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chr14:63,623,678-66,266,677

Best TWAS P=1.09e-33 · Best GWAS P=5.71e-32 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
47	YFS	Blood	MAX	0.04	0.02	lasso	4	0.02	2.8e-06	-11.8	12.1	1.1e-33	-0.99	0.00	1.00	TRUE
23	GTEx	Heart Left Ventricle	SYNE2	0.20	0.14	lasso	5	0.09	1.6e-05	6.0	-6.3	2.3e-10	0.01	0.27	0.70	TRUE
21	GTEx	Esophagus Muscularis	PLEKHG3	0.21	0.03	enet	19	0.03	4.5e-03	5.0	6.1	9.0e-10	-0.15	0.92	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	MAX	0.15	0.16	lasso	2	0.16	1.2e-18	-10.7	10.5	9.9e-26	-0.80	0.97	0.03	FALSE
26	GTEx	Muscle Skeletal	FNTB	0.05	0.02	lasso	6	0.01	5.8e-02	-10.0	10.3	7.8e-25	-0.75	0.12	0.75	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	RAB15	0.04	0.00	blup	49	0.01	6.9e-02	-10.1	-9.9	5.8e-23	0.57	0.00	0.96	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB15	0.14	0.07	enet	15	0.09	5.5e-10	-10.1	-9.3	1.6e-20	0.55	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAB15	0.11	0.01	enet	12	0.06	1.1e-04	-6.9	-9.2	2.4e-20	0.50	0.02	0.89	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB15	0.02	0.01	blup	49	0.02	6.7e-05	-5.6	-8.9	5.4e-19	0.56	0.09	0.84	FALSE
31	GTEx	Pituitary	RAB15	0.32	0.03	enet	16	0.10	1.9e-03	-9.8	-8.9	5.7e-19	0.70	0.05	0.82	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	FNTB	0.14	0.06	enet	18	0.14	1.4e-13	-3.0	8.7	2.6e-18	-0.64	0.30	0.70	FALSE
46	METSIM	Adipose	RAB15	0.10	0.04	enet	22	0.08	3.8e-12	-7.7	-8.5	2.9e-17	0.51	1.00	0.00	FALSE
22	GTEx	Esophagus Muscularis	RAB15	0.35	0.06	enet	23	0.17	1.2e-10	-5.5	-8.4	5.3e-17	0.50	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB15	0.03	0.00	blup	49	0.01	1.8e-02	-10.1	-7.9	3.1e-15	0.57	0.01	0.94	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB15	0.04	0.05	blup	49	0.06	2.5e-07	-5.6	-7.5	5.1e-14	0.53	0.37	0.60	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB15	0.04	0.01	enet	5	0.03	1.9e-04	-8.4	-7.5	7.8e-14	0.56	0.03	0.81	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	FNTB	0.02	0.03	enet	8	0.03	2.0e-07	-7.9	7.2	4.7e-13	-0.54	0.94	0.04	FALSE
14	GTEx	Cells Transformed fibroblasts	RAB15	0.64	0.08	enet	41	0.33	1.3e-25	-5.5	-7.2	4.9e-13	0.45	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Esophageal Carcinoma	FNTB	0.09	0.05	lasso	3	0.04	2.6e-02	-7.8	7.1	1.5e-12	-0.47	0.05	0.29	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FNTB	0.10	0.03	blup	107	0.07	7.9e-07	-3.1	6.7	2.1e-11	-0.46	0.68	0.21	FALSE
