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chr14:91,531,030-93,268,359

Best TWAS P=1.4e-34 · Best GWAS P=1.66e-36 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Artery Tibial	RP11-529H20.5	0.07	0.00	lasso	4	0.00	4.7e-01	-12.36	-12.3	1.4e-34	0.95	0.03	0.87	TRUE
90	METSIM	Adipose	TC2N	0.08	0.05	enet	23	0.05	3.4e-08	-6.56	6.1	8.7e-10	0.26	0.96	0.04	TRUE
93	YFS	Blood	TC2N	0.44	0.34	lasso	12	0.38	2.0e-132	-3.60	5.4	6.5e-08	0.00	1.00	0.00	TRUE
91	METSIM	Adipose	TRIP11	0.05	0.04	enet	13	0.02	3.8e-04	-12.52	-11.9	1.8e-32	0.89	0.00	1.00	FALSE
81	GTEx	Testis	RP11-529H20.5	0.19	0.05	lasso	10	0.05	4.2e-03	-10.33	-11.8	3.5e-32	0.83	0.04	0.94	FALSE
45	GTEx	Esophagus Mucosa	RP11-529H20.6	0.13	0.11	lasso	10	0.13	7.9e-09	-10.38	-11.7	1.9e-31	0.87	0.08	0.92	FALSE
105	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIP11	0.14	0.04	blup	70	0.09	1.6e-03	-8.93	-11.6	2.7e-31	0.90	0.03	0.62	FALSE
75	GTEx	Spleen	RP11-529H20.5	0.31	0.15	lasso	3	0.18	2.3e-05	-11.58	-11.6	3.0e-31	0.80	0.08	0.50	FALSE
54	GTEx	Lung	RP11-529H20.6	0.08	0.05	enet	15	0.05	1.8e-04	-10.46	-11.6	4.6e-31	0.83	0.58	0.38	FALSE
3	GTEx	Adipose Subcutaneous	RP11-529H20.5	0.14	0.16	lasso	3	0.15	3.0e-12	-10.33	-11.5	8.0e-31	0.83	0.68	0.32	FALSE
96	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIP11	0.04	0.01	blup	70	0.01	4.4e-02	9.37	-11.5	1.1e-30	0.82	0.04	0.48	FALSE
87	GTEx	Whole Blood	RP11-529H20.5	0.13	0.09	lasso	5	0.08	1.2e-07	-11.58	-11.5	1.2e-30	0.82	0.39	0.60	FALSE
88	GTEx	Whole Blood	RP11-529H20.6	0.15	0.13	lasso	4	0.16	3.8e-14	-10.46	-11.5	1.3e-30	0.80	0.50	0.50	FALSE
24	GTEx	Breast Mammary Tissue (Female)	ATXN3	0.18	0.04	lasso	4	0.03	3.3e-02	-11.05	-11.1	7.8e-29	0.84	0.15	0.70	FALSE
69	GTEx	Prostate	RP11-529H20.6	0.28	0.00	lasso	5	0.05	2.5e-02	-10.46	-11.1	7.8e-29	0.59	0.15	0.08	FALSE
14	GTEx	Artery Tibial	ATXN3	0.13	0.11	lasso	3	0.10	5.8e-08	-11.05	-11.0	2.9e-28	0.85	0.89	0.11	FALSE
66	GTEx	Pituitary	RP11-529H20.5	0.37	0.14	enet	7	0.07	6.3e-03	-11.58	-11.0	5.5e-28	0.79	0.20	0.23	FALSE
64	GTEx	Ovary	RP11-529H20.6	0.20	0.23	lasso	4	0.18	4.3e-05	-10.46	-10.9	6.8e-28	0.76	0.06	0.86	FALSE
77	GTEx	Stomach	ATXN3	0.24	0.09	lasso	3	0.11	5.0e-06	-10.46	-10.9	9.4e-28	0.78	0.87	0.11	FALSE
46	GTEx	Esophagus Muscularis	ATXN3	0.16	0.17	lasso	5	0.17	2.0e-10	-10.33	-10.9	1.5e-27	0.79	0.99	0.01	FALSE
65	GTEx	Pituitary	ATXN3	0.33	0.03	lasso	2	0.03	4.7e-02	-10.46	-10.8	3.6e-27	0.75	0.26	0.10	FALSE
