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chr11:56,716,782-58,284,951

Best TWAS P=4.33e-10 · Best GWAS P=2.98e-10 conditioned to 0.149

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Testis	MED19	0.16	0.15	enet	12	0.15	3.0e-07	6.3	-6.2	4.3e-10	-0.92	0.02	0.98	TRUE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	YPEL4	0.02	0.03	lasso	3	0.02	5.4e-06	6.3	-6.2	4.8e-10	-0.99	0.00	1.00	FALSE
1	GTEx	Cells Transformed fibroblasts	MED19	0.10	0.09	lasso	3	0.09	4.7e-07	-5.2	-6.1	1.2e-09	-0.55	0.88	0.10	FALSE
5	GTEx	Skin Sun Exposed Lower leg	YPEL4	0.09	0.07	lasso	10	0.07	3.2e-06	6.3	-6.1	1.3e-09	-0.88	0.03	0.97	FALSE
8	NTR	Blood	MED19	0.04	0.04	enet	18	0.04	2.4e-13	-5.2	-5.8	7.5e-09	-0.53	0.89	0.11	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMX2	0.01	0.01	enet	7	0.01	3.3e-03	6.0	-5.7	1.0e-08	-0.97	0.01	0.91	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZDHHC5	0.02	0.01	blup	34	0.01	1.5e-03	-5.2	-5.6	2.0e-08	-0.71	0.07	0.37	FALSE
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMX2	0.03	0.02	blup	29	0.02	3.7e-03	6.0	-5.6	2.4e-08	-0.97	0.01	0.91	FALSE
2	GTEx	Esophagus Muscularis	MED19	0.20	0.15	lasso	4	0.12	5.7e-08	-5.2	-5.5	4.2e-08	-0.53	0.90	0.09	FALSE
3	GTEx	Lung	YPEL4	0.05	0.06	lasso	3	0.05	6.7e-05	5.0	-5.5	4.3e-08	-0.95	0.03	0.96	FALSE
4	GTEx	Nerve Tibial	CTNND1	0.06	0.02	lasso	11	0.04	1.0e-03	6.0	5.4	5.5e-08	0.83	0.05	0.94	FALSE
7	GTEx	Uterus	MED19	0.33	0.11	lasso	17	0.08	8.8e-03	-4.7	-5.3	8.8e-08	-0.56	0.16	0.28	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	YPEL4	0.04	0.05	blup	33	0.04	2.6e-05	5.0	-5.3	1.0e-07	-0.92	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	ZDHHC5	0.10	0.05	blup	34	0.04	1.8e-03	-5.2	-5.2	1.7e-07	-0.54	0.09	0.19	FALSE
16	The Cancer Genome Atlas	Soft Tissue Sarcoma	MED19	0.09	0.08	lasso	1	0.08	1.2e-05	-5.2	-5.2	2.0e-07	-0.52	0.44	0.18	FALSE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZDHHC5	0.10	0.11	lasso	3	0.11	2.9e-11	-5.2	-5.2	2.2e-07	-0.51	0.74	0.26	FALSE