TWAS hub - DGKE

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1570	0.0290	1.9e-13	0.146	0.108	0.146	0.130	0.156	2.4e-17	5.1e-13	2.5e-17	1.5e-15	1.6e-18
2	GTEx	Cells EBV-transformed lymphocytes	0.3500	0.0760	3.6e-05	0.220	NA	0.243	NA	0.264	9.8e-08	NA	1.7e-08	NA	3.6e-09
3	METSIM	Adipose	0.0763	0.0250	2.5e-04	0.026	0.029	0.015	NA	0.028	8.3e-05	2.7e-05	2.1e-03	NA	3.5e-05
4	YFS	Blood	0.0240	0.0103	5.9e-03	-0.001	0.002	-0.001	0.001	-0.001	7.0e-01	4.3e-02	5.7e-01	1.6e-01	9.5e-01
5	TCGA	Thyroid Carcinoma	0.0640	0.0320	9.8e-04	-0.002	0.022	0.009	NA	0.005	6.6e-01	2.9e-03	3.7e-02	NA	9.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Comparative height size at age 10	6.0	33.1	59.0	-7.7	4.7	-5.4	-6.5	3.7
Relative age voice broke	5.9	9.0	10.0	3.1	-3.1	2.9	2.6	-3.2
Height	4.7	90.9	179.6	-13.4	7.6	-8.7	-10.3	6.0
Ever had stillbirth, spontaneous miscarriage or termination	4.5	4.8	6.7	-2.6	2.6	-2.2	-1.9	1.5
Schizophrenia vs Biploar Disorder	4.0	5.3	9.3	3.1	-3.0	1.9	2.1	-0.6
Health satisfaction	4.0	5.2	6.9	-2.4	2.4	-2.6	-2.6	1.1
Ever taken oral contraceptive pill	3.9	4.3	7.9	-2.2	2.8	-2.7	-0.7	0.9
Crohns Disease (2017)	3.8	8.4	19.9	3.2	-4.5	1.5	2.6	-1.8
Sitting height	3.8	26.8	50.6	-7.1	5.0	-4.3	-6.2	1.4
Irritable Bowel Disease (IBD)	3.4	8.2	17.8	3.2	-4.2	2.1	2.3	-1.8
Standing height	3.2	32.1	66.1	-8.1	4.3	-5.5	-6.1	3.0
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.7	16.2	-4.0	2.9	-2.5	-1.4	1.1
Medication: Ramipril	3.0	3.8	6.0	2.2	-2.0	1.8	1.1	-2.5
Neck or shoulder pain in last month	3.0	4.2	7.0	-2.5	1.9	-2.6	-0.8	2.0
Shortness of breath walking on level ground	2.9	3.5	8.9	-1.2	2.0	-3.0	-1.7	0.2
Noisy workplace	2.8	3.4	7.8	-2.1	1.7	-2.8	-1.3	0.6
Number of children fathered	2.8	3.2	6.2	-1.9	1.9	-2.5	-1.5	0.5
Hearing aid user	2.8	3.1	10.1	-1.2	0.9	-1.4	-1.2	-3.2
Had major operations	2.7	3.1	14.2	0.3	-0.2	-0.2	1.1	-3.8
Number of operations (self-reported)	2.5	3.7	7.7	2.1	-2.0	-0.2	1.6	-2.8
Arm fat-free mass (right)	2.4	12.5	22.3	-4.5	3.7	-4.7	-2.2	1.3
Leg fat-free mass (right)	2.3	12.1	19.7	-4.2	4.2	-4.4	-1.5	1.8
Ever had bowel cancer screening	2.3	2.7	5.1	-1.6	0.5	-2.3	-1.9	1.4
Leg predicted mass (right)	2.3	12.2	19.4	-4.2	4.2	-4.4	-1.5	1.8
Leg fat-free mass (left)	2.2	11.7	18.7	-4.1	4.2	-4.3	-1.4	2.0
Leg predicted mass (left)	2.2	11.7	18.3	-4.1	4.2	-4.3	-1.4	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	5.5	-2.0	2.3	-1.0	-1.8	0.8
Emphysema/chronic bronchitis	2.2	2.5	3.7	-1.3	1.5	-1.9	-1.0	1.9
Had menopause	2.1	2.6	6.1	-1.4	0.7	-0.9	-1.9	2.5
Birth weight of first child	2.1	3.8	7.8	1.7	-1.9	1.8	1.1	-2.8
Arm predicted mass (right)	2.1	10.6	19.2	-4.1	3.4	-4.4	-2.0	1.2
Age at last live birth	2.1	3.0	6.2	-2.5	2.1	-0.8	-1.4	1.5
Whole body water mass	2.1	12.2	21.0	-4.4	3.9	-4.6	-2.0	1.3
Basal metabolic rate	2.1	11.4	18.8	-4.2	3.9	-4.3	-1.9	1.4
