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chr17:78,392,234-81,051,007

Best TWAS P=5.68e-15 · Best GWAS P=2.38e-14 conditioned to 0.839

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRC45	0.02	0.03	blup	36	0.02	1.5e-03	-7.5	7.8	5.7e-15	0.09	0.00	0.93	TRUE
20	GTEx	Brain Cerebellum	RP11-1055B8.4	0.25	0.27	lasso	2	0.27	1.3e-08	7.5	-7.5	6.4e-14	-0.94	0.00	1.00	TRUE
55	NTR	Blood	ACTG1	0.04	0.00	blup	260	0.02	4.2e-06	-3.5	5.7	1.4e-08	-0.04	0.06	0.05	TRUE
8	GTEx	Adipose Visceral Omentum	FN3KRP	0.52	0.40	enet	26	0.47	3.5e-27	4.5	-5.5	3.1e-08	-0.08	0.79	0.20	TRUE
56	YFS	Blood	AATK	0.06	0.04	lasso	1	0.03	8.6e-11	-5.4	5.5	5.1e-08	-0.05	0.99	0.01	TRUE
1	CommonMind	Brain Pre-frontal Cortex	LRRC45	0.09	0.10	enet	7	0.10	1.2e-11	-7.5	7.7	1.4e-14	0.10	0.00	1.00	FALSE
23	GTEx	Cells Transformed fibroblasts	LRRC45	0.08	0.08	enet	3	0.08	2.6e-06	-7.5	7.6	3.1e-14	0.12	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC45	0.05	0.07	lasso	6	0.06	9.5e-08	-7.5	7.5	5.2e-14	0.11	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	STRA13	0.07	0.12	lasso	6	0.10	3.2e-10	-7.1	7.5	7.4e-14	0.07	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	STRA13	0.05	0.03	lasso	3	0.02	1.8e-03	-7.5	7.5	7.6e-14	0.11	0.00	0.98	FALSE
49	GTEx	Skin Sun Exposed Lower leg	RP11-1055B8.4	0.21	0.10	lasso	3	0.10	7.4e-09	7.5	-7.3	3.2e-13	-0.91	0.00	1.00	FALSE
34	GTEx	Heart Atrial Appendage	STRA13	0.25	0.15	enet	4	0.16	1.2e-07	-6.6	7.3	3.9e-13	0.09	0.08	0.91	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRA13	0.05	0.04	blup	33	0.05	5.0e-06	-7.5	7.2	4.9e-13	0.08	0.00	1.00	FALSE
14	GTEx	Artery Tibial	LRRC45	0.09	0.07	lasso	4	0.04	2.0e-04	-7.5	7.2	6.2e-13	0.07	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	LRRC45	0.23	0.06	lasso	3	0.05	1.0e-04	-7.5	7.2	7.5e-13	0.11	0.00	1.00	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRRC45	0.10	0.02	blup	35	0.04	8.0e-03	-5.5	7.1	1.0e-12	0.12	0.01	0.48	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	STRA13	0.20	0.14	enet	4	0.16	3.1e-06	-6.6	7.0	1.8e-12	0.10	0.25	0.65	FALSE
6	GTEx	Adipose Subcutaneous	RP11-1055B8.4	0.33	0.12	lasso	7	0.14	3.2e-11	7.5	-7.0	3.6e-12	-0.86	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	STRA13	0.45	0.38	lasso	4	0.40	1.6e-51	-6.5	6.9	5.0e-12	0.09	0.55	0.45	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	STRA13	0.23	0.18	enet	5	0.10	6.6e-06	-6.5	6.8	1.2e-11	0.10	0.60	0.40	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC45	0.08	0.07	lasso	3	0.04	1.4e-03	-6.6	6.7	1.6e-11	0.09	0.09	0.63	FALSE
38	GTEx	Muscle Skeletal	STRA13	0.20	0.09	lasso	6	0.10	5.4e-10	-6.5	6.7	1.7e-11	0.08	0.10	0.90	FALSE