7	GTEx	Artery Aorta	SPTB	0.13	0.00	enet	11	0.01	9.0e-02	-2.4	-6.7	2.3e-11	0.37	0.08	0.05	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNTB	0.06	0.02	blup	106	0.04	3.7e-05	-3.0	6.7	2.5e-11	-0.48	0.23	0.10	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SPTB	0.06	0.05	bslmm	528	0.05	9.5e-07	-4.3	6.6	3.4e-11	-0.38	0.73	0.19	FALSE
38	GTEx	Testis	PPP1R36	0.29	0.25	enet	17	0.28	1.1e-12	4.2	-6.4	1.6e-10	0.26	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FNTB	0.04	0.02	lasso	3	0.04	2.3e-05	-3.0	6.3	2.7e-10	-0.48	0.90	0.02	FALSE
37	GTEx	Testis	RAB15	0.23	0.16	lasso	5	0.13	2.8e-06	-5.5	-6.3	2.8e-10	0.42	0.66	0.08	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	RAB15	0.04	0.01	blup	49	0.01	2.6e-02	-5.4	-6.2	6.5e-10	0.36	0.02	0.05	FALSE
32	GTEx	Prostate	MTHFD1	0.36	0.04	enet	30	0.09	3.2e-03	-4.9	6.2	7.0e-10	-0.09	0.12	0.33	FALSE
41	GTEx	Thyroid	CTD-2555O16.2	0.09	0.03	enet	9	0.04	5.1e-04	-4.8	6.2	7.2e-10	0.02	0.07	0.91	FALSE
9	GTEx	Artery Tibial	CTD-2555O16.2	0.17	0.12	enet	21	0.11	3.8e-09	-5.8	6.1	8.0e-10	-0.01	0.50	0.50	FALSE
60	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FNTB	0.18	0.12	blup	107	0.18	6.5e-08	-4.4	6.1	8.3e-10	-0.48	0.91	0.07	FALSE
39	GTEx	Thyroid	MTHFD1	0.37	0.29	enet	33	0.30	1.4e-23	-4.8	6.1	9.7e-10	0.02	1.00	0.00	FALSE
30	GTEx	Ovary	CHURC1	0.48	0.27	enet	16	0.24	1.1e-06	-4.4	6.1	1.1e-09	-0.42	0.38	0.14	FALSE
13	GTEx	Breast Mammary Tissue (Male)	MTHFD1	0.17	0.03	lasso	3	0.04	4.1e-02	-4.8	6.1	1.3e-09	0.00	0.06	0.15	FALSE
44	GTEx	Vagina	CHURC1	0.43	0.24	lasso	12	0.27	5.4e-07	-4.4	6.0	1.6e-09	-0.46	0.37	0.07	FALSE
15	GTEx	Colon Transverse	MTHFD1	0.20	0.01	enet	49	0.02	6.2e-02	-4.2	6.0	2.0e-09	-0.12	0.16	0.32	FALSE
35	GTEx	Skin Sun Exposed Lower leg	CTD-2555O16.4	0.09	0.04	enet	11	0.02	1.5e-02	-4.9	6.0	2.3e-09	-0.01	0.37	0.21	FALSE
36	GTEx	Testis	MTHFD1	0.19	0.10	enet	12	0.08	3.0e-04	-5.8	5.9	2.7e-09	0.01	0.28	0.65	FALSE
8	GTEx	Artery Tibial	MTHFD1	0.29	0.23	enet	21	0.24	3.3e-19	-4.9	5.9	3.4e-09	0.01	0.96	0.04	FALSE
12	GTEx	Breast Mammary Tissue	MTHFD1	0.11	0.13	enet	10	0.05	1.8e-03	-4.8	5.8	4.9e-09	0.00	0.77	0.12	FALSE
29	GTEx	Nerve Tibial	CTD-2555O16.4	0.09	0.06	lasso	6	0.04	7.7e-04	5.1	5.8	5.1e-09	0.00	0.28	0.20	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	MTHFD1	0.26	0.26	enet	16	0.27	1.7e-26	-4.8	5.8	6.2e-09	0.03	0.10	0.89	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	CHURC1	0.40	0.40	lasso	6	0.43	2.9e-17	-6.5	5.7	9.6e-09	-0.41	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Soft Tissue Sarcoma	FNTB	0.05	0.04	blup	107	0.03	6.5e-03	-3.1	5.7	1.1e-08	-0.49	0.23	0.12	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ESR2	0.02	0.00	blup	88	0.01	2.1e-02	-4.3	5.7	1.2e-08	0.01	0.03	0.62	FALSE
