TWAS hub - UXS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1370	0.0450	0.00033	0.067	NA	0.062	NA	0.060	2.9e-05	NA	5.5e-05	NA	7.3e-05
2	METSIM	Adipose	0.0443	0.0164	0.00029	0.049	0.016	0.028	0.027	0.035	6.7e-08	0.0014	3.8e-05	5.1e-05	5.0e-06
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0570	0.0292	0.00940	0.011	0.009	0.008	NA	0.015	1.9e-02	0.0270	3.8e-02	NA	7.3e-03
4	TCGA	Brain Lower Grade Glioma	0.0418	0.0217	0.00620	0.027	0.006	0.023	NA	0.013	4.1e-04	0.0570	1.1e-03	NA	1.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Tinnitus: Yes, but not now, but have in the past	4.9	5.2	13.3	3.6	1.7	0.9	2.0
Emphysema/chronic bronchitis	4.6	5.2	10.0	-0.1	3.2	2.0	2.6
Frequency of tiredness / lethargy in last 2 weeks	4.1	6.6	13.9	-0.2	3.7	2.1	2.9
Medication: Atorvastatin	4.1	5.1	11.1	-0.7	2.3	1.9	3.3
Sitting height	3.9	27.8	45.8	-3.3	-4.6	-5.8	-6.8
Handedness (chirality/laterality): Left-handed	3.9	4.7	8.8	0.8	-2.3	-2.1	-3.0
Diastolic blood pressure, automated reading	3.7	11.4	23.1	1.3	-3.2	-4.8	-3.3
Loneliness, isolation	3.5	4.9	9.9	1.2	2.1	2.0	3.1
Ever had bowel cancer screening	3.0	3.5	8.2	2.9	-1.4	-1.7	-1.1
Heart attack	2.7	3.4	5.0	1.0	2.2	1.6	2.2
Average weekly champagne plus white wine intake	2.7	3.7	8.8	0.7	-2.2	0.8	-3.0
Supplements: Calcium	2.7	2.9	8.1	0.7	-1.5	-2.8	-0.9
Heart attack/myocardial infarction (self-reported)	2.7	3.4	5.1	1.1	2.1	1.7	2.3
Risk taking	2.6	3.8	5.8	-0.3	2.2	2.2	2.4
Had other major operations	2.3	2.8	4.8	-1.0	2.2	0.9	2.2
Arm fat-free mass (right)	2.3	11.9	18.2	-2.2	-2.8	-4.3	-4.1
Arm predicted mass (right)	2.3	11.7	18.4	-1.7	-3.0	-4.3	-4.1
Trunk fat-free mass	2.2	12.5	18.2	-2.4	-3.0	-4.3	-4.1
Neck or shoulder pain in last month	2.2	3.1	4.9	1.4	2.0	1.2	2.2
Comparative height size at age 10	2.2	11.9	30.9	-0.7	-2.5	-3.1	-5.6
Smoking status: Current	2.2	3.4	5.0	-2.2	1.9	1.5	1.7
Number of self-reported non-cancer illnesses	2.2	3.8	8.4	2.9	0.3	-2.0	1.7
Trunk predicted mass	2.1	12.2	17.5	-2.4	-3.0	-4.2	-4.1
Standing height	2.1	21.1	46.0	-3.0	-3.3	-4.3	-6.8
Chest pain or discomfort	2.1	3.0	4.1	-1.2	1.8	2.0	1.9
Mineral and other dietary supplements	2.1	2.8	6.6	-0.3	2.0	2.6	0.4
Whole body water mass	2.1	11.7	17.3	-2.0	-3.1	-4.0	-4.2
Alcohol drinker status: Previous	2.1	2.4	3.5	1.5	1.6	1.1	1.9
Angina	2.0	2.7	5.8	0.1	1.5	1.6	2.4
Current tobacco smoking	2.0	3.3	7.2	-2.7	1.7	1.4	1.2
Whole body fat-free mass	2.0	11.2	15.8	-2.2	-3.0	-3.9	-4.0
Medication: Paracetamol	2.0	3.0	4.2	1.3	2.1	1.9	1.6
Unable to work because of sickness or disability	2.0	2.6	5.0	0.6	2.2	1.1	2.0
Bipolar Disorder (2011)	1.9	1.9	6.1	2.5	-1.0	-0.7	-0.2
