Best TWAS P=6.15e-11 · Best GWAS P=3.74e-11 conditioned to 0.159
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SYTL2 | 0.08 | 0.00 | enet | 17 | 0.00 | 4.2e-01 | -5.3 | 5.6 | 2.4e-08 | -0.51 | 0.14 | 0.15 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SYTL2 | 0.14 | 0.03 | lasso | 5 | 0.05 | 1.1e-04 | -6.6 | 6.5 | 6.1e-11 | -0.94 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | CCDC89 | 0.06 | 0.07 | lasso | 4 | 0.05 | 8.3e-05 | -5.9 | -5.7 | 1.6e-08 | 0.76 | 0.12 | 0.83 | FALSE |
| 4 | GTEx | Muscle Skeletal | SYTL2 | 0.10 | 0.11 | lasso | 5 | 0.10 | 2.2e-10 | -5.4 | 6.0 | 2.2e-09 | -0.80 | 0.21 | 0.79 | FALSE |
| 5 | GTEx | Nerve Tibial | SYTL2 | 0.05 | 0.03 | enet | 9 | 0.02 | 2.4e-02 | -6.1 | 6.2 | 5.3e-10 | -0.90 | 0.02 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SYTL2 | 0.04 | 0.03 | lasso | 4 | 0.03 | 1.9e-04 | -6.1 | 6.2 | 5.2e-10 | -0.90 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | SYTL2 | 0.01 | 0.03 | lasso | 3 | 0.02 | 6.3e-04 | -5.9 | 6.1 | 1.3e-09 | -0.79 | 0.07 | 0.66 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC83 | 0.06 | 0.00 | blup | 79 | 0.03 | 4.0e-04 | -3.4 | -6.2 | 5.1e-10 | 0.60 | 0.01 | 0.32 | FALSE |