Whole body fat-free mass	2.0	11.6	19.7	-4.3	3.8	-4.4	-1.9	1.2
Arm predicted mass (left)	2.0	10.2	18.3	-4.0	3.3	-4.3	-2.1	1.2
Average weekly spirits intake	1.9	2.4	5.4	-2.3	1.9	-0.5	-0.9	1.4
Average weekly champagne plus white wine intake	1.9	2.7	6.3	1.6	-2.5	1.1	0.9	-1.5
Arm fat-free mass (left)	1.9	9.9	18.2	-3.9	3.3	-4.3	-1.9	1.2
Financial difficulties in last 2 years	1.8	2.5	5.3	-1.6	2.3	-2.0	-0.4	0.1
Weight	1.8	8.7	12.9	-3.4	3.5	-3.6	-1.3	2.2
Trunk fat-free mass	1.8	10.2	18.5	-4.2	3.2	-4.3	-2.1	0.4
Trunk predicted mass	1.8	10.3	18.5	-4.2	3.2	-4.3	-2.1	0.5
Age at first live birth	1.8	3.1	5.1	-2.3	2.1	-0.7	-1.8	1.6
Ulcerative Colitis	1.7	2.5	5.7	1.9	-2.4	1.3	1.2	-0.0
Age when periods started (menarche)	1.7	4.2	5.5	2.1	-2.1	2.4	0.9	-2.3
Medication: Seretide 50 evohaler	1.7	2.0	4.4	-1.4	1.8	0.7	-2.1	0.1
Miserableness	1.7	3.0	6.3	-1.3	2.3	-2.5	-1.1	0.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.3	-1.5	1.2	-2.1	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.5	-1.9	1.7	-1.1	-1.5	0.4
Medication: Lansoprazole	1.6	1.8	4.1	-1.0	0.3	-1.5	-2.0	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.2	1.6	-1.7	0.2	1.8	-0.9
Commuting to job workplace: Car/motor vehicle	1.6	1.8	6.3	1.2	-1.0	0.6	2.5	0.1
Pain type(s) experienced in last month: Hip pain	1.6	2.0	6.2	-0.5	0.1	-1.8	0.3	2.5
Medication: Omeprazole	1.5	1.8	3.0	1.7	-1.5	0.6	1.5	-0.9
Medication: Lisinopril	1.5	1.9	2.8	-1.7	0.9	-0.8	-1.6	1.7
Alcohol drinker status: Previous	1.5	1.7	3.0	-1.3	1.7	-1.2	-1.4	0.7
Ulcerative Colitis (UC)	1.4	2.7	5.4	1.9	-2.3	1.6	1.0	-1.0
Primary Biliary Cirrhosis	1.4	2.0	4.4	-1.5	1.1	-1.1	-2.1	0.9
Trunk fat mass	1.4	6.1	8.6	-2.6	2.9	-2.5	-1.1	2.8
Alcohol usually taken with meals	1.4	2.2	4.2	1.4	-2.0	1.6	-0.3	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.6	3.0	1.6	-1.2	0.5	1.7	-0.9
Average weekly fortified wine intake	1.3	1.6	5.3	0.4	-0.5	2.3	1.3	-0.7
Maternal smoking around birth	1.3	1.9	3.5	-1.2	1.8	-1.9	0.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.6	3.6	-1.5	1.9	-1.0	-0.9	0.4
Osteoporosis (self-reported)	1.3	1.6	2.6	1.4	-1.6	1.4	1.2	-0.3
Wears glasses or contact lenses	1.3	1.5	3.3	-1.0	0.0	-1.8	-1.8	-0.0
Cholesterol lowering medication	1.3	1.9	2.4	1.5	-1.6	1.3	1.5	0.9
Stomach or abdominal pain in last month	1.2	1.5	2.6	1.4	-1.6	1.2	1.2	0.2
Worrier / anxious feelings	1.2	2.3	5.9	1.5	-1.4	1.2	0.5	-2.4
Falls in the last year	1.2	1.7	3.6	-1.8	1.9	-0.5	-0.8	0.8
Leg pain on walking	1.2	1.5	3.2	-1.2	1.8	-1.4	-0.1	1.0
Financial situation satisfaction	1.2	1.4	5.2	1.1	-0.3	0.1	0.8	-2.3
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.0	-1.6	0.9	-0.6	-2.0	0.7
Major Depression (MDD)	1.1	1.3	3.6	-1.1	1.2	-0.4	-1.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.9	-1.1	1.5	-1.7	-0.6	0.8
