Best TWAS P=4.15e-16 · Best GWAS P=7.5e-33 conditioned to 1.75e-20
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DGKE | 0.16 | 0.15 | lasso | 12 | 0.16 | 1.6e-18 | 4.5 | -8.1 | 4.1e-16 | -0.83 | 0.33 | 0.67 | TRUE |
| 2 | GTEx | Artery Tibial | C17orf67 | 0.11 | 0.03 | lasso | 3 | 0.02 | 5.1e-03 | 4.3 | -6.7 | 2.6e-11 | -0.62 | 0.06 | 0.83 | FALSE |
| 3 | GTEx | Brain Cerebellum | RP11-670E13.2 | 0.40 | -0.01 | enet | 14 | 0.03 | 4.3e-02 | 11.1 | 5.5 | 5.2e-08 | 0.66 | 0.05 | 0.58 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | RP11-670E13.2 | 0.48 | 0.18 | lasso | 10 | 0.20 | 4.5e-07 | 4.3 | 7.3 | 3.1e-13 | 0.79 | 0.09 | 0.89 | FALSE |
| 5 | GTEx | Testis | RP11-670E13.2 | 0.22 | 0.02 | lasso | 8 | 0.04 | 8.3e-03 | 2.3 | 6.8 | 1.1e-11 | 0.58 | 0.03 | 0.69 | FALSE |
| 6 | METSIM | Adipose | DGKE | 0.08 | 0.03 | blup | 461 | 0.03 | 2.7e-05 | 4.3 | -5.5 | 4.1e-08 | -0.47 | 0.85 | 0.10 | FALSE |
| 7 | YFS | Blood | DGKE | 0.02 | 0.00 | blup | 444 | 0.00 | 4.3e-02 | 4.3 | -6.1 | 1.1e-09 | -0.54 | 0.15 | 0.73 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C17orf67 | 0.06 | 0.01 | blup | 57 | 0.02 | 1.2e-05 | -2.9 | -6.2 | 7.0e-10 | -0.52 | 0.11 | 0.40 | FALSE |