Hub : Genes

C21orf7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0162 0.0085 0.00120 0.010 0.011 0.012 0.011 0.010 2.6e-04 0.00014 5.2e-05 0.00017 2.9e-04
2 TCGA Kidney Renal Papillary Cell Carcinoma 0.1040 0.0540 0.00021 0.103 0.044 0.069 NA 0.076 1.7e-06 0.00160 8.9e-05 NA 3.7e-05
3 TCGA Thyroid Carcinoma 0.0350 0.0200 0.00130 0.017 0.026 0.029 NA 0.006 7.2e-03 0.00140 7.3e-04 NA 8.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 2.3 3.6 4.5 -2.1 1.9 1.5
Bipolar Disorder or Schizophrenia 1.2 2.8 3.7 -1.5 1.9 1.6
Depressed Affect (Nagel 2018) 0.2 0.4 0.6 0.8 0.8 -0.3
Depression (Nagel 2018) 0.5 0.7 1.4 0.7 0.4 -1.2
Intelligence (Savage-Jansen 2018) 1.2 3.6 6.5 -0.9 1.9 2.6
Neuroticism (Nagel 2018) 0.4 1.0 2.1 0.3 1.4 0.9
Schizophrenia (2018) 0.2 0.5 0.8 -0.3 0.9 0.8
Schizophrenia vs Biploar Disorder 3.1 4.1 5.6 2.0 -2.4 -1.6
Worry (Nagel 2018) 0.5 1.0 1.7 -0.2 1.3 1.2
Alzheimer’s Disease (in mother) 0.7 0.8 1.0 -0.9 1.0 0.8
Alzheimer’s Disease (in father) 0.6 0.7 1.2 1.1 -0.5 -0.7
Alzheimer’s Disease (including proxy) 0.2 0.2 0.5 -0.1 0.7 0.5
Crohns Disease (2017) 2.7 5.9 7.3 -2.5 2.7 2.1
Irritable Bowel Disease (IBD) 2.7 6.5 6.9 -2.5 2.6 2.5
Ulcerative Colitis (UC) 1.6 3.1 4.1 -1.7 1.5 2.0
Major Depression (MDD) 0.2 0.2 0.4 0.5 0.6 0.1
Reaction Time 0.3 0.5 0.8 -0.2 0.9 0.8
Verbal and Numeric Reasoning (VNR) 0.9 2.2 4.4 -1.1 1.0 2.1
Breast Cancer 0.3 0.8 1.2 1.1 -1.1 -0.1
Ovarian Cancer 0.2 0.3 0.7 -0.4 0.1 -0.8
Prostate Cancer 0.0 0.0 0.1 0.0 0.3 -0.2
Age at First Birth 0.3 0.4 0.8 0.9 -0.4 -0.5
Bipolar Disorder (2011) 5.1 5.0 6.6 -2.6 2.2 1.9
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 0.1 0.5 -0.8
Coronary Artery Disease (CAD) 2.4 2.8 5.6 -2.4 1.5 0.8
Crohns Disease (2012) 2.5 4.0 5.3 -2.2 2.3 1.5
Mean Putamen Volume 0.1 0.1 0.3 -0.5 0.1 -0.2
Fasting Glucose 0.4 0.5 0.7 -0.5 0.9 0.7
HbA1C 0.3 0.3 0.5 -0.7 0.1 0.6
HDL Cholesterol 0.3 0.5 0.9 -0.8 1.0 0.0
LDL Cholesterol 0.0 0.0 0.1 -0.0 0.0 -0.2
Lupus 1.6 2.4 4.0 1.1 -2.0 -1.5
Neuroticism (2016) 0.6 0.8 1.5 1.2 0.9 0.4
Primary Biliary Cirrhosis 1.2 1.7 3.5 -0.5 -1.2 -1.9
Rheumatoid Arthritis 0.1 0.1 0.3 -0.2 -0.5 -0.2
Schizophrenia (2014) 0.3 0.7 0.9 -0.9 0.9 0.5
Triglycerides 0.0 0.0 0.0 -0.2 -0.2 -0.2
Type 2 Diabetes (T2D) (2012) 2.0 2.3 3.8 -1.3 1.9 1.1
Ulcerative Colitis 0.3 0.5 1.1 -0.2 0.6 1.0
Blood Eosinophil Count 1.0 7.4 14.6 -0.3 2.8 3.8
Blood Platelet Count 0.2 2.2 2.4 -1.5 1.6 1.4
Blood Red Count 2.2 21.3 25.2 -4.4 4.4 5.0
Blood White Count 1.4 10.4 10.8 -3.2 3.2 3.3
Heel T-Score 1.4 11.1 18.2 -4.3 2.7 2.8
BMI 0.1 0.4 0.5 -0.7 0.6 -0.7
Height 0.4 7.9 18.6 1.5 -4.3 -1.7
Waist Hip Ratio (WHR) 0.1 0.5 1.1 0.5 0.1 -1.0
Systolic Blood Pressure 0.4 1.9 4.6 -2.1 0.9 0.7
Smoking Status 0.4 0.9 2.0 0.7 -0.6 -1.4