36	GTEx	Lung	STRA13	0.16	0.16	lasso	3	0.15	1.2e-11	-6.5	6.7	2.0e-11	0.09	0.42	0.58	FALSE
10	GTEx	Adipose Visceral Omentum	STRA13	0.18	0.15	lasso	4	0.14	8.0e-08	-6.5	-6.7	2.2e-11	-0.11	0.59	0.35	FALSE
42	GTEx	Nerve Tibial	RP11-1055B8.4	0.13	0.14	enet	30	0.19	1.6e-13	7.5	-6.6	3.9e-11	-0.75	0.00	1.00	FALSE
16	GTEx	Artery Tibial	CCDC57	0.08	0.03	enet	7	0.05	5.8e-05	-5.7	6.6	4.3e-11	0.08	0.68	0.08	FALSE
33	GTEx	Heart Atrial Appendage	LRRC45	0.19	0.06	enet	9	0.12	6.7e-06	-3.1	6.6	5.2e-11	0.10	0.01	0.99	FALSE
40	GTEx	Nerve Tibial	STRA13	0.18	0.17	enet	2	0.12	1.4e-08	-6.5	6.5	7.7e-11	0.10	0.73	0.27	FALSE
9	GTEx	Adipose Visceral Omentum	LRRC45	0.18	0.03	enet	12	0.10	9.0e-06	-7.5	6.5	7.8e-11	0.10	0.00	0.99	FALSE
24	GTEx	Cells Transformed fibroblasts	STRA13	0.19	0.23	lasso	1	0.22	4.9e-16	-6.5	6.5	7.9e-11	0.10	0.73	0.27	FALSE
51	GTEx	Thyroid	STRA13	0.40	0.34	lasso	5	0.34	2.3e-26	-6.5	6.5	8.3e-11	0.10	0.74	0.26	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRA13	0.06	0.07	blup	33	0.07	3.3e-08	-6.5	6.5	8.6e-11	0.10	0.01	0.99	FALSE
32	GTEx	Esophagus Muscularis	STRA13	0.40	0.33	lasso	2	0.32	4.2e-20	-6.5	6.5	9.6e-11	0.10	0.73	0.27	FALSE
4	GTEx	Adipose Subcutaneous	STRA13	0.28	0.26	lasso	3	0.26	5.0e-21	-6.5	6.5	1.0e-10	0.10	0.74	0.26	FALSE
47	GTEx	Skin Sun Exposed Lower leg	STRA13	0.12	0.13	lasso	3	0.12	7.9e-10	-6.5	6.5	1.0e-10	0.10	0.54	0.46	FALSE
11	GTEx	Artery Aorta	STRA13	0.20	0.14	enet	16	0.11	7.9e-07	-6.5	6.5	1.1e-10	0.05	0.47	0.45	FALSE
29	GTEx	Esophagus Mucosa	STRA13	0.19	0.14	lasso	2	0.12	2.8e-08	-6.5	6.4	1.3e-10	0.11	0.55	0.45	FALSE
52	GTEx	Thyroid	DUS1L	0.07	0.05	lasso	5	0.02	7.1e-03	5.2	6.2	4.5e-10	0.10	0.32	0.56	FALSE
57	YFS	Blood	ASPSCR1	0.11	0.07	lasso	9	0.06	7.9e-20	-5.8	6.2	5.3e-10	0.11	0.15	0.85	FALSE
30	GTEx	Esophagus Mucosa	CCDC57	0.13	0.10	lasso	2	0.08	2.9e-06	-5.9	6.0	1.6e-09	0.07	0.97	0.02	FALSE
31	GTEx	Esophagus Mucosa	RP11-1376P16.2	0.06	0.04	lasso	9	0.00	1.5e-01	-6.0	6.0	2.2e-09	0.08	0.34	0.04	FALSE
21	GTEx	Brain Cerebellum	RP11-1376P16.2	0.15	0.19	lasso	2	0.16	2.3e-05	-6.0	6.0	2.7e-09	0.07	0.68	0.06	FALSE
18	GTEx	Brain Cerebellar Hemisphere	CCDC57	0.36	0.35	lasso	2	0.34	1.9e-09	-6.0	5.9	2.9e-09	0.08	0.97	0.02	FALSE
19	GTEx	Brain Cerebellum	CCDC57	0.40	0.44	lasso	21	0.42	7.1e-14	-5.9	5.9	3.7e-09	0.08	0.98	0.02	FALSE
39	GTEx	Muscle Skeletal	FASN	0.04	0.05	enet	5	0.03	3.1e-04	-6.0	5.9	4.7e-09	0.09	0.91	0.01	FALSE
48	GTEx	Skin Sun Exposed Lower leg	CCDC57	0.18	0.15	lasso	5	0.22	3.0e-18	4.7	5.9	4.7e-09	0.07	0.99	0.01	FALSE
44	GTEx	Prostate	CCDC57	0.20	0.17	lasso	3	0.15	1.6e-04	4.7	5.8	4.9e-09	0.07	0.33	0.18	FALSE
