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chr14:102,089,185-106,199,579

Best TWAS P=2.17e-26 · Best GWAS P=7.75e-28 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf153	0.20	0.05	lasso	2	0.04	8.8e-04	-10.91	10.6	2.2e-26	-0.95	0.00	0.98	TRUE
48	GTEx	Spleen	KLC1	0.15	0.05	lasso	3	0.03	6.4e-02	-10.91	-9.2	2.9e-20	0.92	0.03	0.68	TRUE
24	GTEx	Cells Transformed fibroblasts	ANKRD9	0.25	0.17	enet	10	0.20	3.2e-15	-8.60	-8.2	2.3e-16	-0.05	0.00	1.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	BTBD6	0.07	0.02	lasso	4	0.04	2.6e-05	-3.95	7.4	1.8e-13	-0.01	0.01	0.92	TRUE
63	YFS	Blood	CKB	0.03	0.02	lasso	4	0.02	6.6e-07	6.23	-7.0	3.5e-12	0.40	0.94	0.05	TRUE
15	GTEx	Brain Cortex	XRCC3	0.12	0.02	lasso	4	0.01	1.7e-01	-2.36	-6.6	4.3e-11	0.72	0.04	0.78	TRUE
27	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	-5.61	-6.3	3.7e-10	0.70	0.08	0.52	TRUE
82	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf153	0.11	0.11	lasso	3	0.10	1.1e-04	4.31	5.1	2.8e-07	-0.54	0.18	0.20	TRUE
17	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	-10.91	9.9	3.9e-23	-0.93	0.03	0.86	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	-10.91	9.7	2.1e-22	-0.93	0.01	0.99	FALSE
30	GTEx	Esophagus Mucosa	MARK3	0.11	0.03	lasso	4	0.04	1.5e-03	6.35	9.6	9.9e-22	-0.77	0.02	0.93	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	-5.56	7.6	2.3e-14	-0.72	0.07	0.37	FALSE
21	GTEx	Breast Mammary Tissue (Female)	CINP	0.28	0.15	lasso	3	0.11	3.4e-04	-6.57	-7.2	5.3e-13	-0.06	0.02	0.92	FALSE
13	GTEx	Artery Tibial	CINP	0.16	0.15	lasso	2	0.15	1.2e-11	-6.57	-7.2	8.1e-13	-0.05	0.72	0.28	FALSE
57	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	-5.63	7.0	1.9e-12	-0.56	0.44	0.55	FALSE
81	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CINP	0.06	0.06	blup	32	0.05	2.0e-04	-6.89	-7.0	2.0e-12	0.00	0.00	0.98	FALSE
51	GTEx	Thyroid	CINP	0.16	0.16	lasso	5	0.14	6.5e-11	-6.57	-7.0	2.3e-12	-0.06	0.24	0.76	FALSE
71	The Cancer Genome Atlas	Glioblastoma Multiforme	MARK3	0.12	0.05	blup	64	0.07	3.3e-03	4.86	7.0	2.8e-12	-0.64	0.02	0.23	FALSE
19	GTEx	Breast Mammary Tissue	CINP	0.19	0.14	lasso	2	0.12	7.0e-07	-6.57	-6.9	4.2e-12	-0.06	0.04	0.96	FALSE
55	GTEx	Whole Blood	TMEM121	0.08	0.10	lasso	3	0.09	1.8e-08	6.77	-6.9	4.6e-12	-0.02	0.01	0.99	FALSE
61	YFS	Blood	ANKRD9	0.18	0.14	enet	24	0.15	1.0e-46	-6.88	6.9	4.9e-12	0.05	1.00	0.00	FALSE
65	YFS	Blood	TRMT61A	0.08	0.11	lasso	4	0.12	1.6e-37	-7.67	-6.9	5.3e-12	0.71	1.00	0.00	FALSE
37	GTEx	Muscle Skeletal	CINP	0.24	0.12	enet	28	0.12	1.6e-11	-6.53	-6.9	5.7e-12	-0.03	0.95	0.05	FALSE