Allergy or Eczema 0.4 0.9 1.4 -0.1 1.1 1.2
Cardiovascular Disease 0.2 0.6 1.2 -1.1 0.8 0.0
Hypothyroidism (self reported) 0.8 1.9 2.4 1.3 -1.6 -1.3
Respiratory disease 1.4 3.1 4.4 -1.2 2.1 1.8
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.2 0.1 0.5 -0.2
Lung FEV1/FVC ratio 0.1 0.5 1.2 -0.2 1.1 0.6
Lung FVC 0.5 2.5 4.0 2.0 -1.3 -1.4
Neuroticism 0.4 1.0 2.2 0.0 1.5 0.9
Chronotype (morning person) 0.6 1.3 1.8 0.7 -1.2 -1.3
Hair Pigment 0.2 4.6 5.6 -2.4 2.2 1.9
Tanning 0.4 4.5 7.7 1.4 -2.0 -2.8
Hand grip strength (left) 2.5 6.5 9.6 1.6 -3.1 -2.7
Number of treatments/medications taken 1.3 2.3 3.2 1.6 -1.2 -1.8
Average weekly spirits intake 0.6 0.7 1.1 1.1 -0.9 -0.5
Sensitivity / hurt feelings 0.0 0.0 0.0 0.1 0.2 0.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.5 0.7 -0.2 -1.2
Hearing difficulty/problems: Yes 0.2 0.3 0.7 0.8 -0.2 0.1
Relative age of first facial hair 0.5 1.1 2.3 -0.7 -0.7 -1.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 -0.1 -0.4 -1.0
Ever used hormone-replacement therapy (HRT) 2.1 2.7 3.2 1.5 -1.8 -1.7
Ever had hysterectomy (womb removed) 0.6 0.7 1.1 0.2 1.1 0.9
Systolic blood pressure, automated reading 0.3 1.0 2.7 -1.7 0.3 0.4
Eye problems/disorders: Diabetes related eye disease 2.3 2.6 3.1 1.8 -1.3 -1.7
Angina 0.4 0.6 1.0 1.0 -0.8 -0.3
Medication for hormone replacement therapy 0.5 0.6 0.9 -0.7 1.0 0.5
Vitamin and mineral supplements 0.5 0.6 1.4 -1.2 -0.0 -0.7
Supplements: Zinc 1.1 1.2 2.3 1.5 -0.9 -0.6
Medication: Co-codamol 2.4 2.8 4.1 1.1 -1.8 -2.0
Medication: Metformin 0.1 0.1 0.2 0.3 0.4 -0.3
Diabetes (father) 2.4 2.9 4.3 1.2 -2.1 -1.7
Diabetes (mother) 1.9 2.5 3.7 -1.4 1.9 1.4
Severe depression (siblings) 0.7 0.8 1.5 0.2 1.2 1.0
Pack years adult smoking proportion 0.6 1.0 1.7 0.9 -0.7 -1.3
Impedance of leg (right) 1.2 5.7 6.6 2.1 -2.6 -2.4
Leg fat-free mass (left) 0.2 1.1 1.7 0.6 -1.3 -1.0
Trunk fat percentage 0.7 2.7 4.9 1.2 -1.4 -2.2
Hand grip strength (right) 4.2 11.5 15.0 2.6 -3.9 -3.6
Townsend deprivation index at recruitment 0.7 1.0 2.1 1.4 -0.7 -0.7
Current tobacco smoking 0.3 0.5 1.1 -0.3 -0.5 -1.1
Average weekly fortified wine intake 0.6 0.7 1.9 1.4 -0.4 -0.0
Maternal smoking around birth 1.0 1.4 2.0 0.3 -1.4 -1.4
Fed-up feelings 0.2 0.3 0.6 0.8 0.6 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.3 0.1 1.1 -0.5
Relative age voice broke 0.3 0.5 1.2 -0.0 -0.5 -1.1
Taking other prescription medications 0.1 0.1 0.3 -0.1 -0.0 -0.6
Age when periods started (menarche) 0.4 1.0 2.4 0.3 -0.6 -1.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.7 0.1 0.7 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.6 -0.8 0.3 0.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.6 0.8 -0.3 -0.2