55	GTEx	Muscle Skeletal	ATXN3	0.04	0.04	lasso	5	0.04	1.2e-04	-10.33	-10.7	1.5e-26	0.76	0.33	0.58	FALSE
33	GTEx	Cells Transformed fibroblasts	RP11-529H20.6	0.27	0.26	lasso	6	0.24	3.1e-18	-10.46	-10.6	1.7e-26	0.74	1.00	0.00	FALSE
21	GTEx	Breast Mammary Tissue	ATXN3	0.20	0.24	lasso	8	0.23	3.5e-12	-10.46	-10.6	2.9e-26	0.74	0.95	0.05	FALSE
10	GTEx	Artery Aorta	RP11-529H20.6	0.20	0.14	lasso	4	0.18	6.4e-10	-10.46	-10.6	3.1e-26	0.71	0.97	0.01	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-529H20.5	0.19	0.05	lasso	6	0.08	9.9e-05	-10.38	-10.6	3.3e-26	0.80	0.46	0.54	FALSE
86	GTEx	Thyroid	RP11-529H20.6	0.17	0.18	lasso	2	0.17	9.6e-13	-10.46	-10.6	4.0e-26	0.73	1.00	0.00	FALSE
31	GTEx	Cells Transformed fibroblasts	TRIP11	0.09	0.04	lasso	2	0.00	3.8e-01	-10.51	-10.6	5.0e-26	0.70	0.24	0.03	FALSE
82	GTEx	Testis	RP11-529H20.6	0.23	0.23	lasso	3	0.22	4.9e-10	-10.46	-10.5	5.5e-26	0.71	0.94	0.06	FALSE
57	GTEx	Muscle Skeletal	RP11-529H20.6	0.11	0.06	lasso	2	0.06	2.9e-06	-10.46	-10.5	5.8e-26	0.72	0.98	0.02	FALSE
2	GTEx	Adipose Subcutaneous	ATXN3	0.19	0.17	lasso	5	0.17	1.7e-13	-10.33	-10.5	1.2e-25	0.72	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	ATXN3	0.19	0.14	lasso	6	0.12	7.0e-07	-10.41	-10.5	1.2e-25	0.72	0.62	0.37	FALSE
30	GTEx	Cells Transformed fibroblasts	ATXN3	0.14	0.10	lasso	9	0.09	6.0e-07	-10.33	-10.5	1.4e-25	0.72	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RP11-529H20.6	0.16	0.26	lasso	2	0.26	4.8e-21	-10.46	-10.4	1.5e-25	0.72	1.00	0.00	FALSE
16	GTEx	Artery Tibial	RP11-529H20.6	0.20	0.22	lasso	8	0.22	2.3e-17	-10.46	-10.5	1.5e-25	0.72	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-529H20.6	0.26	0.29	lasso	4	0.28	1.1e-14	-10.53	-10.4	1.8e-25	0.73	1.00	0.00	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIP11	0.02	0.02	lasso	1	0.01	1.1e-02	-10.41	-10.4	2.2e-25	0.72	0.14	0.12	FALSE
79	GTEx	Stomach	RP11-529H20.6	0.20	0.27	lasso	4	0.25	2.5e-12	-10.33	-10.4	2.5e-25	0.72	1.00	0.00	FALSE
61	GTEx	Nerve Tibial	RP11-529H20.6	0.29	0.30	lasso	4	0.29	4.4e-21	-10.33	-10.4	3.3e-25	0.72	1.00	0.00	FALSE
50	GTEx	Heart Atrial Appendage	RP11-529H20.6	0.27	0.20	lasso	5	0.18	2.5e-08	-10.46	-10.4	3.7e-25	0.71	0.98	0.01	FALSE
60	GTEx	Nerve Tibial	RP11-529H20.5	0.28	0.26	lasso	5	0.25	9.2e-18	-10.33	-10.4	3.8e-25	0.73	1.00	0.00	FALSE