70	The Cancer Genome Atlas	Glioblastoma Multiforme	CINP	0.20	0.16	lasso	4	0.15	2.5e-05	-6.53	-6.9	7.3e-12	-0.06	0.01	0.96	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	CINP	0.17	0.15	enet	9	0.14	1.1e-05	-6.57	-6.9	7.4e-12	-0.05	0.18	0.73	FALSE
26	GTEx	Colon Transverse	CINP	0.22	0.16	lasso	3	0.16	3.2e-08	-6.55	-6.8	7.8e-12	-0.05	0.43	0.52	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	3.87	6.8	1.1e-11	-0.69	0.16	0.42	FALSE
23	GTEx	Cells Transformed fibroblasts	CINP	0.18	0.13	lasso	4	0.13	7.5e-10	-6.54	-6.7	1.5e-11	-0.06	0.76	0.24	FALSE
32	GTEx	Esophagus Muscularis	CINP	0.22	0.22	enet	5	0.22	1.5e-13	-6.57	-6.7	1.7e-11	-0.06	0.73	0.27	FALSE
46	GTEx	Skin Sun Exposed Lower leg	CINP	0.19	0.17	lasso	4	0.18	4.6e-15	-6.53	-6.7	1.7e-11	-0.05	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	CINP	0.03	0.04	lasso	3	0.03	2.4e-07	-6.89	-6.7	1.7e-11	-0.06	0.00	1.00	FALSE
5	GTEx	Adipose Subcutaneous	KLC1	0.05	0.03	lasso	3	0.03	1.8e-03	-5.56	-6.7	1.8e-11	0.73	0.15	0.49	FALSE
4	GTEx	Adipose Subcutaneous	CINP	0.21	0.18	lasso	3	0.16	2.3e-13	-6.57	-6.7	2.1e-11	-0.06	0.99	0.01	FALSE
31	GTEx	Esophagus Mucosa	CINP	0.36	0.22	lasso	5	0.21	2.8e-14	-6.53	-6.7	2.2e-11	-0.06	1.00	0.00	FALSE
54	GTEx	Whole Blood	CINP	0.08	0.05	lasso	3	0.04	2.3e-04	-6.54	-6.7	2.2e-11	-0.07	0.14	0.31	FALSE
11	GTEx	Artery Aorta	TRMT61A	0.14	0.07	lasso	5	0.12	6.4e-07	5.09	6.7	2.3e-11	-0.31	0.82	0.01	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	CINP	0.24	0.13	lasso	5	0.15	1.0e-05	-6.57	-6.7	2.5e-11	-0.05	0.23	0.60	FALSE
25	GTEx	Colon Sigmoid	CINP	0.33	0.17	lasso	3	0.14	1.8e-05	-6.57	-6.6	3.0e-11	-0.06	0.04	0.95	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	CINP	0.08	0.05	lasso	5	0.04	7.7e-04	-6.53	-6.6	3.9e-11	-0.05	0.00	0.98	FALSE
52	GTEx	Thyroid	TRMT61A	0.11	0.03	lasso	4	0.02	1.2e-02	6.43	-6.6	4.1e-11	0.49	0.58	0.04	FALSE
8	GTEx	Adipose Visceral Omentum	CINP	0.21	0.17	lasso	3	0.14	1.0e-07	-6.57	-6.6	4.9e-11	-0.06	0.27	0.73	FALSE
10	GTEx	Artery Aorta	CINP	0.17	0.18	lasso	1	0.16	4.5e-09	-6.57	-6.6	5.0e-11	-0.06	1.00	0.00	FALSE
34	GTEx	Heart Atrial Appendage	CINP	0.16	0.11	lasso	1	0.10	3.2e-05	-6.57	-6.6	5.0e-11	-0.06	0.50	0.44	FALSE
39	GTEx	Nerve Tibial	CINP	0.17	0.18	lasso	2	0.18	1.6e-12	-6.57	-6.6	5.0e-11	-0.06	0.99	0.01	FALSE
