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chr18:12,090,696-13,822,256

Best TWAS P=8.45e-14 · Best GWAS P=2.09e-13 conditioned to 0.291

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	GTEx	Cells Transformed fibroblasts	CEP192	0.32	0.32	enet	39	0.39	2.7e-31	7.1	7.5	8.5e-14	0.93	0.02	0.98	TRUE
64	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CEP192	0.11	0.16	lasso	3	0.16	7.6e-08	7.3	7.4	1.7e-13	0.99	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CEP192	0.07	0.09	lasso	2	0.09	9.4e-08	7.3	7.3	2.1e-13	1.00	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	CEP192	0.06	0.05	blup	84	0.04	1.5e-03	6.8	7.3	2.7e-13	0.93	0.03	0.91	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	CEP192	0.52	0.34	lasso	5	0.36	1.6e-12	6.8	7.2	4.2e-13	0.90	0.03	0.97	FALSE
21	GTEx	Breast Mammary Tissue (Male)	CEP192	0.58	0.26	lasso	11	0.30	1.3e-07	7.0	7.1	1.0e-12	0.95	0.02	0.98	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CEP192	0.12	0.06	blup	84	0.08	2.0e-04	6.3	7.1	1.0e-12	0.95	0.02	0.97	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEP192	0.33	0.49	lasso	5	0.49	1.0e-57	7.1	7.1	1.2e-12	0.98	0.01	0.99	FALSE
39	GTEx	Ovary	CEP192	0.43	0.42	enet	25	0.43	6.5e-12	6.8	7.1	1.3e-12	0.97	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	CEP192	0.06	0.13	enet	9	0.13	3.4e-26	7.0	7.1	1.4e-12	0.97	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CEP192	0.13	0.13	lasso	6	0.14	1.1e-16	7.1	7.0	2.0e-12	0.97	0.03	0.97	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	CEP192	0.38	0.39	lasso	4	0.39	4.7e-15	6.8	7.0	2.0e-12	0.97	0.02	0.98	FALSE
47	GTEx	Thyroid	CEP192	0.37	0.48	lasso	7	0.52	3.2e-46	7.0	7.0	2.0e-12	0.97	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	CEP192	0.36	0.53	enet	19	0.54	2.6e-61	7.1	7.0	2.0e-12	0.98	0.01	0.99	FALSE
20	GTEx	Breast Mammary Tissue	CEP192	0.38	0.40	lasso	4	0.42	4.7e-23	6.8	7.0	2.2e-12	0.96	0.02	0.98	FALSE
48	GTEx	Uterus	CEP192	0.52	0.43	lasso	6	0.41	1.7e-09	6.8	7.0	2.2e-12	0.96	0.02	0.98	FALSE
6	GTEx	Artery Coronary	CEP192	0.32	0.35	lasso	5	0.33	8.2e-12	7.1	7.0	2.5e-12	0.97	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CEP192	0.16	0.20	lasso	4	0.19	1.6e-09	7.1	7.0	2.6e-12	0.98	0.02	0.98	FALSE
46	GTEx	Stomach	CEP192	0.37	0.44	lasso	5	0.43	1.5e-22	6.8	7.0	3.1e-12	0.96	0.05	0.95	FALSE
38	GTEx	Nerve Tibial	CEP192	0.44	0.52	lasso	12	0.55	3.1e-46	6.9	7.0	3.5e-12	0.97	0.02	0.98	FALSE
45	GTEx	Spleen	CEP192	0.54	0.52	lasso	5	0.49	2.8e-14	6.8	6.9	4.0e-12	0.97	0.03	0.97	FALSE
8	GTEx	Brain Caudate basal ganglia	CEP192	0.48	0.36	enet	19	0.36	4.2e-11	7.1	6.9	4.2e-12	0.96	0.02	0.98	FALSE
7	GTEx	Artery Tibial	CEP192	0.40	0.50	enet	29	0.54	7.3e-50	7.0	6.9	4.3e-12	0.97	0.03	0.97	FALSE
