (father)	1.4	1.6	3.1	-1.8	0.2	-1.3
Medication: Seretide 50 evohaler	1.4	1.6	3.4	-1.8	1.2	-0.1
Arm predicted mass (right)	1.4	7.2	19.6	1.0	-1.0	4.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	5.4	2.3	0.0	1.8
Chronic bronchitis/emphysema (father)	1.3	1.6	3.0	1.7	0.3	-1.3
Body mass index (BMI)	1.3	5.5	13.9	-3.7	1.6	0.1
Alcohol usually taken with meals	1.3	2.2	6.1	-0.7	2.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	4.2	2.0	0.8	1.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.8	0.1	2.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.8	-1.2	0.5	1.7
Long-standing illness, disability or infirmity	1.3	1.9	3.2	-1.4	1.8	0.8
Ever taken oral contraceptive pill	1.3	1.4	2.3	-1.3	0.7	-1.5
Ever depressed for a whole week	1.3	1.6	3.2	0.2	-1.2	1.8
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.8	-1.4	-1.7	-0.0
Schizophrenia (2018)	1.2	2.5	5.9	2.4	0.8	0.9
Mean Putamen Volume	1.2	1.3	3.3	-1.8	0.8	0.2
Relative age voice broke	1.2	1.9	4.7	0.9	-2.2	-0.2
Serious illness, injury or assault to yourself	1.2	1.5	2.4	-1.0	1.5	-1.1
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.5	0.6	2.1	-1.7
Number of live births	1.2	1.7	3.7	1.0	-1.9	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	7.3	2.7	1.4	1.6
Tense / ‘highly strung’	1.2	1.9	2.9	1.2	1.2	1.7
Gout (self-reported)	1.2	1.6	3.4	-1.8	0.1	-1.2
Forced vital capacity (FVC), Best measure	1.2	4.6	10.3	3.2	-0.0	1.8
Comparative body size at age 10	1.2	3.3	8.0	-2.8	1.1	-0.8
Wheeze or whistling in the chest in last year	1.2	2.1	3.4	-1.3	1.9	-1.1
Mean time to correctly identify matches	1.2	2.4	3.1	1.8	-1.4	1.4
Heart disease (mother)	1.2	1.5	3.0	-1.1	1.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.5	-0.5	1.9	-0.9
Whole body fat-free mass	1.2	6.7	17.9	1.4	-0.5	4.2
Average weekly red wine intake	1.2	1.7	2.5	-0.5	1.6	1.5
Medication: Gliclazide	1.2	1.3	1.9	-0.5	1.4	-1.3
Whole body water mass	1.2	6.9	18.1	1.5	-0.5	4.2
Unable to work because of sickness or disability	1.2	1.6	2.2	1.1	1.5	1.2
Arm predicted mass (left)	1.2	5.9	17.1	0.6	-0.5	4.1
Bipolar Disorder (2011)	1.1	1.0	2.1	0.2	1.4	-1.0
HbA1C	1.1	1.2	3.5	0.0	-0.2	1.9
Medication: Co-codamol	1.1	1.3	2.9	-1.0	0.1	1.7
High blood pressure	1.1	3.2	6.9	-1.3	1.0	2.6
Impedance of arm (left)	1.1	5.3	9.3	3.0	-0.5	-2.5
Osteoarthritis (self-reported)	1.1	1.4	3.7	-1.9	-0.7	0.2
Arm fat-free mass (left)	1.1	5.6	16.4	0.6	-0.4	4.0
Ever had prostate specific antigen (PSA) test	1.1	1.2	1.5	-0.9	-1.1	-1.2
Prostate Cancer	1.0	1.5	4.1	-0.3	2.0	-0.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.0	0.6	-1.7	0.6
Heart attack	1.0	1.3	3.8	-0.3	-0.3	-1.9
Fluid intelligence score	1.0	2.0	3.7	1.9	-1.0	1.1
Illnesses of siblings	1.0	1.4	4.0	0.3	-0.3	-2.0
Impedance of arm (right)	1.0	4.6	8.0	2.4	0.0	-2.8
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.8	1.1	0.3	2.0
Mouth/teeth dental problems: Dentures	1.0	1.8	3.5	0.7	1.1	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.8	1.7	1.2	-0.5
Pulse rate, automated reading	1.0	3.1	4.9	-2.1	-0.2	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.5	-0.5	-1.2	1.2