47	GTEx	Spleen	CINP	0.25	0.07	lasso	3	0.10	1.3e-03	-6.57	-6.6	5.1e-11	-0.06	0.13	0.37	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	CINP	0.10	0.12	lasso	5	0.12	1.5e-12	-6.53	-6.6	5.2e-11	-0.05	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CINP	0.03	0.04	enet	3	0.03	1.0e-04	-6.53	-6.5	5.9e-11	-0.05	0.01	0.97	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CINP	0.08	0.07	lasso	3	0.06	3.3e-04	-6.51	-6.5	6.1e-11	-0.05	0.01	0.97	FALSE
91	The Cancer Genome Atlas	Thyroid Carcinoma	CINP	0.17	0.19	lasso	2	0.19	6.8e-18	-6.53	-6.5	6.2e-11	-0.05	0.01	0.99	FALSE
50	GTEx	Testis	CINP	0.23	0.15	lasso	3	0.12	4.8e-06	-6.57	-6.5	6.4e-11	-0.05	0.28	0.57	FALSE
36	GTEx	Lung	CINP	0.19	0.14	lasso	2	0.12	2.3e-09	-6.57	-6.5	6.6e-11	-0.05	0.62	0.38	FALSE
12	GTEx	Artery Coronary	CINP	0.22	0.24	lasso	2	0.24	1.2e-08	-6.53	-6.5	6.7e-11	-0.05	0.42	0.52	FALSE
62	YFS	Blood	CINP	0.07	0.03	lasso	2	0.03	3.9e-10	-6.16	-6.4	1.4e-10	-0.13	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	-5.67	6.4	1.5e-10	-0.79	0.02	0.55	FALSE
41	GTEx	Nerve Tibial	TMEM121	0.11	0.10	lasso	5	0.08	4.9e-06	6.28	6.3	2.2e-10	-0.01	0.02	0.98	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	CINP	0.20	0.19	enet	13	0.19	1.5e-10	-6.55	-6.3	2.2e-10	-0.02	0.28	0.72	FALSE
58	METSIM	Adipose	TECPR2	0.05	0.02	lasso	4	0.03	5.4e-05	4.07	6.3	2.5e-10	0.11	0.14	0.82	FALSE
2	CommonMind	Brain Pre-frontal Cortex	C14orf80	0.05	0.01	blup	146	0.02	2.2e-03	6.65	-6.3	3.3e-10	0.03	0.01	0.94	FALSE
42	GTEx	Ovary	ZNF839	0.28	0.05	enet	20	0.19	2.5e-05	-5.04	-6.2	4.9e-10	0.00	0.04	0.72	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CINP	0.15	0.04	blup	31	0.12	1.3e-05	-2.20	-6.2	5.6e-10	0.01	0.02	0.84	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf153	0.09	0.08	blup	38	0.09	6.2e-10	4.31	6.2	6.4e-10	-0.64	0.98	0.02	FALSE
59	METSIM	Adipose	TMEM121	0.04	0.02	bslmm	122	0.01	2.6e-03	6.77	-6.2	6.9e-10	-0.02	0.01	0.98	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	KLC1	0.04	0.01	blup	82	0.03	5.4e-04	-5.63	-6.1	8.7e-10	0.66	0.04	0.74	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	CINP	0.04	0.02	lasso	3	0.03	2.1e-04	-5.28	-6.1	9.0e-10	-0.03	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CINP	0.06	-0.01	blup	32	0.02	4.6e-02	-6.51	-6.1	1.2e-09	0.02	0.00	0.65	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	RP11-73M18.8	0.12	0.03	lasso	4	0.01	1.4e-01	1.70	-5.8	5.4e-09	0.52	0.06	0.25	FALSE
28	GTEx	Colon Transverse	BAG5	0.14	0.05	lasso	10	0.02	4.8e-02	-6.49	-5.8	8.0e-09	0.57	0.19	0.40	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CINP	0.06	0.06	enet	4	0.06	1.4e-07	-6.53	-5.7	9.4e-09	-0.02	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	CINP	0.16	0.08	blup	31	0.12	3.3e-07	-6.53	-5.7	1.0e-08	-0.05	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	TECPR2	0.04	0.00	blup	78	0.00	9.0e-02	-8.23	5.7	1.0e-08	0.07	0.01	0.48	FALSE