Qualifications: CSEs or equivalent 0.1 0.1 0.2 -0.2 0.4 -0.1
Serious illness, injury or assault to yourself 0.5 0.6 1.2 0.5 -0.6 -1.1
High blood pressure 0.1 0.4 0.9 -1.0 0.5 0.1
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.4 -0.5 0.5 1.2
Multivitamins +/- minerals 0.6 0.7 1.9 1.4 -0.6 -0.1
Stomach or abdominal pain in last month 0.6 0.7 1.7 -0.3 -0.6 -1.3
Supplements: Glucosamine 0.4 0.5 0.9 0.3 -1.0 -0.8
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 0.2 0.0 0.1
Medication: Atenolol 0.4 0.5 0.8 0.5 -0.7 -0.9
Medication: Levothyroxine sodium 0.0 0.0 0.1 0.0 -0.2 -0.0
Sitting height 0.3 1.9 5.3 -0.5 -0.1 2.3
Chronic bronchitis/emphysema (father) 1.9 2.2 2.9 -1.7 1.7 0.9
High blood pressure (mother) 0.2 0.3 0.7 -0.2 0.8 0.5
Body mass index (BMI) 0.3 1.3 3.6 0.2 -0.6 -1.9
Impedance of leg (left) 1.2 5.7 6.4 2.4 -2.5 -2.2
Leg predicted mass (left) 0.2 0.8 1.4 0.6 -1.2 -0.9
Trunk fat mass 1.2 5.1 7.9 1.6 -2.2 -2.8
Waist circumference 0.9 3.5 7.0 1.0 -1.6 -2.6
Number of incorrect matches in round 1.5 2.5 3.3 1.8 -1.2 -1.6
Past tobacco smoking 0.4 0.7 1.1 -0.6 0.8 1.1
Alcohol usually taken with meals 0.1 0.2 0.5 0.7 -0.3 0.2
Nervous feelings 0.2 0.4 0.6 -0.4 0.8 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.1 -0.7 1.0 0.8
Hearing difficulty/problems with background noise 0.2 0.4 0.9 0.9 -0.4 0.3
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 -0.2 0.8 0.7
Had menopause 1.4 1.7 2.6 1.6 -1.5 -0.5
Had other major operations 0.3 0.4 0.9 -0.1 -0.5 0.9
Forced vital capacity (FVC) 2.4 9.2 13.0 3.6 -3.0 -2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 2.8 -1.7 1.3 0.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.3 -0.5 1.0 1.1
Qualifications: None of the above 0.2 0.3 0.9 -0.2 1.0 0.2
Financial difficulties in last 2 years 1.9 2.5 3.7 1.2 -1.9 -1.6
Mouth/teeth dental problems 0.1 0.1 0.1 0.3 -0.2 0.3
Heart attack 1.7 2.2 2.9 1.3 -1.4 -1.7
Allergy 0.4 0.9 1.6 0.8 -0.8 -1.2
Pain all over the body in last month 1.4 1.5 3.4 0.4 -1.0 -1.8
Diabetes (self-reported) 0.1 0.2 0.3 0.6 -0.0 -0.5
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.6 -0.0 -0.8 -0.0
Medication: Ramipril 0.2 0.2 0.4 -0.5 0.6 -0.3
Medication: Simvastatin 0.3 0.5 1.3 -0.3 -0.1 -1.1
Fluid intelligence score 1.6 3.4 4.4 -2.0 1.3 2.1
Illnesses of siblings 0.7 0.9 1.2 -0.7 1.0 1.1
Neuroticism score 0.1 0.1 0.4 0.3 0.6 0.1
Weight 1.3 6.3 9.1 1.6 -2.7 -3.0
Impedance of arm (right) 0.1 0.3 0.9 0.0 0.3 0.9
Arm fat percentage (right) 0.2 0.9 2.7 0.2 -0.4 -1.6
Trunk fat-free mass 1.1 6.2 8.7 1.8 -2.9 -2.6
Hip circumference 1.6 6.7 9.6 1.8 -2.7 -3.1
Time employed in main current job 6.3 7.3 8.3 -2.3 2.9 2.9
Alcohol intake versus 10 years previously 2.6 3.9 5.9 -2.4 1.7 1.6
Father’s age at death 1.9 2.5 5.2 -0.8 1.3 2.3