Medication for cholesterol	1.0	1.6	3.8	2.0	-0.7	-0.6
Basal metabolic rate	1.0	5.4	15.0	1.0	-0.3	3.9
Leg fat percentage (left)	1.0	3.5	9.9	-3.1	0.8	-0.0
Diastolic blood pressure, automated reading	1.0	3.2	5.0	-2.2	-2.0	0.8
Cholesterol lowering medication	1.0	1.4	3.6	-1.9	0.6	0.5
Bipolar Disorder or Schizophrenia	0.9	2.1	5.2	2.3	0.0	1.1
Neuroticism (Nagel 2018)	0.9	2.1	4.1	2.0	1.0	1.0
Alzheimer’s Disease (including proxy)	0.9	1.3	3.0	0.8	-0.3	1.7
HDL Cholesterol	0.9	1.6	4.3	0.3	0.6	-2.1
LDL Cholesterol	0.9	1.5	2.8	-0.4	1.2	-1.7
Respiratory disease	0.9	1.9	3.4	-1.9	1.2	1.0
High blood pressure (mother)	0.9	1.3	1.9	1.3	-0.4	1.4
Medication: Simvastatin	0.9	1.4	1.6	-1.2	1.3	-1.0
Arm fat percentage (right)	0.9	3.4	6.1	-2.5	1.6	-1.3
Falls in the last year	0.9	1.2	3.2	0.6	1.8	-0.0
Length of working week for main job	0.9	1.0	2.2	1.5	0.7	0.4
Birth weight	0.9	1.9	4.0	1.1	-0.6	2.0
Qualifications: College or University degree	0.9	2.8	4.2	2.0	-1.8	1.1
Medication: Omeprazole	0.9	1.1	2.9	-0.6	-1.7	0.0
Hypertension (Self-reported)	0.9	2.4	5.6	-1.1	0.7	2.4
Average weekly champagne plus white wine intake	0.9	1.2	3.5	-1.9	-0.3	-0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.5	-0.1	-0.1	-1.9
Major Depression (MDD)	0.8	0.9	1.4	-0.4	1.2	1.1
Reaction Time	0.8	1.5	2.0	1.4	-1.0	1.1
BMI	0.8	4.8	11.1	-3.3	1.8	0.2
Sensitivity / hurt feelings	0.8	1.3	2.0	1.4	1.4	0.2
Relative age of first facial hair	0.8	1.7	4.4	2.1	-0.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	0.9	-1.0	-0.9	0.9
Diabetes (mother)	0.8	1.1	2.6	1.6	0.7	-0.4
Age when periods started (menarche)	0.8	2.0	3.5	1.0	1.3	-1.9
Neuroticism score	0.8	1.6	3.0	0.7	1.7	1.2
Medication: Cholesterol lowering	0.8	1.3	2.9	-0.4	0.9	-1.7
Pulse wave reflection index	0.8	1.0	1.8	0.4	-1.0	1.3
Medication: Allopurinol	0.8	1.0	1.3	-1.0	1.1	-0.8
Loneliness, isolation	0.8	1.1	1.5	1.2	0.9	1.0
Guilty feelings	0.8	1.2	1.9	0.6	1.2	1.4
Medication: Bendroflumethiazide	0.8	1.2	3.5	0.4	-0.0	1.9
Medication: Lisinopril	0.8	1.0	2.0	-1.4	0.6	0.8
Impedance of whole body	0.8	3.8	7.1	2.7	-1.1	-1.8
Smoking Status	0.7	1.8	4.5	-2.1	0.1	-0.9
Neuroticism	0.7	1.7	1.8	1.3	1.3	1.3
Number of treatments/medications taken	0.7	1.3	3.6	-0.4	1.9	-0.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.9	-1.4	0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	2.8	0.3	1.7	-0.5
Headache pain in last month	0.7	1.2	3.0	1.7	0.7	0.3
Leg fat percentage (right)	0.7	2.7	7.7	-2.8	0.5	0.1
Neck or shoulder pain in last month	0.7	0.9	1.5	1.2	0.5	1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	-0.5	-0.8	1.2
Arm fat percentage (left)	0.7	2.9	5.5	-2.3	1.3	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	1.5	0.1	0.5
Medication: Paracetamol	0.7	1.1	1.6	-0.9	1.3	-1.0
Illnesses of father: High blood pressure	0.7	0.8	1.3	1.0	0.4	1.1
Average weekly beer plus cider intake	0.7	1.0	2.2	0.8	-1.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.1	0.4	-0.6	1.4
Ulcerative Colitis (UC)	0.6	1.0	3.1	0.2	1.8	-0.1
Fasting Glucose	0.6	0.7	1.2	-0.3	0.9	-1.1
Neuroticism (2016)	0.6	0.9	1.2	1.1	0.9	0.9
Triglycerides	0.6	1.0	2.3	-0.1	-0.9	1.5