Pulse wave Arterial Stiffness index	1.9	2.3	3.5	-0.5	-1.9	-1.7	-1.6
Migraine (self-reported)	1.9	2.4	7.0	2.6	-0.9	-1.3	-0.6
Supplements: Vitamin C	1.9	2.3	3.8	1.4	-1.7	-0.5	-2.0
Illnesses of father: None of the above (group 1)	1.9	2.3	6.2	-2.5	-0.6	0.3	-1.6
Illnesses of father: High blood pressure	1.9	2.4	6.0	2.4	-1.5	-1.0	-0.4
Basal metabolic rate	1.9	10.6	15.4	-2.3	-2.7	-3.8	-3.9
Arm fat-free mass (left)	1.9	9.8	15.2	-2.3	-2.5	-3.9	-3.5
Systolic blood pressure, automated reading	1.8	5.2	7.5	2.4	-2.0	-2.7	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.2	7.8	1.1	-2.5	-1.2	-2.8
Pain type(s) experienced in last month: Hip pain	1.8	2.2	4.0	1.9	-1.1	-2.0	0.2
Arm predicted mass (left)	1.8	9.3	14.5	-2.4	-2.4	-3.8	-3.4
Height	1.7	32.3	67.9	-2.9	-3.9	-6.2	-8.2
Number of children fathered	1.7	1.9	5.2	0.2	-1.4	-0.6	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.1	1.8	-1.1	-1.3	-1.4
Angina (self-reported)	1.7	2.2	5.2	0.1	1.4	1.3	2.3
Leg predicted mass (right)	1.7	9.0	14.7	-1.7	-2.8	-3.2	-3.8
Financial situation satisfaction	1.7	2.1	2.8	-1.1	1.6	1.4	1.7
Alzheimer’s Disease (including proxy)	1.6	2.4	4.8	-2.2	0.5	1.9	0.8
Coronary Artery Disease (CAD)	1.6	1.9	3.1	-1.6	1.1	-0.8	1.8
Mean Putamen Volume	1.6	1.8	4.4	-0.9	1.1	2.1	1.0
Multivitamins +/- minerals	1.6	2.0	6.4	-0.3	1.1	-0.6	2.5
High blood pressure (mother)	1.6	2.3	7.6	2.8	-0.4	-1.0	-0.4
Falls in the last year	1.6	2.2	4.2	1.8	2.0	0.4	1.0
Hair/balding pattern: Pattern 4	1.6	3.9	6.9	-0.3	-2.6	-2.0	-2.1
Illnesses of father: Heart disease	1.6	2.2	5.3	1.4	1.2	0.1	2.3
Smoking status: Previous	1.6	2.4	3.3	1.5	-1.8	-1.7	-0.9
Leg fat-free mass (right)	1.6	8.7	14.2	-1.7	-2.8	-3.2	-3.8
Basal cell carcinoma (self-reported)	1.6	1.8	4.3	-0.5	-1.2	-2.1	-1.2
Leg fat-free mass (left)	1.5	8.1	12.7	-1.8	-2.5	-3.2	-3.6
Leg predicted mass (left)	1.5	8.2	12.8	-1.8	-2.5	-3.2	-3.6
Alcohol usually taken with meals	1.5	2.5	3.7	1.9	0.7	1.9	1.5
Forced expiratory volume in 1-second (FEV1)	1.5	4.9	9.4	-0.2	-3.1	-0.9	-3.1
Pulse wave peak to peak time	1.5	1.8	3.1	0.1	1.8	1.5	1.3
Qualifications: nursing, teaching	1.5	2.3	5.0	-1.6	-1.2	-0.3	-2.2
Commuting to job workplace: Walk	1.5	1.6	2.8	0.0	1.0	1.6	1.7
Schizophrenia vs Biploar Disorder	1.4	1.8	4.9	2.2	0.2	1.5	0.5
Major Depression (MDD)	1.4	1.7	3.5	-1.0	-1.2	-1.9	-0.8
Systolic Blood Pressure	1.4	7.2	15.8	0.8	-2.5	-4.0	-2.5
Forced vital capacity (FVC)	1.4	5.4	11.2	-0.7	-2.8	-1.4	-3.4
Alcohol intake versus 10 years previously	1.4	2.1	6.7	0.2	0.9	2.6	1.0
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.0	-0.6	1.6	0.7	1.7
