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chr11:73,767,497-75,612,878

Best TWAS P=6.25e-15 · Best GWAS P=5.01e-49 conditioned to 6.8e-278

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NEU3	0.05	0.04	lasso	3	0.04	3.6e-05	-5.7	6.7	2.8e-11	0.06	0.07	0.88	TRUE
2	CommonMind	Brain Pre-frontal Cortex	RNF169	0.07	0.04	bslmm	495	0.03	1.1e-04	6.3	6.8	1.2e-11	0.11	0.14	0.84	FALSE
3	CommonMind	Brain Pre-frontal Cortex	XRRA1	0.59	0.79	lasso	3	0.78	5.8e-152	7.0	7.1	1.1e-12	0.05	0.06	0.94	FALSE
4	GTEx	Adipose Subcutaneous	XRRA1	0.49	0.62	enet	27	0.64	6.1e-67	7.2	6.9	4.9e-12	0.04	0.05	0.95	FALSE
5	GTEx	Adipose Subcutaneous	RP11-147I3.1	0.18	0.14	lasso	7	0.17	1.0e-13	6.5	-6.2	5.4e-10	-0.02	0.16	0.84	FALSE
6	GTEx	Adipose Visceral Omentum	XRRA1	0.51	0.54	lasso	7	0.55	3.8e-33	7.2	7.0	3.0e-12	0.04	0.07	0.93	FALSE
7	GTEx	Adrenal Gland	XRRA1	0.63	0.69	enet	25	0.69	3.9e-33	7.0	6.5	1.1e-10	0.05	0.07	0.93	FALSE
8	GTEx	Adrenal Gland	RP11-147I3.1	0.31	0.24	enet	24	0.28	1.6e-10	7.0	-6.0	2.7e-09	-0.02	0.08	0.92	FALSE
9	GTEx	Artery Aorta	XRRA1	0.57	0.65	lasso	7	0.68	1.1e-50	7.0	7.0	2.4e-12	0.04	0.07	0.93	FALSE
10	GTEx	Artery Coronary	XRRA1	0.72	0.71	enet	24	0.73	4.8e-35	7.0	6.8	9.2e-12	0.04	0.09	0.91	FALSE
11	GTEx	Artery Tibial	XRRA1	0.63	0.72	lasso	10	0.74	1.9e-83	7.0	7.0	2.1e-12	0.04	0.06	0.94	FALSE
12	GTEx	Brain Caudate basal ganglia	XRRA1	0.72	0.61	lasso	5	0.60	2.6e-21	7.1	6.9	4.4e-12	0.04	0.07	0.93	FALSE
13	GTEx	Brain Cerebellar Hemisphere	XRRA1	0.79	0.74	lasso	8	0.74	2.5e-27	7.0	7.0	2.1e-12	0.04	0.06	0.94	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-147I3.1	0.36	0.12	lasso	7	0.13	2.6e-04	7.0	-7.0	2.8e-12	-0.04	0.09	0.87	FALSE
15	GTEx	Brain Cerebellum	XRRA1	0.67	0.65	lasso	9	0.69	2.7e-27	7.1	7.2	9.0e-13	0.04	0.06	0.94	FALSE
16	GTEx	Brain Hippocampus	XRRA1	0.57	0.48	lasso	6	0.49	2.3e-13	7.1	6.9	4.2e-12	0.04	0.08	0.92	FALSE
17	GTEx	Brain Hypothalamus	XRRA1	0.51	0.44	enet	13	0.44	1.4e-11	7.2	6.4	1.7e-10	0.04	0.09	0.91	FALSE
18	GTEx	Brain Hypothalamus	RP11-147I3.1	0.25	0.19	enet	19	0.20	1.9e-05	7.1	-5.8	5.2e-09	-0.02	0.10	0.75	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	XRRA1	0.70	0.50	lasso	8	0.51	1.0e-15	7.1	7.3	2.6e-13	0.03	0.07	0.93	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	RP11-147I3.1	0.23	0.20	lasso	1	0.17	2.9e-05	7.0	-7.0	1.9e-12	-0.04	0.08	0.76	FALSE
21	GTEx	Brain Putamen basal ganglia	XRRA1	0.55	0.50	lasso	3	0.50	9.3e-14	7.1	7.1	1.0e-12	0.05	0.07	0.93	FALSE
22	GTEx	Brain Putamen basal ganglia	RP11-147I3.1	0.19	0.20	lasso	2	0.20	2.0e-05	7.1	-7.1	1.1e-12	-0.05	0.08	0.83	FALSE
23	GTEx	Breast Mammary Tissue	XRRA1	0.48	0.57	lasso	1	0.57	8.3e-35	7.0	7.0	2.0e-12	0.04	0.07	0.93	FALSE
