TWAS
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Genes
Traits
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Traits
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Standing height
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chr2:105,982,753-107,391,406
Best TWAS P=5.37e-12 · Best GWAS P=1.76e-10 conditioned to 0.000478
106M
106.2M
106.4M
106.6M
106.8M
107M
107.2M
107.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
C2orf40
0.20
0.11
bslmm
483
0.13
7.8e-16
3.8
-6.9
5.4e-12
-0.48
1.00
0.00
TRUE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
UXS1
0.04
0.03
enet
4
0.02
1.1e-03
-4.4
-6.8
1.2e-11
-0.45
0.03
0.31
FALSE
2
GTEx
Muscle Skeletal
C2orf40
0.30
0.05
lasso
6
0.14
6.2e-14
-3.0
-5.5
3.2e-08
-0.36
1.00
0.00
FALSE
3
METSIM
Adipose
C2orf40
0.17
0.04
blup
472
0.09
1.3e-13
3.5
-5.2
1.7e-07
-0.35
0.27
0.73
FALSE