Best TWAS P=5.65e-09 · Best GWAS P=3.48e-12 conditioned to 7.1e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | N6AMT1 | 0.33 | 0.37 | bslmm | 477 | 0.37 | 9.5e-48 | -5.0 | 5.5 | 3.6e-08 | -0.80 | 1.00 | 0.00 | FALSE |
2 | GTEx | Brain Cortex | N6AMT1 | 0.17 | 0.24 | enet | 12 | 0.22 | 1.3e-06 | -5.4 | 5.5 | 3.7e-08 | -0.79 | 0.21 | 0.61 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | N6AMT1 | 0.12 | 0.12 | lasso | 5 | 0.09 | 2.1e-07 | -5.0 | 5.4 | 6.8e-08 | -0.79 | 0.88 | 0.11 | FALSE |
4 | GTEx | Esophagus Mucosa | LTN1 | 0.14 | 0.09 | enet | 22 | 0.14 | 8.3e-10 | -5.2 | 5.6 | 1.8e-08 | -0.47 | 0.98 | 0.02 | FALSE |
5 | GTEx | Muscle Skeletal | N6AMT1 | 0.13 | 0.08 | lasso | 6 | 0.11 | 7.0e-11 | -4.3 | 5.3 | 1.3e-07 | -0.75 | 0.58 | 0.42 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | LTN1 | 0.10 | 0.05 | lasso | 4 | 0.03 | 8.6e-03 | -5.0 | 5.5 | 3.0e-08 | -0.70 | 0.16 | 0.59 | FALSE |
7 | METSIM | Adipose | N6AMT1 | 0.09 | 0.08 | lasso | 11 | 0.09 | 2.6e-13 | -3.6 | 5.2 | 2.0e-07 | -0.68 | 1.00 | 0.00 | FALSE |
8 | NTR | Blood | N6AMT1 | 0.01 | 0.01 | blup | 469 | 0.01 | 1.3e-03 | 5.2 | -5.8 | 5.7e-09 | 0.55 | 0.50 | 0.37 | TRUE |
9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | N6AMT1 | 0.10 | 0.06 | blup | 56 | 0.05 | 2.1e-05 | -5.4 | 5.3 | 1.2e-07 | -0.79 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C21orf7 | 0.10 | 0.10 | lasso | 4 | 0.08 | 3.7e-05 | 5.1 | -5.1 | 3.1e-07 | 0.29 | 0.17 | 0.78 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | N6AMT1 | 0.11 | 0.14 | lasso | 6 | 0.15 | 1.5e-15 | -5.4 | 5.3 | 9.8e-08 | -0.75 | 0.01 | 0.99 | FALSE |