24	GTEx	Breast Mammary Tissue (Male)	XRRA1	0.49	0.32	lasso	4	0.29	1.6e-07	7.0	6.7	2.6e-11	0.04	0.07	0.92	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	XRRA1	0.64	0.72	lasso	4	0.71	6.1e-32	7.2	7.2	7.5e-13	0.04	0.06	0.94	FALSE
26	GTEx	Cells Transformed fibroblasts	RP11-147I3.1	0.13	0.14	lasso	6	0.14	1.1e-10	7.2	-5.5	3.2e-08	-0.03	0.06	0.94	FALSE
27	GTEx	Colon Transverse	XRRA1	0.64	0.66	lasso	7	0.68	6.8e-43	6.6	6.9	5.4e-12	0.04	0.08	0.92	FALSE
28	GTEx	Colon Transverse	RP11-147I3.1	0.26	0.27	enet	14	0.29	2.8e-14	7.2	-6.3	3.7e-10	-0.03	0.06	0.94	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	XRRA1	0.55	0.68	enet	17	0.68	5.2e-33	7.0	6.9	4.8e-12	0.04	0.07	0.93	FALSE
30	GTEx	Esophagus Mucosa	XRRA1	0.64	0.76	lasso	7	0.76	5.9e-75	7.0	7.1	1.6e-12	0.04	0.06	0.94	FALSE
31	GTEx	Esophagus Mucosa	RP11-147I3.1	0.20	0.12	lasso	4	0.12	1.2e-08	7.0	-7.0	3.0e-12	-0.04	0.08	0.92	FALSE
32	GTEx	Esophagus Muscularis	XRRA1	0.59	0.70	lasso	5	0.70	1.2e-58	7.2	7.1	9.5e-13	0.04	0.06	0.94	FALSE
33	GTEx	Esophagus Muscularis	RP11-147I3.1	0.08	0.03	lasso	5	0.04	2.6e-03	6.4	-6.7	1.7e-11	-0.03	0.14	0.79	FALSE
34	GTEx	Heart Atrial Appendage	RP11-147I3.1	0.14	0.11	lasso	3	0.10	3.8e-05	6.5	-6.7	2.9e-11	-0.03	0.09	0.90	FALSE
35	GTEx	Heart Left Ventricle	XRRA1	0.58	0.69	lasso	6	0.69	1.0e-49	7.0	7.1	1.5e-12	0.04	0.06	0.94	FALSE
36	GTEx	Heart Left Ventricle	RP11-147I3.1	0.21	0.14	lasso	3	0.14	4.6e-08	6.5	-6.8	9.3e-12	-0.03	0.08	0.92	FALSE
37	GTEx	Liver	XRRA1	0.73	0.63	lasso	7	0.65	1.5e-23	7.0	6.5	9.3e-11	0.03	0.07	0.93	FALSE
38	GTEx	Liver	RP11-147I3.1	0.35	0.34	lasso	5	0.33	6.0e-10	7.2	-6.3	3.7e-10	-0.02	0.07	0.93	FALSE
39	GTEx	Lung	XRRA1	0.66	0.70	enet	35	0.72	1.1e-78	7.0	7.2	6.5e-13	0.04	0.06	0.94	FALSE
40	GTEx	Muscle Skeletal	XRRA1	0.53	0.68	enet	16	0.72	8.9e-100	7.0	7.1	1.6e-12	0.03	0.06	0.94	FALSE
41	GTEx	Muscle Skeletal	RP11-147I3.1	0.16	0.18	lasso	7	0.17	3.5e-16	7.0	-6.8	1.3e-11	-0.03	0.07	0.93	FALSE
42	GTEx	Nerve Tibial	XRRA1	0.52	0.67	lasso	5	0.68	3.6e-64	7.2	7.1	1.6e-12	0.04	0.05	0.95	FALSE
43	GTEx	Ovary	XRRA1	0.69	0.56	enet	18	0.65	1.7e-20	7.0	6.5	1.0e-10	0.04	0.09	0.91	FALSE
44	GTEx	Ovary	RP11-147I3.1	0.22	0.20	lasso	3	0.22	5.3e-06	7.0	-6.2	5.2e-10	-0.03	0.14	0.83	FALSE
45	GTEx	Pancreas	XRRA1	0.56	0.64	lasso	5	0.64	1.4e-34	7.2	7.3	3.4e-13	0.04	0.06	0.94	FALSE
46	GTEx	Pancreas	RP11-147I3.1	0.28	0.18	lasso	7	0.20	1.2e-08	7.2	-7.6	3.4e-14	-0.04	0.08	0.92	FALSE
47	GTEx	Pituitary	XRRA1	0.67	0.68	lasso	3	0.68	6.4e-23	7.0	7.1	1.4e-12	0.04	0.06	0.94	FALSE
48	GTEx	Pituitary	RP11-147I3.1	0.40	0.37	enet	19	0.39	8.9e-11	7.2	-6.6	3.6e-11	-0.02	0.07	0.93	FALSE