Worrier / anxious feelings 0.4 0.7 1.6 0.5 0.6 1.3
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 4.3 2.1 -1.1 -1.8
Falls in the last year 0.0 0.0 0.1 -0.2 -0.3 0.1
Hair/balding pattern: Pattern 3 0.9 1.4 1.6 1.3 -1.0 -1.2
Number of live births 0.4 0.5 0.9 0.4 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1) 1.5 5.1 8.7 3.0 -2.0 -1.6
Pulse rate 2.0 3.3 5.4 2.3 -1.4 -1.7
Happiness 0.1 0.2 0.4 0.2 0.2 0.7
Noisy workplace 0.6 0.8 2.0 1.4 -0.4 -0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.1 1.1 -0.5 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.7 0.8 -0.0 -0.4
Mouth/teeth dental problems: Dentures 0.3 0.6 1.0 -0.8 0.1 -1.0
Asthma 0.6 1.2 1.6 -1.3 1.0 1.0
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 4.0 2.0 -1.7 -0.8
Medication: Cholesterol lowering 0.5 0.7 1.2 -0.5 1.1 0.8
Depression (self-reported) 0.5 0.6 1.2 -0.5 1.1 0.6
Medication: Lansoprazole 0.4 0.5 1.5 -0.2 1.2 0.2
Prospective memory result 0.3 0.4 1.0 -1.0 0.4 0.1
Lung cancer (father) 0.5 0.5 1.3 1.1 -0.5 0.3
Illnesses of mother 0.1 0.1 0.2 -0.4 -0.4 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.7 8.6 2.9 -1.9 -1.3
Pulse wave Arterial Stiffness index 1.0 1.1 1.4 1.0 -1.2 -1.0
Impedance of arm (left) 0.1 0.4 1.0 0.2 0.4 1.0
Arm fat mass (right) 0.7 2.9 5.9 0.9 -1.4 -2.4
Trunk predicted mass 1.0 5.7 8.0 1.7 -2.8 -2.5
Standing height 1.6 15.7 26.2 3.4 -5.1 -3.0
Length of working week for main job 0.7 0.8 2.0 0.2 -0.6 -1.4
Exposure to tobacco smoke at home 0.1 0.2 0.3 0.5 -0.2 0.4
Breastfed as a baby 1.1 1.3 2.3 1.2 -1.5 -0.5
Tense / ‘highly strung’ 0.0 0.1 0.2 0.0 0.5 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 2.1 1.3 -1.4 -1.4
Hair/balding pattern: Pattern 4 0.2 0.4 1.2 -0.2 -1.1 -0.3
Birth weight of first child 0.4 0.7 1.7 -1.3 0.3 0.4
Peak expiratory flow (PEF) 0.4 0.9 2.0 1.4 -0.4 -0.8
Pulse wave reflection index 0.2 0.3 0.5 0.4 -0.7 -0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 0.4 0.4 0.0
Loud music exposure frequency 0.0 0.0 0.0 0.1 -0.1 -0.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.3 -0.6 -0.1 -0.1
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.0 -0.2 0.1 0.0
Blood clot in the leg (DVT) 0.6 0.7 1.6 -1.3 0.5 0.6
Medication: Paracetamol 1.2 1.9 3.4 0.8 -1.8 -1.3
Headache pain in last month 0.1 0.2 0.3 -0.5 0.6 0.3
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 1.9 1.2 -1.4 -0.4
Glaucoma (self-reported) 8.6 10.1 15.7 -2.2 3.1 4.0
Gout (self-reported) 1.1 1.5 1.6 1.1 -1.3 -1.2
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.4 0.7 -1.5 -1.1
Medication: Amlodipine 0.3 0.5 1.1 -0.5 0.4 -1.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 -0.5 0.3 0.1
Birth weight 0.0 0.1 0.3 0.5 -0.1 0.2
