Hub : Genes

C21orf7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0162	0.0085	0.00120	0.010	0.011	0.012	0.011	0.010	2.6e-04	0.00014	5.2e-05	0.00017	2.9e-04
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1040	0.0540	0.00021	0.103	0.044	0.069	NA	0.076	1.7e-06	0.00160	8.9e-05	NA	3.7e-05
3	TCGA	Thyroid Carcinoma	0.0350	0.0200	0.00130	0.017	0.026	0.029	NA	0.006	7.2e-03	0.00140	7.3e-04	NA	8.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.3	3.6	4.5	-2.1	1.9	1.5
Bipolar Disorder or Schizophrenia	1.2	2.8	3.7	-1.5	1.9	1.6
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	0.8	0.8	-0.3
Depression (Nagel 2018)	0.5	0.7	1.4	0.7	0.4	-1.2
Intelligence (Savage-Jansen 2018)	1.2	3.6	6.5	-0.9	1.9	2.6
Neuroticism (Nagel 2018)	0.4	1.0	2.1	0.3	1.4	0.9
Schizophrenia (2018)	0.2	0.5	0.8	-0.3	0.9	0.8
Schizophrenia vs Biploar Disorder	3.1	4.1	5.6	2.0	-2.4	-1.6
Worry (Nagel 2018)	0.5	1.0	1.7	-0.2	1.3	1.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.0	-0.9	1.0	0.8
Alzheimer’s Disease (in father)	0.6	0.7	1.2	1.1	-0.5	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	-0.1	0.7	0.5
Crohns Disease (2017)	2.7	5.9	7.3	-2.5	2.7	2.1
Irritable Bowel Disease (IBD)	2.7	6.5	6.9	-2.5	2.6	2.5
Ulcerative Colitis (UC)	1.6	3.1	4.1	-1.7	1.5	2.0
Major Depression (MDD)	0.2	0.2	0.4	0.5	0.6	0.1
Reaction Time	0.3	0.5	0.8	-0.2	0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.4	-1.1	1.0	2.1
Breast Cancer	0.3	0.8	1.2	1.1	-1.1	-0.1
Ovarian Cancer	0.2	0.3	0.7	-0.4	0.1	-0.8
Prostate Cancer	0.0	0.0	0.1	0.0	0.3	-0.2
Age at First Birth	0.3	0.4	0.8	0.9	-0.4	-0.5
Bipolar Disorder (2011)	5.1	5.0	6.6	-2.6	2.2	1.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.1	0.5	-0.8
Coronary Artery Disease (CAD)	2.4	2.8	5.6	-2.4	1.5	0.8
Crohns Disease (2012)	2.5	4.0	5.3	-2.2	2.3	1.5
Mean Putamen Volume	0.1	0.1	0.3	-0.5	0.1	-0.2
Fasting Glucose	0.4	0.5	0.7	-0.5	0.9	0.7
HbA1C	0.3	0.3	0.5	-0.7	0.1	0.6
HDL Cholesterol	0.3	0.5	0.9	-0.8	1.0	0.0
LDL Cholesterol	0.0	0.0	0.1	-0.0	0.0	-0.2
Lupus	1.6	2.4	4.0	1.1	-2.0	-1.5
Neuroticism (2016)	0.6	0.8	1.5	1.2	0.9	0.4
Primary Biliary Cirrhosis	1.2	1.7	3.5	-0.5	-1.2	-1.9
Rheumatoid Arthritis	0.1	0.1	0.3	-0.2	-0.5	-0.2
Schizophrenia (2014)	0.3	0.7	0.9	-0.9	0.9	0.5
Triglycerides	0.0	0.0	0.0	-0.2	-0.2	-0.2
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.8	-1.3	1.9	1.1
Ulcerative Colitis	0.3	0.5	1.1	-0.2	0.6	1.0
Blood Eosinophil Count	1.0	7.4	14.6	-0.3	2.8	3.8
Blood Platelet Count	0.2	2.2	2.4	-1.5	1.6	1.4
Blood Red Count	2.2	21.3	25.2	-4.4	4.4	5.0
Blood White Count	1.4	10.4	10.8	-3.2	3.2	3.3
Heel T-Score	1.4	11.1	18.2	-4.3	2.7	2.8
BMI	0.1	0.4	0.5	-0.7	0.6	-0.7
Height	0.4	7.9	18.6	1.5	-4.3	-1.7
Waist Hip Ratio (WHR)	0.1	0.5	1.1	0.5	0.1	-1.0