49	GTEx	Prostate	XRRA1	0.80	0.63	lasso	12	0.69	1.5e-23	7.1	7.0	1.8e-12	0.03	0.07	0.93	FALSE
50	GTEx	Prostate	RP11-147I3.1	0.32	0.29	lasso	10	0.24	9.0e-07	6.4	-5.8	5.9e-09	-0.01	0.09	0.90	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	XRRA1	0.51	0.59	enet	12	0.60	5.3e-41	7.0	7.1	1.4e-12	0.04	0.06	0.94	FALSE
52	GTEx	Skin Sun Exposed Lower leg	XRRA1	0.50	0.65	lasso	6	0.66	7.4e-72	7.0	7.0	2.3e-12	0.04	0.08	0.92	FALSE
53	GTEx	Small Intestine Terminal Ileum	RP11-147I3.1	0.32	0.08	lasso	6	0.06	2.1e-02	7.0	-7.0	2.0e-12	-0.04	0.12	0.54	FALSE
54	GTEx	Spleen	XRRA1	0.67	0.63	lasso	8	0.68	5.8e-23	7.0	6.5	1.0e-10	0.03	0.08	0.92	FALSE
55	GTEx	Stomach	XRRA1	0.57	0.64	lasso	6	0.66	7.9e-41	7.1	7.1	9.8e-13	0.03	0.06	0.94	FALSE
56	GTEx	Testis	SLCO2B1	0.28	0.11	lasso	7	0.15	2.9e-07	4.4	-5.9	4.0e-09	0.03	0.76	0.01	FALSE
57	GTEx	Thyroid	XRRA1	0.66	0.76	lasso	4	0.76	1.1e-88	7.0	7.1	1.5e-12	0.05	0.07	0.93	FALSE
58	GTEx	Thyroid	RP11-147I3.1	0.34	0.35	lasso	8	0.37	1.9e-29	7.2	-6.5	1.0e-10	-0.03	0.05	0.95	FALSE
59	GTEx	Uterus	XRRA1	0.59	0.59	lasso	7	0.59	6.9e-15	7.2	7.1	1.6e-12	0.04	0.08	0.92	FALSE
60	GTEx	Uterus	RP11-147I3.1	0.29	0.06	lasso	4	0.09	6.2e-03	6.5	-5.3	1.5e-07	-0.01	0.11	0.44	FALSE
61	GTEx	Vagina	XRRA1	0.72	0.75	lasso	4	0.76	2.5e-25	7.2	6.8	1.0e-11	0.04	0.06	0.94	FALSE
62	GTEx	Whole Blood	XRRA1	0.44	0.56	enet	13	0.55	4.0e-60	7.0	6.8	9.1e-12	0.04	0.07	0.93	FALSE
63	METSIM	Adipose	XRRA1	0.31	0.40	lasso	13	0.40	3.6e-65	7.1	6.7	3.0e-11	0.03	0.06	0.94	FALSE
64	NTR	Blood	XRRA1	0.09	0.16	lasso	3	0.16	3.2e-49	7.2	7.1	1.2e-12	0.04	0.05	0.95	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	XRRA1	0.56	0.72	bslmm	505	0.72	6.2e-136	7.2	7.2	4.4e-13	0.04	0.06	0.94	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	RP11-147I3.1	0.28	0.41	lasso	4	0.41	6.9e-57	7.1	-7.0	2.3e-12	-0.04	0.06	0.94	FALSE
67	YFS	Blood	XRRA1	0.14	0.18	lasso	6	0.18	5.1e-58	7.0	6.7	2.2e-11	0.04	0.06	0.94	FALSE
68	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	XRRA1	0.34	0.39	enet	10	0.39	5.6e-35	7.0	7.0	2.9e-12	0.04	0.10	0.90	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	POLD3	0.02	0.01	lasso	3	0.01	1.8e-03	5.7	-6.4	1.7e-10	0.00	0.04	0.57	TRUE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	XRRA1	0.29	0.43	lasso	4	0.43	2.7e-97	7.0	7.0	1.8e-12	0.04	0.08	0.92	FALSE
71	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	XRRA1	0.34	0.30	lasso	3	0.29	1.0e-14	7.2	7.2	6.1e-13	0.05	0.05	0.95	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	XRRA1	0.54	0.55	lasso	3	0.57	8.9e-40	7.0	6.8	1.1e-11	0.04	0.06	0.94	FALSE
73	The Cancer Genome Atlas	Esophageal Carcinoma	XRRA1	0.43	0.39	lasso	5	0.36	2.8e-12	7.0	6.6	4.0e-11	0.03	0.06	0.94	FALSE