32	GTEx	Cells Transformed fibroblasts	RP11-529H20.5	0.10	0.13	lasso	11	0.12	3.1e-09	-10.36	-10.3	4.2e-25	0.72	1.00	0.00	FALSE
49	GTEx	Esophagus Muscularis	RP11-529H20.6	0.21	0.24	lasso	2	0.22	9.2e-14	-10.33	-10.3	5.3e-25	0.72	1.00	0.00	FALSE
80	GTEx	Testis	TRIP11	0.10	0.05	lasso	4	0.02	3.5e-02	-10.51	-10.3	5.4e-25	0.72	0.09	0.74	FALSE
23	GTEx	Breast Mammary Tissue	RP11-529H20.6	0.20	0.23	enet	13	0.27	3.5e-14	-10.46	-10.3	6.0e-25	0.75	0.96	0.04	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	RP11-529H20.6	0.41	0.30	lasso	2	0.28	6.9e-10	-10.46	-10.3	7.0e-25	0.70	0.97	0.02	FALSE
59	GTEx	Nerve Tibial	TRIP11	0.21	0.14	lasso	6	0.11	3.7e-08	-10.33	-10.3	8.2e-25	0.73	1.00	0.00	FALSE
73	GTEx	Small Intestine Terminal Ileum	RP11-529H20.6	0.36	0.32	lasso	8	0.26	1.8e-06	-10.53	-10.1	3.9e-24	0.70	0.53	0.36	FALSE
62	GTEx	Ovary	ATXN3	0.32	0.18	lasso	8	0.18	2.9e-05	-10.33	-10.1	5.5e-24	0.72	0.16	0.69	FALSE
58	GTEx	Nerve Tibial	ATXN3	0.30	0.29	lasso	4	0.29	1.6e-20	-10.33	-10.1	7.1e-24	0.72	1.00	0.00	FALSE
63	GTEx	Ovary	RP11-529H20.5	0.24	0.10	lasso	5	0.11	1.2e-03	-10.33	-10.1	8.3e-24	0.74	0.05	0.81	FALSE
52	GTEx	Heart Left Ventricle	RP11-529H20.5	0.10	0.03	enet	8	0.06	2.7e-04	-11.58	-10.0	1.0e-23	0.77	0.03	0.90	FALSE
38	GTEx	Colon Sigmoid	RP11-529H20.6	0.24	0.24	lasso	3	0.27	4.8e-10	-10.46	-10.0	1.1e-23	0.71	1.00	0.00	FALSE
8	GTEx	Adrenal Gland	RP11-529H20.6	0.22	0.21	lasso	7	0.18	4.8e-07	-10.51	-10.0	2.2e-23	0.71	0.84	0.09	FALSE
53	GTEx	Heart Left Ventricle	RP11-529H20.6	0.13	0.12	enet	14	0.12	3.4e-07	-10.46	-9.9	2.6e-23	0.76	0.80	0.18	FALSE
48	GTEx	Esophagus Muscularis	RP11-529H20.5	0.17	0.11	enet	19	0.11	2.9e-07	-10.33	-9.9	2.7e-23	0.75	0.76	0.24	FALSE
41	GTEx	Esophagus Gastroesophageal Junction	TRIP11	0.16	0.13	lasso	11	0.12	3.7e-05	-11.01	-9.9	4.2e-23	0.78	0.54	0.16	FALSE
56	GTEx	Muscle Skeletal	TRIP11	0.05	0.04	lasso	6	0.03	7.9e-04	-10.39	-9.9	6.3e-23	0.72	0.38	0.43	FALSE
11	GTEx	Artery Coronary	ATXN3	0.21	0.20	lasso	2	0.24	1.4e-08	-10.46	-9.8	8.7e-23	0.64	0.64	0.29	FALSE
47	GTEx	Esophagus Muscularis	TRIP11	0.10	0.11	lasso	4	0.10	8.3e-07	-10.33	-9.7	2.0e-22	0.71	0.56	0.44	FALSE
28	GTEx	Breast Mammary Tissue (Female)	RP11-529H20.6	0.22	0.13	lasso	3	0.09	1.5e-03	-10.41	-9.7	2.5e-22	0.71	0.14	0.83	FALSE
94	YFS	Blood	TRIP11	0.06	0.04	blup	510	0.04	4.4e-14	-11.05	-9.7	3.1e-22	0.74	0.59	0.41	FALSE
101	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TRIP11	0.16	0.16	lasso	12	0.15	4.4e-06	-11.05	-9.6	6.2e-22	0.71	0.30	0.59	FALSE