Systolic Blood Pressure	0.4	1.9	4.6	-2.1	0.9	0.7
Smoking Status	0.4	0.9	2.0	0.7	-0.6	-1.4
Allergy or Eczema	0.4	0.9	1.4	-0.1	1.1	1.2
Cardiovascular Disease	0.2	0.6	1.2	-1.1	0.8	0.0
Hypothyroidism (self reported)	0.8	1.9	2.4	1.3	-1.6	-1.3
Respiratory disease	1.4	3.1	4.4	-1.2	2.1	1.8
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	0.1	0.5	-0.2
Lung FEV1/FVC ratio	0.1	0.5	1.2	-0.2	1.1	0.6
Lung FVC	0.5	2.5	4.0	2.0	-1.3	-1.4
Neuroticism	0.4	1.0	2.2	0.0	1.5	0.9
Chronotype (morning person)	0.6	1.3	1.8	0.7	-1.2	-1.3
Hair Pigment	0.2	4.6	5.6	-2.4	2.2	1.9
Tanning	0.4	4.5	7.7	1.4	-2.0	-2.8
Hand grip strength (left)	2.5	6.5	9.6	1.6	-3.1	-2.7
Number of treatments/medications taken	1.3	2.3	3.2	1.6	-1.2	-1.8
Average weekly spirits intake	0.6	0.7	1.1	1.1	-0.9	-0.5
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	0.2	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	0.7	-0.2	-1.2
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.8	-0.2	0.1
Relative age of first facial hair	0.5	1.1	2.3	-0.7	-0.7	-1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.1	-0.4	-1.0
Ever used hormone-replacement therapy (HRT)	2.1	2.7	3.2	1.5	-1.8	-1.7
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	0.2	1.1	0.9
Systolic blood pressure, automated reading	0.3	1.0	2.7	-1.7	0.3	0.4
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	3.1	1.8	-1.3	-1.7
Angina	0.4	0.6	1.0	1.0	-0.8	-0.3
Medication for hormone replacement therapy	0.5	0.6	0.9	-0.7	1.0	0.5
Vitamin and mineral supplements	0.5	0.6	1.4	-1.2	-0.0	-0.7
Supplements: Zinc	1.1	1.2	2.3	1.5	-0.9	-0.6
Medication: Co-codamol	2.4	2.8	4.1	1.1	-1.8	-2.0
Medication: Metformin	0.1	0.1	0.2	0.3	0.4	-0.3
Diabetes (father)	2.4	2.9	4.3	1.2	-2.1	-1.7
Diabetes (mother)	1.9	2.5	3.7	-1.4	1.9	1.4
Severe depression (siblings)	0.7	0.8	1.5	0.2	1.2	1.0
Pack years adult smoking proportion	0.6	1.0	1.7	0.9	-0.7	-1.3
Impedance of leg (right)	1.2	5.7	6.6	2.1	-2.6	-2.4
Leg fat-free mass (left)	0.2	1.1	1.7	0.6	-1.3	-1.0
Trunk fat percentage	0.7	2.7	4.9	1.2	-1.4	-2.2
Hand grip strength (right)	4.2	11.5	15.0	2.6	-3.9	-3.6
Townsend deprivation index at recruitment	0.7	1.0	2.1	1.4	-0.7	-0.7
Current tobacco smoking	0.3	0.5	1.1	-0.3	-0.5	-1.1
Average weekly fortified wine intake	0.6	0.7	1.9	1.4	-0.4	-0.0
Maternal smoking around birth	1.0	1.4	2.0	0.3	-1.4	-1.4
Fed-up feelings	0.2	0.3	0.6	0.8	0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.3	0.1	1.1	-0.5
Relative age voice broke	0.3	0.5	1.2	-0.0	-0.5	-1.1
Taking other prescription medications	0.1	0.1	0.3	-0.1	-0.0	-0.6
Age when periods started (menarche)	0.4	1.0	2.4	0.3	-0.6	-1.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.7	0.1	0.7	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	-0.8	0.3	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.6	0.8	-0.3	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.2	0.4	-0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.2	0.5	-0.6	-1.1