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	-0.8	1.6	-1.2	-1.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.7	1.3	-1.9	0.8	0.5	-0.5
Breast cancer (self-reported)	1.1	1.3	3.2	1.1	-1.1	0.2	0.8	-1.8
Commuting to job workplace: Cycle	1.1	1.3	4.0	-0.8	1.1	-0.4	-2.0	0.8
Basal cell carcinoma (self-reported)	1.1	1.3	2.2	-0.9	0.7	-1.5	1.2	1.3
Relative age of first facial hair	1.0	2.0	6.1	1.5	-0.9	0.7	0.6	-2.5
Ever had hysterectomy (womb removed)	1.0	1.1	2.0	1.4	-1.3	0.9	1.1	0.0
Vitamin and mineral supplements	1.0	1.4	4.4	-0.6	0.5	-1.1	0.9	2.1
Pulse wave Arterial Stiffness index	1.0	1.2	1.8	-1.3	0.7	-1.2	-1.4	0.5
Birth weight	1.0	2.2	6.0	1.0	-1.5	1.4	0.5	-2.5
Medication: Allopurinol	1.0	1.4	3.0	-1.2	1.3	0.3	-0.7	1.7
Whole body fat mass	1.0	4.3	6.6	-2.1	2.6	-2.2	-0.5	2.3
Illnesses of father: Heart disease	1.0	1.4	4.5	1.1	-1.1	0.5	2.1	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.5	0.9	-0.8	0.4	-1.3	-1.6
Medication: Gliclazide	1.0	1.1	2.4	-0.8	1.6	-0.7	-0.6	1.3
Heart attack/myocardial infarction (self-reported)	1.0	1.2	1.7	1.3	-1.0	1.3	0.9	-1.1
Ovarian Cancer	0.9	1.2	2.3	1.3	-1.3	0.2	0.5	-1.5
Prostate Cancer	0.9	1.3	1.9	1.0	-1.3	1.3	1.4	-0.6
Crohns Disease (2012)	0.9	1.4	4.0	1.1	-2.0	0.3	1.2	-0.6
HDL Cholesterol	0.9	1.5	6.3	0.4	-0.7	0.5	-0.5	-2.5
Multivitamins +/- minerals	0.9	1.1	3.5	0.8	-0.7	0.8	-0.5	-1.9
Heart attack	0.9	1.2	1.7	1.2	-0.9	1.3	0.9	-1.1
Hip circumference	0.9	3.8	5.7	-1.7	2.4	-2.3	-0.4	2.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.6	-1.1	0.9	-1.8	-0.5	2.1
Loud music exposure frequency	0.9	1.0	4.4	-0.3	0.0	-0.5	2.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.9	-1.7	1.4	-2.0	-0.4	0.4
Supplements: Vitamin C	0.9	1.1	2.3	-0.6	1.5	-1.4	-0.8	-0.5
Long-standing illness, disability or infirmity	0.9	1.4	2.0	-1.4	1.3	-1.4	-0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.6	1.4	-1.4	1.9	1.2	-0.6
Arm fat mass (left)	0.9	3.7	8.0	-1.6	2.8	-2.0	-0.3	2.0
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.0	-1.2	1.0	-1.7	-0.1	-0.0
Leg fat mass (left)	0.9	3.4	5.4	-1.6	2.3	-2.2	-0.2	2.0
Bipolar Disorder (2018)	0.8	1.2	2.1	-1.1	1.0	-1.5	-1.4	-0.2
Depression (Nagel 2018)	0.8	1.1	1.7	-0.9	1.1	-0.9	-1.3	1.1
Alzheimer’s Disease (including proxy)	0.8	1.1	2.2	1.5	-1.0	1.0	1.0	-0.8
Smoking Status	0.8	2.0	4.6	-1.2	2.1	-1.7	0.5	0.9
Trunk fat percentage	0.8	3.0	7.8	-1.4	2.0	-1.1	-0.4	2.8
Current tobacco smoking	0.8	1.3	3.3	-1.1	1.8	-1.2	-0.0	-0.6
Supplements: Glucosamine	0.8	1.0	2.0	-1.1	1.0	-0.2	-0.9	1.4
Chronic bronchitis/emphysema (father)	0.8	0.9	1.5	1.1	-1.2	1.2	-0.3	-0.5
Past tobacco smoking	0.8	1.5	3.4	0.4	-1.4	1.5	-0.0	-1.8
Diabetes (self-reported)	0.8	1.3	2.1	-0.9	1.2	-1.4	-1.5	0.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.5	0.5	-1.2	1.6	0.4	-0.4
Forced vital capacity (FVC), Best measure	0.8	3.0	7.2	-2.7	1.3	-0.8	-2.0	1.1