74	The Cancer Genome Atlas	Glioblastoma Multiforme	XRRA1	0.63	0.58	lasso	4	0.58	2.7e-21	6.6	6.9	6.7e-12	0.05	0.06	0.94	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	XRRA1	0.28	0.38	lasso	4	0.38	1.3e-44	7.0	7.0	2.3e-12	0.04	0.06	0.94	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRRA1	0.52	0.69	lasso	6	0.70	2.8e-111	7.1	6.9	5.0e-12	0.04	0.05	0.95	FALSE
77	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	XRRA1	0.40	0.54	lasso	7	0.54	1.2e-35	7.2	7.2	8.3e-13	0.04	0.05	0.95	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	XRRA1	0.53	0.64	enet	34	0.65	1.2e-97	7.0	7.0	1.8e-12	0.05	0.08	0.92	FALSE
79	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	XRRA1	0.37	0.36	blup	73	0.36	5.7e-18	7.0	7.8	6.3e-15	0.05	0.06	0.94	TRUE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	SPCS2	0.04	0.03	lasso	2	0.02	1.3e-03	-7.2	6.1	1.4e-09	0.08	0.00	0.97	TRUE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	XRRA1	0.39	0.54	lasso	4	0.53	5.7e-73	7.0	7.1	1.4e-12	0.04	0.08	0.92	FALSE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	XRRA1	0.29	0.43	lasso	2	0.43	9.7e-54	7.0	6.9	3.9e-12	0.04	0.09	0.91	FALSE
83	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	XRRA1	0.45	0.53	lasso	3	0.53	4.2e-42	7.1	7.1	1.3e-12	0.05	0.05	0.95	FALSE
84	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	XRRA1	0.45	0.58	enet	15	0.61	2.4e-31	7.2	6.6	3.5e-11	0.04	0.05	0.95	TRUE
85	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	XRRA1	0.53	0.35	enet	6	0.39	9.9e-17	7.0	6.8	9.1e-12	0.04	0.10	0.90	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	XRRA1	0.50	0.64	enet	12	0.65	2.8e-90	7.2	6.8	1.5e-11	0.03	0.05	0.95	FALSE
87	The Cancer Genome Atlas	Rectum Adenocarcinoma	XRRA1	0.65	0.69	lasso	3	0.69	1.6e-21	7.1	7.1	1.2e-12	0.04	0.05	0.95	FALSE
88	The Cancer Genome Atlas	Soft Tissue Sarcoma	XRRA1	0.27	0.34	lasso	4	0.34	7.5e-21	7.0	6.9	5.1e-12	0.04	0.05	0.95	FALSE
89	The Cancer Genome Atlas	Skin Cutaneous Melanoma	XRRA1	0.37	0.40	lasso	8	0.37	5.7e-11	7.0	7.1	1.6e-12	0.04	0.06	0.94	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	XRRA1	0.49	0.58	lasso	9	0.57	6.3e-50	7.0	6.9	5.3e-12	0.04	0.06	0.94	FALSE
91	The Cancer Genome Atlas	Testicular Germ Cell Tumors	XRRA1	0.43	0.32	lasso	6	0.31	1.9e-11	7.1	6.9	4.1e-12	0.04	0.06	0.94	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	POLD3	0.03	0.00	blup	77	0.01	1.3e-02	5.6	-6.2	7.4e-10	0.03	0.01	0.77	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	XRRA1	0.59	0.69	lasso	6	0.70	5.4e-96	7.0	6.8	1.4e-11	0.04	0.07	0.93	FALSE
94	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	XRRA1	0.41	0.32	lasso	8	0.30	3.4e-09	7.0	7.0	2.8e-12	0.05	0.06	0.94	FALSE