High blood pressure	0.1	0.4	0.9	-1.0	0.5	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.4	-0.5	0.5	1.2
Multivitamins +/- minerals	0.6	0.7	1.9	1.4	-0.6	-0.1
Stomach or abdominal pain in last month	0.6	0.7	1.7	-0.3	-0.6	-1.3
Supplements: Glucosamine	0.4	0.5	0.9	0.3	-1.0	-0.8
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	0.0	0.1
Medication: Atenolol	0.4	0.5	0.8	0.5	-0.7	-0.9
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.0	-0.2	-0.0
Sitting height	0.3	1.9	5.3	-0.5	-0.1	2.3
Chronic bronchitis/emphysema (father)	1.9	2.2	2.9	-1.7	1.7	0.9
High blood pressure (mother)	0.2	0.3	0.7	-0.2	0.8	0.5
Body mass index (BMI)	0.3	1.3	3.6	0.2	-0.6	-1.9
Impedance of leg (left)	1.2	5.7	6.4	2.4	-2.5	-2.2
Leg predicted mass (left)	0.2	0.8	1.4	0.6	-1.2	-0.9
Trunk fat mass	1.2	5.1	7.9	1.6	-2.2	-2.8
Waist circumference	0.9	3.5	7.0	1.0	-1.6	-2.6
Number of incorrect matches in round	1.5	2.5	3.3	1.8	-1.2	-1.6
Past tobacco smoking	0.4	0.7	1.1	-0.6	0.8	1.1
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	-0.3	0.2
Nervous feelings	0.2	0.4	0.6	-0.4	0.8	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.1	-0.7	1.0	0.8
Hearing difficulty/problems with background noise	0.2	0.4	0.9	0.9	-0.4	0.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.2	0.8	0.7
Had menopause	1.4	1.7	2.6	1.6	-1.5	-0.5
Had other major operations	0.3	0.4	0.9	-0.1	-0.5	0.9
Forced vital capacity (FVC)	2.4	9.2	13.0	3.6	-3.0	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.8	-1.7	1.3	0.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.3	-0.5	1.0	1.1
Qualifications: None of the above	0.2	0.3	0.9	-0.2	1.0	0.2
Financial difficulties in last 2 years	1.9	2.5	3.7	1.2	-1.9	-1.6
Mouth/teeth dental problems	0.1	0.1	0.1	0.3	-0.2	0.3
Heart attack	1.7	2.2	2.9	1.3	-1.4	-1.7
Allergy	0.4	0.9	1.6	0.8	-0.8	-1.2
Pain all over the body in last month	1.4	1.5	3.4	0.4	-1.0	-1.8
Diabetes (self-reported)	0.1	0.2	0.3	0.6	-0.0	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.0	-0.8	-0.0
Medication: Ramipril	0.2	0.2	0.4	-0.5	0.6	-0.3
Medication: Simvastatin	0.3	0.5	1.3	-0.3	-0.1	-1.1
Fluid intelligence score	1.6	3.4	4.4	-2.0	1.3	2.1
Illnesses of siblings	0.7	0.9	1.2	-0.7	1.0	1.1
Neuroticism score	0.1	0.1	0.4	0.3	0.6	0.1
Weight	1.3	6.3	9.1	1.6	-2.7	-3.0
Impedance of arm (right)	0.1	0.3	0.9	0.0	0.3	0.9
Arm fat percentage (right)	0.2	0.9	2.7	0.2	-0.4	-1.6
Trunk fat-free mass	1.1	6.2	8.7	1.8	-2.9	-2.6
Hip circumference	1.6	6.7	9.6	1.8	-2.7	-3.1
Time employed in main current job	6.3	7.3	8.3	-2.3	2.9	2.9
