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chr16:52,772,129-54,235,440

Best TWAS P=3.86e-27 · Best GWAS P=3.68e-32 conditioned to 1.65e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	YFS	Blood	AKTIP	0.19	0.27	lasso	13	0.30	3.3e-99	11.8	10.8	3.9e-27	0.93	0.00	1.00	TRUE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RBL2	0.11	0.08	blup	44	0.06	1.5e-03	11.2	-10.8	4.0e-27	-0.91	0.01	0.78	FALSE
41	The Cancer Genome Atlas	Esophageal Carcinoma	RBL2	0.08	0.04	lasso	3	0.03	4.4e-02	11.8	10.1	3.5e-24	0.85	0.01	0.82	FALSE
26	GTEx	Muscle Skeletal	RBL2	0.11	0.00	lasso	5	0.00	2.9e-01	11.1	-9.8	1.7e-22	-0.86	0.01	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RBL2	0.22	0.24	enet	15	0.26	1.8e-31	7.6	-9.8	1.8e-22	-0.86	0.79	0.21	FALSE
8	GTEx	Artery Tibial	RBL2	0.16	0.17	enet	11	0.20	2.1e-15	7.6	-9.5	2.1e-21	-0.83	0.53	0.47	FALSE
17	GTEx	Colon Sigmoid	RBL2	0.38	0.37	lasso	12	0.29	8.4e-11	7.8	-8.9	5.6e-19	-0.79	0.58	0.42	FALSE
29	GTEx	Pancreas	RBL2	0.36	0.36	enet	26	0.36	5.9e-16	7.7	-8.9	6.0e-19	-0.78	0.85	0.15	FALSE
11	GTEx	Brain Cortex	RBL2	0.51	0.45	enet	12	0.46	3.5e-14	6.9	-8.9	7.4e-19	-0.80	0.29	0.71	FALSE
37	GTEx	Vagina	RBL2	0.41	0.37	enet	13	0.34	1.6e-08	8.3	-8.6	7.9e-18	-0.75	0.33	0.63	FALSE
20	GTEx	Esophagus Mucosa	RBL2	0.36	0.36	enet	37	0.37	2.9e-26	7.8	-8.6	1.1e-17	-0.78	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBL2	0.03	0.06	enet	5	0.05	8.2e-07	6.9	-8.5	1.3e-17	-0.78	0.83	0.16	FALSE
22	GTEx	Heart Atrial Appendage	RBL2	0.28	0.14	enet	25	0.23	8.6e-11	7.6	-8.4	4.7e-17	-0.76	0.11	0.89	FALSE
33	GTEx	Skin Sun Exposed Lower leg	RBL2	0.35	0.39	enet	25	0.37	2.9e-32	7.6	-8.4	4.8e-17	-0.72	1.00	0.00	FALSE
27	GTEx	Nerve Tibial	RBL2	0.46	0.52	enet	19	0.53	1.6e-43	7.6	-8.3	1.2e-16	-0.74	1.00	0.00	FALSE
25	GTEx	Lung	RBL2	0.29	0.37	enet	16	0.35	9.1e-28	7.8	-8.2	2.4e-16	-0.73	1.00	0.00	FALSE
9	GTEx	Brain Cerebellar Hemisphere	RBL2	0.55	0.55	enet	20	0.46	2.1e-13	7.8	-8.2	2.5e-16	-0.70	0.97	0.03	FALSE
18	GTEx	Colon Transverse	RBL2	0.59	0.44	enet	13	0.52	4.4e-28	7.8	-8.2	3.4e-16	-0.75	1.00	0.00	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	RBL2	0.35	0.33	enet	16	0.34	2.6e-19	7.6	-8.1	6.8e-16	-0.74	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RBL2	0.34	0.28	enet	18	0.30	1.0e-24	7.8	-8.0	9.6e-16	-0.74	1.00	0.00	FALSE
10	GTEx	Brain Cerebellum	RBL2	0.66	0.72	enet	16	0.70	5.7e-28	7.7	-8.0	1.1e-15	-0.71	1.00	0.00	FALSE
36	GTEx	Thyroid	RBL2	0.34	0.47	lasso	4	0.45	3.6e-38	7.8	-7.9	3.8e-15	-0.70	1.00	0.00	FALSE