Exposure to tobacco smoke outside home	0.8	1.0	2.5	-0.8	1.6	-1.1	-0.4	0.8
Migraine (self-reported)	0.8	1.0	3.8	0.9	-0.2	-0.1	2.0	0.6
Leg fat mass (right)	0.8	3.0	4.4	-1.4	2.1	-2.0	-0.1	2.1
Family relationship satisfaction	0.8	1.0	2.2	-1.1	1.2	-1.5	0.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.5	1.1	-1.6	0.8	0.3	0.4
Illnesses of siblings: Diabetes	0.8	1.0	1.4	1.1	-1.2	0.4	1.1	-1.0
Asthma (self-reported)	0.8	1.5	3.1	1.8	-1.0	1.4	-0.0	-1.1
Commuting to job workplace: Public transport	0.8	0.9	1.8	-1.2	1.4	-0.3	-1.1	-0.1
Average weekly beer plus cider intake	0.8	1.2	2.4	-0.8	0.6	-0.8	-1.6	1.4
Age started oral contraceptive pill	0.8	1.0	3.1	0.1	-0.8	1.8	0.1	1.2
Schizophrenia (2018)	0.7	1.5	3.0	1.7	-1.6	-0.6	1.1	-0.8
Neuroticism (2016)	0.7	1.0	1.8	0.6	0.6	1.1	1.3	-1.1
Triglycerides	0.7	1.2	3.9	0.2	0.4	-0.7	2.0	1.1
Blood Platelet Count	0.7	7.9	15.8	2.9	-1.9	1.5	4.0	-3.1
Blood White Count	0.7	5.0	8.3	2.5	-1.2	2.0	2.2	-2.9
Hypothyroidism (self reported)	0.7	1.7	3.1	-1.5	1.6	-1.8	-0.8	-0.0
Lung FVC	0.7	3.4	8.8	1.6	-1.3	3.0	1.2	-1.6
Qualifications: CSEs or equivalent	0.7	0.9	2.6	1.1	-0.4	0.4	1.6	-0.7
Waist circumference	0.7	2.7	5.5	-0.9	1.8	-2.3	-0.1	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.0	-0.7	1.4	-1.3	-1.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.9	0.9	-1.4	2.0	-0.1	0.9
Allergy	0.7	1.6	3.0	-1.6	1.7	-1.2	-1.0	0.0
Asthma	0.7	1.3	3.0	1.7	-1.1	1.3	0.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	5.1	-2.2	1.2	-0.4	-1.0	1.7
Arm fat mass (right)	0.7	3.0	6.4	-1.4	2.5	-1.8	0.1	1.8
Exposure to tobacco smoke at home	0.7	0.8	2.6	-0.6	1.6	-0.6	-0.4	0.6
Peak expiratory flow (PEF)	0.7	1.6	2.7	1.1	-0.9	1.6	1.6	0.8
Medication for pain relief, constipation, heartburn	0.7	1.2	2.3	-1.1	0.4	-0.5	-1.5	1.4
Heart disease (mother)	0.7	0.9	4.2	0.3	-0.2	0.1	-0.4	2.1
Alcohol intake frequency.	0.7	1.6	4.1	-0.7	0.9	-1.2	-1.0	-2.0
Knee pain experienced in last month	0.7	1.0	3.8	-0.0	0.2	-0.5	1.0	1.9
Commuting to job workplace: Walk	0.7	0.7	1.4	0.9	-1.0	1.2	0.1	-0.5
Osteoarthritis (self-reported)	0.7	1.0	2.1	-1.4	0.9	-0.7	0.2	1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	-1.0	1.0	-0.8	-1.3	0.1
Smoking status: Current	0.7	1.2	3.2	-1.2	1.8	-1.1	-0.2	-0.2
Ever smoked	0.7	1.2	2.9	-0.3	1.3	-1.1	0.4	1.7
Myopia	0.7	1.0	1.8	-0.9	1.0	-0.3	-1.3	1.2
Alzheimer’s Disease (in father)	0.6	0.6	1.5	0.5	-0.5	1.2	0.8	0.8
Bipolar Disorder (2011)	0.6	0.6	2.0	-0.5	0.8	-1.4	-0.1	-0.1
LDL Cholesterol	0.6	0.9	1.6	1.1	-0.6	1.3	1.1	-0.5
Lupus	0.6	0.8	1.3	0.7	-0.4	1.0	1.1	-1.1
Rheumatoid Arthritis	0.6	0.8	1.6	-0.7	1.2	-0.5	1.0	0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.0	-0.7	0.2	-0.0	-1.7	0.1
Lung FEV1/FVC ratio	0.6	3.1	9.2	1.4	-0.4	0.6	3.0	1.9
Medication: Co-codamol	0.6	0.7	2.2	0.2	-1.0	-1.5	-0.5	-0.3
