Best TWAS P=5.73e-16 · Best GWAS P=1.6e-19 conditioned to 9.63e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | SMOC1 | 0.14 | 0.12 | enet | 11 | 0.09 | 6.8e-06 | 5.5 | -6.5 | 8.2e-11 | -0.72 | 0.09 | 0.90 | FALSE |
| 2 | GTEx | Artery Coronary | SMOC1 | 0.24 | 0.33 | lasso | 2 | 0.32 | 1.9e-11 | -7.1 | -7.1 | 1.5e-12 | -0.79 | 0.84 | 0.15 | FALSE |
| 3 | GTEx | Artery Tibial | SMOC1 | 0.33 | 0.32 | lasso | 10 | 0.33 | 3.0e-26 | -7.1 | -7.5 | 7.6e-14 | -0.79 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC8A3 | 0.05 | 0.00 | blup | 156 | 0.02 | 1.4e-03 | 5.4 | 6.8 | 1.4e-11 | 0.59 | 0.02 | 0.29 | FALSE |
| 5 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SMOC1 | 0.07 | 0.00 | blup | 188 | 0.02 | 1.9e-02 | 9.0 | -8.1 | 5.7e-16 | -0.76 | 0.00 | 0.94 | TRUE |