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.6 -0.8 0.8 0.3
High blood pressure (siblings) 0.4 0.5 1.3 1.1 -0.5 -0.1
Forced vital capacity (FVC), Best measure 2.1 7.6 11.5 3.4 -2.7 -1.9
Body fat percentage 0.9 3.5 6.4 1.3 -1.5 -2.5
Leg fat percentage (right) 1.8 6.5 11.9 1.7 -2.2 -3.5
Arm fat-free mass (right) 1.4 7.3 9.7 2.0 -3.1 -2.8
Exposure to tobacco smoke outside home 1.6 2.2 2.6 -1.6 1.6 1.2
Comparative body size at age 10 0.3 0.9 1.1 0.8 -1.0 -1.0
Number of full brothers 0.8 1.0 1.5 -0.8 0.9 1.2
Worry too long after embarrassment 0.2 0.3 0.6 0.8 0.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 1.0 -0.1 -0.6
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 -0.2 -0.2 -0.1
Number of children fathered 1.0 1.1 2.3 0.2 -1.0 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 1.7 1.3 -1.1 -1.3
Age at first live birth 0.6 1.0 2.0 -0.9 0.5 1.4
Pulse wave peak to peak time 0.7 0.8 1.0 -0.8 1.0 0.9
Health satisfaction 1.0 1.4 1.4 1.1 -1.2 -1.2
Shortness of breath walking on level ground 5.5 6.5 7.1 2.3 -2.7 -2.6
Qualifications: College or University degree 0.4 1.3 2.3 1.2 -1.5 -0.5
Eye problems/disorders: None of the above 0.3 0.3 0.7 0.2 -0.5 -0.8
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.3 0.5 -0.4 -0.2
Emphysema/chronic bronchitis 0.3 0.3 1.0 -0.3 1.0 0.0
Medication for pain relief, constipation, heartburn 1.6 2.7 4.4 -0.9 1.7 2.1
Neck or shoulder pain in last month 0.4 0.6 0.9 0.9 -0.6 -0.6
Medication: Blood pressure 1.0 1.7 2.6 -1.5 1.6 0.7
Angina (self-reported) 0.7 0.9 1.4 1.2 -1.0 -0.6
Migraine (self-reported) 5.5 6.8 10.4 3.2 -2.3 -2.2
Medication: Ibuprofen 1.8 2.2 3.7 1.9 -1.7 -0.2
Medication: Allopurinol 1.4 1.8 2.6 0.9 -1.6 -1.4
Medication: Omeprazole 3.2 3.8 5.2 1.5 -2.0 -2.3
Medication: Seretide 50 evohaler 0.4 0.4 0.8 -0.6 -0.4 -0.9
Mean time to correctly identify matches 0.2 0.4 0.7 -0.2 0.8 0.6
Heart disease (mother) 1.4 1.8 2.3 1.3 -1.1 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.8 2.2 3.7 1.1 -1.3 -1.9
Whole body fat mass 1.5 6.1 9.4 1.8 -2.4 -3.1
Leg fat mass (right) 1.6 6.2 10.5 1.7 -2.3 -3.2
Arm predicted mass (right) 1.1 5.9 7.8 1.8 -2.8 -2.6
Pulse rate, automated reading 2.3 7.5 11.4 3.4 -2.5 -2.2
Alcohol intake frequency. 0.2 0.5 0.7 -0.8 0.7 0.5
Comparative height size at age 10 2.1 11.7 16.3 3.6 -4.0 -2.3
Number of full sisters 0.8 1.0 1.5 -0.6 1.2 1.1
Suffer from ‘nerves’ 0.1 0.2 0.5 0.7 0.4 0.2
Overall health rating 1.0 2.2 4.3 1.0 -1.2 -2.1
Chest pain or discomfort 0.1 0.1 0.3 -0.0 0.1 0.5
Had major operations 0.3 0.3 0.9 1.0 -0.2 0.1
Age at last live birth 0.2 0.3 0.4 -0.5 -0.6 -0.3
Family relationship satisfaction 0.7 0.9 1.1 -0.8 1.0 1.0
Leg pain on walking 0.2 0.3 0.6 -0.1 -0.8 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 1.0 -0.2 -0.8 -1.0