Blood Platelet Count	0.6	6.6	13.2	-3.6	1.1	-2.4
Systolic Blood Pressure	0.6	2.8	4.7	-1.0	-1.7	2.2
Hand grip strength (right)	0.6	1.6	4.0	0.6	0.6	2.0
Average weekly fortified wine intake	0.6	0.7	1.7	-0.2	0.6	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.1	0.5	-0.3	1.5
Waist circumference	0.6	2.1	5.0	-2.2	0.6	1.0
Noisy workplace	0.6	0.7	1.7	-0.2	-0.6	1.3
Medication: Lansoprazole	0.6	0.7	1.2	-1.1	-0.9	-0.2
Loud music exposure frequency	0.6	0.7	1.0	0.8	1.0	0.7
Number of children fathered	0.6	0.7	1.7	0.1	-0.6	1.3
Shortness of breath walking on level ground	0.6	0.7	1.8	0.2	1.3	0.5
Supplements: Vitamin C	0.6	0.7	1.6	-0.7	0.2	1.3
Knee pain experienced in last month	0.6	0.9	2.5	0.2	1.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.6	0.5	-1.0	1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	-1.0	-1.1	-0.1
Smoking status: Current	0.6	1.0	3.0	-1.7	-0.0	-0.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.5	1.1	-0.7	-1.9
Depressed Affect (Nagel 2018)	0.5	1.0	1.8	-0.0	1.3	-1.1
Ovarian Cancer	0.5	0.7	2.0	0.2	0.3	-1.4
Age at First Birth	0.5	0.7	1.3	-0.6	-1.1	0.7
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-0.7	1.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.5	-0.2	-0.0	1.2
Cardiovascular Disease	0.5	1.6	1.9	-1.4	1.4	1.1
Supplements: Zinc	0.5	0.5	1.3	0.5	0.0	1.2
Diabetes (father)	0.5	0.6	1.4	-0.5	-0.2	1.2
Impedance of leg (right)	0.5	2.6	5.1	2.2	-1.6	-0.4
Leg fat-free mass (left)	0.5	2.5	7.1	0.5	0.3	2.7
Multivitamins +/- minerals	0.5	0.6	1.7	1.3	-0.2	0.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	0.9	0.2	1.0
Allergy	0.5	1.2	2.9	-0.3	-1.7	0.8
Diabetes (self-reported)	0.5	0.7	2.0	-1.4	0.3	-0.2
Weight	0.5	2.5	7.3	-0.2	0.5	2.7
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	1.3	0.0	-0.7
Illnesses of mother	0.5	0.7	1.5	-0.7	-0.3	-1.2
Exposure to tobacco smoke at home	0.5	0.5	1.2	1.1	-0.6	0.0
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.6	-1.3	0.4	-0.4
Body fat percentage	0.5	2.0	5.2	-2.3	0.5	-0.7
Worry too long after embarrassment	0.5	0.9	1.3	1.2	0.2	1.1
Migraine (self-reported)	0.5	0.7	1.9	-1.4	0.1	-0.3
Chest pain or discomfort	0.5	0.7	1.1	0.4	1.0	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	0.6	-0.7	-1.0
Leg fat-free mass (right)	0.5	2.9	8.2	0.5	0.6	2.9
Qualifications: nursing, teaching	0.5	0.8	2.4	-1.5	0.0	0.1
Eye problems/disorders: Cataract	0.5	0.6	1.7	0.2	-1.3	-0.2
Leg predicted mass (right)	0.5	2.8	7.9	0.4	0.6	2.8
Primary Biliary Cirrhosis	0.4	0.6	1.7	0.5	0.0	1.3
Rheumatoid Arthritis	0.4	0.5	1.3	-1.2	-0.1	-0.4
Heel T-Score	0.4	3.1	8.8	-3.0	0.7	0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	-1.1	0.9	0.5
Lung FVC	0.4	1.8	4.2	2.0	-0.4	-1.0
Hand grip strength (left)	0.4	1.0	2.6	0.3	0.6	1.6
Average weekly spirits intake	0.4	0.5	0.9	-0.8	-0.2	1.0
Hearing difficulty/problems: Yes	0.4	0.6	1.0	-1.0	0.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	0.1	-0.2	1.2
Current tobacco smoking	0.4	0.7	1.9	-1.4	0.3	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	0.3	0.4	1.0
Qualifications: CSEs or equivalent	0.4	0.6	1.0	-0.7	1.0	0.3