22	GTEx	Breast Mammary Tissue	CCDC57	0.14	0.07	lasso	6	0.07	2.6e-04	4.5	5.8	7.3e-09	0.06	0.74	0.03	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC57	0.08	0.02	blup	73	0.03	9.9e-04	-6.0	-5.8	7.4e-09	-0.06	0.04	0.92	FALSE
7	GTEx	Adipose Subcutaneous	RP11-1376P16.2	0.06	0.04	enet	10	0.03	3.5e-03	-5.7	5.8	8.7e-09	0.08	0.84	0.03	FALSE
37	GTEx	Lung	CCDC57	0.11	0.08	enet	18	0.05	8.4e-05	5.3	5.8	8.8e-09	0.09	0.99	0.01	FALSE
12	GTEx	Artery Coronary	LRRC45	0.18	0.00	enet	22	0.00	3.8e-01	-5.9	5.8	9.1e-09	0.13	0.03	0.42	FALSE
58	YFS	Blood	FASN	0.08	0.09	lasso	10	0.13	4.8e-41	4.6	-5.7	1.0e-08	-0.08	0.22	0.78	FALSE
43	GTEx	Ovary	CCDC57	0.39	0.30	enet	13	0.42	2.2e-11	4.5	5.7	1.1e-08	0.07	0.92	0.02	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	RFNG	0.06	0.04	lasso	5	0.03	1.1e-04	-5.7	-5.7	1.4e-08	-0.08	0.24	0.03	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC57	0.21	0.02	blup	73	0.06	3.3e-07	-6.0	-5.7	1.5e-08	-0.03	0.04	0.96	FALSE
25	GTEx	Cells Transformed fibroblasts	RP11-1376P16.2	0.09	0.06	lasso	4	0.07	8.1e-06	5.2	5.6	1.8e-08	0.11	0.97	0.01	FALSE
15	GTEx	Artery Tibial	STRA13	0.37	0.22	enet	14	0.22	1.6e-17	-6.5	5.6	2.6e-08	0.03	0.73	0.27	FALSE
35	GTEx	Heart Atrial Appendage	CCDC57	0.20	0.14	enet	23	0.14	5.5e-07	-5.9	5.5	2.9e-08	0.06	0.97	0.02	FALSE
69	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FN3KRP	0.44	0.14	enet	15	0.25	2.7e-09	4.7	-5.5	3.4e-08	-0.09	0.00	0.97	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	CCDC57	0.11	0.05	enet	6	0.04	2.3e-03	4.7	5.5	4.6e-08	0.07	0.47	0.07	FALSE
54	NTR	Blood	AATK	0.06	0.06	lasso	2	0.06	1.7e-17	-5.4	5.4	6.1e-08	-0.05	0.99	0.01	FALSE
50	GTEx	Stomach	CCDC57	0.11	0.09	lasso	3	0.10	2.0e-05	5.2	5.4	7.0e-08	0.10	0.80	0.02	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	BAIAP2	0.17	0.06	lasso	6	0.14	2.9e-13	2.1	-5.4	7.8e-08	0.02	0.90	0.09	FALSE
27	GTEx	Colon Transverse	CCDC57	0.11	0.09	enet	8	0.08	8.2e-05	4.5	5.4	8.5e-08	0.07	0.64	0.02	FALSE
13	GTEx	Artery Tibial	SLC16A3	0.08	0.06	lasso	2	0.04	4.9e-04	-5.7	5.3	1.1e-07	0.06	0.30	0.06	FALSE
41	GTEx	Nerve Tibial	CCDC57	0.39	0.40	enet	11	0.40	2.5e-30	4.5	5.3	1.1e-07	0.07	1.00	0.00	FALSE
17	GTEx	Brain Caudate basal ganglia	CCDC57	0.14	0.16	lasso	5	0.10	8.3e-04	5.0	5.2	1.5e-07	0.10	0.57	0.03	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	NOTUM	0.06	0.02	enet	2	0.02	4.7e-03	-4.4	-5.2	1.5e-07	-0.05	0.02	0.27	FALSE
5	GTEx	Adipose Subcutaneous	CCDC57	0.15	0.14	enet	9	0.16	3.2e-13	4.5	5.2	2.2e-07	0.07	1.00	0.00	FALSE
53	GTEx	Thyroid	RAC3	0.17	0.12	enet	41	0.12	1.8e-09	-6.4	5.2	2.4e-07	0.09	0.97	0.03	FALSE
26	GTEx	Colon Sigmoid	STRA13	0.36	0.26	enet	16	0.24	3.9e-09	-6.5	5.2	2.5e-07	0.09	0.28	0.70	FALSE