Townsend deprivation index at recruitment	0.6	0.9	2.3	0.9	-0.6	0.7	0.7	-1.5
Fed-up feelings	0.6	1.1	2.8	0.7	-0.2	-0.0	1.5	-1.7
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.4	1.3	-1.5	1.5	0.8	0.0
Medication: Atenolol	0.6	0.8	1.2	1.0	0.1	-0.8	-1.1	1.0
Number of incorrect matches in round	0.6	1.1	2.9	-0.3	-0.6	1.2	-0.7	1.7
Hair/balding pattern: Pattern 3	0.6	0.8	2.0	0.5	-0.4	1.3	1.4	-0.1
Illnesses of mother	0.6	0.7	1.9	-0.7	0.6	-0.7	0.7	-1.4
Headache pain in last month	0.6	1.0	1.9	-0.7	1.1	-1.4	0.5	1.1
Number of full sisters	0.6	0.7	2.6	-0.6	0.7	0.2	-1.6	0.5
Medication for cholesterol	0.6	0.8	1.6	-1.0	0.9	-1.2	-0.2	-0.9
Medication: Paracetamol	0.6	0.9	2.7	-0.7	0.6	-0.3	-1.6	-1.0
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.4	-0.2	-0.1	0.5	-1.5	-0.7
Verbal and Numeric Reasoning (VNR)	0.5	1.3	4.1	-1.3	0.4	-0.9	0.0	2.0
HbA1C	0.5	0.5	0.8	-0.7	0.8	-0.7	-0.4	0.9
Hearing difficulty/problems: Yes	0.5	0.8	2.1	-0.7	0.6	-1.4	-0.9	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.2	0.5	-0.9	1.1	-0.7	0.7
Impedance of leg (right)	0.5	2.3	4.5	0.1	-2.1	2.1	-1.6	0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.1	1.1	-0.9	-0.0	0.8	0.3
Father’s age at death	0.5	0.7	2.1	-0.5	-0.1	-0.0	-1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.0	0.8	-0.3	0.4	1.4	-0.6
Impedance of arm (left)	0.5	2.4	4.4	-0.8	-0.7	2.1	-1.6	1.9
Medication: Paracetamol	0.5	0.9	1.9	-0.8	0.7	-0.7	-1.4	-0.9
Gout (self-reported)	0.5	0.7	2.8	-0.2	0.2	0.7	-0.2	1.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-0.2	1.2	-0.0	-0.8	1.0
High blood pressure (siblings)	0.5	0.7	1.1	0.9	-1.0	1.0	0.7	-0.4
Pulse wave peak to peak time	0.5	0.6	1.1	0.8	-0.4	1.0	1.0	-0.3
Medication: Ibuprofen	0.5	0.6	1.3	1.1	-0.3	0.7	0.9	-0.8
Overall health rating	0.5	1.1	3.3	-0.4	0.9	-1.8	-0.3	1.0
Smoking status: Previous	0.5	0.7	2.8	0.3	0.3	-0.8	0.4	1.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.7	0.9	-1.3	0.2	-0.1	-0.8
Friendships satisfaction	0.5	0.6	1.6	-0.8	0.9	-1.3	-0.1	-0.2
Pack years of smoking	0.5	0.8	2.5	-1.0	0.5	-0.3	-1.6	-0.2
Impedance of whole body	0.5	2.3	3.8	-0.5	-1.5	2.0	-1.9	1.3
Alzheimer’s Disease (in mother)	0.4	0.4	1.6	0.6	-0.2	-0.3	0.1	-1.3
Body Mass Index (BMI) (2010)	0.4	0.6	1.4	-0.3	0.9	-1.2	0.4	0.7
Blood Red Count	0.4	4.3	9.3	2.2	-2.0	3.0	0.1	-1.8
Allergy or Eczema	0.4	1.1	1.5	1.0	-1.0	1.2	0.9	1.1
Sensitivity / hurt feelings	0.4	0.7	1.0	0.9	-1.0	1.0	0.7	-0.2
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	-0.3	0.7	-0.7	-1.2	0.5
Diabetes (mother)	0.4	0.5	0.9	0.9	-0.6	0.9	0.5	0.3
Pack years adult smoking proportion	0.4	0.6	2.0	-1.0	0.5	-0.2	-1.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.9	0.3	-0.9	1.7	-0.8	0.7
Medication: Levothyroxine sodium	0.4	0.7	1.5	-1.1	0.5	-1.2	-0.9	-0.2
High blood pressure (mother)	0.4	0.6	0.8	0.8	-0.9	0.9	-0.6	-0.6
Body mass index (BMI)	0.4	1.5	2.9	0.2	1.7	-1.3	1.5	0.9