43	GTEx	Esophagus Gastroesophageal Junction	RP11-529H20.6	0.26	0.27	enet	26	0.26	6.2e-10	-10.33	-9.5	1.3e-21	0.73	0.99	0.01	FALSE
20	GTEx	Brain Putamen basal ganglia	RP11-529H20.6	0.44	0.14	enet	45	0.26	6.1e-07	-12.52	-9.5	3.0e-21	0.85	0.01	0.98	FALSE
22	GTEx	Breast Mammary Tissue	RP11-529H20.5	0.22	0.10	enet	23	0.12	1.1e-06	-10.41	-9.4	7.0e-21	0.75	0.23	0.77	FALSE
92	YFS	Blood	ATXN3	0.20	0.14	enet	52	0.24	1.1e-75	-10.35	-9.4	7.9e-21	0.78	1.00	0.00	FALSE
74	GTEx	Spleen	ATXN3	0.27	0.03	lasso	3	0.01	1.5e-01	-10.33	-9.3	9.9e-21	0.69	0.06	0.65	FALSE
84	GTEx	Thyroid	TRIP11	0.08	0.04	lasso	4	0.02	6.3e-03	-10.43	-9.3	9.9e-21	0.69	0.42	0.23	FALSE
78	GTEx	Stomach	RP11-529H20.5	0.19	0.12	enet	32	0.12	2.2e-06	-10.46	-9.2	2.8e-20	0.73	0.19	0.80	FALSE
44	GTEx	Esophagus Mucosa	TRIP11	0.09	0.01	lasso	4	0.00	2.4e-01	-10.05	-9.2	4.0e-20	0.74	0.12	0.28	FALSE
34	GTEx	Colon Sigmoid	ATXN3	0.31	0.30	lasso	2	0.33	3.4e-12	-10.46	-9.2	5.0e-20	0.68	1.00	0.00	FALSE
12	GTEx	Artery Coronary	TRIP11	0.18	0.01	lasso	3	0.00	3.2e-01	-10.06	-9.1	9.1e-20	0.74	0.09	0.24	FALSE
85	GTEx	Thyroid	RP11-529H20.5	0.14	0.12	enet	14	0.13	7.7e-10	-11.58	-9.0	1.6e-19	0.67	0.26	0.74	FALSE
39	GTEx	Colon Transverse	RP11-529H20.6	0.18	0.14	lasso	5	0.18	3.7e-09	-10.46	-8.9	5.5e-19	0.68	1.00	0.00	FALSE
83	GTEx	Thyroid	ATXN3	0.13	0.05	enet	11	0.14	5.5e-11	-10.46	-8.8	1.1e-18	0.66	0.11	0.88	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	TRIP11	0.08	0.04	blup	70	0.06	3.6e-06	-8.17	-8.7	3.1e-18	0.74	0.35	0.62	FALSE
26	GTEx	Breast Mammary Tissue (Female)	RP11-529H20.5	0.17	-0.01	enet	35	-0.01	5.8e-01	-10.41	-8.5	1.4e-17	0.66	0.05	0.56	FALSE
37	GTEx	Colon Sigmoid	RP11-529H20.5	0.27	0.05	lasso	8	0.04	1.9e-02	-10.05	-8.5	1.7e-17	0.76	0.42	0.14	FALSE
76	GTEx	Spleen	RP11-529H20.6	0.53	0.22	enet	40	0.32	6.2e-09	-10.33	-8.5	1.7e-17	0.68	0.29	0.70	FALSE
9	GTEx	Artery Aorta	TRIP11	0.20	0.00	enet	8	0.02	4.0e-02	-10.33	-8.4	5.8e-17	0.75	0.15	0.24	FALSE
89	METSIM	Adipose	ATXN3	0.08	0.02	bslmm	541	0.04	3.1e-06	-10.51	-8.0	1.0e-15	0.54	0.88	0.10	FALSE
42	GTEx	Esophagus Gastroesophageal Junction	RP11-529H20.5	0.17	0.02	enet	23	0.01	9.6e-02	-10.39	-7.9	3.9e-15	0.59	0.28	0.23	FALSE
99	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TC2N	0.17	0.12	blup	83	0.12	2.1e-05	-6.56	7.9	4.0e-15	0.06	0.36	0.22	FALSE