20	GTEx	Breast Mammary Tissue	KLC1	0.12	0.02	enet	26	0.07	2.9e-04	-2.35	-5.7	1.1e-08	0.67	0.29	0.67	FALSE
33	GTEx	Esophagus Muscularis	APOPT1	0.16	0.02	enet	11	0.04	2.2e-03	6.23	5.7	1.1e-08	-0.53	0.06	0.76	FALSE
53	GTEx	Thyroid	APOPT1	0.11	0.12	lasso	1	0.10	1.9e-08	-5.68	5.7	1.3e-08	-0.65	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TECPR2	0.05	0.01	blup	79	0.03	1.6e-04	-6.68	5.6	2.1e-08	0.04	0.01	0.75	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	CINP	0.05	0.04	blup	32	0.03	6.7e-05	-6.51	-5.6	2.2e-08	0.00	0.00	0.99	FALSE
88	The Cancer Genome Atlas	Soft Tissue Sarcoma	CINP	0.08	0.02	blup	32	0.04	2.3e-03	-6.89	-5.5	3.0e-08	-0.08	0.00	0.92	FALSE
16	GTEx	Brain Cortex	RP11-73M18.8	0.35	0.13	enet	34	0.25	1.2e-07	-5.67	-5.5	3.3e-08	0.39	0.62	0.29	FALSE
40	GTEx	Nerve Tibial	KLC1	0.07	0.00	enet	22	0.01	8.5e-02	-7.67	-5.5	3.6e-08	0.64	0.08	0.74	FALSE
56	METSIM	Adipose	MARK3	0.03	0.02	lasso	6	0.03	6.3e-05	-5.67	5.5	3.8e-08	-0.80	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf153	0.14	0.01	blup	40	0.03	3.5e-02	3.87	5.5	3.9e-08	-0.61	0.01	0.46	FALSE
35	GTEx	Heart Left Ventricle	CINP	0.12	0.01	lasso	2	0.01	6.0e-02	-6.57	-5.4	6.5e-08	-0.05	0.12	0.58	FALSE
60	NTR	Blood	KLC1	0.04	0.02	blup	393	0.04	8.2e-12	-3.39	-5.4	6.7e-08	0.55	0.99	0.01	FALSE
45	GTEx	Skin Sun Exposed Lower leg	MARK3	0.10	0.09	enet	13	0.08	7.5e-07	4.92	5.4	7.5e-08	-0.65	0.91	0.09	FALSE
9	GTEx	Adrenal Gland	CKB	0.18	0.00	enet	16	0.02	6.9e-02	-3.39	-5.4	7.7e-08	0.38	0.07	0.18	FALSE
49	GTEx	Stomach	MARK3	0.10	0.09	lasso	2	0.04	4.5e-03	5.04	5.3	1.3e-07	-0.56	0.14	0.58	FALSE
64	YFS	Blood	MARK3	0.04	0.04	lasso	3	0.04	1.6e-12	5.51	5.3	1.5e-07	-0.36	1.00	0.00	FALSE
14	GTEx	Artery Tibial	TECPR2	0.11	0.09	lasso	3	0.09	2.3e-07	4.73	5.2	1.6e-07	0.10	0.70	0.28	FALSE
43	GTEx	Prostate	MARK3	0.18	0.22	enet	11	0.20	8.0e-06	5.02	5.2	2.4e-07	-0.56	0.30	0.41	FALSE
6	GTEx	Adipose Subcutaneous	XRCC3	0.09	0.08	lasso	5	0.07	3.8e-06	-5.68	-5.1	2.6e-07	0.61	0.93	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	CINP	0.09	0.00	bslmm	345	0.03	9.7e-05	-0.74	-5.1	2.8e-07	0.01	0.11	0.21	FALSE
7	GTEx	Adipose Subcutaneous	APOPT1	0.06	0.02	lasso	5	0.02	8.2e-03	-3.60	5.1	2.9e-07	-0.60	0.20	0.55	FALSE
38	GTEx	Muscle Skeletal	APOPT1	0.14	0.21	enet	10	0.22	6.7e-21	3.87	-5.1	2.9e-07	0.58	1.00	0.00	FALSE