Mood swings	1.4	2.5	3.0	-1.7	1.7	1.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	5.2	-0.1	-1.1	-2.3	0.3
Alzheimer’s Disease (in father)	1.3	1.4	2.2	-1.1	0.6	1.4	1.5
Pain all over the body in last month	1.3	1.4	3.1	-1.8	1.1	0.6	1.0
Lung cancer (father)	1.3	1.5	3.7	0.2	1.0	1.1	1.9
Leg pain on walking	1.3	1.6	3.3	0.1	1.7	0.4	1.8
Ever taken oral contraceptive pill	1.3	1.4	3.0	-1.7	1.0	-0.1	1.3
Irritability	1.3	2.2	7.7	-2.8	0.8	0.7	-0.4
Blood Eosinophil Count	1.2	9.1	27.2	5.2	-1.8	-1.2	-2.1
Pack years adult smoking proportion	1.2	1.8	4.7	-2.2	1.1	0.9	0.6
Medication: Ramipril	1.2	1.6	1.7	1.3	-1.3	-1.3	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	7.8	0.2	-2.7	-0.9	-2.8
Forced vital capacity (FVC), Best measure	1.2	4.2	9.8	-0.2	-2.4	-1.2	-3.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.8	1.5	0.7	0.7	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	6.2	-1.1	-1.3	-1.0	-2.5
Commuting to job workplace: Public transport	1.2	1.5	3.0	-0.7	1.7	0.1	1.5
Hand grip strength (left)	1.1	2.8	5.6	-0.2	-2.2	-2.4	-0.9
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.7	-0.9	1.6	1.4	0.8
Ever had hysterectomy (womb removed)	1.1	1.2	2.1	-1.5	-0.6	-1.5	-0.6
Vitamin and mineral supplements	1.1	1.5	3.8	-0.7	-1.0	0.8	-2.0
Supplements: Zinc	1.1	1.2	3.3	1.8	-0.5	-0.8	-0.7
Townsend deprivation index at recruitment	1.1	1.5	3.3	-1.0	1.8	0.4	1.3
Age when periods started (menarche)	1.1	2.8	4.5	-0.6	-1.9	-2.1	-1.6
Financial difficulties in last 2 years	1.1	1.4	3.8	-1.9	1.2	0.7	0.2
Weight	1.1	5.4	7.3	-2.2	-1.3	-2.7	-2.7
Exposure to tobacco smoke at home	1.1	1.2	4.1	-0.6	2.0	0.6	0.2
Medication: Paracetamol	1.1	1.9	2.9	1.7	1.2	1.6	0.8
Health satisfaction	1.1	1.4	3.2	1.8	-0.5	-0.7	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.8	-1.4	1.2	1.3	0.4
Knee pain experienced in last month	1.1	1.6	3.6	-1.9	0.5	0.6	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.6	0.5	0.3	-1.5	1.6
Medication: Lisinopril	1.1	1.5	1.6	-1.2	1.3	1.1	1.2
Pack years of smoking	1.1	1.6	2.7	-1.6	1.3	1.0	1.0
HbA1C	1.0	1.1	2.4	0.1	1.2	1.6	0.7
Hair/balding pattern: Pattern 2	1.0	1.3	3.3	0.7	-1.1	-1.8	0.4
Loud music exposure frequency	1.0	1.1	2.2	0.4	-1.5	-1.1	-1.0
Long-standing illness, disability or infirmity	1.0	1.6	4.5	2.1	0.3	-1.2	0.5
Pain experienced in last month	1.0	1.6	3.4	0.8	-1.8	0.1	-1.6
Fasting Glucose	0.9	1.1	2.8	-1.7	0.3	-1.2	-0.3
Allergy or Eczema	0.9	2.5	8.7	3.0	0.4	0.7	0.7
Stomach or abdominal pain in last month	0.9	1.1	2.7	0.9	0.8	0.3	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.0	1.0	-1.5	-1.3	-1.7
Hip circumference	0.9	3.7	7.2	-1.6	-1.2	-2.7	-1.9