67	GTEx	Prostate	ATXN3	0.30	0.04	lasso	5	0.06	1.4e-02	-10.46	-7.8	7.4e-15	0.56	0.09	0.09	FALSE
40	GTEx	Esophagus Gastroesophageal Junction	ATXN3	0.32	0.17	enet	41	0.18	6.1e-07	-10.33	-7.2	6.0e-13	0.65	0.93	0.04	FALSE
35	GTEx	Colon Sigmoid	TRIP11	0.15	0.09	enet	18	0.07	1.7e-03	-3.49	-7.1	1.3e-12	0.53	0.15	0.33	FALSE
18	GTEx	Brain Hippocampus	ATXN3	0.28	0.03	lasso	16	0.12	8.9e-04	-4.95	-7.0	2.4e-12	0.61	0.14	0.29	FALSE
95	The Cancer Genome Atlas	Breast Invasive Carcinoma	FBLN5	0.05	0.01	lasso	3	0.02	1.2e-04	4.23	7.0	3.1e-12	-0.22	0.34	0.02	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	TC2N	0.07	0.06	enet	10	0.06	2.8e-06	-6.56	7.0	3.6e-12	0.03	0.74	0.25	FALSE
70	GTEx	Skin Sun Exposed Lower leg	ATXN3	0.07	0.02	enet	15	0.02	5.8e-03	4.69	-6.8	1.1e-11	0.68	0.05	0.75	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIP11	0.04	0.01	blup	71	0.02	1.4e-03	-3.85	-6.3	2.2e-10	0.40	0.09	0.04	FALSE
72	GTEx	Small Intestine Terminal Ileum	RP11-747H7.3	0.31	0.14	lasso	2	0.04	3.8e-02	6.16	6.2	7.4e-10	0.09	0.07	0.05	FALSE
27	GTEx	Breast Mammary Tissue (Female)	RP11-747H7.3	0.10	0.06	lasso	6	0.07	4.9e-03	6.19	6.1	9.6e-10	0.08	0.12	0.05	FALSE
51	GTEx	Heart Left Ventricle	TC2N	0.13	0.10	enet	15	0.10	6.5e-06	6.19	6.1	9.6e-10	0.13	0.88	0.02	FALSE
68	GTEx	Prostate	TRIP11	0.42	-0.01	enet	79	0.05	1.8e-02	-12.52	-6.0	2.4e-09	0.31	0.03	0.70	FALSE
71	GTEx	Skin Sun Exposed Lower leg	TC2N	0.09	0.06	lasso	5	0.06	4.6e-06	6.16	5.9	4.2e-09	0.10	0.98	0.00	FALSE
100	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TC2N	0.20	0.04	enet	18	0.04	2.4e-02	3.53	5.7	1.5e-08	0.16	0.02	0.11	FALSE
25	GTEx	Breast Mammary Tissue (Female)	TC2N	0.04	-0.01	lasso	5	0.06	7.0e-03	6.19	5.7	1.6e-08	0.10	0.05	0.08	FALSE
17	GTEx	Brain Frontal Cortex BA9	RP11-747H7.3	0.20	0.15	lasso	2	0.09	2.1e-03	6.16	5.4	5.5e-08	0.12	0.14	0.20	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATXN3	0.10	0.06	enet	10	0.11	5.4e-13	-8.68	5.3	1.2e-07	-0.34	1.00	0.00	FALSE
19	GTEx	Brain Hypothalamus	RP11-747H7.3	0.34	0.12	lasso	6	0.18	6.0e-05	6.16	5.3	1.3e-07	0.04	0.20	0.04	FALSE
13	GTEx	Artery Coronary	RP11-529H20.6	0.44	-0.01	enet	49	0.08	1.1e-03	0.26	-5.3	1.4e-07	0.38	0.49	0.10	FALSE
36	GTEx	Colon Sigmoid	TC2N	0.18	0.03	enet	14	0.02	6.6e-02	-11.87	-5.2	1.8e-07	0.58	0.06	0.70	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	CATSPERB	0.10	0.01	lasso	6	0.03	6.8e-04	-2.83	5.2	1.9e-07	0.13	0.00	0.04	FALSE