10	GTEx	Artery Tibial	CTD-2555O16.4	0.14	0.09	enet	15	0.07	3.0e-06	-5.8	5.7	1.3e-08	0.01	0.57	0.43	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	FNTB	0.05	0.05	blup	107	0.06	3.6e-07	-5.7	5.6	1.7e-08	-0.43	0.99	0.00	FALSE
19	GTEx	Esophagus Mucosa	CTD-2555O16.2	0.08	0.00	enet	15	0.03	2.9e-03	5.6	5.6	2.0e-08	-0.07	0.22	0.08	FALSE
24	GTEx	Lung	MTHFD1	0.12	0.12	enet	17	0.08	7.6e-07	-4.8	5.6	2.0e-08	0.02	0.98	0.01	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	ESR2	0.05	0.05	lasso	3	0.05	9.6e-06	5.5	5.6	2.8e-08	0.02	0.70	0.12	FALSE
27	GTEx	Nerve Tibial	MTHFD1	0.31	0.28	enet	13	0.29	1.2e-20	-4.8	5.6	2.9e-08	0.04	1.00	0.00	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	RAB15	0.20	0.13	lasso	13	0.16	2.4e-06	-3.1	-5.5	3.1e-08	0.45	0.60	0.28	FALSE
33	GTEx	Skin Sun Exposed Lower leg	MTHFD1	0.25	0.24	enet	36	0.25	8.0e-21	-4.8	5.5	3.4e-08	0.00	1.00	0.00	FALSE
42	GTEx	Thyroid	CTD-2555O16.4	0.10	0.05	enet	17	0.04	8.1e-04	-4.9	5.5	3.8e-08	-0.02	0.40	0.53	FALSE
43	GTEx	Uterus	CHURC1	0.34	0.13	lasso	7	0.31	3.6e-07	-5.8	5.5	4.3e-08	-0.43	0.19	0.08	FALSE
68	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CHURC1	0.35	0.22	enet	14	0.24	2.9e-07	-3.1	-5.5	4.3e-08	0.35	0.58	0.29	FALSE
4	GTEx	Adipose Subcutaneous	CTD-2555O16.2	0.09	0.09	enet	11	0.07	5.1e-06	-4.8	5.5	4.9e-08	0.02	0.97	0.02	FALSE
34	GTEx	Skin Sun Exposed Lower leg	CTD-2555O16.2	0.12	0.11	lasso	3	0.10	7.4e-09	-4.3	5.3	1.0e-07	0.05	1.00	0.00	FALSE
40	GTEx	Thyroid	RAB15	0.26	0.04	enet	52	0.08	1.5e-06	-5.5	-5.3	1.1e-07	0.35	0.97	0.01	FALSE
20	GTEx	Esophagus Muscularis	MTHFD1	0.11	0.04	enet	9	0.03	6.6e-03	-4.8	5.3	1.2e-07	-0.02	0.18	0.16	FALSE
28	GTEx	Nerve Tibial	CTD-2555O16.2	0.15	0.11	enet	9	0.08	3.2e-06	-4.8	5.2	1.7e-07	0.05	0.99	0.00	FALSE
5	GTEx	Adipose Subcutaneous	CTD-2555O16.4	0.11	0.10	enet	18	0.08	3.8e-07	-4.8	5.2	1.8e-07	-0.03	0.98	0.01	FALSE
6	GTEx	Adipose Visceral Omentum	CHURC1	0.40	0.37	lasso	5	0.39	3.0e-21	-4.4	5.2	1.8e-07	-0.39	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	MTHFD1	0.11	0.13	enet	13	0.12	5.6e-10	-4.8	5.2	1.9e-07	0.03	1.00	0.00	FALSE
45	GTEx	Whole Blood	CHURC1	0.30	0.27	lasso	6	0.33	3.9e-31	-5.6	5.2	2.1e-07	-0.40	1.00	0.00	FALSE
25	GTEx	Lung	PLEKHG3	0.16	0.04	lasso	3	0.09	3.8e-07	4.3	5.2	2.5e-07	-0.01	0.61	0.04	FALSE
18	GTEx	Esophagus Mucosa	RAB15	0.23	0.04	enet	41	0.14	1.2e-09	-3.1	-5.1	2.9e-07	0.31	0.82	0.06	FALSE
11	GTEx	Brain Hippocampus	CHURC1	0.32	0.03	enet	9	0.08	5.3e-03	-5.7	5.1	3.1e-07	-0.36	0.12	0.31	FALSE