Hypertension (Self-reported)	0.9	2.6	8.2	2.9	-0.2	-1.4	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.2	-0.9	0.6	0.8	1.5
Friendships satisfaction	0.9	1.1	1.7	0.2	1.2	1.3	1.0
Medication for cholesterol	0.9	1.3	2.6	-1.5	0.6	1.6	0.4
Miserableness	0.9	1.5	5.4	-2.3	0.7	-0.2	-0.3
Breast Cancer	0.8	1.9	2.3	-1.2	-1.3	-1.5	-1.5
LDL Cholesterol	0.8	1.3	2.5	1.3	-0.9	0.1	-1.6
Number of treatments/medications taken	0.8	1.4	2.3	0.9	1.1	-1.0	1.5
High blood pressure	0.8	2.3	6.3	2.5	-0.5	-1.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.4	-1.2	-0.4	-1.2	-0.9
Medication: Lansoprazole	0.8	0.9	2.7	1.6	0.4	-0.1	0.8
Prospective memory result	0.8	1.0	2.9	0.8	0.6	-0.4	1.7
Headache pain in last month	0.8	1.3	2.7	0.4	1.6	0.6	1.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.8	-0.7	-1.4	-1.9	0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.1	-0.2	-1.1	-0.5	-1.4
Back pain experienced in last month	0.8	1.1	2.7	-0.7	1.6	0.3	1.1
Fractured/broken bones in last 5 years	0.8	1.0	2.0	1.4	-0.3	-1.4	-0.4
Heart disease (siblings)	0.8	0.9	2.5	-0.8	0.1	-1.6	-0.8
Alzheimer’s Disease (in mother)	0.7	0.9	1.7	-1.3	-0.1	1.3	-0.4
Crohns Disease (2017)	0.7	1.6	3.6	0.1	1.9	0.3	1.7
Neuroticism (2016)	0.7	1.1	2.3	-0.7	1.5	0.4	1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	-0.1	-0.6	-0.9	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.2	-0.7	1.5	0.7	0.8
Medication: Atenolol	0.7	0.9	1.4	0.3	-0.9	-1.2	-1.2
Trunk fat mass	0.7	3.0	6.2	-1.6	-0.9	-1.6	-2.5
Qualifications: A levels/AS levels or equivalent	0.7	1.4	2.4	1.6	-1.2	0.8	-1.2
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-1.4	1.0	0.5	0.5
Comparative body size at age 10	0.7	1.8	3.3	-0.8	1.3	1.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.7	0.5	1.6	0.3	0.7
Medication: Ibuprofen	0.7	0.9	1.9	-0.6	1.1	1.4	0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.6	1.6	-0.4	-0.5	0.8
Mother’s age at death	0.7	0.9	3.0	0.5	-0.5	-0.1	-1.7
Medication: Blood pressure	0.7	1.3	2.8	1.5	-0.1	-1.7	0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.9	0.2	-1.2	-1.4	0.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	5.3	-2.3	0.1	1.4	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	-0.8	1.6	0.4	0.4
Schizophrenia (2018)	0.6	1.3	3.0	1.7	-1.4	-0.4	-0.6
Ovarian Cancer	0.6	0.8	2.6	0.4	0.0	1.6	0.6
Schizophrenia (2014)	0.6	1.4	3.8	1.9	-1.2	-0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.9	-0.9	1.7	0.2	1.0
Lung FVC	0.6	3.2	8.5	1.5	-2.9	-0.6	-1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.2	-0.8	0.8	0.7	1.1
Diabetes (father)	0.6	0.8	1.2	-1.1	0.6	-0.8	-1.0