Impedance of leg (left)	0.4	2.0	4.2	-0.1	-2.0	1.7	-1.7	0.1
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.2	0.3	-1.1	-0.5	1.2
Medication: Simvastatin	0.4	0.5	2.2	0.3	0.0	-1.5	-0.5	0.1
Neuroticism score	0.4	0.9	1.8	1.2	-0.5	0.3	0.8	-1.4
Impedance of arm (right)	0.4	1.8	3.2	-0.8	-0.7	1.8	-1.5	1.6
Length of working week for main job	0.4	0.4	0.9	0.3	0.9	-0.3	0.6	0.9
Hair/balding pattern: Pattern 4	0.4	1.0	2.3	-0.6	-0.7	-0.8	1.1	1.5
Glaucoma (self-reported)	0.4	0.5	0.9	0.6	-0.7	0.3	-0.8	-0.9
Body fat percentage	0.4	1.5	5.0	-0.5	1.4	-0.7	0.3	2.2
Comparative body size at age 10	0.4	1.2	3.7	1.3	-0.5	0.1	1.9	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.5	0.9	-1.0	-0.7	-0.4
Mood swings	0.4	0.7	1.2	0.6	0.8	-0.8	0.6	-1.1
Guilty feelings	0.4	0.6	1.5	1.2	-0.4	0.4	-0.0	-1.0
Medication: Bendroflumethiazide	0.4	0.6	1.0	1.0	-0.8	0.3	0.9	-0.6
Illnesses of father: High blood pressure	0.4	0.5	1.3	-0.1	0.8	-0.4	0.6	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.9	-1.4	0.9	-0.9	-1.1	0.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.5	-0.7	0.0	-0.3	1.5	1.6
Worry (Nagel 2018)	0.3	0.7	1.7	0.5	-1.1	0.3	-0.3	-1.3
Coronary Artery Disease (CAD)	0.3	0.4	0.9	1.0	-0.9	-0.0	-0.5	0.1
BMI	0.3	1.9	4.0	0.4	2.0	-1.6	1.4	0.9
Cardiovascular Disease	0.3	1.0	1.9	1.4	-1.3	0.8	0.8	-0.1
Neuroticism	0.3	0.8	1.7	0.9	-0.9	-0.4	0.6	-1.3
Chronotype (morning person)	0.3	0.8	1.6	-1.0	0.9	0.1	-0.4	-1.3
Number of treatments/medications taken	0.3	0.5	1.4	1.2	-0.7	-0.1	0.1	-0.8
Medication for hormone replacement therapy	0.3	0.3	1.3	-0.4	-0.3	-0.0	-0.5	1.1
Hand grip strength (right)	0.3	0.8	1.4	-0.3	-0.3	1.2	1.0	-1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.5	-0.1	-0.6	0.8	-0.4
High blood pressure	0.3	0.8	1.3	1.2	-1.0	0.5	1.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-0.0	0.3	-1.0	0.9	0.2
Qualifications: None of the above	0.3	0.6	2.2	-0.1	0.3	0.6	-1.5	-0.7
Mouth/teeth dental problems	0.3	0.4	1.8	0.0	-0.1	-0.3	-1.3	0.1
Pain all over the body in last month	0.3	0.3	0.8	-0.3	0.9	-0.2	-0.8	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.9	0.0	-0.1	1.0	0.1	-0.8
Arm fat percentage (right)	0.3	1.1	2.6	0.4	1.3	-0.2	1.1	1.6
Time employed in main current job	0.3	0.4	0.8	0.7	-0.6	0.9	-0.3	0.5
Alcohol intake versus 10 years previously	0.3	0.5	1.4	-0.6	0.9	-1.2	-0.0	-0.3
Happiness	0.3	0.3	1.5	0.2	-0.1	0.2	0.3	-1.2
Medication: Cholesterol lowering	0.3	0.4	0.9	-0.1	0.5	-0.9	-1.0	-0.4
Breastfed as a baby	0.3	0.4	0.9	0.4	-0.5	0.6	0.7	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.4	0.7	-0.5	0.6	0.6	0.0
Qualifications: College or University degree	0.3	0.9	4.0	-0.4	-0.3	-0.1	-0.1	2.0
Angina (self-reported)	0.3	0.3	1.2	0.3	0.4	1.1	-0.5	-0.2
Mean time to correctly identify matches	0.3	0.5	1.1	-1.1	0.7	-0.4	-1.0	0.2