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.9 -0.4 0.9 -0.3
Illness, injury, bereavement, stress in last 2 years 1.7 2.0 2.3 -1.5 1.2 1.5
Medication: Aspirin 1.5 2.0 3.4 1.1 -1.1 -1.8
Supplements: Vitamin C 0.3 0.3 0.8 0.1 0.4 0.9
Knee pain experienced in last month 3.5 5.4 7.0 2.7 -2.6 -1.6
Hypertension (Self-reported) 0.1 0.2 0.5 -0.7 0.2 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 0.6 -0.1 -0.3
Illnesses of father: Heart disease 0.3 0.3 0.8 0.0 -0.5 -0.9
Illnesses of siblings: Diabetes 0.4 0.5 0.7 -0.9 0.8 -0.1
Smoking status: Previous 0.7 1.1 1.4 1.0 -0.9 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.6 -0.1 0.6 0.8
Whole body fat-free mass 0.7 4.0 5.7 1.4 -2.4 -2.0
Leg fat-free mass (right) 0.1 0.6 1.1 0.6 -1.0 -0.6
Arm fat percentage (left) 0.3 1.1 3.0 0.5 -0.5 -1.7
Average weekly red wine intake 0.4 0.6 0.9 -0.7 0.7 1.0
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.3 1.0 -1.5 -0.4
Mood swings 0.4 0.7 1.6 -0.3 1.3 0.7
Loneliness, isolation 0.2 0.3 0.5 0.5 0.7 -0.1
Long-standing illness, disability or infirmity 2.4 3.6 5.7 1.2 -1.9 -2.4
Ever had bowel cancer screening 0.5 0.6 1.1 1.1 -0.6 -0.5
Diabetes diagnosed by doctor 0.1 0.2 0.2 0.4 0.4 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 0.3 -1.0 -0.1
Friendships satisfaction 0.9 1.2 1.4 -1.2 0.8 1.2
Qualifications: nursing, teaching 0.5 0.8 1.0 0.9 -1.0 -0.7
Commuting to job workplace: Walk 1.2 1.3 1.8 1.2 -1.3 -0.9
Eye problems/disorders: Cataract 1.2 1.4 1.5 1.2 -1.2 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.9 1.4 -0.5 0.2
Medication for cholesterol 0.5 0.7 1.6 1.3 -0.6 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.6 -0.8 -0.1 -0.8
Back pain experienced in last month 2.2 3.1 3.5 1.9 -1.8 -1.7
Mineral and other dietary supplements 0.0 0.0 0.1 -0.2 0.1 -0.3
Breast cancer (self-reported) 0.5 0.6 1.1 0.7 -1.1 -0.5
Asthma (self-reported) 0.2 0.4 0.7 -0.9 0.5 0.6
Osteoporosis (self-reported) 0.3 0.4 0.9 1.0 -0.4 0.2
Osteoarthritis (self-reported) 1.2 1.6 2.1 0.8 -1.4 -1.4
Medication: Aspirin 0.8 1.1 1.9 0.9 -0.7 -1.4
Medication: Gliclazide 0.2 0.2 0.7 -0.1 -0.1 0.8
Illnesses of father: None of the above (group 1) 0.2 0.3 0.4 0.6 -0.5 -0.5
Smoking status: Current 0.2 0.4 0.8 -0.3 -0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.9 0.9 -0.1 -0.6
Whole body water mass 0.7 3.9 5.6 1.4 -2.4 -2.0
Leg predicted mass (right) 0.1 0.6 1.1 0.5 -1.0 -0.6
Arm fat mass (left) 0.8 3.2 6.3 1.0 -1.5 -2.5
Number of self-reported non-cancer illnesses 0.5 0.9 1.6 1.3 -1.0 -0.5
Average weekly champagne plus white wine intake 0.1 0.1 0.2 -0.5 0.0 -0.0
Miserableness 1.7 2.9 3.7 1.6 -1.5 -1.9
Guilty feelings 0.3 0.4 0.9 0.3 0.5 0.9
