Best TWAS P=4.33e-10 · Best GWAS P=2.98e-10 conditioned to 0.149
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | MED19 | 0.10 | 0.09 | lasso | 3 | 0.09 | 4.7e-07 | -5.2 | -6.1 | 1.2e-09 | -0.55 | 0.88 | 0.10 | FALSE |
| 2 | GTEx | Esophagus Muscularis | MED19 | 0.20 | 0.15 | lasso | 4 | 0.12 | 5.7e-08 | -5.2 | -5.5 | 4.2e-08 | -0.53 | 0.90 | 0.09 | FALSE |
| 3 | GTEx | Lung | YPEL4 | 0.05 | 0.06 | lasso | 3 | 0.05 | 6.7e-05 | 5.0 | -5.5 | 4.3e-08 | -0.95 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Nerve Tibial | CTNND1 | 0.06 | 0.02 | lasso | 11 | 0.04 | 1.0e-03 | 6.0 | 5.4 | 5.5e-08 | 0.83 | 0.05 | 0.94 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | YPEL4 | 0.09 | 0.07 | lasso | 10 | 0.07 | 3.2e-06 | 6.3 | -6.1 | 1.3e-09 | -0.88 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Testis | MED19 | 0.16 | 0.15 | enet | 12 | 0.15 | 3.0e-07 | 6.3 | -6.2 | 4.3e-10 | -0.92 | 0.02 | 0.98 | TRUE |
| 7 | GTEx | Uterus | MED19 | 0.33 | 0.11 | lasso | 17 | 0.08 | 8.8e-03 | -4.7 | -5.3 | 8.8e-08 | -0.56 | 0.16 | 0.28 | FALSE |
| 8 | NTR | Blood | MED19 | 0.04 | 0.04 | enet | 18 | 0.04 | 2.4e-13 | -5.2 | -5.8 | 7.5e-09 | -0.53 | 0.89 | 0.11 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMX2 | 0.01 | 0.01 | enet | 7 | 0.01 | 3.3e-03 | 6.0 | -5.7 | 1.0e-08 | -0.97 | 0.01 | 0.91 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | YPEL4 | 0.02 | 0.03 | lasso | 3 | 0.02 | 5.4e-06 | 6.3 | -6.2 | 4.8e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZDHHC5 | 0.02 | 0.01 | blup | 34 | 0.01 | 1.5e-03 | -5.2 | -5.6 | 2.0e-08 | -0.71 | 0.07 | 0.37 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZDHHC5 | 0.10 | 0.05 | blup | 34 | 0.04 | 1.8e-03 | -5.2 | -5.2 | 1.7e-07 | -0.54 | 0.09 | 0.19 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | YPEL4 | 0.04 | 0.05 | blup | 33 | 0.04 | 2.6e-05 | 5.0 | -5.3 | 1.0e-07 | -0.92 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMX2 | 0.03 | 0.02 | blup | 29 | 0.02 | 3.7e-03 | 6.0 | -5.6 | 2.4e-08 | -0.97 | 0.01 | 0.91 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZDHHC5 | 0.10 | 0.11 | lasso | 3 | 0.11 | 2.9e-11 | -5.2 | -5.2 | 2.2e-07 | -0.51 | 0.74 | 0.26 | FALSE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | MED19 | 0.09 | 0.08 | lasso | 1 | 0.08 | 1.2e-05 | -5.2 | -5.2 | 2.0e-07 | -0.52 | 0.44 | 0.18 | FALSE |