Arm fat percentage (left)	0.3	1.4	3.3	0.0	1.7	-0.4	0.8	1.8
Average weekly red wine intake	0.3	0.4	0.8	-0.3	-0.9	0.2	-0.6	0.9
Diabetes diagnosed by doctor	0.3	0.5	1.1	-0.3	0.5	-1.0	-1.0	0.5
Eye problems/disorders: Cataract	0.3	0.4	0.8	-0.4	0.7	0.2	-0.6	0.9
Back pain experienced in last month	0.3	0.4	0.9	-0.3	0.8	-0.3	-1.0	-0.4
Medication: Blood pressure	0.3	0.5	1.1	1.0	-0.6	1.0	-0.3	0.5
Irritability	0.3	0.5	0.8	0.1	0.9	-0.8	0.8	0.5
Ever depressed for a whole week	0.3	0.4	0.8	-0.4	0.3	-0.6	-0.8	-0.9
Unable to work because of sickness or disability	0.3	0.3	1.0	0.4	-0.4	-0.7	0.0	-1.0
Supplements: Calcium	0.3	0.4	1.4	-0.4	0.3	-1.2	-0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	-1.0	0.4	-0.4	-0.8	0.3
Bipolar Disorder or Schizophrenia	0.2	0.6	1.6	0.7	-0.6	-1.3	0.1	-0.6
Depressed Affect (Nagel 2018)	0.2	0.5	1.4	0.6	0.1	-1.2	0.3	-0.8
Reaction Time	0.2	0.4	0.9	-0.9	0.5	-0.8	-0.6	0.1
Age at First Birth	0.2	0.3	1.0	-0.1	-0.2	0.6	-0.4	1.0
Mean Putamen Volume	0.2	0.2	0.6	-0.6	0.3	-0.8	-0.1	0.2
Fasting Glucose	0.2	0.3	1.0	0.2	-0.2	1.0	-0.2	-0.3
Schizophrenia (2014)	0.2	0.4	2.0	0.1	-0.1	-1.4	0.0	0.4
Blood Eosinophil Count	0.2	1.7	4.0	2.0	-0.8	1.8	0.5	-0.6
Heel T-Score	0.2	1.6	4.2	1.3	-1.4	2.0	-0.2	-0.3
Systolic Blood Pressure	0.2	0.8	2.2	1.0	-0.7	1.5	-0.2	-0.5
Respiratory disease	0.2	0.4	0.9	1.0	-0.3	0.7	0.3	-0.4
Hair Pigment	0.2	4.5	10.8	2.1	-1.7	3.3	1.8	-1.0
Hand grip strength (left)	0.2	0.6	1.8	-1.3	1.0	-0.6	0.0	0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	-0.8	0.8	-0.2	0.1	-0.2
Systolic blood pressure, automated reading	0.2	0.6	2.0	-0.2	0.7	0.2	-0.5	1.4
Angina	0.2	0.2	0.5	0.1	0.6	0.7	-0.5	-0.1
Supplements: Zinc	0.2	0.3	0.8	-0.1	0.1	0.9	-0.7	0.2
Medication: Metformin	0.2	0.3	0.7	-0.3	0.1	-0.8	-0.7	0.1
Diabetes (father)	0.2	0.2	0.4	-0.1	0.0	-0.7	0.7	-0.5
Severe depression (siblings)	0.2	0.2	0.5	0.4	0.0	0.7	0.6	0.0
Taking other prescription medications	0.2	0.3	0.6	0.3	-0.6	0.8	0.5	0.4
Had other major operations	0.2	0.2	0.4	0.5	-0.5	0.6	-0.1	0.2
Forced vital capacity (FVC)	0.2	0.6	2.2	-1.5	0.0	-0.6	-0.8	0.1
Fluid intelligence score	0.2	0.4	1.4	-0.5	-0.0	-0.2	0.6	1.2
Number of live births	0.2	0.2	0.6	-0.3	0.8	-0.1	-0.5	0.5
Pulse rate	0.2	0.3	0.7	-0.4	-0.1	-0.8	-0.6	-0.7
Lung cancer (father)	0.2	0.2	0.6	0.4	0.0	-0.3	0.1	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.5	1.0	-0.1	-0.7	0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	0.1	-0.1	0.1	1.0	-0.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.8	0.3	-0.5	-0.6	-0.1
Medication: Amlodipine	0.2	0.2	0.8	0.2	0.4	0.9	-0.3	0.4
Leg fat percentage (right)	0.2	0.7	2.3	0.7	0.3	-0.0	0.8	1.5
Number of full brothers	0.2	0.2	0.9	0.2	0.1	0.2	-0.2	-1.0
Medication: Blood pressure	0.2	0.3	0.9	1.0	-0.6	-0.3	0.4	-0.2
Pulse rate, automated reading	0.2	0.8	1.1	0.4	-1.0	1.0	1.0	-0.9