Alcohol intake versus 10 years previously	2.6	3.9	5.9	-2.4	1.7	1.6
Father’s age at death	1.9	2.5	5.2	-0.8	1.3	2.3
Worrier / anxious feelings	0.4	0.7	1.6	0.5	0.6	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	4.3	2.1	-1.1	-1.8
Falls in the last year	0.0	0.0	0.1	-0.2	-0.3	0.1
Hair/balding pattern: Pattern 3	0.9	1.4	1.6	1.3	-1.0	-1.2
Number of live births	0.4	0.5	0.9	0.4	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	8.7	3.0	-2.0	-1.6
Pulse rate	2.0	3.3	5.4	2.3	-1.4	-1.7
Happiness	0.1	0.2	0.4	0.2	0.2	0.7
Noisy workplace	0.6	0.8	2.0	1.4	-0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	1.1	-0.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.7	0.8	-0.0	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.6	1.0	-0.8	0.1	-1.0
Asthma	0.6	1.2	1.6	-1.3	1.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	4.0	2.0	-1.7	-0.8
Medication: Cholesterol lowering	0.5	0.7	1.2	-0.5	1.1	0.8
Depression (self-reported)	0.5	0.6	1.2	-0.5	1.1	0.6
Medication: Lansoprazole	0.4	0.5	1.5	-0.2	1.2	0.2
Prospective memory result	0.3	0.4	1.0	-1.0	0.4	0.1
Lung cancer (father)	0.5	0.5	1.3	1.1	-0.5	0.3
Illnesses of mother	0.1	0.1	0.2	-0.4	-0.4	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	8.6	2.9	-1.9	-1.3
Pulse wave Arterial Stiffness index	1.0	1.1	1.4	1.0	-1.2	-1.0
Impedance of arm (left)	0.1	0.4	1.0	0.2	0.4	1.0
Arm fat mass (right)	0.7	2.9	5.9	0.9	-1.4	-2.4
Trunk predicted mass	1.0	5.7	8.0	1.7	-2.8	-2.5
Standing height	1.6	15.7	26.2	3.4	-5.1	-3.0
Length of working week for main job	0.7	0.8	2.0	0.2	-0.6	-1.4
Exposure to tobacco smoke at home	0.1	0.2	0.3	0.5	-0.2	0.4
Breastfed as a baby	1.1	1.3	2.3	1.2	-1.5	-0.5
Tense / ‘highly strung’	0.0	0.1	0.2	0.0	0.5	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	2.1	1.3	-1.4	-1.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	-0.2	-1.1	-0.3
Birth weight of first child	0.4	0.7	1.7	-1.3	0.3	0.4
Peak expiratory flow (PEF)	0.4	0.9	2.0	1.4	-0.4	-0.8
Pulse wave reflection index	0.2	0.3	0.5	0.4	-0.7	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.4	0.4	0.0
Loud music exposure frequency	0.0	0.0	0.0	0.1	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.6	-0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	-0.2	0.1	0.0
Blood clot in the leg (DVT)	0.6	0.7	1.6	-1.3	0.5	0.6
Medication: Paracetamol	1.2	1.9	3.4	0.8	-1.8	-1.3
Headache pain in last month	0.1	0.2	0.3	-0.5	0.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.9	1.2	-1.4	-0.4
Glaucoma (self-reported)	8.6	10.1	15.7	-2.2	3.1	4.0
Gout (self-reported)	1.1	1.5	1.6	1.1	-1.3	-1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.4	0.7	-1.5	-1.1
Medication: Amlodipine	0.3	0.5	1.1	-0.5	0.4	-1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.5	0.3	0.1