30	GTEx	Pituitary	RBL2	0.36	0.39	lasso	6	0.40	4.5e-11	7.7	7.8	8.1e-15	0.68	0.73	0.25	FALSE
4	GTEx	Adipose Visceral Omentum	RBL2	0.30	0.27	lasso	2	0.27	4.3e-14	7.8	-7.8	8.3e-15	-0.69	1.00	0.00	FALSE
28	GTEx	Ovary	RBL2	0.41	0.26	enet	29	0.18	3.2e-05	7.7	-7.7	1.9e-14	-0.72	0.08	0.88	FALSE
6	GTEx	Artery Aorta	RBL2	0.27	0.21	enet	14	0.19	1.5e-10	7.6	-7.7	2.0e-14	-0.69	1.00	0.00	FALSE
31	GTEx	Prostate	RBL2	0.55	0.45	lasso	4	0.45	1.0e-12	7.6	-7.6	2.2e-14	-0.69	0.97	0.03	FALSE
38	NTR	Blood	RBL2	0.09	0.11	bslmm	419	0.11	1.1e-33	7.8	-7.6	3.6e-14	-0.68	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue (Male)	RBL2	0.40	0.29	lasso	2	0.25	1.4e-06	7.5	-7.5	5.2e-14	-0.68	0.47	0.23	FALSE
7	GTEx	Artery Coronary	RBL2	0.36	0.33	enet	14	0.27	1.4e-09	7.7	-7.5	6.5e-14	-0.68	0.98	0.02	FALSE
21	GTEx	Esophagus Muscularis	RBL2	0.36	0.38	enet	10	0.41	6.8e-27	7.7	-7.5	6.8e-14	-0.68	1.00	0.00	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RBL2	0.38	0.40	enet	17	0.38	1.1e-14	7.7	-7.5	9.2e-14	-0.69	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue	RBL2	0.36	0.35	lasso	3	0.36	3.0e-19	7.5	-7.4	1.2e-13	-0.68	1.00	0.00	FALSE
23	GTEx	Heart Left Ventricle	RBL2	0.12	0.11	enet	12	0.08	3.3e-05	7.6	-7.4	1.2e-13	-0.62	0.71	0.25	FALSE
35	GTEx	Stomach	RBL2	0.33	0.26	enet	20	0.26	8.7e-13	7.8	-7.4	1.5e-13	-0.62	1.00	0.00	FALSE
34	GTEx	Spleen	RBL2	0.59	0.47	enet	51	0.46	3.2e-13	7.7	-7.3	2.5e-13	-0.65	0.38	0.62	FALSE
40	YFS	Blood	RBL2	0.18	0.26	bslmm	381	0.27	6.9e-90	7.7	-7.2	5.3e-13	-0.63	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKTIP	0.04	0.03	blup	42	0.05	1.9e-06	7.6	-7.2	7.1e-13	-0.67	0.98	0.01	FALSE
5	GTEx	Adrenal Gland	RBL2	0.35	0.27	enet	22	0.25	2.3e-09	7.8	-7.2	7.3e-13	-0.67	0.94	0.06	FALSE
15	GTEx	Breast Mammary Tissue (Female)	RBL2	0.47	0.27	lasso	7	0.20	1.1e-06	6.9	-7.0	2.5e-12	-0.67	0.78	0.20	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AKTIP	0.12	0.09	enet	10	0.08	1.9e-10	7.7	-6.8	8.8e-12	-0.63	1.00	0.00	FALSE
16	GTEx	Cells Transformed fibroblasts	RBL2	0.13	0.05	enet	9	0.02	8.9e-03	7.6	-6.5	7.5e-11	-0.64	0.35	0.37	FALSE
24	GTEx	Liver	RBL2	0.38	0.22	enet	21	0.20	4.0e-06	7.1	-5.6	2.3e-08	-0.55	0.19	0.70	FALSE
45	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AKTIP	0.18	-0.01	enet	10	0.08	6.9e-04	-2.4	-5.5	2.8e-08	-0.48	0.01	0.29	FALSE
12	GTEx	Brain Frontal Cortex BA9	AKTIP	0.29	0.04	enet	27	0.07	6.3e-03	7.7	-5.5	4.6e-08	-0.37	0.13	0.09	FALSE