Taking other prescription medications	0.6	1.0	3.0	0.5	0.3	-1.7	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	-1.4	0.1	-1.0	0.0
Hayfever, allergic rhinitis or eczema	0.6	1.4	5.2	2.3	-0.4	0.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.4	0.1	1.2	1.1	1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.3	-0.4	0.2	-1.5	0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.7	1.0	0.5	-0.1	1.3
Medication: Simvastatin	0.6	0.9	2.3	0.4	-0.7	-1.5	-0.9
Fluid intelligence score	0.6	1.2	2.0	0.7	0.6	1.4	1.4
Illnesses of siblings	0.6	0.8	2.3	-1.5	0.5	0.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.2	-0.4	0.8	1.5	-0.1
Tense / ‘highly strung’	0.6	1.0	1.6	0.3	-1.2	-1.3	-0.9
Eye problems/disorders: None of the above	0.6	0.7	1.2	-0.9	0.2	0.8	1.1
Heart disease (mother)	0.6	0.8	2.2	0.1	0.9	1.5	-0.1
Had major operations	0.6	0.7	2.0	-0.5	-0.6	-1.4	-0.4
Age at last live birth	0.6	0.9	2.7	1.6	-0.6	-0.6	0.3
Osteoporosis (self-reported)	0.6	0.7	1.4	0.4	-0.8	-1.2	-0.7
Osteoarthritis (self-reported)	0.6	0.8	1.9	0.1	-0.5	-1.4	-1.0
Wears glasses or contact lenses	0.6	0.7	2.6	-1.6	0.2	-0.4	0.3
Hearing aid user	0.6	0.7	1.6	-1.3	0.9	-0.4	-0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.3	1.5	-0.6	0.2	-0.2
Commuting to job workplace: Cycle	0.6	0.7	2.0	1.4	0.1	-0.3	0.9
Cholesterol lowering medication	0.6	0.8	1.6	1.2	0.2	-1.2	0.4
Crohns Disease (2012)	0.5	0.8	1.5	0.3	1.1	-0.4	1.2
Lupus	0.5	0.8	2.6	1.6	0.2	-0.4	-0.7
Diabetes (mother)	0.5	0.6	1.3	0.3	-0.7	-1.1	-0.7
Impedance of leg (right)	0.5	2.2	4.8	-0.4	2.2	1.9	0.6
Fed-up feelings	0.5	0.8	1.8	-1.0	-0.7	-0.5	-1.3
Medication: Levothyroxine sodium	0.5	0.9	1.9	-0.4	-1.1	-1.4	0.4
Qualifications: None of the above	0.5	1.1	2.3	-0.6	1.5	-0.8	1.2
Time employed in main current job	0.5	0.6	1.9	1.4	0.3	-0.6	0.1
Father’s age at death	0.5	0.7	1.7	1.3	0.0	0.9	0.5
Noisy workplace	0.5	0.6	1.1	-1.1	0.9	0.5	0.6
Mouth/teeth dental problems: Dentures	0.5	0.8	1.9	0.5	1.4	0.5	1.0
Impedance of arm (left)	0.5	2.2	6.1	0.6	1.5	2.5	0.2
Length of working week for main job	0.5	0.6	1.8	0.3	0.5	0.1	1.3
Birth weight of first child	0.5	0.9	2.0	1.4	1.0	0.8	0.2
Blood clot in the leg (DVT)	0.5	0.6	1.7	-0.8	1.3	0.3	0.3
Medication: Amlodipine	0.5	0.8	1.8	0.8	0.8	-0.4	1.3
Age at first live birth	0.5	0.9	3.3	1.8	-0.7	0.0	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	-1.1	0.4	0.7	0.8
Overall health rating	0.5	1.2	1.8	1.1	1.3	-1.0	0.8
Average weekly red wine intake	0.5	0.8	1.5	-0.1	-1.2	-0.9	-0.8
Eye problems/disorders: Cataract	0.5	0.6	1.1	0.8	1.1	0.6	0.5
Medication: Aspirin	0.5	0.6	1.4	-0.3	0.9	0.3	1.2
High cholesterol (Self-reported)	0.5	0.8	2.1	1.5	-0.1	-0.9	0.7