Wears glasses or contact lenses 2.1 2.5 4.0 1.0 -2.0 -1.5
Ever taken oral contraceptive pill 1.3 1.4 1.7 -1.0 1.2 1.3
Hearing aid user 0.2 0.2 0.6 -0.8 -0.2 0.1
Mother’s age at death 0.3 0.3 0.5 0.3 0.6 0.7
Financial situation satisfaction 0.9 1.1 1.4 0.9 -1.1 -1.2
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 0.5 0.2 -0.6
Commuting to job workplace: Public transport 0.2 0.2 0.4 0.4 -0.6 -0.2
Eye problems/disorders: Glaucoma 4.3 5.1 5.9 -2.4 1.9 2.4
Medication: Blood pressure 0.1 0.2 0.5 -0.7 0.1 -0.1
Pain type(s) experienced in last month: Hip pain 1.3 1.6 3.2 0.7 -1.8 -1.0
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 -0.5 0.1 -0.1
High cholesterol (Self-reported) 0.5 1.0 1.3 -1.1 0.8 1.0
Medication: Bendroflumethiazide 0.4 0.6 1.0 -1.0 0.9 -0.2
Medication: Paracetamol 0.6 1.0 1.6 0.5 -1.3 -1.1
Medication: Lisinopril 1.0 1.3 2.3 0.5 -1.1 -1.5
Medication: Atorvastatin 2.8 3.5 4.2 -1.9 1.6 2.0
Illnesses of father: High blood pressure 0.5 0.6 1.7 1.3 -0.3 0.2
Alcohol drinker status: Never 1.0 1.2 1.7 -0.9 1.3 1.0
Ever smoked 0.1 0.1 0.4 -0.1 -0.2 -0.6
Basal metabolic rate 0.9 4.8 6.5 1.5 -2.5 -2.4
Leg fat percentage (left) 1.4 4.9 9.0 1.5 -1.9 -3.0
Arm fat-free mass (left) 1.2 6.3 8.4 1.7 -2.9 -2.7
Number of operations (self-reported) 0.1 0.1 0.2 0.4 -0.3 -0.1
Average weekly beer plus cider intake 0.3 0.5 1.0 -0.5 0.4 1.0
Irritability 1.4 2.3 3.0 -1.5 1.7 1.3
Risk taking 0.6 0.9 1.7 1.3 -0.4 -1.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.4 0.5 -0.9 -1.2
Fractured/broken bones in last 5 years 0.7 0.9 1.2 -0.7 1.1 1.0
Age started oral contraceptive pill 0.1 0.2 0.4 0.1 -0.7 0.2
Diastolic blood pressure, automated reading 2.3 7.2 9.6 2.2 -2.7 -3.1
Ever depressed for a whole week 0.4 0.5 1.4 1.2 -0.3 -0.2
Unable to work because of sickness or disability 1.1 1.5 2.4 1.0 -1.0 -1.6
Commuting to job workplace: Cycle 0.1 0.2 0.3 0.0 -0.4 0.6
Myopia 0.3 0.4 0.7 0.2 -0.7 -0.9
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.9 1.0 -0.5 0.2
Cholesterol lowering medication 0.3 0.4 0.6 -0.8 -0.1 -0.7
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 2.4 1.1 -1.5 -1.5
Pain experienced in last month 0.6 1.0 1.4 -0.8 1.2 1.1
Supplements: Calcium 0.5 0.5 1.4 1.2 -0.5 0.1
Basal cell carcinoma (self-reported) 0.7 0.9 1.4 -1.2 1.0 0.3
Heart attack/myocardial infarction (self-reported) 0.9 1.2 1.7 1.0 -1.0 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.2 -1.1 0.2 0.3
Heart disease (siblings) 7.7 9.4 13.4 2.2 -3.2 -3.7
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.0 0.4 0.4
Pack years of smoking 0.9 1.4 2.1 1.0 -1.0 -1.5
Impedance of whole body 0.2 0.9 1.4 1.2 -1.0 -0.3
Leg fat mass (left) 1.3 5.1 8.7 1.5 -2.1 -3.0
Arm predicted mass (left) 1.4 7.0 9.2 1.9 -3.0 -2.9