5	GTEx	Artery Aorta	CEP192	0.43	0.50	lasso	11	0.55	2.5e-35	7.0	6.9	4.7e-12	0.97	0.03	0.97	FALSE
31	GTEx	Esophagus Muscularis	CEP192	0.39	0.46	lasso	9	0.52	2.1e-36	7.1	6.9	5.3e-12	0.97	0.02	0.98	FALSE
44	GTEx	Skin Sun Exposed Lower leg	CEP192	0.34	0.36	lasso	3	0.38	3.5e-33	6.8	6.9	5.4e-12	0.97	0.07	0.93	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEP192	0.21	0.31	lasso	4	0.31	1.0e-35	7.0	6.9	5.7e-12	0.97	0.03	0.97	FALSE
50	GTEx	Whole Blood	CEP192	0.17	0.16	enet	15	0.17	3.7e-15	6.8	6.9	6.4e-12	0.97	0.03	0.97	FALSE
36	GTEx	Lung	CEP192	0.32	0.29	lasso	7	0.34	3.8e-27	6.8	6.9	7.0e-12	0.96	0.03	0.97	FALSE
30	GTEx	Esophagus Mucosa	CEP192	0.39	0.51	enet	29	0.52	7.4e-40	7.0	6.9	7.1e-12	0.97	0.02	0.98	FALSE
13	GTEx	Brain Frontal Cortex BA9	CEP192	0.27	0.19	lasso	11	0.18	1.3e-05	6.8	6.8	7.6e-12	0.93	0.02	0.96	FALSE
49	GTEx	Vagina	CEP192	0.51	0.31	lasso	4	0.37	2.3e-09	6.8	6.8	7.9e-12	0.94	0.02	0.98	FALSE
33	GTEx	Heart Left Ventricle	CEP192	0.24	0.06	lasso	4	0.09	1.4e-05	6.8	6.8	8.1e-12	0.91	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	CEP192	0.38	0.44	enet	24	0.48	1.3e-44	6.8	6.8	8.6e-12	0.97	0.05	0.95	FALSE
42	GTEx	Prostate	CEP192	0.57	0.59	enet	23	0.66	1.8e-21	7.0	6.8	8.9e-12	0.96	0.02	0.98	FALSE
4	GTEx	Adrenal Gland	CEP192	0.44	0.56	lasso	2	0.56	9.6e-24	6.8	6.8	9.5e-12	0.96	0.06	0.94	FALSE
11	GTEx	Brain Cortex	CEP192	0.40	0.26	lasso	6	0.26	9.9e-08	7.1	6.8	1.1e-11	0.93	0.02	0.97	FALSE
22	GTEx	Breast Mammary Tissue (Female)	CEP192	0.34	0.23	lasso	11	0.26	2.4e-08	7.0	6.8	1.1e-11	0.94	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CEP192	0.30	0.33	lasso	2	0.33	1.8e-19	6.9	6.8	1.1e-11	0.95	0.04	0.96	FALSE
66	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CEP192	0.09	0.07	blup	84	0.09	2.1e-06	6.6	6.8	1.1e-11	0.92	0.04	0.96	FALSE
51	METSIM	Adipose	CEP192	0.19	0.32	lasso	5	0.32	1.0e-48	6.9	6.8	1.3e-11	0.96	0.05	0.95	FALSE
28	GTEx	Colon Transverse	CEP192	0.45	0.54	lasso	8	0.57	1.2e-32	6.8	6.8	1.4e-11	0.96	0.04	0.96	FALSE
32	GTEx	Heart Atrial Appendage	CEP192	0.29	0.28	lasso	5	0.26	4.3e-12	6.8	6.8	1.4e-11	0.95	0.02	0.98	FALSE
15	GTEx	Brain Hypothalamus	SEH1L	0.26	0.21	lasso	2	0.13	6.6e-04	6.6	6.7	1.5e-11	0.92	0.04	0.83	FALSE
19	GTEx	Brain Putamen basal ganglia	CEP192	0.50	0.39	lasso	5	0.36	2.4e-09	7.1	6.7	1.6e-11	0.95	0.02	0.98	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	CEP192	0.34	0.35	enet	20	0.40	1.6e-23	7.1	6.7	2.0e-11	0.96	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEH1L	0.05	0.00	blup	60	0.01	1.0e-02	6.8	6.7	2.5e-11	0.74	0.01	0.59	FALSE
37	GTEx	Muscle Skeletal	CEP192	0.10	0.07	lasso	3	0.07	3.1e-07	6.8	6.7	2.8e-11	0.95	0.02	0.98	FALSE