Medication: Bendroflumethiazide	0.5	0.7	1.7	1.3	0.5	-1.0	0.2
Alcohol drinker status: Never	0.5	0.7	1.1	-0.6	1.0	1.1	0.3
Impedance of whole body	0.5	2.5	6.2	0.0	1.9	2.5	0.3
Bipolar Disorder or Schizophrenia	0.4	1.1	2.0	1.4	-1.2	-0.7	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.5	-1.6	0.5	0.2	0.6
Triglycerides	0.4	0.7	1.0	0.9	-0.9	-0.1	-1.0
Cardiovascular Disease	0.4	1.2	2.3	1.5	-0.2	-1.4	0.5
Respiratory disease	0.4	0.9	2.7	0.5	1.6	0.1	0.7
Hearing difficulty/problems: Yes	0.4	0.7	2.1	-0.8	-0.3	-0.1	-1.4
Medication for hormone replacement therapy	0.4	0.4	1.2	-0.3	-0.6	0.2	-1.1
Medication: Metformin	0.4	0.6	1.3	0.1	0.8	-0.5	1.1
Average weekly fortified wine intake	0.4	0.4	0.8	0.6	0.9	0.2	0.7
Relative age voice broke	0.4	0.6	1.0	-0.1	0.7	1.0	1.0
Supplements: Glucosamine	0.4	0.6	1.1	-0.1	0.1	-1.1	1.1
Impedance of leg (left)	0.4	2.1	3.9	-0.8	2.0	1.9	0.4
Allergy	0.4	0.9	3.6	-1.9	-0.3	0.3	0.1
Neuroticism score	0.4	0.7	1.9	-1.4	0.7	-0.1	0.8
Impedance of arm (right)	0.4	1.9	5.1	0.6	1.5	2.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.7	-0.8	0.8	0.8	0.4
Illnesses of mother	0.4	0.5	1.1	-1.0	-0.7	-0.3	0.5
High blood pressure (siblings)	0.4	0.5	1.3	1.1	0.6	0.3	0.6
Wheeze or whistling in the chest in last year	0.4	0.6	1.2	0.8	1.1	-0.2	0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	1.3	0.2	-1.1	-0.3	-1.1
Mean time to correctly identify matches	0.4	0.7	1.2	0.0	1.1	0.9	0.8
Whole body fat mass	0.4	1.7	2.6	-1.6	-0.3	-1.3	-1.6
Suffer from ‘nerves’	0.4	0.6	0.9	0.9	-0.6	-0.9	0.7
Family relationship satisfaction	0.4	0.5	1.4	0.4	-0.6	0.3	-1.2
Medication: Aspirin	0.4	0.6	1.1	-0.4	1.0	0.2	1.1
Illnesses of siblings: Diabetes	0.4	0.5	0.8	-0.3	-0.9	-0.8	-0.8
Number of operations (self-reported)	0.4	0.6	0.8	0.9	0.6	-0.7	0.9
Age started oral contraceptive pill	0.4	0.5	1.5	1.2	0.1	0.3	0.6
Reaction Time	0.3	0.5	0.8	-0.9	0.7	0.7	0.6
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	0.0	-0.3	-1.0	-0.7
Rheumatoid Arthritis	0.3	0.4	0.8	0.7	0.0	-0.3	0.9
Ulcerative Colitis	0.3	0.4	0.8	-0.7	-0.4	-0.2	-0.9
Blood Platelet Count	0.3	3.3	11.1	3.3	-1.1	0.6	-0.7
Waist Hip Ratio (WHR)	0.3	1.3	1.7	1.2	1.2	0.8	1.3
Sensitivity / hurt feelings	0.3	0.4	0.6	-0.6	0.7	0.8	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.1	0.9	-0.3	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.7	-0.3	-0.8	0.2
Medication: Co-codamol	0.3	0.4	1.0	0.1	1.0	0.8	-0.1
Severe depression (siblings)	0.3	0.4	1.3	0.0	0.0	-1.1	0.4
Hand grip strength (right)	0.3	0.9	2.1	-1.1	-0.6	-1.5	-0.1
Qualifications: CSEs or equivalent	0.3	0.3	1.3	0.1	-0.1	0.1	-1.1
Waist circumference	0.3	1.1	2.6	-1.0	0.0	-1.6	-0.9