Birth weight	0.0	0.1	0.3	0.5	-0.1	0.2
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.6	-0.8	0.8	0.3
High blood pressure (siblings)	0.4	0.5	1.3	1.1	-0.5	-0.1
Forced vital capacity (FVC), Best measure	2.1	7.6	11.5	3.4	-2.7	-1.9
Body fat percentage	0.9	3.5	6.4	1.3	-1.5	-2.5
Leg fat percentage (right)	1.8	6.5	11.9	1.7	-2.2	-3.5
Arm fat-free mass (right)	1.4	7.3	9.7	2.0	-3.1	-2.8
Exposure to tobacco smoke outside home	1.6	2.2	2.6	-1.6	1.6	1.2
Comparative body size at age 10	0.3	0.9	1.1	0.8	-1.0	-1.0
Number of full brothers	0.8	1.0	1.5	-0.8	0.9	1.2
Worry too long after embarrassment	0.2	0.3	0.6	0.8	0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	1.0	-0.1	-0.6
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	-0.2	-0.2	-0.1
Number of children fathered	1.0	1.1	2.3	0.2	-1.0	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	1.7	1.3	-1.1	-1.3
Age at first live birth	0.6	1.0	2.0	-0.9	0.5	1.4
Pulse wave peak to peak time	0.7	0.8	1.0	-0.8	1.0	0.9
Health satisfaction	1.0	1.4	1.4	1.1	-1.2	-1.2
Shortness of breath walking on level ground	5.5	6.5	7.1	2.3	-2.7	-2.6
Qualifications: College or University degree	0.4	1.3	2.3	1.2	-1.5	-0.5
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.2	-0.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.5	-0.4	-0.2
Emphysema/chronic bronchitis	0.3	0.3	1.0	-0.3	1.0	0.0
Medication for pain relief, constipation, heartburn	1.6	2.7	4.4	-0.9	1.7	2.1
Neck or shoulder pain in last month	0.4	0.6	0.9	0.9	-0.6	-0.6
Medication: Blood pressure	1.0	1.7	2.6	-1.5	1.6	0.7
Angina (self-reported)	0.7	0.9	1.4	1.2	-1.0	-0.6
Migraine (self-reported)	5.5	6.8	10.4	3.2	-2.3	-2.2
Medication: Ibuprofen	1.8	2.2	3.7	1.9	-1.7	-0.2
Medication: Allopurinol	1.4	1.8	2.6	0.9	-1.6	-1.4
Medication: Omeprazole	3.2	3.8	5.2	1.5	-2.0	-2.3
Medication: Seretide 50 evohaler	0.4	0.4	0.8	-0.6	-0.4	-0.9
Mean time to correctly identify matches	0.2	0.4	0.7	-0.2	0.8	0.6
Heart disease (mother)	1.4	1.8	2.3	1.3	-1.1	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	3.7	1.1	-1.3	-1.9
Whole body fat mass	1.5	6.1	9.4	1.8	-2.4	-3.1
Leg fat mass (right)	1.6	6.2	10.5	1.7	-2.3	-3.2
Arm predicted mass (right)	1.1	5.9	7.8	1.8	-2.8	-2.6
Pulse rate, automated reading	2.3	7.5	11.4	3.4	-2.5	-2.2
Alcohol intake frequency.	0.2	0.5	0.7	-0.8	0.7	0.5
Comparative height size at age 10	2.1	11.7	16.3	3.6	-4.0	-2.3
Number of full sisters	0.8	1.0	1.5	-0.6	1.2	1.1
Suffer from ‘nerves’	0.1	0.2	0.5	0.7	0.4	0.2
Overall health rating	1.0	2.2	4.3	1.0	-1.2	-2.1
Chest pain or discomfort	0.1	0.1	0.3	-0.0	0.1	0.5
Had major operations	0.3	0.3	0.9	1.0	-0.2	0.1
Age at last live birth	0.2	0.3	0.4	-0.5	-0.6	-0.3
Family relationship satisfaction	0.7	0.9	1.1	-0.8	1.0	1.0
