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chr14:74,176,318-77,117,550

Best TWAS P=1.06e-18 · Best GWAS P=1.19e-35 conditioned to 1.27e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	YFS	Blood	NPC2	0.09	0.06	enet	10	0.07	1.6e-22	-8.1	8.8	1.1e-18	-0.73	1.00	0.00	TRUE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	TTLL5	0.03	0.01	blup	122	0.02	3.2e-03	6.0	-7.8	4.4e-15	0.01	0.05	0.87	TRUE
25	GTEx	Small Intestine Terminal Ileum	RPS6KL1	0.57	0.12	lasso	16	0.10	2.9e-03	-4.3	-6.7	2.3e-11	0.12	0.12	0.06	TRUE
15	GTEx	Esophagus Gastroesophageal Junction	TTLL5	0.16	0.03	lasso	3	0.01	1.2e-01	5.3	-5.5	4.8e-08	-0.01	0.21	0.42	TRUE
33	NTR	Blood	NPC2	0.02	0.01	lasso	5	0.01	6.3e-03	-7.9	8.6	7.1e-18	-0.73	0.03	0.96	FALSE
9	GTEx	Brain Cortex	TTLL5	0.23	0.09	lasso	13	0.07	5.9e-03	7.4	-7.8	5.7e-15	0.02	0.07	0.70	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TTLL5	0.02	0.01	blup	121	0.02	2.5e-03	6.4	-7.3	3.7e-13	0.00	0.08	0.33	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TTLL5	0.13	0.15	lasso	10	0.19	1.2e-22	6.0	-7.3	3.9e-13	0.01	0.88	0.12	FALSE
14	GTEx	Cells Transformed fibroblasts	AC007182.6	0.18	0.20	lasso	7	0.18	2.1e-13	7.0	7.2	4.7e-13	-0.01	0.24	0.76	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	TTLL5	0.07	0.04	blup	121	0.06	2.4e-04	7.1	-7.1	9.7e-13	0.02	0.10	0.87	FALSE
13	GTEx	Cells Transformed fibroblasts	FLVCR2	0.21	0.16	lasso	8	0.17	1.2e-12	7.0	7.1	1.1e-12	0.00	0.18	0.82	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	TTLL5	0.01	0.02	enet	7	0.02	3.6e-05	5.9	-7.0	2.0e-12	0.01	0.10	0.67	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTLL5	0.04	0.02	blup	121	0.04	1.1e-05	6.0	-7.0	2.2e-12	0.01	0.38	0.61	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	TTLL5	0.06	0.05	blup	121	0.05	6.3e-06	5.6	-7.0	2.3e-12	0.01	0.94	0.06	FALSE
20	GTEx	Nerve Tibial	TTLL5	0.08	0.05	lasso	3	0.04	5.1e-04	6.4	-6.7	1.5e-11	0.01	0.10	0.56	FALSE
34	YFS	Blood	ISCA2	0.22	0.19	enet	11	0.21	7.1e-66	6.4	6.7	1.7e-11	-0.61	1.00	0.00	FALSE
36	YFS	Blood	TTLL5	0.04	0.04	lasso	6	0.03	1.4e-10	5.7	-6.7	1.7e-11	-0.01	1.00	0.00	FALSE
31	METSIM	Adipose	TTLL5	0.12	0.01	blup	624	0.05	2.1e-07	5.4	-6.6	3.5e-11	0.02	0.24	0.57	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TTLL5	0.04	0.03	blup	121	0.04	2.8e-05	6.0	-6.6	3.5e-11	0.01	0.75	0.18	FALSE
12	GTEx	Cells Transformed fibroblasts	TTLL5	0.09	0.09	lasso	6	0.11	1.6e-08	6.4	-6.6	4.8e-11	0.01	0.77	0.22	FALSE
17	GTEx	Lung	TTLL5	0.15	0.08	enet	17	0.11	9.0e-09	5.6	-6.6	5.6e-11	0.00	0.92	0.08	FALSE
8	GTEx	Brain Cerebellar Hemisphere	TTLL5	0.19	0.06	lasso	2	0.02	9.7e-02	6.2	-6.4	1.5e-10	0.05	0.11	0.31	FALSE
30	METSIM	Adipose	NPC2	0.03	0.01	lasso	2	0.01	1.4e-02	6.4	6.3	2.3e-10	-0.50	0.19	0.60	FALSE