Past tobacco smoking	0.3	0.6	0.8	-0.9	0.9	0.9	-0.1
Had menopause	0.3	0.3	0.6	0.7	-0.2	-0.8	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.0	0.0	0.2	0.5	-1.0
Glaucoma (self-reported)	0.3	0.3	0.6	-0.4	0.8	0.6	0.5
Shortness of breath walking on level ground	0.3	0.4	1.5	-0.0	0.1	-1.2	-0.1
Qualifications: College or University degree	0.3	1.1	2.5	1.6	-0.9	-0.5	0.9
Medication: Blood pressure	0.3	0.5	0.7	0.8	0.1	-0.7	0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.5	-0.6	0.3	-0.7	-0.7
Leg fat mass (right)	0.3	1.0	1.9	-1.3	0.1	-1.4	-0.7
Pulse rate, automated reading	0.3	0.8	2.9	-0.3	0.5	-1.7	0.3
Number of full sisters	0.3	0.4	1.3	-0.4	-0.2	-1.1	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	-0.7	0.6	0.1	-0.6
Ever depressed for a whole week	0.3	0.4	0.8	-0.5	0.9	0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	0.5	0.3	-1.1	0.3
Leg fat mass (left)	0.3	1.1	2.2	-1.5	0.1	-1.3	-0.7
Depression (Nagel 2018)	0.2	0.3	0.7	-0.2	0.4	0.5	0.8
Neuroticism (Nagel 2018)	0.2	0.5	1.1	-1.1	-0.0	-0.8	0.6
Worry (Nagel 2018)	0.2	0.4	1.6	0.0	-0.2	-1.2	0.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	0.4	1.1	0.4	0.8
Ulcerative Colitis (UC)	0.2	0.4	1.0	1.0	-0.4	0.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.4	0.7	0.0	0.6	1.2
Prostate Cancer	0.2	0.2	0.9	0.1	0.2	0.2	0.9
Age at First Birth	0.2	0.3	0.4	0.2	-0.6	-0.7	0.4
HDL Cholesterol	0.2	0.4	1.3	1.1	0.2	-0.3	0.4
Primary Biliary Cirrhosis	0.2	0.2	0.5	-0.6	-0.3	-0.0	0.7
Heel T-Score	0.2	1.4	2.5	1.1	-1.6	-0.9	-1.0
Hypothyroidism (self reported)	0.2	0.5	0.9	0.7	-0.9	-0.8	0.0
Lung FEV1/FVC ratio	0.2	1.0	2.3	0.4	-0.9	1.5	-0.7
Chronotype (morning person)	0.2	0.4	1.1	-0.3	-0.3	-1.0	-0.6
Tanning	0.2	2.5	6.2	-0.0	-1.7	-0.9	-2.5
Average weekly spirits intake	0.2	0.3	0.5	-0.5	0.4	-0.3	-0.7
Relative age of first facial hair	0.2	0.4	1.6	-0.2	-0.1	0.3	1.3
Trunk fat percentage	0.2	0.9	1.9	-1.2	0.1	-0.2	-1.4
Serious illness, injury or assault to yourself	0.2	0.3	0.6	0.8	-0.5	0.1	-0.4
Number of incorrect matches in round	0.2	0.3	0.8	0.5	0.9	0.2	0.3
Diabetes (self-reported)	0.2	0.3	0.5	-0.6	0.6	-0.7	-0.3
Worrier / anxious feelings	0.2	0.4	0.9	0.2	0.9	-0.4	0.7
Number of live births	0.2	0.3	1.1	-1.0	0.1	0.4	-0.1
Pulse rate	0.2	0.3	0.7	0.1	0.4	-0.9	-0.7
Asthma	0.2	0.5	1.3	1.1	0.4	-0.6	-0.2
Depression (self-reported)	0.2	0.2	0.3	-0.4	0.4	-0.4	0.5
Arm fat mass (right)	0.2	1.0	1.4	-1.2	-0.3	-1.1	-1.0
Breastfed as a baby	0.2	0.2	0.6	-0.8	-0.3	-0.5	0.0
Peak expiratory flow (PEF)	0.2	0.5	1.8	-0.2	-1.3	0.3	-0.3
Pulse wave reflection index	0.2	0.3	0.9	-0.3	-0.9	-0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.5	-0.4	0.8	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.0	-0.3	0.9	-0.7