70	The Cancer Genome Atlas	Soft Tissue Sarcoma	CEP192	0.10	0.07	blup	84	0.08	1.2e-05	6.8	6.6	3.7e-11	0.96	0.03	0.97	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	CEP192	0.38	0.28	lasso	9	0.28	4.8e-08	7.1	6.6	5.2e-11	0.93	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	CEP192	0.27	0.38	blup	84	0.38	1.5e-45	6.9	6.5	6.3e-11	0.95	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Stomach Adenocarcinoma	CEP192	0.07	0.04	blup	84	0.07	1.7e-05	6.3	6.5	6.4e-11	0.97	0.02	0.98	FALSE
9	GTEx	Brain Cerebellar Hemisphere	CEP192	0.44	0.20	enet	22	0.26	2.2e-07	6.8	6.5	6.5e-11	0.93	0.02	0.98	FALSE
16	GTEx	Brain Hypothalamus	CEP192	0.35	0.33	enet	29	0.33	1.8e-08	7.1	6.5	6.5e-11	0.94	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	CEP192	0.09	0.14	blup	85	0.14	8.4e-16	7.1	6.5	6.5e-11	0.94	0.03	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	CEP192	0.38	0.35	lasso	4	0.43	3.0e-24	7.1	6.5	6.9e-11	0.95	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	CEP192	0.24	0.13	blup	84	0.13	7.9e-05	7.0	6.5	1.0e-10	0.88	0.02	0.97	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	SEH1L	0.18	0.13	lasso	4	0.08	1.3e-03	6.8	6.4	1.2e-10	0.93	0.04	0.77	FALSE
40	GTEx	Pancreas	CEP192	0.44	0.37	lasso	8	0.44	3.1e-20	6.8	6.4	1.5e-10	0.94	0.04	0.96	FALSE
10	GTEx	Brain Cerebellum	CEP192	0.52	0.44	enet	31	0.52	5.6e-18	7.1	6.4	1.8e-10	0.92	0.02	0.98	FALSE
14	GTEx	Brain Hippocampus	CEP192	0.43	0.35	lasso	9	0.44	9.8e-12	7.1	6.4	2.0e-10	0.93	0.02	0.98	FALSE
27	GTEx	Colon Sigmoid	CEP192	0.33	0.32	enet	23	0.32	3.6e-12	7.0	6.3	2.2e-10	0.96	0.02	0.98	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	PTPN2	0.32	0.02	lasso	10	0.05	2.2e-02	-3.3	-6.3	2.4e-10	-0.80	0.04	0.62	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	CEP192	0.30	0.42	enet	46	0.45	4.1e-64	7.3	6.3	3.0e-10	0.94	0.01	0.99	FALSE
41	GTEx	Pituitary	CEP192	0.51	0.24	enet	29	0.39	1.0e-10	6.8	6.3	3.1e-10	0.86	0.03	0.97	FALSE
52	NTR	Blood	CEP192	0.02	0.01	lasso	7	0.02	1.1e-06	6.9	6.3	3.3e-10	0.82	0.04	0.96	FALSE
34	GTEx	Liver	CEP192	0.41	0.29	lasso	6	0.41	1.6e-12	7.0	6.3	3.6e-10	0.92	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEH1L	0.03	0.01	blup	60	0.01	4.0e-02	-4.4	6.2	7.4e-10	0.70	0.02	0.32	FALSE
12	GTEx	Brain Frontal Cortex BA9	SEH1L	0.29	-0.01	lasso	4	0.00	3.0e-01	6.5	6.1	1.1e-09	0.75	0.04	0.27	FALSE
68	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CEP192	0.49	0.07	enet	29	0.05	3.2e-03	7.1	6.1	1.3e-09	0.73	0.01	0.90	FALSE
35	GTEx	Lung	SEH1L	0.13	0.09	lasso	9	0.09	2.9e-07	6.9	6.0	1.6e-09	0.92	0.04	0.96	FALSE
71	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CEP192	0.16	0.15	enet	6	0.14	1.8e-04	6.6	5.4	5.5e-08	0.90	0.03	0.90	FALSE
25	GTEx	Cells Transformed fibroblasts	SEH1L	0.10	0.03	enet	18	0.04	7.8e-04	7.0	5.3	1.2e-07	0.63	0.04	0.94	FALSE