Impedance of leg (left)	0.4	2.2	4.2	2.1	-1.4	-0.4
Leg predicted mass (left)	0.4	2.4	6.9	0.4	0.3	2.6
Father’s age at death	0.4	0.5	1.1	-0.5	1.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	0.6	-1.0	-0.5
Arm fat mass (right)	0.4	1.9	4.2	-2.1	1.1	0.4
Breastfed as a baby	0.4	0.5	1.4	-1.2	-0.0	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	0.9	0.8	-0.4	0.9
Medication: Paracetamol	0.4	0.7	0.9	-0.7	0.9	-0.9
Glaucoma (self-reported)	0.4	0.4	1.0	0.5	-0.3	1.0
High blood pressure (siblings)	0.4	0.6	1.7	-0.5	-0.0	1.3
Eye problems/disorders: None of the above	0.4	0.5	0.9	-0.5	0.9	-0.4
Leg fat mass (right)	0.4	1.4	2.9	-1.7	0.2	1.1
Family relationship satisfaction	0.4	0.5	0.9	0.4	-1.0	-0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-0.5	-1.0	0.6
Medication: Aspirin	0.4	0.6	0.8	0.9	-0.8	0.6
Illnesses of father: Heart disease	0.4	0.5	1.0	0.7	1.0	-0.0
Diabetes diagnosed by doctor	0.4	0.7	1.2	-0.9	1.1	-0.4
Mother’s age at death	0.4	0.5	1.3	0.2	-0.3	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.1	-0.4	1.1	0.2
Number of operations (self-reported)	0.4	0.6	1.6	0.3	0.4	1.3
Commuting to job workplace: Cycle	0.4	0.5	1.2	-1.1	0.1	0.4
Leg fat mass (left)	0.4	1.6	3.5	-1.9	0.4	1.1
Bipolar Disorder (2018)	0.3	0.5	0.8	0.6	-0.9	0.6
Ulcerative Colitis	0.3	0.5	1.0	1.0	0.7	-0.0
Hypothyroidism (self reported)	0.3	0.7	1.5	1.2	-0.8	-0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	0.7	0.3	0.8
Vitamin and mineral supplements	0.3	0.4	1.1	-1.1	-0.1	-0.4
Trunk fat percentage	0.3	1.2	2.9	-1.7	0.5	-0.7
Medication: Atenolol	0.3	0.3	0.7	-0.5	0.9	0.1
Had menopause	0.3	0.4	0.7	-0.2	-0.6	0.8
Financial difficulties in last 2 years	0.3	0.3	0.7	0.8	0.4	0.4
Medication: Ramipril	0.3	0.4	0.6	0.8	0.6	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.6	0.8	1.2	0.3
Prospective memory result	0.3	0.4	0.8	0.9	-0.0	0.5
Hair/balding pattern: Pattern 4	0.3	0.7	1.5	-0.7	-1.2	-0.5
Peak expiratory flow (PEF)	0.3	0.6	1.3	0.3	1.1	0.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.2	-0.3	-0.9
Health satisfaction	0.3	0.3	0.7	0.8	-0.6	0.0
Angina (self-reported)	0.3	0.3	0.6	-0.3	0.8	-0.5
Whole body fat mass	0.3	1.1	2.5	-1.6	0.3	0.9
Number of full sisters	0.3	0.3	0.7	-0.6	-0.8	0.2
Age at last live birth	0.3	0.4	0.6	-0.6	-0.5	-0.8
Ever had bowel cancer screening	0.3	0.4	1.0	0.2	-0.2	-1.0
Osteoporosis (self-reported)	0.3	0.4	0.9	0.4	-0.4	0.9
Arm fat mass (left)	0.3	1.3	3.0	-1.7	0.9	0.5
Risk taking	0.3	0.4	1.0	0.4	0.2	-1.0
Pain experienced in last month	0.3	0.5	0.9	-0.8	0.2	-0.9
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.8	0.2	-0.2
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	-0.2	1.0	0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.6	-0.0	0.7
Lupus	0.2	0.3	0.8	0.9	0.2	-0.4
Blood Eosinophil Count	0.2	1.3	1.9	-1.3	0.7	1.4
Blood Red Count	0.2	1.7	3.6	-1.9	-1.2	-0.0
Waist Hip Ratio (WHR)	0.2	0.8	1.3	-1.0	-0.4	1.1
Allergy or Eczema	0.2	0.6	0.8	0.7	0.7	0.9
Lung FEV1/FVC ratio	0.2	1.0	1.5	0.9	1.2	0.9
Tanning	0.2	2.1	5.6	0.2	0.7	2.4
Severe depression (siblings)	0.2	0.2	0.7	-0.8	0.0	0.2
