Best TWAS P=6.22e-09 · Best GWAS P=1.37e-08 conditioned to 0.000332
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Muscle Skeletal | AP000442.1 | 0.07 | 0.05 | enet | 9 | 0.05 | 4.9e-06 | -5.6 | -5.3 | 1.3e-07 | 0.87 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Nerve Tibial | STX3 | 0.16 | 0.15 | enet | 12 | 0.15 | 4.6e-11 | -5.0 | 5.2 | 1.5e-07 | -0.86 | 0.25 | 0.74 | FALSE |
| 3 | GTEx | Pituitary | AP000442.1 | 0.24 | 0.28 | enet | 15 | 0.24 | 1.3e-06 | -5.6 | -5.1 | 2.8e-07 | 0.91 | 0.02 | 0.98 | FALSE |
| 4 | NTR | Blood | TCN1 | 0.03 | 0.02 | blup | 373 | 0.02 | 6.2e-06 | -3.9 | -5.8 | 6.2e-09 | 0.42 | 0.93 | 0.03 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | STX3 | 0.07 | 0.08 | lasso | 9 | 0.08 | 1.6e-10 | -5.6 | 5.5 | 3.3e-08 | -0.95 | 0.03 | 0.97 | FALSE |
| 6 | YFS | Blood | STX3 | 0.08 | 0.10 | lasso | 6 | 0.09 | 3.4e-29 | -5.6 | 5.6 | 2.7e-08 | -0.95 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Esophageal Carcinoma | PATL1 | 0.14 | 0.04 | blup | 32 | 0.06 | 4.3e-03 | -5.6 | 5.4 | 7.4e-08 | -0.93 | 0.00 | 0.86 | FALSE |