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chr11:60,839,578-62,346,131

Best TWAS P=1.07e-13 · Best GWAS P=3.22e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
13	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-7.3	7.4	1.1e-13	-0.99	0.01	0.99	TRUE
5	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-7.3	7.4	1.4e-13	-0.92	0.01	0.99	FALSE
6	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-7.3	7.3	3.3e-13	-0.99	0.01	0.94	FALSE
20	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	-7.0	7.2	8.0e-13	-0.85	0.01	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-7.0	-7.1	1.3e-12	0.91	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-7.0	7.0	1.9e-12	-0.91	0.03	0.97	FALSE
4	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-6.9	-7.0	2.3e-12	0.89	0.03	0.96	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-7.0	-7.0	2.3e-12	0.84	0.02	0.98	FALSE
14	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-7.0	-7.0	3.1e-12	0.85	0.04	0.96	FALSE
7	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	-7.0	6.9	4.4e-12	-0.72	0.01	0.94	FALSE
11	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	-7.3	6.9	4.5e-12	-0.80	0.01	0.96	FALSE
9	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-7.0	-6.9	5.9e-12	0.75	0.02	0.97	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-6.7	6.9	6.6e-12	-0.94	0.02	0.98	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-6.3	-6.9	7.1e-12	0.92	0.02	0.75	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	-7.3	6.5	6.3e-11	-0.85	0.00	0.96	FALSE
12	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-7.0	-6.5	6.7e-11	0.78	0.04	0.96	FALSE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-7.0	-6.4	1.3e-10	0.85	0.02	0.80	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-6.3	6.4	1.4e-10	-0.74	0.06	0.93	FALSE
8	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	-4.8	-6.2	4.8e-10	0.71	0.03	0.60	FALSE
18	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	-7.3	5.8	4.8e-09	-0.92	0.01	0.81	FALSE
3	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-7.0	-5.8	7.7e-09	0.68	0.04	0.92	FALSE
17	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-3.5	-5.7	1.4e-08	0.82	1.00	0.00	FALSE
10	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-3.5	-5.6	2.6e-08	0.80	0.01	0.98	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	-3.5	-5.3	9.2e-08	0.72	0.05	0.94	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	-7.0	-5.3	1.3e-07	0.61	0.02	0.64	FALSE