Leg pain on walking	0.2	0.3	0.6	-0.1	-0.8	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	1.0	-0.2	-0.8	-1.0
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	-0.4	0.9	-0.3
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	2.3	-1.5	1.2	1.5
Medication: Aspirin	1.5	2.0	3.4	1.1	-1.1	-1.8
Supplements: Vitamin C	0.3	0.3	0.8	0.1	0.4	0.9
Knee pain experienced in last month	3.5	5.4	7.0	2.7	-2.6	-1.6
Hypertension (Self-reported)	0.1	0.2	0.5	-0.7	0.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.6	-0.1	-0.3
Illnesses of father: Heart disease	0.3	0.3	0.8	0.0	-0.5	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	0.7	-0.9	0.8	-0.1
Smoking status: Previous	0.7	1.1	1.4	1.0	-0.9	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.6	-0.1	0.6	0.8
Whole body fat-free mass	0.7	4.0	5.7	1.4	-2.4	-2.0
Leg fat-free mass (right)	0.1	0.6	1.1	0.6	-1.0	-0.6
Arm fat percentage (left)	0.3	1.1	3.0	0.5	-0.5	-1.7
Average weekly red wine intake	0.4	0.6	0.9	-0.7	0.7	1.0
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.3	1.0	-1.5	-0.4
Mood swings	0.4	0.7	1.6	-0.3	1.3	0.7
Loneliness, isolation	0.2	0.3	0.5	0.5	0.7	-0.1
Long-standing illness, disability or infirmity	2.4	3.6	5.7	1.2	-1.9	-2.4
Ever had bowel cancer screening	0.5	0.6	1.1	1.1	-0.6	-0.5
Diabetes diagnosed by doctor	0.1	0.2	0.2	0.4	0.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.3	-1.0	-0.1
Friendships satisfaction	0.9	1.2	1.4	-1.2	0.8	1.2
Qualifications: nursing, teaching	0.5	0.8	1.0	0.9	-1.0	-0.7
Commuting to job workplace: Walk	1.2	1.3	1.8	1.2	-1.3	-0.9
Eye problems/disorders: Cataract	1.2	1.4	1.5	1.2	-1.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.9	1.4	-0.5	0.2
Medication for cholesterol	0.5	0.7	1.6	1.3	-0.6	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.8	-0.1	-0.8
Back pain experienced in last month	2.2	3.1	3.5	1.9	-1.8	-1.7
Mineral and other dietary supplements	0.0	0.0	0.1	-0.2	0.1	-0.3
Breast cancer (self-reported)	0.5	0.6	1.1	0.7	-1.1	-0.5
Asthma (self-reported)	0.2	0.4	0.7	-0.9	0.5	0.6
Osteoporosis (self-reported)	0.3	0.4	0.9	1.0	-0.4	0.2
Osteoarthritis (self-reported)	1.2	1.6	2.1	0.8	-1.4	-1.4
Medication: Aspirin	0.8	1.1	1.9	0.9	-0.7	-1.4
Medication: Gliclazide	0.2	0.2	0.7	-0.1	-0.1	0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	0.6	-0.5	-0.5
Smoking status: Current	0.2	0.4	0.8	-0.3	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	0.9	-0.1	-0.6
Whole body water mass	0.7	3.9	5.6	1.4	-2.4	-2.0
Leg predicted mass (right)	0.1	0.6	1.1	0.5	-1.0	-0.6
Arm fat mass (left)	0.8	3.2	6.3	1.0	-1.5	-2.5
Number of self-reported non-cancer illnesses	0.5	0.9	1.6	1.3	-1.0	-0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.5	0.0	-0.0
Miserableness	1.7	2.9	3.7	1.6	-1.5	-1.9
Guilty feelings	0.3	0.4	0.9	0.3	0.5	0.9