Chest pain or discomfort	0.2	0.4	0.6	0.4	0.6	0.6	-0.7	-0.6
Hypertension (Self-reported)	0.2	0.6	1.0	0.9	-1.0	0.2	1.0	-0.2
Qualifications: nursing, teaching	0.2	0.3	0.4	-0.5	0.3	-0.4	0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.0	-0.9	-0.2	-1.0	0.3	0.2
Mineral and other dietary supplements	0.2	0.3	1.3	0.4	-0.2	0.1	1.1	0.2
Medication: Aspirin	0.2	0.3	0.6	0.2	0.4	0.8	0.3	-0.6
High cholesterol (Self-reported)	0.2	0.3	0.5	0.6	-0.6	-0.5	-0.2	-0.7
Alcohol drinker status: Never	0.2	0.2	0.6	-0.2	-0.6	0.8	-0.3	-0.4
Leg fat percentage (left)	0.2	0.6	1.8	0.6	0.5	-0.3	0.7	1.4
Heart disease (siblings)	0.2	0.2	0.6	-0.5	0.8	0.2	-0.3	0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.7	-0.2	-0.6	0.0	-0.5
Waist Hip Ratio (WHR)	0.1	0.4	0.8	0.9	-0.8	-0.4	-0.0	0.7
Tanning	0.1	0.6	1.6	0.5	-0.6	1.3	0.8	-0.5
Nervous feelings	0.1	0.3	0.9	0.3	-0.6	0.1	0.0	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.0	0.6	-0.3	0.5	-0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.0	-0.8	-0.2	-0.2	0.1	1.0
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.2	0.4	0.7	0.0	0.7
Prospective memory result	0.1	0.2	0.7	-0.1	0.2	-0.8	-0.3	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.4	0.4	-0.1	-0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	1.0	-0.3	0.2	1.0	0.2	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.6	-0.3	0.4	-0.0	-0.3
Worry too long after embarrassment	0.1	0.1	0.3	0.2	-0.1	0.5	0.4	0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	0.6	-0.0	0.4	-0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.7	0.1	0.2	0.1	0.3	0.8
Suffer from ‘nerves’	0.1	0.1	0.4	0.0	-0.2	0.3	-0.2	-0.7
Medication: Aspirin	0.1	0.2	0.5	-0.2	0.7	0.6	-0.1	-0.1
Loneliness, isolation	0.1	0.1	0.3	0.2	-0.1	-0.6	0.4	0.2
Mother’s age at death	0.1	0.1	0.4	-0.0	-0.5	0.6	-0.1	-0.0
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	-0.3	0.1	-0.0	-0.6	-0.6
Medication: Atorvastatin	0.1	0.1	0.3	-0.1	0.5	-0.1	-0.3	0.2
Risk taking	0.1	0.2	0.6	0.3	0.1	-0.8	0.4	-0.3
Fractured/broken bones in last 5 years	0.1	0.2	0.3	0.2	-0.5	0.5	-0.4	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.8	0.2	-0.3	0.6	0.9	0.7
Pain experienced in last month	0.1	0.1	0.3	0.2	-0.3	0.6	0.0	-0.3
Breast Cancer	0.0	0.1	0.2	-0.2	0.5	0.1	0.3	0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.1	0.5	-0.3	-0.3	-0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.2	-0.3
Illnesses of siblings	0.0	0.1	0.1	-0.2	0.3	-0.3	-0.2	0.0
Depression (self-reported)	0.0	0.0	0.2	-0.0	0.1	-0.4	-0.0	0.1
Tense / ‘highly strung’	0.0	0.1	0.2	-0.1	-0.1	-0.5	-0.3	-0.1
Pulse wave reflection index	0.0	0.1	0.1	0.3	-0.3	0.1	0.3	-0.1
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.2	-0.1
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	0.1	0.2	-0.2	0.3	-0.3

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