5	GTEx	Artery Aorta	TTLL5	0.09	0.11	lasso	3	0.07	1.1e-04	6.3	-6.3	3.4e-10	0.03	0.65	0.17	FALSE
4	GTEx	Adipose Subcutaneous	TTLL5	0.13	0.10	lasso	4	0.11	2.2e-09	5.6	-6.2	4.7e-10	0.00	0.97	0.03	FALSE
26	GTEx	Spleen	ACYP1	0.27	0.00	lasso	4	0.01	1.5e-01	4.1	-6.2	5.7e-10	0.03	0.06	0.15	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTLL5	0.03	0.03	lasso	3	0.02	1.6e-03	5.7	-6.2	6.3e-10	0.03	0.11	0.44	FALSE
29	GTEx	Whole Blood	ISCA2	0.15	0.05	enet	18	0.08	5.4e-08	6.1	6.2	7.2e-10	-0.53	0.74	0.13	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SYNDIG1L	0.19	0.09	enet	17	0.12	4.5e-14	-4.7	-6.1	9.3e-10	0.67	0.99	0.01	FALSE
27	GTEx	Thyroid	NPC2	0.13	0.05	lasso	4	0.02	4.9e-03	6.1	6.1	1.1e-09	-0.47	0.12	0.59	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	ISCA2	0.03	0.02	lasso	3	0.00	2.3e-01	6.4	6.1	1.4e-09	-0.44	0.02	0.03	FALSE
23	GTEx	Skin Sun Exposed Lower leg	NPC2	0.11	0.11	enet	11	0.10	2.7e-08	6.4	6.0	1.8e-09	-0.56	0.99	0.01	FALSE
19	GTEx	Nerve Tibial	NPC2	0.11	0.09	lasso	2	0.07	1.6e-05	6.4	6.0	1.9e-09	-0.48	0.70	0.03	FALSE
6	GTEx	Artery Tibial	NPC2	0.17	0.14	lasso	2	0.14	4.1e-11	6.4	6.0	2.1e-09	-0.43	1.00	0.00	FALSE
16	GTEx	Esophagus Mucosa	TTLL5	0.11	0.00	lasso	5	0.00	2.4e-01	5.7	-6.0	2.2e-09	0.00	0.28	0.27	FALSE
32	NTR	Blood	ISCA2	0.10	0.07	lasso	6	0.07	1.6e-21	6.1	6.0	2.2e-09	-0.49	1.00	0.00	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	RPS6KL1	0.08	0.08	enet	11	0.07	1.5e-04	-5.0	-5.9	3.5e-09	0.02	0.87	0.00	FALSE
7	GTEx	Artery Tibial	TTLL5	0.09	0.05	lasso	4	0.05	1.3e-04	5.3	-5.9	4.8e-09	-0.01	0.80	0.08	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	TTLL5	0.24	0.01	enet	27	0.15	1.1e-05	6.0	-5.9	4.9e-09	0.00	0.10	0.62	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTLL5	0.06	0.07	blup	121	0.06	1.3e-07	6.0	-5.7	9.4e-09	0.02	0.77	0.22	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DLST	0.09	0.11	lasso	2	0.11	4.0e-13	5.7	-5.7	9.9e-09	0.00	1.00	0.00	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	RP11-950C14.3	0.07	0.03	enet	8	0.03	1.2e-02	4.3	-5.5	2.9e-08	0.04	0.36	0.04	FALSE
28	GTEx	Thyroid	RPS6KL1	0.23	0.14	enet	14	0.14	1.3e-10	-4.7	-5.5	3.5e-08	0.13	1.00	0.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TTLL5	0.15	0.05	enet	23	0.07	2.8e-06	5.3	-5.4	8.4e-08	-0.02	0.54	0.43	FALSE
10	GTEx	Brain Frontal Cortex BA9	TTLL5	0.24	0.00	enet	18	0.00	3.0e-01	6.6	-5.3	1.2e-07	0.02	0.09	0.49	FALSE
18	GTEx	Muscle Skeletal	TTLL5	0.05	0.04	lasso	2	0.03	1.2e-03	5.4	-5.2	1.5e-07	0.02	0.57	0.21	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS6KL1	0.04	0.04	lasso	3	0.03	1.8e-04	-5.1	-5.2	1.8e-07	0.02	0.02	0.96	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS6KL1	0.03	0.02	lasso	3	0.02	8.5e-06	-5.1	-5.2	1.9e-07	0.03	0.02	0.98	FALSE