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chr11:29,646,947-32,824,150

Best TWAS P=1.99e-15 · Best GWAS P=3.96e-17 conditioned to 3.5e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RCN1	0.19	0.13	lasso	5	0.15	1.1e-17	4.2	5.2	2.2e-07	-0.04	0.06	0.81	FALSE
2	GTEx	Artery Aorta	RCN1	0.19	0.17	enet	13	0.15	1.9e-08	-5.0	5.3	1.1e-07	-0.02	0.00	1.00	TRUE
3	GTEx	Heart Left Ventricle	MPPED2	0.13	0.01	lasso	5	-0.01	8.1e-01	4.9	6.0	2.0e-09	0.46	0.13	0.10	FALSE
4	GTEx	Thyroid	MPPED2	0.16	0.01	enet	13	0.07	2.3e-06	7.0	-5.4	5.7e-08	-0.66	0.17	0.76	FALSE
5	GTEx	Whole Blood	ARL14EP	0.07	0.05	lasso	2	0.05	3.3e-05	-6.0	6.1	9.2e-10	0.42	0.82	0.01	FALSE
6	ROSMAP	Brain Pre-frontal Cortex	MPPED2	0.25	0.29	lasso	7	0.29	4.4e-37	5.5	-5.2	1.6e-07	-0.50	1.00	0.00	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf46	0.05	0.05	lasso	5	0.06	6.2e-12	-6.2	6.9	4.4e-12	0.43	0.58	0.42	FALSE
8	The Cancer Genome Atlas	Colon Adenocarcinoma	C11orf46	0.12	0.08	blup	34	0.07	5.7e-05	7.3	7.9	2.0e-15	0.61	0.00	0.99	TRUE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C11orf46	0.06	0.06	lasso	2	0.05	5.5e-06	-6.1	5.9	3.4e-09	0.41	0.72	0.26	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C11orf46	0.36	0.27	lasso	5	0.30	8.3e-34	-6.1	7.3	3.0e-13	0.48	0.76	0.24	FALSE
11	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C11orf46	0.13	0.12	lasso	3	0.11	8.9e-07	-6.1	6.1	1.2e-09	0.42	0.59	0.39	FALSE
12	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C11orf46	0.12	0.07	blup	34	0.07	4.4e-04	-6.1	7.9	3.2e-15	0.55	0.04	0.51	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	C11orf46	0.09	0.11	lasso	4	0.10	1.2e-11	-6.1	6.7	2.6e-11	0.46	0.71	0.29	FALSE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf46	0.05	0.02	lasso	2	0.02	9.9e-04	4.3	6.0	2.3e-09	0.47	0.02	0.72	FALSE
15	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C11orf46	0.07	0.04	blup	34	0.07	2.5e-05	4.1	5.5	3.2e-08	0.49	0.06	0.85	FALSE
16	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C11orf46	0.22	0.22	lasso	3	0.20	1.1e-08	-6.1	6.2	7.1e-10	0.41	0.71	0.28	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf46	0.09	0.07	lasso	2	0.06	2.4e-07	-6.1	6.1	1.4e-09	0.41	0.68	0.31	FALSE
18	The Cancer Genome Atlas	Stomach Adenocarcinoma	C11orf46	0.11	0.05	enet	7	0.09	3.4e-07	-6.2	6.5	7.9e-11	0.48	0.50	0.48	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf46	0.12	0.06	blup	34	0.10	1.4e-09	-6.1	6.3	2.2e-10	0.38	0.70	0.30	FALSE
20	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MPPED2	0.20	-0.01	blup	147	0.05	2.0e-02	2.6	6.2	5.6e-10	0.67	0.03	0.09	FALSE