Best TWAS P=1.07e-13 · Best GWAS P=3.22e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FADS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.2e-19 | -7.0 | 7.0 | 1.9e-12 | -0.91 | 0.03 | 0.97 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FEN1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 1.1e-07 | -7.0 | -7.1 | 1.3e-12 | 0.91 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Tibial | FADS2 | 0.08 | 0.02 | lasso | 4 | 0.02 | 6.9e-03 | -7.0 | -5.8 | 7.7e-09 | 0.68 | 0.04 | 0.92 | FALSE |
| 4 | GTEx | Artery Tibial | TMEM258 | 0.08 | 0.05 | lasso | 5 | 0.02 | 1.1e-02 | -6.9 | -7.0 | 2.3e-12 | 0.89 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Brain Cerebellum | FADS1 | 0.35 | 0.24 | enet | 16 | 0.30 | 2.1e-09 | -7.3 | 7.4 | 1.4e-13 | -0.92 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Brain Cerebellum | FADS3 | 0.26 | 0.18 | lasso | 4 | 0.14 | 5.7e-05 | -7.3 | 7.3 | 3.3e-13 | -0.99 | 0.01 | 0.94 | FALSE |
| 7 | GTEx | Brain Putamen basal ganglia | FADS1 | 0.29 | 0.21 | enet | 30 | 0.16 | 1.4e-04 | -7.0 | 6.9 | 4.4e-12 | -0.72 | 0.01 | 0.94 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | TMEM258 | 0.20 | 0.02 | lasso | 7 | 0.00 | 2.3e-01 | -4.8 | -6.2 | 4.8e-10 | 0.71 | 0.03 | 0.60 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | TMEM258 | 0.15 | 0.05 | enet | 15 | 0.07 | 1.1e-05 | -7.0 | -6.9 | 5.9e-12 | 0.75 | 0.02 | 0.97 | FALSE |
| 10 | GTEx | Colon Transverse | FADS2 | 0.18 | 0.11 | lasso | 7 | 0.16 | 8.1e-08 | -3.5 | -5.6 | 2.6e-08 | 0.80 | 0.01 | 0.98 | FALSE |
| 11 | GTEx | Esophagus Mucosa | FADS1 | 0.11 | 0.00 | lasso | 4 | 0.02 | 1.9e-02 | -7.3 | 6.9 | 4.5e-12 | -0.80 | 0.01 | 0.96 | FALSE |
| 12 | GTEx | Muscle Skeletal | FADS2 | 0.08 | 0.04 | lasso | 2 | 0.03 | 5.9e-04 | -7.0 | -6.5 | 6.7e-11 | 0.78 | 0.04 | 0.96 | FALSE |
| 13 | GTEx | Pancreas | FADS1 | 0.17 | 0.13 | lasso | 6 | 0.12 | 1.2e-05 | -7.3 | 7.4 | 1.1e-13 | -0.99 | 0.01 | 0.99 | TRUE |
| 14 | NTR | Blood | C11orf10 | 0.06 | 0.08 | bslmm | 399 | 0.08 | 1.3e-24 | -7.0 | -7.0 | 3.1e-12 | 0.85 | 0.04 | 0.96 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | TMEM258 | 0.14 | 0.16 | lasso | 4 | 0.15 | 4.7e-19 | -7.0 | -7.0 | 2.3e-12 | 0.84 | 0.02 | 0.98 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | FADS1 | 0.08 | 0.08 | enet | 10 | 0.09 | 1.5e-11 | -6.7 | 6.9 | 6.6e-12 | -0.94 | 0.02 | 0.98 | FALSE |
| 17 | YFS | Blood | FADS1 | 0.11 | 0.08 | lasso | 8 | 0.09 | 6.1e-29 | -3.5 | -5.7 | 1.4e-08 | 0.82 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FADS1 | 0.06 | 0.03 | lasso | 4 | 0.04 | 7.4e-03 | -7.3 | 5.8 | 4.8e-09 | -0.92 | 0.01 | 0.81 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FADS1 | 0.05 | 0.05 | blup | 53 | 0.04 | 6.8e-05 | -6.3 | 6.4 | 1.4e-10 | -0.74 | 0.06 | 0.93 | FALSE |
| 20 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FADS1 | 0.20 | 0.01 | blup | 51 | 0.07 | 3.2e-04 | -7.0 | 7.2 | 8.0e-13 | -0.85 | 0.01 | 0.94 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FADS2 | 0.02 | 0.01 | blup | 71 | 0.02 | 1.9e-03 | -7.0 | -6.4 | 1.3e-10 | 0.85 | 0.02 | 0.80 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf10 | 0.02 | 0.01 | enet | 11 | 0.01 | 1.6e-02 | -7.0 | -5.3 | 1.3e-07 | 0.61 | 0.02 | 0.64 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FADS1 | 0.06 | 0.04 | blup | 53 | 0.03 | 2.0e-04 | -7.3 | 6.5 | 6.3e-11 | -0.85 | 0.00 | 0.96 | FALSE |
| 24 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FADS2 | 0.15 | 0.05 | blup | 71 | 0.11 | 2.5e-08 | -3.5 | -5.3 | 9.2e-08 | 0.72 | 0.05 | 0.94 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf10 | 0.02 | 0.02 | blup | 44 | 0.02 | 1.8e-03 | -6.3 | -6.9 | 7.1e-12 | 0.92 | 0.02 | 0.75 | FALSE |