Wears glasses or contact lenses	2.1	2.5	4.0	1.0	-2.0	-1.5
Ever taken oral contraceptive pill	1.3	1.4	1.7	-1.0	1.2	1.3
Hearing aid user	0.2	0.2	0.6	-0.8	-0.2	0.1
Mother’s age at death	0.3	0.3	0.5	0.3	0.6	0.7
Financial situation satisfaction	0.9	1.1	1.4	0.9	-1.1	-1.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.5	0.2	-0.6
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.4	-0.6	-0.2
Eye problems/disorders: Glaucoma	4.3	5.1	5.9	-2.4	1.9	2.4
Medication: Blood pressure	0.1	0.2	0.5	-0.7	0.1	-0.1
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.2	0.7	-1.8	-1.0
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.5	0.1	-0.1
High cholesterol (Self-reported)	0.5	1.0	1.3	-1.1	0.8	1.0
Medication: Bendroflumethiazide	0.4	0.6	1.0	-1.0	0.9	-0.2
Medication: Paracetamol	0.6	1.0	1.6	0.5	-1.3	-1.1
Medication: Lisinopril	1.0	1.3	2.3	0.5	-1.1	-1.5
Medication: Atorvastatin	2.8	3.5	4.2	-1.9	1.6	2.0
Illnesses of father: High blood pressure	0.5	0.6	1.7	1.3	-0.3	0.2
Alcohol drinker status: Never	1.0	1.2	1.7	-0.9	1.3	1.0
Ever smoked	0.1	0.1	0.4	-0.1	-0.2	-0.6
Basal metabolic rate	0.9	4.8	6.5	1.5	-2.5	-2.4
Leg fat percentage (left)	1.4	4.9	9.0	1.5	-1.9	-3.0
Arm fat-free mass (left)	1.2	6.3	8.4	1.7	-2.9	-2.7
Number of operations (self-reported)	0.1	0.1	0.2	0.4	-0.3	-0.1
Average weekly beer plus cider intake	0.3	0.5	1.0	-0.5	0.4	1.0
Irritability	1.4	2.3	3.0	-1.5	1.7	1.3
Risk taking	0.6	0.9	1.7	1.3	-0.4	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	0.5	-0.9	-1.2
Fractured/broken bones in last 5 years	0.7	0.9	1.2	-0.7	1.1	1.0
Age started oral contraceptive pill	0.1	0.2	0.4	0.1	-0.7	0.2
Diastolic blood pressure, automated reading	2.3	7.2	9.6	2.2	-2.7	-3.1
Ever depressed for a whole week	0.4	0.5	1.4	1.2	-0.3	-0.2
Unable to work because of sickness or disability	1.1	1.5	2.4	1.0	-1.0	-1.6
Commuting to job workplace: Cycle	0.1	0.2	0.3	0.0	-0.4	0.6
Myopia	0.3	0.4	0.7	0.2	-0.7	-0.9
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.9	1.0	-0.5	0.2
Cholesterol lowering medication	0.3	0.4	0.6	-0.8	-0.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	2.4	1.1	-1.5	-1.5
Pain experienced in last month	0.6	1.0	1.4	-0.8	1.2	1.1
Supplements: Calcium	0.5	0.5	1.4	1.2	-0.5	0.1
Basal cell carcinoma (self-reported)	0.7	0.9	1.4	-1.2	1.0	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	1.7	1.0	-1.0	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-1.1	0.2	0.3
Heart disease (siblings)	7.7	9.4	13.4	2.2	-3.2	-3.7
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.0	0.4	0.4
Pack years of smoking	0.9	1.4	2.1	1.0	-1.0	-1.5
Impedance of whole body	0.2	0.9	1.4	1.2	-1.0	-0.3
Leg fat mass (left)	1.3	5.1	8.7	1.5	-2.1	-3.0
Arm predicted mass (left)	1.4	7.0	9.2	1.9	-3.0	-2.9