Best TWAS P=5.54e-12 · Best GWAS P=3.82e-09 conditioned to 0.421
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | CLNS1A | 0.11 | 0.01 | enet | 25 | 0.03 | 7.4e-03 | 5.7 | -6.7 | 2.7e-11 | -0.65 | 0.03 | 0.92 | FALSE |
| 2 | GTEx | Artery Tibial | AAMDC | 0.16 | 0.23 | lasso | 3 | 0.23 | 5.2e-18 | -4.9 | 5.2 | 2.3e-07 | 0.18 | 0.52 | 0.48 | FALSE |
| 3 | GTEx | Artery Tibial | AP000580.1 | 0.12 | 0.08 | lasso | 7 | 0.09 | 1.1e-07 | 5.1 | -5.8 | 6.3e-09 | -0.86 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | AP000580.1 | 0.31 | 0.04 | lasso | 4 | 0.09 | 3.6e-03 | -4.4 | -5.4 | 6.1e-08 | -0.52 | 0.04 | 0.50 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | AP000580.1 | 0.12 | 0.02 | enet | 18 | 0.08 | 1.1e-06 | 5.8 | -6.9 | 5.5e-12 | -0.78 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Colon Transverse | AP000580.1 | 0.11 | 0.09 | lasso | 3 | 0.08 | 1.3e-04 | -4.9 | -5.1 | 2.7e-07 | -0.20 | 0.44 | 0.32 | FALSE |
| 7 | GTEx | Esophagus Muscularis | AAMDC | 0.14 | 0.13 | lasso | 4 | 0.12 | 8.3e-08 | -4.9 | 5.1 | 2.9e-07 | 0.19 | 0.61 | 0.39 | FALSE |
| 8 | GTEx | Esophagus Muscularis | RP11-91P24.7 | 0.17 | 0.15 | lasso | 5 | 0.15 | 3.1e-09 | -4.9 | 5.3 | 1.1e-07 | 0.24 | 0.61 | 0.39 | FALSE |
| 9 | GTEx | Pituitary | AAMDC | 0.15 | 0.07 | enet | 7 | 0.06 | 1.2e-02 | -4.2 | 5.3 | 1.1e-07 | 0.25 | 0.12 | 0.19 | FALSE |
| 10 | GTEx | Pituitary | RP11-91P24.7 | 0.17 | 0.13 | lasso | 4 | 0.06 | 1.3e-02 | -4.6 | 5.6 | 2.3e-08 | 0.29 | 0.14 | 0.17 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | AP000580.1 | 0.09 | 0.09 | lasso | 4 | 0.07 | 1.1e-06 | 5.7 | -5.9 | 3.6e-09 | -0.94 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Thyroid | AP000580.1 | 0.08 | 0.04 | lasso | 3 | 0.05 | 1.2e-04 | 5.8 | -6.1 | 1.1e-09 | -0.90 | 0.02 | 0.96 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | AQP11 | 0.07 | 0.02 | blup | 320 | 0.05 | 1.5e-06 | 5.6 | -5.9 | 4.3e-09 | -0.66 | 0.04 | 0.96 | FALSE |
| 14 | YFS | Blood | CLNS1A | 0.08 | 0.16 | enet | 25 | 0.17 | 3.8e-52 | -4.3 | -5.6 | 2.6e-08 | -0.29 | 0.86 | 0.14 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C11orf67 | 0.02 | 0.02 | blup | 60 | 0.01 | 9.2e-04 | -4.9 | 5.2 | 1.9e-07 | 0.26 | 0.20 | 0.54 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AQP11 | 0.04 | 0.01 | blup | 39 | 0.02 | 9.1e-04 | -4.3 | -5.5 | 4.0e-08 | -0.36 | 0.08 | 0.45 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C11orf67 | 0.03 | 0.01 | enet | 11 | 0.02 | 1.8e-03 | -5.1 | 5.4 | 5.4e-08 | 0.28 | 0.03 | 0.21 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C11orf67 | 0.07 | 0.06 | enet | 8 | 0.07 | 1.3e-04 | -4.6 | 6.1 | 1.3e-09 | 0.48 | 0.06 | 0.34 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | C11orf67 | 0.04 | 0.04 | lasso | 4 | 0.02 | 7.3e-04 | -4.9 | 5.2 | 1.7e-07 | 0.21 | 0.19 | 0.53 | FALSE |
| 20 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C11orf67 | 0.08 | 0.09 | lasso | 9 | 0.07 | 1.0e-03 | -5.7 | 5.6 | 1.9e-08 | 0.38 | 0.01 | 0.83 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf67 | 0.07 | 0.04 | blup | 60 | 0.04 | 2.5e-05 | -4.5 | 5.9 | 3.6e-09 | 0.50 | 0.15 | 0.66 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf67 | 0.11 | 0.09 | blup | 60 | 0.12 | 7.8e-12 | -4.9 | 6.3 | 2.4e-10 | 0.38 | 0.32 | 0.68 | FALSE |