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chr18:19,692,435-21,863,589

Best TWAS P=2.33e-31 · Best GWAS P=6.94e-129 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	CommonMind	Brain Pre-frontal Cortex	RIOK3	0.02	0.01	bslmm	348	0.00	1.8e-01	-8.4	-11.6	2.3e-31	0.44	0.14	0.06	TRUE
24	GTEx	Nerve Tibial	TMEM241	0.16	0.04	enet	10	0.07	1.8e-05	-8.5	-11.1	2.2e-28	0.48	0.70	0.03	TRUE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf45	0.04	0.02	lasso	3	0.03	2.7e-04	6.0	-8.2	2.9e-16	0.34	0.70	0.02	TRUE
10	GTEx	Brain Cerebellar Hemisphere	RBBP8	0.22	0.16	enet	20	0.13	3.0e-04	-7.7	7.5	5.4e-14	-0.32	0.17	0.10	TRUE
34	ROSMAP	Brain Pre-frontal Cortex	CABLES1	0.11	0.05	enet	30	0.07	4.1e-09	-8.6	7.3	2.7e-13	-0.27	0.98	0.01	TRUE
20	GTEx	Esophagus Mucosa	NPC1	0.09	0.04	lasso	3	0.05	1.5e-04	-5.7	-7.0	2.9e-12	0.30	0.57	0.02	TRUE
2	CommonMind	Brain Pre-frontal Cortex	RBBP8	0.07	0.00	blup	352	0.02	5.9e-04	1.8	6.9	6.4e-12	-0.28	0.07	0.05	TRUE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	CABLES1	0.10	0.00	enet	14	0.01	2.0e-02	4.3	-6.5	1.1e-10	0.15	0.01	0.03	TRUE
9	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	-5.9	-5.7	1.1e-08	0.22	0.44	0.03	TRUE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPC1	0.05	0.02	blup	65	0.03	9.9e-04	-6.0	-5.3	1.3e-07	0.25	0.06	0.42	TRUE
35	YFS	Blood	RIOK3	0.04	0.02	lasso	5	0.02	1.5e-07	2.5	-5.2	2.3e-07	0.12	1.00	0.00	TRUE
31	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	-5.8	-11.1	2.2e-28	0.43	0.14	0.56	FALSE
32	GTEx	Vagina	NPC1	0.27	0.09	lasso	7	0.14	4.9e-04	-7.4	-8.4	3.9e-17	0.37	0.22	0.12	FALSE
33	METSIM	Adipose	C18orf8	0.08	0.02	enet	23	0.04	1.0e-06	4.9	-8.2	3.3e-16	0.26	0.80	0.01	FALSE
7	GTEx	Adipose Visceral Omentum	C18orf8	0.18	0.11	enet	10	0.04	4.5e-03	-6.2	-7.8	8.2e-15	0.30	0.85	0.01	FALSE
4	GTEx	Adipose Subcutaneous	TMEM241	0.07	0.00	enet	12	0.01	4.1e-02	-7.2	-7.3	1.9e-13	0.33	0.31	0.14	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	CABLES1	0.06	0.02	enet	12	0.04	6.8e-05	4.3	-6.9	4.7e-12	0.26	0.07	0.03	FALSE
12	GTEx	Brain Cerebellum	RBBP8	0.35	0.23	lasso	4	0.19	2.4e-06	-6.3	6.5	8.1e-11	-0.22	0.45	0.09	FALSE
30	GTEx	Testis	RBBP8	0.20	0.12	lasso	3	0.08	2.2e-04	-6.3	-6.4	1.7e-10	0.22	0.76	0.01	FALSE
13	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	-5.8	-6.3	3.0e-10	0.26	0.82	0.04	FALSE
22	GTEx	Esophagus Muscularis	NPC1	0.11	0.07	enet	4	0.09	7.3e-06	-6.2	-6.3	3.8e-10	0.25	0.76	0.01	FALSE
5	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	-5.8	-6.0	1.5e-09	0.23	1.00	0.00	FALSE
11	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	-5.8	-6.0	1.9e-09	0.24	0.96	0.00	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPC1	0.03	0.04	lasso	2	0.05	4.2e-06	-6.0	-6.0	1.9e-09	0.27	0.45	0.49	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	-5.8	-5.9	3.5e-09	0.23	0.99	0.00	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	4.8	-5.9	3.8e-09	0.20	0.98	0.02	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	C18orf8	0.21	0.27	enet	6	0.23	6.9e-13	-5.7	-5.8	5.1e-09	0.24	1.00	0.00	FALSE
28	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	-5.9	-5.8	5.1e-09	0.24	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	-5.8	-5.8	5.5e-09	0.22	1.00	0.00	FALSE
15	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	-5.8	-5.8	7.2e-09	0.23	0.48	0.03	FALSE
14	GTEx	Brain Cortex	TMEM241	0.37	0.12	enet	19	0.22	1.3e-06	1.9	-5.6	2.0e-08	0.26	0.67	0.04	FALSE
19	GTEx	Breast Mammary Tissue (Female)	NPC1	0.43	0.24	lasso	3	0.27	1.1e-08	-5.1	-5.6	2.0e-08	0.26	0.98	0.00	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	TMEM241	0.17	0.02	lasso	6	-0.01	5.6e-01	-5.8	-5.6	2.1e-08	0.24	0.10	0.06	FALSE
8	GTEx	Adipose Visceral Omentum	NPC1	0.20	0.19	lasso	3	0.17	2.9e-09	-5.7	-5.5	3.8e-08	0.24	1.00	0.00	FALSE
23	GTEx	Heart Left Ventricle	NPC1	0.19	0.15	enet	12	0.17	1.6e-09	-5.6	-5.5	4.2e-08	0.26	1.00	0.00	FALSE
29	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	-5.7	-5.4	5.6e-08	0.23	1.00	0.00	FALSE
21	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	4.8	-5.4	6.0e-08	0.17	0.96	0.00	FALSE
18	GTEx	Breast Mammary Tissue	NPC1	0.27	0.13	enet	27	0.19	5.0e-10	-5.7	-5.4	7.0e-08	0.22	1.00	0.00	FALSE
25	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	4.8	-5.4	7.6e-08	0.21	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Soft Tissue Sarcoma	C18orf45	0.08	0.06	blup	114	0.06	1.7e-04	-9.6	-5.3	8.8e-08	0.21	0.60	0.02	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	4.8	-5.3	1.3e-07	0.19	0.10	0.23	FALSE
6	GTEx	Adipose Subcutaneous	NPC1	0.27	0.27	enet	12	0.30	2.4e-25	-5.7	-5.2	1.6e-07	0.25	1.00	0.00	FALSE
16	GTEx	Brain Frontal Cortex BA9	C18orf8	0.42	0.30	enet	12	0.08	3.4e-03	-5.6	-5.2	2.2e-07	0.22	0.90	0.01	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPC1	0.06	0.01	enet	6	0.05	2.2e-04	-6.3	-5.2	2.4e-07	0.29	0.03	0.72	FALSE