Gout (self-reported)	0.2	0.2	0.4	0.2	-0.5	-0.6	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	-0.4	0.4	-0.8	-0.3
Leg fat percentage (right)	0.2	0.7	1.1	-1.1	1.1	-0.3	0.8
Number of full brothers	0.2	0.3	0.9	0.2	-0.4	-1.0	0.1
Worry too long after embarrassment	0.2	0.4	1.1	-0.1	-0.5	-1.1	-0.0
Medication: Allopurinol	0.2	0.3	0.5	0.7	-0.4	-0.3	0.6
Medication: Omeprazole	0.2	0.2	0.8	0.1	0.0	-0.9	0.2
Alcohol intake frequency.	0.2	0.6	1.2	0.5	1.1	0.7	0.5
Asthma (self-reported)	0.2	0.4	1.1	1.1	0.7	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.7	0.4	-0.8	0.6	0.5
Arm fat mass (left)	0.2	0.7	1.0	-1.0	-0.2	-1.0	-1.0
Guilty feelings	0.2	0.3	0.4	-0.4	-0.6	-0.4	-0.7
Leg fat percentage (left)	0.2	0.7	1.3	-1.1	1.0	-0.2	0.7
Average weekly beer plus cider intake	0.2	0.4	0.5	-0.7	-0.5	-0.3	-0.7
Bipolar Disorder (2018)	0.1	0.1	0.4	0.1	-0.2	-0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.8	-0.1	-0.3	0.8
Blood Red Count	0.1	1.1	1.3	-1.0	-0.8	-1.1	-1.1
BMI	0.1	0.5	1.0	-1.0	0.0	-1.0	0.2
Smoking Status	0.1	0.2	0.3	-0.1	-0.5	-0.3	0.6
Neuroticism	0.1	0.2	0.6	-0.0	0.8	-0.2	0.6
Hair Pigment	0.1	2.2	3.2	-1.6	1.5	1.8	0.9
Maternal smoking around birth	0.1	0.1	0.2	-0.3	-0.1	-0.5	-0.4
Chronic bronchitis/emphysema (father)	0.1	0.2	0.6	0.7	0.2	-0.2	0.2
Body mass index (BMI)	0.1	0.4	0.8	-0.9	0.2	-0.7	0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.4	0.3	0.2	-0.6
Mouth/teeth dental problems	0.1	0.2	0.8	-0.9	0.2	-0.1	-0.1
Arm fat percentage (right)	0.1	0.3	0.6	-0.8	0.7	0.2	0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.4	0.7	0.0	-0.3
Medication: Cholesterol lowering	0.1	0.1	0.1	-0.3	0.3	-0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.4	0.5	-0.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.0	0.5	0.3	0.4
Body fat percentage	0.1	0.6	1.6	-1.2	0.6	-0.2	-0.6
Arm fat percentage (left)	0.1	0.2	0.5	-0.5	0.7	0.3	0.2
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	0.7	-0.4	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.5	-0.3	-0.1	-0.3
Breast cancer (self-reported)	0.1	0.2	0.5	0.7	0.2	0.4	-0.0
Medication: Gliclazide	0.1	0.1	0.4	-0.1	0.6	-0.2	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	0.4	0.5	0.0
Myopia	0.1	0.1	0.3	0.1	0.1	-0.1	0.5
Blood White Count	0.0	0.3	0.6	-0.8	-0.1	-0.5	-0.5
Nervous feelings	0.0	0.0	0.1	0.4	0.0	-0.2	-0.1
Happiness	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.2
Birth weight	0.0	0.1	0.4	0.6	0.1	0.1	0.1
Ever smoked	0.0	0.0	0.1	-0.0	0.0	0.2	0.2

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