Pack years adult smoking proportion	0.2	0.3	0.4	-0.7	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	-0.6	0.1	0.5
Medication: Levothyroxine sodium	0.2	0.4	1.1	1.1	-0.4	-0.0
Past tobacco smoking	0.2	0.4	0.7	0.6	0.1	0.8
Hip circumference	0.2	0.9	1.6	-0.0	1.1	1.2
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.1	0.9	-0.3
Asthma	0.2	0.4	1.0	-0.4	1.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.5	-1.0	-0.3
Number of full brothers	0.2	0.3	0.3	0.5	-0.6	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.3	0.4	0.7
Smoking status: Previous	0.2	0.4	1.0	-0.4	-0.0	-1.0
Mood swings	0.2	0.3	0.6	-0.6	0.8	0.2
Back pain experienced in last month	0.2	0.2	0.3	-0.6	0.6	0.1
Asthma (self-reported)	0.2	0.3	0.7	-0.3	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	0.2	0.9	0.8
Number of self-reported non-cancer illnesses	0.2	0.4	1.2	-0.1	1.1	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.4	0.6	0.6	-0.3
Medication: Atorvastatin	0.2	0.2	0.3	0.5	0.5	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.5	-0.0	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	-0.1	0.7	0.5
Pack years of smoking	0.2	0.3	0.5	-0.7	0.4	0.4
Depression (Nagel 2018)	0.1	0.1	0.1	0.3	0.0	0.4
Crohns Disease (2017)	0.1	0.3	0.8	-0.9	-0.0	-0.4
Breast Cancer	0.1	0.3	0.7	-0.2	-0.0	0.8
Crohns Disease (2012)	0.1	0.1	0.2	-0.4	0.3	-0.0
Angina	0.1	0.1	0.1	0.2	0.3	-0.4
Medication for hormone replacement therapy	0.1	0.1	0.1	0.0	-0.4	-0.4
Medication: Metformin	0.1	0.1	0.3	-0.5	-0.1	0.2
Taking other prescription medications	0.1	0.1	0.2	0.4	0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.2	-0.5	0.4	-0.4
Trunk fat mass	0.1	0.6	0.8	-0.9	0.2	0.9
Number of incorrect matches in round	0.1	0.1	0.3	-0.0	0.6	0.1
Had other major operations	0.1	0.1	0.4	-0.2	-0.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.5	0.2	-0.5
Qualifications: None of the above	0.1	0.3	0.8	-0.3	-0.2	0.9
Time employed in main current job	0.1	0.1	0.3	0.0	0.4	0.5
Birth weight of first child	0.1	0.3	0.5	0.5	0.2	0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.5	0.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.2	-0.6	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.3	0.4	0.0
Overall health rating	0.1	0.3	0.5	0.6	0.7	0.2
Had major operations	0.1	0.1	0.2	0.1	-0.3	-0.4
Leg pain on walking	0.1	0.1	0.1	-0.3	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.3	-0.5	0.4
Mineral and other dietary supplements	0.1	0.1	0.1	-0.0	-0.3	-0.3
Medication: Aspirin	0.1	0.2	0.3	0.6	-0.4	-0.1
Miserableness	0.1	0.2	0.3	0.6	-0.5	0.3
Wears glasses or contact lenses	0.1	0.1	0.1	0.3	-0.4	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.3	-0.5	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.5	-0.4	0.2
Ever smoked	0.1	0.2	0.3	-0.4	0.4	-0.5
Myopia	0.1	0.1	0.2	-0.4	-0.0	-0.3
Hair Pigment	0.0	0.8	1.3	1.1	-0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.1	-0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	0.1	0.2	0.1
Age at first live birth	0.0	0.0	0.1	-0.2	0.0	-0.2
Medication: Blood pressure	0.0	0.0	0.1	-0.2	0.1	0.3
Friendships satisfaction	0.0	0.1	0.1	-0.3	0.2	-0.1

Hub : Genes

HECTD2

Models

Trait associations